BR112012002246A2 - composto, composto ou sal farmaceutico aceitavel deste, composição farmaceutica, metodo para inibir, tratar e/ou reduzir o declinio cognitivol e/ou doença de akzhmer em um paciente - Google Patents
composto, composto ou sal farmaceutico aceitavel deste, composição farmaceutica, metodo para inibir, tratar e/ou reduzir o declinio cognitivol e/ou doença de akzhmer em um pacienteInfo
- Publication number
- BR112012002246A2 BR112012002246A2 BR112012002246A BR112012002246A BR112012002246A2 BR 112012002246 A2 BR112012002246 A2 BR 112012002246A2 BR 112012002246 A BR112012002246 A BR 112012002246A BR 112012002246 A BR112012002246 A BR 112012002246A BR 112012002246 A2 BR112012002246 A2 BR 112012002246A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- akzhmer
- inhibiting
- disease
- patient
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title 2
- 230000006999 cognitive decline Effects 0.000 title 1
- 208000010877 cognitive disease Diseases 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 230000002401 inhibitory effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/25—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/05—Alcohols containing rings other than six-membered aromatic rings
- C07C33/14—Alcohols containing rings other than six-membered aromatic rings containing six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/28—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings
- C07C33/30—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings monocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
- C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/18—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23032609P | 2009-07-31 | 2009-07-31 | |
| US30868610P | 2010-02-26 | 2010-02-26 | |
| PCT/US2010/044136 WO2011014880A1 (en) | 2009-07-31 | 2010-08-02 | Inhibitors of cognitive decline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012002246A2 true BR112012002246A2 (pt) | 2019-09-24 |
Family
ID=43529740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012002246A BR112012002246A2 (pt) | 2009-07-31 | 2010-08-02 | composto, composto ou sal farmaceutico aceitavel deste, composição farmaceutica, metodo para inibir, tratar e/ou reduzir o declinio cognitivol e/ou doença de akzhmer em um paciente |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9192585B2 (https=) |
| EP (1) | EP2458983B1 (https=) |
| JP (1) | JP2013501006A (https=) |
| CN (1) | CN102595884B (https=) |
| AU (2) | AU2010278711A1 (https=) |
| BR (1) | BR112012002246A2 (https=) |
| DK (1) | DK2458983T3 (https=) |
| ES (1) | ES2547730T3 (https=) |
| IL (1) | IL217833A0 (https=) |
| RU (1) | RU2012107457A (https=) |
| SG (2) | SG10201506978UA (https=) |
| WO (1) | WO2011014880A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201404913QA (en) | 2009-04-09 | 2014-11-27 | Cognition Therapeutics Inc | Inhibitors of cognitive decline |
| RU2012107457A (ru) * | 2009-07-31 | 2013-09-10 | Когнишн Терапьютикс, Инк. | Ингибиторы ухудшения когнитивных способностей |
| US20130071330A1 (en) * | 2010-02-26 | 2013-03-21 | Susan Catalano | Methods of identifying agents effective to treat cognitive decline and diseases associated therewith |
| US9499462B2 (en) | 2011-02-02 | 2016-11-22 | Cognition Therapeutics, Inc. | Isolated compounds from turmeric oil and methods of use |
| EP2690969B1 (en) * | 2011-03-29 | 2018-10-03 | Council of Scientific & Industrial Research | Process for the modification of curcuma aromatica essential oil |
| GB201111319D0 (en) * | 2011-07-04 | 2011-08-17 | Univ Leuven Kath | Anticonvulsant activity of tumeric oil and bisabolene sesquiterpenoids of curcuma longa |
