DE69404560D1 - Verfahren zur Herstellung von kristallisiertem Loracarbef Monohydrat - Google Patents

Verfahren zur Herstellung von kristallisiertem Loracarbef Monohydrat

Info

Publication number
DE69404560D1
DE69404560D1 DE69404560T DE69404560T DE69404560D1 DE 69404560 D1 DE69404560 D1 DE 69404560D1 DE 69404560 T DE69404560 T DE 69404560T DE 69404560 T DE69404560 T DE 69404560T DE 69404560 D1 DE69404560 D1 DE 69404560D1
Authority
DE
Germany
Prior art keywords
crystallized
preparation
loracarbef monohydrate
loracarbef
monohydrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69404560T
Other languages
English (en)
Other versions
DE69404560T2 (de
Inventor
Robert Louis Nist
Marvin Emanuel Wildfeuer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69404560D1 publication Critical patent/DE69404560D1/de
Application granted granted Critical
Publication of DE69404560T2 publication Critical patent/DE69404560T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
DE69404560T 1993-06-04 1994-06-01 Verfahren zur Herstellung von kristallisiertem Loracarbef Monohydrat Expired - Fee Related DE69404560T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/071,552 US5352782A (en) 1993-06-04 1993-06-04 Process for preparing crystalline β-lactam monohydrate

Publications (2)

Publication Number Publication Date
DE69404560D1 true DE69404560D1 (de) 1997-09-04
DE69404560T2 DE69404560T2 (de) 1997-12-18

Family

ID=22102062

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69404560T Expired - Fee Related DE69404560T2 (de) 1993-06-04 1994-06-01 Verfahren zur Herstellung von kristallisiertem Loracarbef Monohydrat

Country Status (29)

Country Link
US (1) US5352782A (de)
EP (1) EP0627431B1 (de)
JP (1) JPH06345761A (de)
KR (1) KR950000702A (de)
CN (1) CN1045296C (de)
AT (1) ATE156129T1 (de)
AU (1) AU682503B2 (de)
BR (1) BR9402150A (de)
CA (1) CA2125000A1 (de)
CO (1) CO4230099A1 (de)
CZ (1) CZ284225B6 (de)
DE (1) DE69404560T2 (de)
DK (1) DK0627431T3 (de)
ES (1) ES2105524T3 (de)
FI (1) FI942632A (de)
GR (1) GR3024989T3 (de)
HU (1) HU217067B (de)
IL (1) IL109870A (de)
MY (1) MY110725A (de)
NO (1) NO307052B1 (de)
NZ (1) NZ260652A (de)
PE (1) PE13295A1 (de)
PH (1) PH30184A (de)
PL (1) PL174535B1 (de)
RU (1) RU2130456C1 (de)
TW (1) TW449596B (de)
UA (1) UA34440C2 (de)
YU (1) YU33494A (de)
ZA (1) ZA943826B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399686A (en) * 1993-06-04 1995-03-21 Eli Lilly And Company Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
US5580977A (en) * 1995-03-01 1996-12-03 Eli Lilly And Company Process for preparing loracarbef monohydrate
AU2003283624A1 (en) * 2002-11-21 2004-06-15 Ranbaxy Laboratories Limited Monohydrate solvates of loracarbef

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3531481A (en) * 1969-04-21 1970-09-29 Lilly Co Eli Method for manufacture of crystalline cephalosporin
US3502663A (en) * 1969-04-21 1970-03-24 Lilly Co Eli Crystalline cephalosporin,method for its manufacture
EG18529A (en) * 1987-10-06 1993-04-30 Lilly Co Eli Process for preparing b-lactam hydrate
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic
CA2002597C (en) * 1988-11-14 1999-03-23 Thomas M. Eckrich Solvates of b-lactam antibiotic
US4977257A (en) * 1988-11-14 1990-12-11 Eli Lilly And Company DMF solvates of a β-lactam antibiotic
CA2034592C (en) * 1990-01-26 2001-06-05 Ralph R. Pfeiffer Crystalline hydrochloride of new beta-lactam antibiotic and process therefor

Also Published As

Publication number Publication date
EP0627431B1 (de) 1997-07-30
AU682503B2 (en) 1997-10-09
NZ260652A (en) 1995-09-26
CN1045296C (zh) 1999-09-29
ZA943826B (en) 1995-12-01
TW449596B (en) 2001-08-11
BR9402150A (pt) 1994-12-27
NO942049D0 (no) 1994-06-02
RU2130456C1 (ru) 1999-05-20
PL174535B1 (pl) 1998-08-31
NO307052B1 (no) 2000-01-31
ATE156129T1 (de) 1997-08-15
PL303677A1 (en) 1995-01-09
UA34440C2 (uk) 2001-03-15
FI942632A (fi) 1994-12-05
NO942049L (no) 1994-12-05
GR3024989T3 (en) 1998-01-30
IL109870A0 (en) 1994-10-07
IL109870A (en) 1998-06-15
CZ134194A3 (en) 1994-12-15
CA2125000A1 (en) 1994-12-05
JPH06345761A (ja) 1994-12-20
YU33494A (sh) 1996-10-18
US5352782A (en) 1994-10-04
HU9401674D0 (en) 1994-09-28
RU94019423A (ru) 1996-04-20
PE13295A1 (es) 1995-05-24
MY110725A (en) 1999-01-30
HU217067B (hu) 1999-11-29
PH30184A (en) 1997-01-21
CN1097755A (zh) 1995-01-25
CZ284225B6 (cs) 1998-09-16
KR950000702A (ko) 1995-01-03
HUT67975A (en) 1995-05-29
FI942632A0 (fi) 1994-06-03
AU6451794A (en) 1994-12-08
DE69404560T2 (de) 1997-12-18
EP0627431A1 (de) 1994-12-07
CO4230099A1 (es) 1995-10-19
ES2105524T3 (es) 1997-10-16
DK0627431T3 (da) 1997-08-25

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee