CO4230099A1 - Procedimiento para preparar b-lactama cristalina monohidrato - Google Patents

Procedimiento para preparar b-lactama cristalina monohidrato

Info

Publication number
CO4230099A1
CO4230099A1 CO94023736A CO94023736A CO4230099A1 CO 4230099 A1 CO4230099 A1 CO 4230099A1 CO 94023736 A CO94023736 A CO 94023736A CO 94023736 A CO94023736 A CO 94023736A CO 4230099 A1 CO4230099 A1 CO 4230099A1
Authority
CO
Colombia
Prior art keywords
crystalline monohydrate
lactam
prepare
procedure
crystalline
Prior art date
Application number
CO94023736A
Other languages
English (en)
Inventor
Robert Louis Nist
Wildfeuer Marvin Emanuel
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CO4230099A1 publication Critical patent/CO4230099A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/085—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a nitrogen atom directly attached in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

REIVINDICACION NUMERO UN PROCEDIMIENTO PARA LA FORMA DE MONOHIDRATO CRISTALINO DEL COMPUESTO DE FORMULA (I) : FIGURA 1 QUE COMPRENDE LAS ETAPAS DE: A) MEZCLAR UNA FORMA DEL COMPUESTO DE FORMULA (I), DISTINTA DE LA FORMA DE NONOHIDRATO CRISTALINO, EN AGUA TEMPERATURA ENTRE APROXIMADAMENTE 30 GRA- DOS CENTIGRADOS Y APROXIMADAMENTE 60 GRADOS CENTI- GRADOS; O B) EXPONER UNA FORMA DEL COMPUESTO DE FORMULA (I) DISTINTA DE LA FORMULA DE MONOHIDRATO CRISTALINO, A VAPOR SATURADO A UNA TEMPERATURA ENTRE APROXIMA- DAMENTE 90 GRADOS CENTIGRADOS Y APROXIMADAMENTE 100 GRADOS CENTIGRADOS. REIVINDICACION NUMERO UN PROCEDIMIENTO PARA LA PREPARACION DE LA FORMA DE MONOHIDRATO CRISTALINO DEL COMPUESTO DE FORMULA (I): FIGURA 2 QUE COMPRENDE LA ETAPA DE MEZCLAR UNA FORMA DEL COMPUESTO DE FORMULA (I), DISTINTA DE LA FORMA DE MONOHIDRATO CRISTALINO, EN AGUA A UNA TEMPERA- TURA ENTRE APROXIMADAMENTE 30 GRADOS CENTIGRADOS Y APROXIMADAMENTE 60 GRADOS CENTIGRADOS.
CO94023736A 1993-06-04 1994-06-02 Procedimiento para preparar b-lactama cristalina monohidrato CO4230099A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/071,552 US5352782A (en) 1993-06-04 1993-06-04 Process for preparing crystalline β-lactam monohydrate

Publications (1)

Publication Number Publication Date
CO4230099A1 true CO4230099A1 (es) 1995-10-19

Family

ID=22102062

Family Applications (1)

Application Number Title Priority Date Filing Date
CO94023736A CO4230099A1 (es) 1993-06-04 1994-06-02 Procedimiento para preparar b-lactama cristalina monohidrato

Country Status (29)

Country Link
US (1) US5352782A (es)
EP (1) EP0627431B1 (es)
JP (1) JPH06345761A (es)
KR (1) KR950000702A (es)
CN (1) CN1045296C (es)
AT (1) ATE156129T1 (es)
AU (1) AU682503B2 (es)
BR (1) BR9402150A (es)
CA (1) CA2125000A1 (es)
CO (1) CO4230099A1 (es)
CZ (1) CZ284225B6 (es)
DE (1) DE69404560T2 (es)
DK (1) DK0627431T3 (es)
ES (1) ES2105524T3 (es)
FI (1) FI942632A (es)
GR (1) GR3024989T3 (es)
HU (1) HU217067B (es)
IL (1) IL109870A (es)
MY (1) MY110725A (es)
NO (1) NO307052B1 (es)
NZ (1) NZ260652A (es)
PE (1) PE13295A1 (es)
PH (1) PH30184A (es)
PL (1) PL174535B1 (es)
RU (1) RU2130456C1 (es)
TW (1) TW449596B (es)
UA (1) UA34440C2 (es)
YU (1) YU33494A (es)
ZA (1) ZA943826B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399686A (en) * 1993-06-04 1995-03-21 Eli Lilly And Company Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
US5580977A (en) * 1995-03-01 1996-12-03 Eli Lilly And Company Process for preparing loracarbef monohydrate
AU2003283624A1 (en) * 2002-11-21 2004-06-15 Ranbaxy Laboratories Limited Monohydrate solvates of loracarbef

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3531481A (en) * 1969-04-21 1970-09-29 Lilly Co Eli Method for manufacture of crystalline cephalosporin
US3502663A (en) * 1969-04-21 1970-03-24 Lilly Co Eli Crystalline cephalosporin,method for its manufacture
YU46699B (sh) * 1987-10-06 1994-04-05 Eli Lilly And Co. Kristalni monohidratni oblik 1-karbacefalosporina
US4977257A (en) * 1988-11-14 1990-12-11 Eli Lilly And Company DMF solvates of a β-lactam antibiotic
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic
CA2002597C (en) * 1988-11-14 1999-03-23 Thomas M. Eckrich Solvates of b-lactam antibiotic
CA2034592C (en) * 1990-01-26 2001-06-05 Ralph R. Pfeiffer Crystalline hydrochloride of new beta-lactam antibiotic and process therefor

Also Published As

Publication number Publication date
PH30184A (en) 1997-01-21
CA2125000A1 (en) 1994-12-05
CN1097755A (zh) 1995-01-25
CZ284225B6 (cs) 1998-09-16
US5352782A (en) 1994-10-04
PL174535B1 (pl) 1998-08-31
YU33494A (sh) 1996-10-18
JPH06345761A (ja) 1994-12-20
HU217067B (hu) 1999-11-29
IL109870A0 (en) 1994-10-07
PE13295A1 (es) 1995-05-24
MY110725A (en) 1999-01-30
GR3024989T3 (en) 1998-01-30
KR950000702A (ko) 1995-01-03
NZ260652A (en) 1995-09-26
PL303677A1 (en) 1995-01-09
DE69404560T2 (de) 1997-12-18
AU682503B2 (en) 1997-10-09
HU9401674D0 (en) 1994-09-28
FI942632A (fi) 1994-12-05
NO942049L (no) 1994-12-05
TW449596B (en) 2001-08-11
BR9402150A (pt) 1994-12-27
CZ134194A3 (en) 1994-12-15
ATE156129T1 (de) 1997-08-15
NO307052B1 (no) 2000-01-31
RU2130456C1 (ru) 1999-05-20
ES2105524T3 (es) 1997-10-16
DE69404560D1 (de) 1997-09-04
CN1045296C (zh) 1999-09-29
UA34440C2 (uk) 2001-03-15
NO942049D0 (no) 1994-06-02
AU6451794A (en) 1994-12-08
ZA943826B (en) 1995-12-01
DK0627431T3 (da) 1997-08-25
EP0627431A1 (en) 1994-12-07
HUT67975A (en) 1995-05-29
IL109870A (en) 1998-06-15
EP0627431B1 (en) 1997-07-30
RU94019423A (ru) 1996-04-20
FI942632A0 (fi) 1994-06-03

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