ATE48278T1 - Verfahren zur herstellung von 2'desoxyadenosinverbindungen. - Google Patents
Verfahren zur herstellung von 2'desoxyadenosinverbindungen.Info
- Publication number
- ATE48278T1 ATE48278T1 AT85108955T AT85108955T ATE48278T1 AT E48278 T1 ATE48278 T1 AT E48278T1 AT 85108955 T AT85108955 T AT 85108955T AT 85108955 T AT85108955 T AT 85108955T AT E48278 T1 ATE48278 T1 AT E48278T1
- Authority
- AT
- Austria
- Prior art keywords
- desoxyadenosine
- compounds
- processes
- preparation
- deoxyadenosine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63819284A | 1984-08-06 | 1984-08-06 | |
| EP85108955A EP0173059B1 (de) | 1984-08-06 | 1985-07-17 | Verfahren zur Herstellung von 2'-Desoxyadenosinverbindungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE48278T1 true ATE48278T1 (de) | 1989-12-15 |
Family
ID=24559020
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT85108955T ATE48278T1 (de) | 1984-08-06 | 1985-07-17 | Verfahren zur herstellung von 2'desoxyadenosinverbindungen. |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP0173059B1 (de) |
| JP (2) | JPS61106594A (de) |
| AT (1) | ATE48278T1 (de) |
| AU (1) | AU572673B2 (de) |
| CA (1) | CA1269659A (de) |
| DE (1) | DE3574472D1 (de) |
| DK (1) | DK165453C (de) |
| ES (1) | ES8606383A1 (de) |
| ZA (1) | ZA855696B (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0217199A (ja) * | 1988-07-05 | 1990-01-22 | Japan Tobacco Inc | ２’−デオキシ−β−アデノシンの製造方法 |
| JPH02160799A (ja) * | 1988-12-13 | 1990-06-20 | Yuki Gosei Kogyo Co Ltd | ２′−デオキシ−β−アデノシンの製造法 |
| US5208327A (en) | 1991-12-18 | 1993-05-04 | Ortho Pharmaceutical Corporation | Intermediates useful in a synthesis of 2-chloro-2'-deoxyadenosine |
| US7572909B2 (en) * | 2002-09-25 | 2009-08-11 | Brigham Young University | Method for the preparation of 2-halo-2′-deoxyadenosine compounds from 2′-deoxyguanosine |
| EP2275110B1 (de) | 2004-12-22 | 2013-07-10 | Merck Serono SA | Cladribin Dosierschema zur Behandlung von multipler Sklerose |
| CA2649810A1 (en) | 2006-05-24 | 2007-11-29 | Laboratoires Serono S.A. | Cladribine regimen for treating multiple sclerosis |
| ES2335796T3 (es) | 2006-12-15 | 2010-04-05 | Explora Laboratories Sa | Metodo para la produccion de cladribina. |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| WO2010075517A2 (en) | 2008-12-23 | 2010-07-01 | Pharmasset, Inc. | Nucleoside analogs |
| NZ593648A (en) | 2008-12-23 | 2013-09-27 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| PA8855801A1 (es) | 2008-12-23 | 2010-07-27 | Sintesis de nucleosidos de purina | |
| US8232387B2 (en) | 2009-08-18 | 2012-07-31 | Scinopharm Taiwan, Ltd. | Process for the preparation of cladribine |
| EP2343074A1 (de) | 2009-12-23 | 2011-07-13 | Merck Serono S.A. | Verwendung von Purinanaloga zur Behandlung von Atemwegserkrankungen |
| WO2011113476A2 (en) | 2010-03-16 | 2011-09-22 | Cilag Ag | Method for producing 2'-deoxyadenosine compounds |
| ES2551944T3 (es) | 2010-03-31 | 2015-11-24 | Gilead Pharmasset Llc | (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-dioxo-3,4-dihidropirimidin-1-(2H)-il)-4-fluoro-3-hidroxi-4-metiltetrahidrofuran-2-il)metoxi)(fenoxi)fosforil)amino)propanoato de isopropilo cristalino |
