DK165453C - Fremgangsmaade til fremstilling af 2'-desoxyadenosinforbindelser - Google Patents

Fremgangsmaade til fremstilling af 2'-desoxyadenosinforbindelser

Info

Publication number
DK165453C
DK165453C DK357585A DK357585A DK165453C DK 165453 C DK165453 C DK 165453C DK 357585 A DK357585 A DK 357585A DK 357585 A DK357585 A DK 357585A DK 165453 C DK165453 C DK 165453C
Authority
DK
Denmark
Prior art keywords
desoxyadenos
preparing
compounds
deoxyadenosine
dichloropurine
Prior art date
Application number
DK357585A
Other languages
English (en)
Other versions
DK165453B (da
DK357585D0 (da
DK357585A (da
Inventor
Roland Kenith Robins
Ganapathi Ramakrishna Revankar
Original Assignee
Univ Brigham Young
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Brigham Young filed Critical Univ Brigham Young
Publication of DK357585D0 publication Critical patent/DK357585D0/da
Publication of DK357585A publication Critical patent/DK357585A/da
Publication of DK165453B publication Critical patent/DK165453B/da
Application granted granted Critical
Publication of DK165453C publication Critical patent/DK165453C/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK357585A 1984-08-06 1985-08-06 Fremgangsmaade til fremstilling af 2'-desoxyadenosinforbindelser DK165453C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63819284A 1984-08-06 1984-08-06
US63819284 1984-08-06

Publications (4)

Publication Number Publication Date
DK357585D0 DK357585D0 (da) 1985-08-06
DK357585A DK357585A (da) 1986-02-07
DK165453B DK165453B (da) 1992-11-30
DK165453C true DK165453C (da) 1993-04-13

Family

ID=24559020

Family Applications (1)

Application Number Title Priority Date Filing Date
DK357585A DK165453C (da) 1984-08-06 1985-08-06 Fremgangsmaade til fremstilling af 2'-desoxyadenosinforbindelser

Country Status (9)

Country Link
EP (1) EP0173059B1 (da)
JP (2) JPS61106594A (da)
AT (1) ATE48278T1 (da)
AU (1) AU572673B2 (da)
CA (1) CA1269659A (da)
DE (1) DE3574472D1 (da)
DK (1) DK165453C (da)
ES (1) ES8606383A1 (da)
ZA (1) ZA855696B (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0217199A (ja) * 1988-07-05 1990-01-22 Japan Tobacco Inc ２’−デオキシ−β−アデノシンの製造方法
JPH02160799A (ja) * 1988-12-13 1990-06-20 Yuki Gosei Kogyo Co Ltd ２′−デオキシ−β−アデノシンの製造法
US5208327A (en) * 1991-12-18 1993-05-04 Ortho Pharmaceutical Corporation Intermediates useful in a synthesis of 2-chloro-2'-deoxyadenosine
JP4757632B2 (ja) * 2002-09-25 2011-08-24 ブリガム ヤング ユニバーシティー ２’−デオキシグアノシンから２−クロロ−２’−デオキシアデノシンを調製する方法
EP4070800A1 (en) 2004-12-22 2022-10-12 Merck Serono S.A. Cladribine regimen for treating multiple sclerosis
AU2007253254B2 (en) 2006-05-24 2013-01-17 Merck Serono Sa Cladribine regimen for treating multiple sclerosis
PT1932918E (pt) 2006-12-15 2010-01-05 Explora Lab Sa Método para a produção de cladribina
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
AU2009329867B2 (en) 2008-12-23 2015-01-29 Gilead Pharmasset Llc Nucleoside phosphoramidates
TW201031675A (en) 2008-12-23 2010-09-01 Pharmasset Inc Synthesis of purine nucleosides
US8551973B2 (en) 2008-12-23 2013-10-08 Gilead Pharmasset Llc Nucleoside analogs
US8232387B2 (en) 2009-08-18 2012-07-31 Scinopharm Taiwan, Ltd. Process for the preparation of cladribine
EP2343074A1 (en) 2009-12-23 2011-07-13 Merck Serono S.A. Use of purine analogues for treating airway diseases
WO2011113476A2 (en) 2010-03-16 2011-09-22 Cilag Ag Method for producing 2'-deoxyadenosine compounds
HUE026235T2 (en) 2010-03-31 2016-06-28 Gilead Pharmasset Llc Crystalline (S) -isopropyl 2 - (((S) - (((2R, 3R, 4R, 5R) -5- (2,4-dioxo-3,4-dihydropyrimidin-1 (2H) -IL) - 4-Fluoro-3-hydroxy-4-methyltetrahydrofuran-2-IL) methoxy) (phenoxy) phosphoryl) amino) propanoate
GB201401465D0 (en) 2014-01-29 2014-03-12 Roach Arthur H Use of cladribine for treating autoimmune inflammatory disease
EP2993177A1 (en) 2014-09-05 2016-03-09 Technische Universität Berlin A chemo-enzymatic preparation method for purine nucleosides and their deaza- and aza- analogues
GB2564717A (en) 2017-07-21 2019-01-23 Chord Therapeutics S A R L Use of cladribine for treating autoimmune neuromuscular disease
WO2019101960A1 (en) 2017-11-24 2019-05-31 Merck Patent Gmbh Cladribine regimen for use intreating progressive forms of multiple sclerosis
CA3194812A1 (en) 2020-09-10 2022-03-17 Merck Patent Gmbh Novel treatment regimen for the treatment of autoimmune disorders
GB2601786A (en) 2020-12-10 2022-06-15 Chord Therapeutics S A R L Use of cladribine for treating immune brain disease
IL305567A (en) 2021-03-03 2023-10-01 Ares Trading Sa A method for predicting the response of a patient treated with Cladribine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3225029A (en) * 1962-03-08 1965-12-21 Yamaoka Naotaka Process for the preparation of nucleosides and products obtained thereby
US3225009A (en) * 1962-05-21 1965-12-21 Scott Paper Co Ethylene dicarboxylic esters of 1,2 alkane carbonates, polymers, and copolymers thereof
DE1795357A1 (de) * 1968-09-18 1972-01-05 Schering Ag 2-Thio-pyrimidin-nucleoside
IL77133A (en) * 1984-12-04 1991-01-31 Lilly Co Eli Antineoplastic pharmaceutical compositions containing pentofuranoside derivatives,some new such compounds and their preparation

Also Published As

Publication number Publication date
DK165453B (da) 1992-11-30
JPH0256497A (ja) 1990-02-26
AU572673B2 (en) 1988-05-12
EP0173059B1 (en) 1989-11-29
ATE48278T1 (de) 1989-12-15
JPH02359B2 (da) 1990-01-08
ES545888A0 (es) 1986-04-01
JPS61106594A (ja) 1986-05-24
ZA855696B (en) 1986-04-30
DE3574472D1 (de) 1990-01-04
AU4513885A (en) 1986-02-13
DK357585D0 (da) 1985-08-06
ES8606383A1 (es) 1986-04-01
EP0173059A2 (en) 1986-03-05
DK357585A (da) 1986-02-07
CA1269659A (en) 1990-05-29
EP0173059A3 (en) 1987-04-29

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