ES2547730T3 - Inhibidores del deterioro cognitivo - Google Patents
Inhibidores del deterioro cognitivo Download PDFInfo
- Publication number
- ES2547730T3 ES2547730T3 ES10805177.2T ES10805177T ES2547730T3 ES 2547730 T3 ES2547730 T3 ES 2547730T3 ES 10805177 T ES10805177 T ES 10805177T ES 2547730 T3 ES2547730 T3 ES 2547730T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- alkyl
- pharmaceutically acceptable
- haloalkyl
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/01—Hydrocarbons
- A61K31/015—Hydrocarbons carbocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/25—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/05—Alcohols containing rings other than six-membered aromatic rings
- C07C33/14—Alcohols containing rings other than six-membered aromatic rings containing six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
- C07C33/28—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings
- C07C33/30—Alcohols containing only six-membered aromatic rings as cyclic part with unsaturation outside the aromatic rings monocyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
- C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/18—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23032609P | 2009-07-31 | 2009-07-31 | |
| US230326P | 2009-07-31 | ||
| US30868610P | 2010-02-26 | 2010-02-26 | |
| US308686P | 2010-02-26 | ||
| PCT/US2010/044136 WO2011014880A1 (en) | 2009-07-31 | 2010-08-02 | Inhibitors of cognitive decline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2547730T3 true ES2547730T3 (es) | 2015-10-08 |
Family
ID=43529740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10805177.2T Active ES2547730T3 (es) | 2009-07-31 | 2010-08-02 | Inhibidores del deterioro cognitivo |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9192585B2 (https=) |
| EP (1) | EP2458983B1 (https=) |
| JP (1) | JP2013501006A (https=) |
| CN (1) | CN102595884B (https=) |
| AU (2) | AU2010278711A1 (https=) |
| BR (1) | BR112012002246A2 (https=) |
| DK (1) | DK2458983T3 (https=) |
| ES (1) | ES2547730T3 (https=) |
| IL (1) | IL217833A0 (https=) |
| RU (1) | RU2012107457A (https=) |
| SG (2) | SG10201506978UA (https=) |
| WO (1) | WO2011014880A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201404913QA (en) | 2009-04-09 | 2014-11-27 | Cognition Therapeutics Inc | Inhibitors of cognitive decline |
| RU2012107457A (ru) * | 2009-07-31 | 2013-09-10 | Когнишн Терапьютикс, Инк. | Ингибиторы ухудшения когнитивных способностей |
| US20130071330A1 (en) * | 2010-02-26 | 2013-03-21 | Susan Catalano | Methods of identifying agents effective to treat cognitive decline and diseases associated therewith |
| US9499462B2 (en) | 2011-02-02 | 2016-11-22 | Cognition Therapeutics, Inc. | Isolated compounds from turmeric oil and methods of use |
| EP2690969B1 (en) * | 2011-03-29 | 2018-10-03 | Council of Scientific & Industrial Research | Process for the modification of curcuma aromatica essential oil |
| GB201111319D0 (en) * | 2011-07-04 | 2011-08-17 | Univ Leuven Kath | Anticonvulsant activity of tumeric oil and bisabolene sesquiterpenoids of curcuma longa |
| RU2014111079A (ru) * | 2011-08-25 | 2015-09-27 | Когнишн Терапьютикс, Инк. | Композиции и способы для лечения нейродегенеративного заболевания |
| CA2846611A1 (en) * | 2011-08-25 | 2013-02-28 | Cognition Therapeutics, Inc. | Compositions and methods for treating neurodegenerative disease |
| DK3099296T3 (en) | 2014-01-31 | 2019-04-15 | Cognition Therapeutics Inc | ISO-INDOLINE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE |
| EP3634394B1 (en) | 2017-05-15 | 2025-12-24 | Cognition Therapeutics, Inc. | Compositions for treating neurodegenerative diseases |
| WO2026030341A1 (en) | 2024-07-29 | 2026-02-05 | Cognition Therapeutics, Inc. | Zervimesine for treating neurodegenerative disease |
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| ZA732136B (en) | 1972-04-12 | 1974-03-27 | Lilly Co Eli | Dopamine derivatives |
| US4321386A (en) | 1981-01-28 | 1982-03-23 | Mead Johnson & Company | Quaternary piperidinium halides |
| DK171627B1 (da) | 1983-01-31 | 1997-03-03 | Lilly Co Eli | Anvendelse af beta-phenethanolamin og farmaceutiskacceptable salte deraf samt dyrefoderpræblanding med indhold deraf |
| JPS62283922A (ja) | 1986-05-30 | 1987-12-09 | Tsumura Juntendo Inc | 血小板凝集抑制剤 |
| US4697024A (en) | 1986-11-24 | 1987-09-29 | Merrell Dow Pharmaceuticals Inc. | Medroxalol intermediates |
| US4958029A (en) | 1987-01-13 | 1990-09-18 | Banyu Pharmaceutical Co., Ltd. | Process for the production of isoindoline derivatives, novel intermediates and process for their production |
| JPH01180822A (ja) | 1988-01-12 | 1989-07-18 | Dainippon Pharmaceut Co Ltd | 抗遅延型アレルギー剤 |
| EP0507863A4 (en) | 1989-12-28 | 1993-07-07 | Virginia Commonwealth University | Sigma receptor ligands and the use thereof |
| DE4000610A1 (de) | 1990-01-11 | 1991-07-18 | Knoll Ag | Verfahren zur herstellung von optisch aktiven 3-amino-1-arylbutanen und 3-benzylamino-1-arylbutanen |
| JP2818958B2 (ja) | 1990-02-23 | 1998-10-30 | 塩野義製薬株式会社 | ４―（４―アルコキシフェニル）―２―ブチルアミン誘導体およびその製造法 |
| JPH045266A (ja) | 1990-04-24 | 1992-01-09 | Toyo Pharma- Kk | ドパミン誘導体の製造方法 |
| DE4142366A1 (de) * | 1991-07-15 | 1993-06-24 | Thomae Gmbh Dr K | Phenylalkylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| DE4123341A1 (de) * | 1991-07-15 | 1993-01-21 | Thomae Gmbh Dr K | Phenylalkylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| US6011068A (en) | 1991-08-23 | 2000-01-04 | Nps Pharmaceuticals, Inc. | Calcium receptor-active molecules |
| CN1192011C (zh) | 1991-08-23 | 2005-03-09 | Nps药物有限公司 | 对钙受体具活性的芳烷基胺化合物 |
| US6610493B1 (en) | 1993-06-17 | 2003-08-26 | Brigham And Women's Hospital | Screening compounds for the ability to alter the production of amyloid-β peptide |
| CA2115900A1 (en) | 1993-02-22 | 1994-08-23 | Gerald W. Becker | Pharmaceutical screens and antibodies |
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| JP3522930B2 (ja) * | 1995-12-06 | 2004-04-26 | 花王株式会社 | 抗菌剤及びこれを含有する口腔用組成物 |
| WO1997030038A1 (en) | 1996-02-15 | 1997-08-21 | Mitsubishi Chemical Corporation | Diarylsultam derivatives |
| US6235731B1 (en) | 1996-04-24 | 2001-05-22 | Takeda Chemical Industries, Ltd. | Fused imidazopyridine derivatives as antihyperlipidemic agents |
| US6518315B1 (en) | 1997-10-21 | 2003-02-11 | The University Of Sydney | Medicinal uses of phenylaikanols and derivatives |
| IL138686A0 (en) | 1999-10-01 | 2001-10-31 | Pfizer Prod Inc | α- SULFONYLAMINO HYDROXAMIC ACID INHIBITORS OF MATRIX METALLOPROTEINASES FOR THE TREATMENT OF PERIPHERAL OR CENTRAL NERVOUS SYSTEM DISORDERS |
| AU2300001A (en) | 1999-10-22 | 2001-05-08 | Board Of Trustees Of The University Of Illinois, The | Pharmaceutical compositions useful in the prevention and treatment of beta-amyloid protein-induced disease |
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| JP4312402B2 (ja) | 2001-07-31 | 2009-08-12 | 有限会社大長企画 | 抗うつ剤、抗更年期障害剤、抗老人性痴呆症剤、抗アルツハイマー剤 |
| US20030073681A1 (en) | 2001-08-21 | 2003-04-17 | Hauske James R. | 2-substituted piperidines that are ligands for monoamine receptors and transporters |
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| DK1794313T3 (da) | 2004-06-21 | 2013-07-22 | Proteome Sciences Plc | Fremgangsmåde til screeninger der anvender C-ABL, FYN og SYK i kombination med tau-protein |
| TW200613272A (en) | 2004-08-13 | 2006-05-01 | Astrazeneca Ab | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators |
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| WO2006066118A2 (en) | 2004-12-15 | 2006-06-22 | Neuralab Limited | Contextual fear test for predicting efficacy of alzheimer immunotherapeutic treatment |
| WO2006094724A2 (en) | 2005-03-05 | 2006-09-14 | Abbott Gmbh & Co. Kg | Screening method, process for purifying of non-diffusible a-beta oligomers, selective antibodies against said non-diffusible a-beta oligomers and a process for manufacturing of said antibodies |
| KR20080041624A (ko) | 2005-06-15 | 2008-05-13 | 대릭 에스. 에치. 엘. 김 | 베타-아밀로이드 단백질-유발 안질환의 치료 방법 |
| EP1745778A3 (en) | 2005-07-20 | 2007-03-07 | Speedel Experimenta AG | Diaminoalcohols as therapeutic compounds |
| ITRM20060007A1 (it) | 2006-01-05 | 2007-07-06 | Univ Bari | Recettore sigma-2 metodo di screening di ligandi specifici e uso degli stessi in metodi diagnostici o terapeutici |
| CA2644093A1 (en) * | 2006-03-17 | 2007-09-27 | Herbalscience Singapore Pte. Ltd. | Extracts and methods comprising curcuma species |
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| KR20100029079A (ko) | 2007-05-15 | 2010-03-15 | 헬리콘 테라퓨틱스 인코퍼레이티드 | Ｇｐｒ12의 저해로 인지 질환을 치료하는 방법 |
| CN101121670A (zh) | 2007-09-11 | 2008-02-13 | 上海紫源制药有限公司 | 一种3,4-二甲氧基-N-[3-(4-甲氧基苯基)-1-甲基-正丙基]-β-苯乙胺盐酸盐的制备方法 |
| RU2461551C2 (ru) | 2007-10-24 | 2012-09-20 | Астеллас Фарма Инк. | Азолкарбоксамидное соединение или его фармацевтически приемлемая соль |
| US8168800B2 (en) | 2007-11-02 | 2012-05-01 | The Regents Of The University Of California | Aβ-binding small molecules |
| EP2138104A1 (en) | 2008-06-25 | 2009-12-30 | Vibra Tech AB | Core biopsy arrangement |
| WO2010062260A1 (en) | 2008-11-29 | 2010-06-03 | The Thailand Research Fund | Virus and target cell interaction inhibition |
| WO2010088450A2 (en) | 2009-01-30 | 2010-08-05 | Celladon Corporation | Methods for treating diseases associated with the modulation of serca |
| EP2408905B1 (en) | 2009-03-16 | 2017-05-10 | Pangu Biopharma Limited | Compositions and methods comprising histidyl-trna synthetase splice variants having non-canonical biological activities |
| SG10201404913QA (en) | 2009-04-09 | 2014-11-27 | Cognition Therapeutics Inc | Inhibitors of cognitive decline |
| RU2012107457A (ru) * | 2009-07-31 | 2013-09-10 | Когнишн Терапьютикс, Инк. | Ингибиторы ухудшения когнитивных способностей |
| US20130071330A1 (en) | 2010-02-26 | 2013-03-21 | Susan Catalano | Methods of identifying agents effective to treat cognitive decline and diseases associated therewith |
| RU2014111079A (ru) | 2011-08-25 | 2015-09-27 | Когнишн Терапьютикс, Инк. | Композиции и способы для лечения нейродегенеративного заболевания |
-
2010
- 2010-08-02 RU RU2012107457/04A patent/RU2012107457A/ru not_active Application Discontinuation
- 2010-08-02 AU AU2010278711A patent/AU2010278711A1/en not_active Abandoned
- 2010-08-02 EP EP10805177.2A patent/EP2458983B1/en active Active
- 2010-08-02 CN CN201080043697.0A patent/CN102595884B/zh not_active Expired - Fee Related
- 2010-08-02 SG SG10201506978UA patent/SG10201506978UA/en unknown
- 2010-08-02 US US13/388,128 patent/US9192585B2/en active Active
- 2010-08-02 JP JP2012523127A patent/JP2013501006A/ja active Pending
- 2010-08-02 BR BR112012002246A patent/BR112012002246A2/pt not_active IP Right Cessation
- 2010-08-02 SG SG2012006805A patent/SG178191A1/en unknown
- 2010-08-02 DK DK10805177.2T patent/DK2458983T3/en active
- 2010-08-02 ES ES10805177.2T patent/ES2547730T3/es active Active
- 2010-08-02 WO PCT/US2010/044136 patent/WO2011014880A1/en not_active Ceased
-
2012
- 2012-01-30 IL IL217833A patent/IL217833A0/en unknown
-
2015
- 2015-10-12 AU AU2015242947A patent/AU2015242947B2/en not_active Ceased
- 2015-10-16 US US14/885,768 patent/US9815770B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20120129945A1 (en) | 2012-05-24 |
| EP2458983A4 (en) | 2012-12-19 |
| EP2458983B1 (en) | 2015-07-08 |
| IL217833A0 (en) | 2012-03-29 |
| AU2015242947A1 (en) | 2015-10-29 |
| HK1171624A1 (en) | 2013-04-05 |
| AU2010278711A1 (en) | 2012-02-23 |
| US9815770B2 (en) | 2017-11-14 |
| SG178191A1 (en) | 2012-03-29 |
| WO2011014880A1 (en) | 2011-02-03 |
| BR112012002246A2 (pt) | 2019-09-24 |
| CN102595884A (zh) | 2012-07-18 |
| US20160137588A1 (en) | 2016-05-19 |
| EP2458983A1 (en) | 2012-06-06 |
| CN102595884B (zh) | 2014-12-03 |
| DK2458983T3 (en) | 2015-10-05 |
| SG10201506978UA (en) | 2015-10-29 |
| AU2015242947B2 (en) | 2017-09-28 |
| JP2013501006A (ja) | 2013-01-10 |
| RU2012107457A (ru) | 2013-09-10 |
| US9192585B2 (en) | 2015-11-24 |
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