| GB201401465D0 (en) | 2014-01-29 | 2014-03-12 | Roach Arthur H | Use of cladribine for treating autoimmune inflammatory disease |
| EP2993177A1 (de) | 2014-09-05 | 2016-03-09 | Technische Universität Berlin | Chemoenzymatisches Herstellungsverfahren für Purinnucleosiden und deren Deaza- und Aza-Analoga |
| GB2564717A (en) | 2017-07-21 | 2019-01-23 | Chord Therapeutics S A R L | Use of cladribine for treating autoimmune neuromuscular disease |
| JP2021504363A (ja) | 2017-11-24 | 2021-02-15 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ | 進行型多発性硬化症の処置における使用のためのクラドリビン処方計画 |
| MX2023002843A (es) | 2020-09-10 | 2023-03-31 | Merck Patent Gmbh | Nuevo regimen de tratamiento para el tratamiento de trastornos autoinmunitarios. |
| GB2601786A (en) | 2020-12-10 | 2022-06-15 | Chord Therapeutics S A R L | Use of cladribine for treating immune brain disease |
| JP2024508151A (ja) | 2021-03-03 | 2024-02-22 | アレス トレーディング ソシエテ アノニム | 自己免疫疾患治療のためのｄｍｄを使用する改善された治療法、並びに該治療法を予測及び／又は最適化するためのバイオマーカー |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3225029A (en) * | 1962-03-08 | 1965-12-21 | Yamaoka Naotaka | Process for the preparation of nucleosides and products obtained thereby |
| US3225009A (en) * | 1962-05-21 | 1965-12-21 | Scott Paper Co | Ethylene dicarboxylic esters of 1,2 alkane carbonates, polymers, and copolymers thereof |
| DE1795357A1 (de) * | 1968-09-18 | 1972-01-05 | Schering Ag | 2-Thio-pyrimidin-nucleoside |
| ATE92499T1 (de) * | 1984-12-04 | 1993-08-15 | Lilly Co Eli | Tumorbehandlung bei saeugetieren. |
-
1985
- 1985-07-15 CA CA000486828A patent/CA1269659A/en not_active Expired - Lifetime
- 1985-07-17 EP EP85108955A patent/EP0173059B1/de not_active Expired
- 1985-07-17 AT AT85108955T patent/ATE48278T1/de not_active IP Right Cessation
- 1985-07-17 DE DE8585108955T patent/DE3574472D1/de not_active Expired - Lifetime
- 1985-07-18 AU AU45138/85A patent/AU572673B2/en not_active Expired
- 1985-07-29 ZA ZA855696A patent/ZA855696B/xx unknown
- 1985-08-02 JP JP60170973A patent/JPS61106594A/ja active Granted
- 1985-08-05 ES ES545888A patent/ES8606383A1/es not_active Expired
- 1985-08-06 DK DK357585A patent/DK165453C/da not_active IP Right Cessation
-
1989
- 1989-07-11 JP JP1178889A patent/JPH0256497A/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP0173059B1 (de) | 1989-11-29 |
| EP0173059A2 (de) | 1986-03-05 |
| JPH02359B2 (de) | 1990-01-08 |
| JPH0256497A (ja) | 1990-02-26 |
| AU4513885A (en) | 1986-02-13 |
| JPS61106594A (ja) | 1986-05-24 |
| AU572673B2 (en) | 1988-05-12 |
| ES8606383A1 (es) | 1986-04-01 |
| ES545888A0 (es) | 1986-04-01 |
| DK357585D0 (da) | 1985-08-06 |
| DK165453B (da) | 1992-11-30 |
| EP0173059A3 (en) | 1987-04-29 |
| DK165453C (da) | 1993-04-13 |
| DK357585A (da) | 1986-02-07 |
| ZA855696B (en) | 1986-04-30 |
| DE3574472D1 (de) | 1990-01-04 |
| CA1269659A (en) | 1990-05-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EELA | Cancelled due to lapse of time |