JPS5528964A - Method of removing protecting group from protected peptide - Google Patents

Method of removing protecting group from protected peptide

Info

Publication number
JPS5528964A
JPS5528964A JP10315778A JP10315778A JPS5528964A JP S5528964 A JPS5528964 A JP S5528964A JP 10315778 A JP10315778 A JP 10315778A JP 10315778 A JP10315778 A JP 10315778A JP S5528964 A JPS5528964 A JP S5528964A
Authority
JP
Japan
Prior art keywords
groups
peptide
protecting
protecting group
removing protecting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP10315778A
Other languages
Japanese (ja)
Other versions
JPS6034960B2 (en
Inventor
Tadahiro Doi
Shizuo Nakamura
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP53103157A priority Critical patent/JPS6034960B2/en
Publication of JPS5528964A publication Critical patent/JPS5528964A/en
Publication of JPS6034960B2 publication Critical patent/JPS6034960B2/en
Expired legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

PURPOSE: Methanesulfonic acid or its substituted analog and a specific thioether derivative are used as reagent for removing protecting groups on peptide, thus removing the protecting groups with one stage without side reaction and producing physiologically active peptide or its synthetic intermediate.
CONSTITUTION: As reagents for removing protecting groups are used (A) an acid selected from methanesulfonic, trichlorosulfonic and trifluosulfonic acids and (B) a thioether derivative of the formula (R ia lower alkyl) as thioanisol preferably in an amount of 4W10 equivalents per one protecting group in one molecule of peptide. The peptide protected with groups is treated with the above reagent preferably at 0°C-room temperature for 0.5W24 hr and both groups protecting carboxyl and amino groups are simultaneously removed.
COPYRIGHT: (C)1980,JPO&Japio
JP53103157A 1978-08-23 1978-08-23 How to remove protecting groups from protected peptides Expired JPS6034960B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP53103157A JPS6034960B2 (en) 1978-08-23 1978-08-23 How to remove protecting groups from protected peptides

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP53103157A JPS6034960B2 (en) 1978-08-23 1978-08-23 How to remove protecting groups from protected peptides

Publications (2)

Publication Number Publication Date
JPS5528964A true JPS5528964A (en) 1980-02-29
JPS6034960B2 JPS6034960B2 (en) 1985-08-12

Family

ID=14346658

Family Applications (1)

Application Number Title Priority Date Filing Date
JP53103157A Expired JPS6034960B2 (en) 1978-08-23 1978-08-23 How to remove protecting groups from protected peptides

Country Status (1)

Country Link
JP (1) JPS6034960B2 (en)

Also Published As

Publication number Publication date
JPS6034960B2 (en) 1985-08-12

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