DK165453C - Fremgangsmaade til fremstilling af 2'-desoxyadenosinforbindelser - Google Patents

Fremgangsmaade til fremstilling af 2'-desoxyadenosinforbindelser

Info

Publication number
DK165453C
DK165453C DK357585A DK357585A DK165453C DK 165453 C DK165453 C DK 165453C DK 357585 A DK357585 A DK 357585A DK 357585 A DK357585 A DK 357585A DK 165453 C DK165453 C DK 165453C
Authority
DK
Denmark
Prior art keywords
desoxyadenos
preparing
compounds
deoxyadenosine
dichloropurine
Prior art date
Application number
DK357585A
Other languages
English (en)
Other versions
DK165453B (da
DK357585D0 (da
DK357585A (da
Inventor
Roland Kenith Robins
Ganapathi Ramakrishna Revankar
Original Assignee
Univ Brigham Young
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Brigham Young filed Critical Univ Brigham Young
Publication of DK357585D0 publication Critical patent/DK357585D0/da
Publication of DK357585A publication Critical patent/DK357585A/da
Publication of DK165453B publication Critical patent/DK165453B/da
Application granted granted Critical
Publication of DK165453C publication Critical patent/DK165453C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK357585A 1984-08-06 1985-08-06 Fremgangsmaade til fremstilling af 2'-desoxyadenosinforbindelser DK165453C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63819284A 1984-08-06 1984-08-06
US63819284 1984-08-06

Publications (4)

Publication Number Publication Date
DK357585D0 DK357585D0 (da) 1985-08-06
DK357585A DK357585A (da) 1986-02-07
DK165453B DK165453B (da) 1992-11-30
DK165453C true DK165453C (da) 1993-04-13

Family

ID=24559020

Family Applications (1)

Application Number Title Priority Date Filing Date
DK357585A DK165453C (da) 1984-08-06 1985-08-06 Fremgangsmaade til fremstilling af 2'-desoxyadenosinforbindelser

Country Status (9)

Country Link
EP (1) EP0173059B1 (da)
JP (2) JPS61106594A (da)
AT (1) ATE48278T1 (da)
AU (1) AU572673B2 (da)
CA (1) CA1269659A (da)
DE (1) DE3574472D1 (da)
DK (1) DK165453C (da)
ES (1) ES8606383A1 (da)
ZA (1) ZA855696B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0217199A (ja) * 1988-07-05 1990-01-22 Japan Tobacco Inc ２’−デオキシ−β−アデノシンの製造方法
JPH02160799A (ja) * 1988-12-13 1990-06-20 Yuki Gosei Kogyo Co Ltd ２′−デオキシ−β−アデノシンの製造法
US5208327A (en) * 1991-12-18 1993-05-04 Ortho Pharmaceutical Corporation Intermediates useful in a synthesis of 2-chloro-2'-deoxyadenosine
US7572909B2 (en) * 2002-09-25 2009-08-11 Brigham Young University Method for the preparation of 2-halo-2′-deoxyadenosine compounds from 2′-deoxyguanosine
SG160391A1 (en) 2004-12-22 2010-04-29 Merck Serono Sa Cladribine regimen for treating multiple sclerosis
US9925151B2 (en) 2006-05-24 2018-03-27 Merck Serono Sa Cladribine regimen for treating multiple sclerosis
SI1932918T1 (sl) 2006-12-15 2010-02-26 Explora Lab Sa Postopek izdelave kladribina
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
WO2010075517A2 (en) 2008-12-23 2010-07-01 Pharmasset, Inc. Nucleoside analogs
CL2009002207A1 (es) 2008-12-23 2011-02-18 Gilead Pharmasset Llc Compuestos derivados de 3-hidroxi-5-(9h-purin-9-il)tetrahidrofuran-2-il, inhibidor de la replicacion de arn viral dependiente de arn; composicion farmaceutica; uso para el tratamiento de hepatitis c.
SG172363A1 (en) 2008-12-23 2011-07-28 Pharmasset Inc Synthesis of purine nucleosides
US8232387B2 (en) 2009-08-18 2012-07-31 Scinopharm Taiwan, Ltd. Process for the preparation of cladribine
EP2343074A1 (en) 2009-12-23 2011-07-13 Merck Serono S.A. Use of purine analogues for treating airway diseases
WO2011113476A2 (en) 2010-03-16 2011-09-22 Cilag Ag Method for producing 2'-deoxyadenosine compounds
AP3515A (en) 2010-03-31 2016-01-11 Gilead Pharmasset Llc Nucleoside phosphoramidates
GB201401465D0 (en) 2014-01-29 2014-03-12 Roach Arthur H Use of cladribine for treating autoimmune inflammatory disease
EP2993177A1 (en) 2014-09-05 2016-03-09 Technische Universität Berlin A chemo-enzymatic preparation method for purine nucleosides and their deaza- and aza- analogues
GB2564717A (en) 2017-07-21 2019-01-23 Chord Therapeutics S A R L Use of cladribine for treating autoimmune neuromuscular disease
BR112020010282A2 (pt) 2017-11-24 2020-11-17 Merck Patent Gmbh regime de cladribina para uso no tratamento de formas progressivas de esclerose múltipla
JP2023541877A (ja) 2020-09-10 2023-10-04 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング 自己免疫障害の処置のための新規の処置レジメン
GB2601786A (en) 2020-12-10 2022-06-15 Chord Therapeutics S A R L Use of cladribine for treating immune brain disease
EP4302091A1 (en) 2021-03-03 2024-01-10 Ares Trading S.A. Improved treatment methods using dmds for the treatment of autoimmune diseases, and biomarker for predicting and/or optimising said treatment methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3225029A (en) * 1962-03-08 1965-12-21 Yamaoka Naotaka Process for the preparation of nucleosides and products obtained thereby
US3225009A (en) * 1962-05-21 1965-12-21 Scott Paper Co Ethylene dicarboxylic esters of 1,2 alkane carbonates, polymers, and copolymers thereof
DE1795357A1 (de) * 1968-09-18 1972-01-05 Schering Ag 2-Thio-pyrimidin-nucleoside
EP0184365B1 (en) * 1984-12-04 1993-08-04 Eli Lilly And Company Improvements in the treatment of tumors in mammals

Also Published As

Publication number Publication date
ZA855696B (en) 1986-04-30
JPS61106594A (ja) 1986-05-24
CA1269659A (en) 1990-05-29
JPH02359B2 (da) 1990-01-08
JPH0256497A (ja) 1990-02-26
EP0173059A3 (en) 1987-04-29
EP0173059B1 (en) 1989-11-29
EP0173059A2 (en) 1986-03-05
DK165453B (da) 1992-11-30
AU572673B2 (en) 1988-05-12
ATE48278T1 (de) 1989-12-15
AU4513885A (en) 1986-02-13
DE3574472D1 (de) 1990-01-04
DK357585D0 (da) 1985-08-06
ES545888A0 (es) 1986-04-01
ES8606383A1 (es) 1986-04-01
DK357585A (da) 1986-02-07

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PUP Patent expired