| RU2014111079A (ru) * | 2011-08-25 | 2015-09-27 | Когнишн Терапьютикс, Инк. | Композиции и способы для лечения нейродегенеративного заболевания |
| CA2846611A1 (en) * | 2011-08-25 | 2013-02-28 | Cognition Therapeutics, Inc. | Compositions and methods for treating neurodegenerative disease |
| DK3099296T3 (en) | 2014-01-31 | 2019-04-15 | Cognition Therapeutics Inc | ISO-INDOLINE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE |
| EP3634394B1 (en) | 2017-05-15 | 2025-12-24 | Cognition Therapeutics, Inc. | Compositions for treating neurodegenerative diseases |
| WO2026030341A1 (en) | 2024-07-29 | 2026-02-05 | Cognition Therapeutics, Inc. | Zervimesine for treating neurodegenerative disease |
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| RU2461551C2 (ru) | 2007-10-24 | 2012-09-20 | Астеллас Фарма Инк. | Азолкарбоксамидное соединение или его фармацевтически приемлемая соль |
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| EP2408905B1 (en) | 2009-03-16 | 2017-05-10 | Pangu Biopharma Limited | Compositions and methods comprising histidyl-trna synthetase splice variants having non-canonical biological activities |
| SG10201404913QA (en) | 2009-04-09 | 2014-11-27 | Cognition Therapeutics Inc | Inhibitors of cognitive decline |
| RU2012107457A (ru) * | 2009-07-31 | 2013-09-10 | Когнишн Терапьютикс, Инк. | Ингибиторы ухудшения когнитивных способностей |
| US20130071330A1 (en) | 2010-02-26 | 2013-03-21 | Susan Catalano | Methods of identifying agents effective to treat cognitive decline and diseases associated therewith |
| RU2014111079A (ru) | 2011-08-25 | 2015-09-27 | Когнишн Терапьютикс, Инк. | Композиции и способы для лечения нейродегенеративного заболевания |
-
2010
- 2010-08-02 RU RU2012107457/04A patent/RU2012107457A/ru not_active Application Discontinuation
- 2010-08-02 AU AU2010278711A patent/AU2010278711A1/en not_active Abandoned
- 2010-08-02 EP EP10805177.2A patent/EP2458983B1/en active Active
- 2010-08-02 CN CN201080043697.0A patent/CN102595884B/zh not_active Expired - Fee Related
- 2010-08-02 SG SG10201506978UA patent/SG10201506978UA/en unknown
- 2010-08-02 US US13/388,128 patent/US9192585B2/en active Active
- 2010-08-02 JP JP2012523127A patent/JP2013501006A/ja active Pending
- 2010-08-02 BR BR112012002246A patent/BR112012002246A2/pt not_active IP Right Cessation
- 2010-08-02 SG SG2012006805A patent/SG178191A1/en unknown
- 2010-08-02 DK DK10805177.2T patent/DK2458983T3/en active
- 2010-08-02 ES ES10805177.2T patent/ES2547730T3/es active Active
- 2010-08-02 WO PCT/US2010/044136 patent/WO2011014880A1/en not_active Ceased
-
2012
- 2012-01-30 IL IL217833A patent/IL217833A0/en unknown
-
2015
- 2015-10-12 AU AU2015242947A patent/AU2015242947B2/en not_active Ceased
- 2015-10-16 US US14/885,768 patent/US9815770B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20120129945A1 (en) | 2012-05-24 |
| EP2458983A4 (en) | 2012-12-19 |
| EP2458983B1 (en) | 2015-07-08 |
| IL217833A0 (en) | 2012-03-29 |
| AU2015242947A1 (en) | 2015-10-29 |
| HK1171624A1 (en) | 2013-04-05 |
| AU2010278711A1 (en) | 2012-02-23 |
| US9815770B2 (en) | 2017-11-14 |
| SG178191A1 (en) | 2012-03-29 |
| WO2011014880A1 (en) | 2011-02-03 |
| CN102595884A (zh) | 2012-07-18 |
| US20160137588A1 (en) | 2016-05-19 |
| EP2458983A1 (en) | 2012-06-06 |
| ES2547730T3 (es) | 2015-10-08 |
| CN102595884B (zh) | 2014-12-03 |
| DK2458983T3 (en) | 2015-10-05 |
| SG10201506978UA (en) | 2015-10-29 |
| AU2015242947B2 (en) | 2017-09-28 |
| JP2013501006A (ja) | 2013-01-10 |
| RU2012107457A (ru) | 2013-09-10 |
| US9192585B2 (en) | 2015-11-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2543 DE 01-10-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |