BR0317595A - Método e aparelho para produzir partìculas, método para produzir uma mistura de pó seco e composição farmacêutica - Google Patents

Método e aparelho para produzir partìculas, método para produzir uma mistura de pó seco e composição farmacêutica

Info

Publication number
BR0317595A
BR0317595A BR0317595-2A BR0317595A BR0317595A BR 0317595 A BR0317595 A BR 0317595A BR 0317595 A BR0317595 A BR 0317595A BR 0317595 A BR0317595 A BR 0317595A
Authority
BR
Brazil
Prior art keywords
producing
particles
drying gas
drying
solvent
Prior art date
Application number
BR0317595-2A
Other languages
English (en)
Inventor
Donald E Chickering Iii
Sridhar Narasimhan
David Altreuter
Paul Kopesky
Mark Keegan
Julie A Straub
Howard Bernstein
Original Assignee
Acusphere Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acusphere Inc filed Critical Acusphere Inc
Publication of BR0317595A publication Critical patent/BR0317595A/pt

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B17/00—Machines or apparatus for drying materials in loose, plastic, or fluidised form, e.g. granules, staple fibres, with progressive movement
    • F26B17/10—Machines or apparatus for drying materials in loose, plastic, or fluidised form, e.g. granules, staple fibres, with progressive movement with movement performed by fluid currents, e.g. issuing from a nozzle, e.g. pneumatic, flash, vortex or entrainment dryers
    • F26B17/101—Machines or apparatus for drying materials in loose, plastic, or fluidised form, e.g. granules, staple fibres, with progressive movement with movement performed by fluid currents, e.g. issuing from a nozzle, e.g. pneumatic, flash, vortex or entrainment dryers the drying enclosure having the shape of one or a plurality of shafts or ducts, e.g. with substantially straight and vertical axis
    • F26B17/102—Machines or apparatus for drying materials in loose, plastic, or fluidised form, e.g. granules, staple fibres, with progressive movement with movement performed by fluid currents, e.g. issuing from a nozzle, e.g. pneumatic, flash, vortex or entrainment dryers the drying enclosure having the shape of one or a plurality of shafts or ducts, e.g. with substantially straight and vertical axis with material recirculation, classifying or disintegrating means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D1/00—Evaporating
    • B01D1/16—Evaporating by spraying
    • B01D1/18—Evaporating by spraying to obtain dry solids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2/00—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
    • B01J2/02—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
    • B01J2/04—Processes or devices for granulating materials, e.g. fertilisers in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops in a gaseous medium
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F26—DRYING
    • F26B—DRYING SOLID MATERIALS OR OBJECTS BY REMOVING LIQUID THEREFROM
    • F26B3/00—Drying solid materials or objects by processes involving the application of heat
    • F26B3/02—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air
    • F26B3/10—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it
    • F26B3/12—Drying solid materials or objects by processes involving the application of heat by convection, i.e. heat being conveyed from a heat source to the materials or objects to be dried by a gas or vapour, e.g. air the gas or vapour carrying the materials or objects to be dried with it in the form of a spray, i.e. sprayed or dispersed emulsions or suspensions

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Mechanical Engineering (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Cyclones (AREA)
  • Glanulating (AREA)
  • Disintegrating Or Milling (AREA)
  • Vaporization, Distillation, Condensation, Sublimation, And Cold Traps (AREA)

Abstract

"MéTODO E APARELHO PARA PRODUZIR PARTìCULAS, MéTODO PARA PRODUZIR UMA MISTURA DE Pó SECO E COMPOSIçãO FARMACêUTICA". Métodos e aparelhos são oferecidos para produzir particulas, compreendendo: (a) aspersão de uma emulsão, solução, ou suspensão, compreendendo um solvente e material a granel (por exemplo um agente farmacêutico) através de um atomizador (14) e dentro de uma primeira câmara de secagem (12), que é atravessada por um gás de secagem, visando formar gotículas, compreendendo o solvente e o material a granel, dispersos no gás de secagem; (b) evaporação, na primeira câmara de secagem (12), ao menos uma parcela do solvente dentro do gás de secagem para solidificar as gotículas e formar partículas dispersas no gás de secagem; e (c) fazer fluir as partículas, e ao menos uma parcela do gás de secagem, por uma unidade de processamento a jato em linha (24) para desaglomerar ou moer as partículas. Acoplando a secagem de spray com a unidade de processamento a jato em linha, é gerado um processo de etapa única de duas operações separadas da unidade, e uma etapa adicional de coleta é vantajosamente eliminada. O processo de etapa única, em linha, tem outras vantagens em tempo e custo de processamento.
BR0317595-2A 2002-12-19 2003-11-20 Método e aparelho para produzir partìculas, método para produzir uma mistura de pó seco e composição farmacêutica BR0317595A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/324,943 US6962006B2 (en) 2002-12-19 2002-12-19 Methods and apparatus for making particles using spray dryer and in-line jet mill
PCT/US2003/037108 WO2004060547A1 (en) 2002-12-19 2003-11-20 Methods and apparatus for making particles using spray dryer and in-line jet mill

Publications (1)

Publication Number Publication Date
BR0317595A true BR0317595A (pt) 2005-11-22

Family

ID=32593605

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0317595-2A BR0317595A (pt) 2002-12-19 2003-11-20 Método e aparelho para produzir partìculas, método para produzir uma mistura de pó seco e composição farmacêutica

Country Status (12)

Country Link
US (4) US6962006B2 (pt)
EP (1) EP1575696A1 (pt)
JP (1) JP2006514879A (pt)
KR (1) KR20050094410A (pt)
CN (1) CN100500275C (pt)
AU (1) AU2003295704B2 (pt)
BR (1) BR0317595A (pt)
CA (1) CA2511376A1 (pt)
IL (2) IL168746A (pt)
RU (1) RU2324533C2 (pt)
WO (1) WO2004060547A1 (pt)
ZA (1) ZA200504300B (pt)

Families Citing this family (141)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
EP1494732B1 (en) 2002-03-20 2008-01-30 MannKind Corporation Inhalation apparatus
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
US6962006B2 (en) * 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
US6669929B1 (en) 2002-12-30 2003-12-30 Colgate Palmolive Company Dentifrice containing functional film flakes
WO2004096113A2 (en) 2003-04-28 2004-11-11 Medical Instill Technologies, Inc. Container with valve assembly for filling and dispensing substances, and apparatus and method for filling
US20050266298A1 (en) * 2003-07-09 2005-12-01 Maxwell Technologies, Inc. Dry particle based electro-chemical device and methods of making same
US20070122698A1 (en) * 2004-04-02 2007-05-31 Maxwell Technologies, Inc. Dry-particle based adhesive and dry film and methods of making same
US7342770B2 (en) * 2003-07-09 2008-03-11 Maxwell Technologies, Inc. Recyclable dry particle based adhesive electrode and methods of making same
US7295423B1 (en) * 2003-07-09 2007-11-13 Maxwell Technologies, Inc. Dry particle based adhesive electrode and methods of making same
US7352558B2 (en) 2003-07-09 2008-04-01 Maxwell Technologies, Inc. Dry particle based capacitor and methods of making same
US20050250011A1 (en) * 2004-04-02 2005-11-10 Maxwell Technologies, Inc. Particle packaging systems and methods
US7791860B2 (en) 2003-07-09 2010-09-07 Maxwell Technologies, Inc. Particle based electrodes and methods of making same
US20060147712A1 (en) * 2003-07-09 2006-07-06 Maxwell Technologies, Inc. Dry particle based adhesive electrode and methods of making same
US7920371B2 (en) 2003-09-12 2011-04-05 Maxwell Technologies, Inc. Electrical energy storage devices with separator between electrodes and methods for fabricating the devices
GB0327723D0 (en) * 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
US7495349B2 (en) 2003-10-20 2009-02-24 Maxwell Technologies, Inc. Self aligning electrode
ES2234420B1 (es) * 2003-12-03 2006-11-01 Tolsa, S.A. Procedimiento para preparar un producto de grado reologico de facil dispersion de un silicato pseudolaminar, producto asi obtenido, y metodos de uso del producto.
DE102004007526A1 (de) * 2004-02-17 2005-09-01 Oetjen, Georg-Wilhelm, Dr. Verfahren und Einrichtung zur Gefriertrocknung von Produkten
US7384433B2 (en) 2004-02-19 2008-06-10 Maxwell Technologies, Inc. Densification of compressible layers during electrode lamination
US7090946B2 (en) 2004-02-19 2006-08-15 Maxwell Technologies, Inc. Composite electrode and method for fabricating same
US20060109608A1 (en) * 2004-04-02 2006-05-25 Maxwell Technologies, Inc. Dry-particle based capacitor and methods of making same
US7227737B2 (en) 2004-04-02 2007-06-05 Maxwell Technologies, Inc. Electrode design
US7245478B2 (en) 2004-08-16 2007-07-17 Maxwell Technologies, Inc. Enhanced breakdown voltage electrode
KR101273120B1 (ko) 2004-08-20 2013-06-13 맨카인드 코포레이션 다이케토피페라진 합성의 촉매 작용
KR20130066695A (ko) 2004-08-23 2013-06-20 맨카인드 코포레이션 약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
WO2006123359A2 (en) * 2005-03-01 2006-11-23 Sun Pharmaceutical Industries Limited A process of making microspheres
US7440258B2 (en) 2005-03-14 2008-10-21 Maxwell Technologies, Inc. Thermal interconnects for coupling energy storage devices
US7276231B2 (en) * 2005-05-23 2007-10-02 E I Du Pont De Nemours And Company Lower-energy process for preparing passivated inorganic nanoparticles
US20060286378A1 (en) * 2005-05-23 2006-12-21 Shivkumar Chiruvolu Nanostructured composite particles and corresponding processes
IN2014DN09128A (pt) 2005-09-14 2015-07-10 Mannkind Corp
EP1933814A2 (en) * 2005-09-15 2008-06-25 Elan Pharma International Limited Nanoparticulate aripiprazole formulations
US20070104866A1 (en) * 2005-09-28 2007-05-10 Mcclements David J Encapsulated emulsions and methods of preparation
JP2007091688A (ja) * 2005-09-30 2007-04-12 Kurimoto Ltd 固形製剤コーティング用微粉末の製造方法
WO2007053904A1 (en) * 2005-11-10 2007-05-18 Alphapharm Pty Ltd Process to control particle size
CA2631492A1 (en) * 2005-12-15 2007-06-21 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for oral administration
US8540666B2 (en) * 2005-12-21 2013-09-24 Boston Scientific Scimed, Inc. Echogenic occlusive balloon and delivery system
BRPI0707991B8 (pt) 2006-02-22 2021-05-25 Mannkind Corp métodos de preparação de um medicamento em pó seco com uma propriedade farmacêutica melhorada, dito pó seco e uso de uma quantidade efetiva do pó seco
US7966746B2 (en) * 2006-04-24 2011-06-28 Medical Instill Technologies, LLC Needle penetrable and laser resealable lyophilization method
KR100780337B1 (ko) * 2006-04-27 2007-11-29 주식회사 케미랜드 분체상 원료 분쇄장치
US8067047B2 (en) * 2006-06-27 2011-11-29 James Fajt Method and devices for forming articles
US8518573B2 (en) 2006-09-29 2013-08-27 Maxwell Technologies, Inc. Low-inductive impedance, thermally decoupled, radii-modulated electrode core
CN101167697B (zh) * 2006-10-26 2011-03-30 中国科学院上海药物研究所 多奈哌齐类化合物长效缓控释组合物及其制备方法
DE102006053375A1 (de) * 2006-11-10 2008-05-15 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Mischung von Pulvern
US20080201925A1 (en) 2007-02-28 2008-08-28 Maxwell Technologies, Inc. Ultracapacitor electrode with controlled sulfur content
US20080204973A1 (en) * 2007-02-28 2008-08-28 Maxwell Technologies, Inc. Ultracapacitor electrode with controlled iron content
JP2010521281A (ja) * 2007-03-15 2010-06-24 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 金属繊維の濾過要素を含む濾過アセンブリー
EP2158029B1 (en) * 2007-04-10 2019-05-29 Gea Process Engineering Inc. Process gas filter and process for cleaning the same
US20090020481A1 (en) * 2007-07-20 2009-01-22 Bailie Robert E Method and system for treating feedwater
US8075740B2 (en) * 2007-07-20 2011-12-13 Aht Solutions, Llc Method and system for treating feedwater
US20090020411A1 (en) * 2007-07-20 2009-01-22 Holunga Dean M Laser pyrolysis with in-flight particle manipulation for powder engineering
US8083162B2 (en) * 2007-08-23 2011-12-27 Liquajet L.L.C. Method for micro-sizing organic, inorganic and engineered compounds
WO2009039281A2 (en) * 2007-09-19 2009-03-26 Amgen Inc. Particle drying apparatus and methods for forming dry particles
US20100055180A1 (en) * 2007-10-10 2010-03-04 Mallinckrodt Baker, Inc. Directly Compressible Granular Microcrystalline Cellulose Based Excipient, Manufacturing Process and Use Thereof
AU2008311289A1 (en) * 2007-10-10 2009-04-16 Avantor Performance Materials, Inc. Directly compressible high functionality granular microcrystalline cellulose based excipient, manufacturing process and use thereof
US20090165974A1 (en) * 2007-12-28 2009-07-02 Weyerhaeuser Co. Methods for blending dried cellulose fibers
US20090197780A1 (en) * 2008-02-01 2009-08-06 Weaver Jimmie D Ultrafine Grinding of Soft Materials
US8337867B2 (en) * 2008-02-08 2012-12-25 Purac Biochem B.V. Metal lactate powder and method for preparation
PL220269B1 (pl) * 2008-04-21 2015-09-30 Przedsiębiorstwo Produkcji Farmaceutycznej Hasco Lek Spółka Akcyjna Kompozytowy nośnik leków proszkowych, sposób wytwarzania nośnika leków oraz urządzenie do wytwarzania cząstek nośnika kompozytowego
AR071375A1 (es) * 2008-04-22 2010-06-16 Solvay Pharm Gmbh Formulaciones para ingredientes farmaceuticos activos de permeabilidad deficiente, proceso de preparacion y producto
US8697098B2 (en) 2011-02-25 2014-04-15 South Dakota State University Polymer conjugated protein micelles
CN109568740B (zh) 2008-06-13 2022-05-27 曼金德公司 干粉吸入器和用于药物输送的系统
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
US7794750B2 (en) * 2008-06-20 2010-09-14 Mutual Pharmaceutical Company, Inc. Controlled-release formulations, method of manufacture, and use thereof
ES2904623T3 (es) 2008-06-20 2022-04-05 Mannkind Corp Aparato interactivo para establecer un perfil en tiempo real de esfuerzos de inhalación
US8632805B2 (en) * 2008-06-20 2014-01-21 Mutual Pharmaceutical Company, Inc. Controlled-release formulations, method of manufacture, and use thereof
TWI494123B (zh) 2008-08-11 2015-08-01 Mannkind Corp 超快起作用胰島素之用途
KR100901741B1 (ko) * 2008-10-24 2009-06-10 김성우 볼텍스 튜브를 이용한 공기 건조기
US8176655B2 (en) * 2008-12-16 2012-05-15 Spx Flow Technology Danmark A/S Vapor atmosphere spray dryer
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
CA2691712A1 (en) * 2009-02-16 2010-08-16 Honda Motor Co., Ltd. Electrostatic coating method and electrostatic coating apparatus
PL2405963T3 (pl) 2009-03-11 2014-04-30 Mannkind Corp Urządzenie, układ i sposób pomiaru oporu inhalatora
KR101875969B1 (ko) 2009-06-12 2018-07-06 맨카인드 코포레이션 한정된 비표면적을 갖는 디케토피페라진 마이크로입자
US8728730B2 (en) 2009-09-03 2014-05-20 Genentech, Inc. Methods for treating, diagnosing, and monitoring rheumatoid arthritis
DE102009045116A1 (de) * 2009-09-29 2011-03-31 Evonik Degussa Gmbh Niederdruckvermahlungsverfahren
EP2496295A1 (en) 2009-11-03 2012-09-12 MannKind Corporation An apparatus and method for simulating inhalation efforts
GB0921481D0 (en) * 2009-12-08 2010-01-20 Vectura Ltd Process and product
EP2555752B1 (en) 2010-04-09 2019-06-26 Pacira Pharmaceuticals, Inc. Method for formulating multivesicular liposomes
KR20130117755A (ko) 2010-06-21 2013-10-28 맨카인드 코포레이션 건조 분말 약물 운반 시스템 및 방법
CN102374759B (zh) * 2010-08-11 2014-08-13 焦作健康元生物制品有限公司 菌渣喷雾干燥系统
US8939388B1 (en) 2010-09-27 2015-01-27 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
US9332776B1 (en) 2010-09-27 2016-05-10 ZoomEssence, Inc. Methods and apparatus for low heat spray drying
CN107998109A (zh) 2010-10-12 2018-05-08 西普拉有限公司 药物组合物
FR2970713B1 (fr) * 2011-01-20 2014-04-25 Arkema France Poudre fine de polyester aliphatique bioressource et procede de fabrication d'une telle poudre
EP2805918B1 (en) * 2011-02-04 2016-02-03 Climax Molybdenum Company Apparatus for producing molybdenum disulfide powders
US8708159B2 (en) * 2011-02-16 2014-04-29 Oakwood Laboratories, Llc Manufacture of microspheres using a hydrocyclone
CA2828253C (en) 2011-02-25 2016-10-18 South Dakota State University Polymer conjugated protein micelles
JP6133270B2 (ja) 2011-04-01 2017-05-24 マンカインド コーポレイション 薬剤カートリッジのためのブリスター包装
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
JP5750689B2 (ja) * 2011-08-15 2015-07-22 国立大学法人山梨大学 熱可塑性ポリマー微粒子からなるマイクロビーズの製造手段
CN102357308B (zh) * 2011-10-19 2013-10-23 江西稀有稀土金属钨业集团有限公司 一种从氯化钴溶液直接制取无水氯化钴粉末的方法
BR112014009686A2 (pt) 2011-10-24 2018-08-07 Mannkind Corp composição analgésica inalável, pó seco e método para tratar dor
PT106237B (pt) 2012-03-30 2015-03-19 Hovione Farmaci Ncia S A Produção de partículas substancialmente monodispersas utilizando moagem e separação por membranas
CN103374241A (zh) * 2012-04-17 2013-10-30 鲍联 粉体改性一体化生产工艺
JP5827178B2 (ja) * 2012-06-05 2015-12-02 北越紀州製紙株式会社 セルロース多孔質体及びその製造方法
CN102728841B (zh) * 2012-07-10 2014-06-04 交城县融和磁材有限公司 一种烧结钕铁硼永磁材料的气流磨制粉装置及方法
AU2013289957B2 (en) 2012-07-12 2017-02-23 Mannkind Corporation Dry powder drug delivery systems and methods
JP6246712B2 (ja) 2012-07-12 2017-12-13 武田薬品工業株式会社 マイクロカプセル粉末の製造方法
CN102788488A (zh) * 2012-08-03 2012-11-21 梁首强 一种高速离心干燥方法及实施该方法的干燥系统
US8968693B2 (en) * 2012-08-30 2015-03-03 Honeywell International Inc. Internal cyclone for fluidized bed reactor
EP2911690A1 (en) 2012-10-26 2015-09-02 MannKind Corporation Inhalable influenza vaccine compositions and methods
ES2754388T3 (es) 2013-03-15 2020-04-17 Mannkind Corp Composiciones y métodos de dicetopiperazina microcristalina
BR122019026637B1 (pt) 2013-07-18 2023-09-26 Mannkind Corporation Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco
WO2015021064A1 (en) 2013-08-05 2015-02-12 Mannkind Corporation Insufflation apparatus and methods
IN2013CH04500A (pt) 2013-10-04 2015-04-10 Kennametal India Ltd
WO2015071841A1 (en) 2013-11-12 2015-05-21 Druggability Technologies Holdings Limited Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
PT107568B (pt) * 2014-03-31 2018-11-05 Hovione Farm S A Processo de secagem por atomização para a produção de pós com propriedades melhoradas.
PT107567B (pt) * 2014-03-31 2019-02-13 Hovione Farm S A Secador por atomização com atomizador múltiplo, método para o aumento de escala de pós para inalação secos por dispositivo de atomização múltiplo e uso de vários atomizadores num secador por atomização
CN104251603A (zh) * 2014-09-03 2014-12-31 嘉善圣莱斯绒业有限公司 粉末烘干处理装置
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
CN104353396B (zh) * 2014-11-06 2016-02-03 四川旭华制药有限公司 一种静电吸附式喷雾干燥制粒机
DK3346990T3 (da) * 2015-09-09 2020-06-02 Vectura Ltd Fremgangsmåde til stråleformaling
FR3042987B1 (fr) * 2015-11-04 2017-12-15 Commissariat Energie Atomique Dispositif de granulation de poudres par atomisation cryogenique
US20190133940A1 (en) * 2016-06-30 2019-05-09 Philip Morris Products S.A. Nicotine particles and compositions
MX2018015119A (es) 2016-06-30 2019-04-15 Philip Morris Products Sa Particulas de nicotina.
CN107188211B (zh) * 2016-08-16 2019-04-05 上海奉坤新材料有限公司 改进的重质碳酸钙的制作方法
CN106496082B (zh) * 2016-10-31 2018-03-06 荆门市欣胱生物工程股份有限公司 一种复合氨基酸喷粉系统和氨基酸粉的生产方法
WO2018112408A1 (en) * 2016-12-15 2018-06-21 Flexion Therapeutics, Inc. Fluticasone formulations and methods of use thereof
US9993787B1 (en) 2017-08-04 2018-06-12 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US10486173B2 (en) 2017-08-04 2019-11-26 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
US9861945B1 (en) 2017-08-04 2018-01-09 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
WO2019028446A1 (en) 2017-08-04 2019-02-07 ZoomEssence, Inc. APPARATUS AND METHOD FOR HIGH-PERFORMANCE SPRAY DRYING
US10155234B1 (en) 2017-08-04 2018-12-18 ZoomEssence, Inc. Ultrahigh efficiency spray drying apparatus and process
CN107510600A (zh) * 2017-08-07 2017-12-26 苏州大学 一种制备药用固体微粒的设备及方法
CN107940900A (zh) * 2017-10-12 2018-04-20 浙江工业大学 一种高活性氟化钾的多级干燥方法及干燥装置
US10955189B2 (en) * 2017-12-18 2021-03-23 Oliver Manufacturing Company, Inc. Vibratory fluidized bed dryer
US10569244B2 (en) 2018-04-28 2020-02-25 ZoomEssence, Inc. Low temperature spray drying of carrier-free compositions
CN108672014B (zh) * 2018-05-15 2020-01-21 安徽省华腾农业科技有限公司 颗粒剂的生产系统、生产方法及颗粒剂
CN109126495B (zh) * 2018-07-09 2021-06-01 山东微研生物科技有限公司 一种节能环保型维生素b2干燥装置
EP3931544A1 (en) * 2019-03-01 2022-01-05 The Chemours Company FC, LLC Process and apparatus for quantifying solid residue on a substrate
US11121354B2 (en) * 2019-06-28 2021-09-14 eJoule, Inc. System with power jet modules and method thereof
CN110327642A (zh) * 2019-07-08 2019-10-15 浙江正裕化学工业有限公司 一种固体染料生产的喷雾干燥机
CN111515000B (zh) * 2020-04-30 2022-02-01 厦门高容纳米新材料科技有限公司 一种纳米粉体的分散方法
CN111624071A (zh) * 2020-06-17 2020-09-04 北京雪迪龙科技股份有限公司 一种多种粒径标准粒子的发生装置及方法
CN111790484A (zh) * 2020-07-20 2020-10-20 袁静 一种移动式薯类淀粉加工机组
CN114669085B (zh) * 2022-01-28 2024-05-31 南京宁源科生物技术有限公司 一种药用颗粒的有机溶剂去除装置
CN114497548B (zh) * 2022-01-28 2023-10-03 佛山市德方纳米科技有限公司 纳米级正极材料及其制备方法、制备装置和锂离子电池
CN114575417B (zh) * 2022-03-28 2022-11-04 哈尔滨工业大学 一种采用阀控主动送风的液态水收集器
CN117208888B (zh) * 2023-09-04 2024-02-27 博路天成新能源科技有限公司 一种钠离子电池用硬碳负极材料制作工艺
CN117772382A (zh) * 2024-02-28 2024-03-29 中科雅丽科技有限公司 一种玻璃微珠研磨粉体细度精控调整方法

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3215572A (en) * 1963-10-09 1965-11-02 Papell Solomon Stephen Low viscosity magnetic fluid obtained by the colloidal suspension of magnetic particles
US4420441A (en) * 1982-02-23 1983-12-13 National Research Development Corp. Method of making a two-phase or multi-phase metallic material
DE3702787A1 (de) * 1987-01-30 1988-08-11 Bayer Ag Verfahren und vorrichtung zum mikronisieren von feststoffen in strahlmuehlen
US5205290A (en) * 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
GB9107628D0 (en) 1991-04-10 1991-05-29 Moonbrook Limited Preparation of diagnostic agents
US5438573A (en) * 1991-09-13 1995-08-01 Sundisk Corporation Flash EEPROM array data and header file structure
ATE154241T1 (de) * 1991-10-01 1997-06-15 Takeda Chemical Industries Ltd Mikropartikeln-zusammenfassung zur verlängerten freigabe und herstellung derselbe
GB9221329D0 (en) 1992-10-10 1992-11-25 Delta Biotechnology Ltd Preparation of further diagnostic agents
DK0669128T3 (da) 1992-11-17 2000-06-19 Yoshitomi Pharmaceutical Sustained-release mikrosfære indeholdende antipsykotikum og fremgangsmåde til at fremstille samme
DE4319990A1 (de) * 1993-06-17 1994-12-22 Messer Griesheim Gmbh Verfahren zum Herstellen von Teilchen aus Kunststoffen
TW402506B (en) 1993-06-24 2000-08-21 Astra Ab Therapeutic preparation for inhalation
IS1796B (is) 1993-06-24 2001-12-31 Ab Astra Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband
ES2231775T5 (es) * 1993-07-30 2011-02-02 Imcor Pharmaceutical Co. Composición de microburbujas estabilizadas para ecografía.
US5667927A (en) 1993-08-30 1997-09-16 Shimadu Corporation Toner for electrophotography and process for the production thereof
US5596815A (en) * 1994-06-02 1997-01-28 Jet-Pro Company, Inc. Material drying process
US6165976A (en) 1994-06-23 2000-12-26 Astra Aktiebolag Therapeutic preparation for inhalation
US6117455A (en) 1994-09-30 2000-09-12 Takeda Chemical Industries, Ltd. Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent
US5983956A (en) * 1994-10-03 1999-11-16 Astra Aktiebolag Formulation for inhalation
GB9423419D0 (en) * 1994-11-19 1995-01-11 Andaris Ltd Preparation of hollow microcapsules
SE9501384D0 (sv) * 1995-04-13 1995-04-13 Astra Ab Process for the preparation of respirable particles
US6045913A (en) 1995-11-01 2000-04-04 Minnesota Mining And Manufacturing Company At least partly fused particulates and methods of making them by flame fusion
US6254981B1 (en) 1995-11-02 2001-07-03 Minnesota Mining & Manufacturing Company Fused glassy particulates obtained by flame fusion
US5611344A (en) 1996-03-05 1997-03-18 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
AU721209B2 (en) 1996-03-05 2000-06-29 Acusphere, Inc. Microencapsulated fluorinated gases for use as imaging agents
US6096339A (en) 1997-04-04 2000-08-01 Alza Corporation Dosage form, process of making and using same
US5855913A (en) * 1997-01-16 1999-01-05 Massachusetts Instite Of Technology Particles incorporating surfactants for pulmonary drug delivery
US5833892A (en) * 1996-07-12 1998-11-10 Kemira Pigments, Inc. Formation of TiO2 pigment by spray calcination
US6139872A (en) * 1996-08-14 2000-10-31 Henkel Corporation Method of producing a vitamin product
AU4571097A (en) 1996-10-09 1998-05-05 Takeda Chemical Industries Ltd. A method for producing a microparticle
US6068600A (en) 1996-12-06 2000-05-30 Quadrant Healthcare (Uk) Limited Use of hollow microcapsules
AU6014098A (en) * 1996-12-31 1998-07-31 Inhale Therapeutic Systems Aerosolized hydrophobic drug
SE9700135D0 (sv) * 1997-01-20 1997-01-20 Astra Ab New formulation
GB9702799D0 (en) * 1997-02-12 1997-04-02 Scherer Corp R P Process for preparing solid pharmaceutical dosage forms
DE19728382C2 (de) 1997-07-03 2003-03-13 Hosokawa Alpine Ag & Co Verfahren und Vorrichtung zur Fließbett-Strahlmahlung
SE9703407D0 (sv) * 1997-09-19 1997-09-19 Astra Ab New use
IT1295226B1 (it) * 1997-10-14 1999-05-04 Magneti Marelli Spa Impianto per la produzione di manufatti pressocolati o stampati ad iniezione impiegando anime in sale.
US6187345B1 (en) 1998-04-14 2001-02-13 Jack Lawrence James Flutamide compositions and preparations
PL343491A1 (en) * 1998-04-18 2001-08-27 Glaxo Group Ltd Pharmaceutical aerosol formulation
US6423345B2 (en) 1998-04-30 2002-07-23 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
US6451349B1 (en) * 1998-08-19 2002-09-17 Quadrant Healthcare (Uk) Limited Spray-drying process for the preparation of microparticles
US6560897B2 (en) 1999-05-03 2003-05-13 Acusphere, Inc. Spray drying apparatus and methods of use
US6223455B1 (en) 1999-05-03 2001-05-01 Acusphere, Inc. Spray drying apparatus and methods of use
US6395300B1 (en) 1999-05-27 2002-05-28 Acusphere, Inc. Porous drug matrices and methods of manufacture thereof
US6443376B1 (en) 1999-12-15 2002-09-03 Hosokawa Micron Powder Systems Apparatus for pulverizing and drying particulate matter
EP1129705A1 (en) 2000-02-17 2001-09-05 Rijksuniversiteit te Groningen Powder formulation for inhalation
GB0012261D0 (en) * 2000-05-19 2000-07-12 Astrazeneca Ab Novel process
GB0012260D0 (en) 2000-05-19 2000-07-12 Astrazeneca Ab Novel composition
US20040022862A1 (en) * 2000-12-22 2004-02-05 Kipp James E. Method for preparing small particles
US6962071B2 (en) * 2001-04-06 2005-11-08 Bracco Research S.A. Method for improved measurement of local physical parameters in a fluid-filled cavity
AU2003263024A1 (en) * 2002-04-23 2003-11-10 Christopher Mcconville Process of forming and modifying particles and compositions produced thereby
US6919068B2 (en) * 2002-05-17 2005-07-19 Point Biomedical Corporation Method of preparing gas-filled polymer matrix microparticles useful for echographic imaging
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
US6962006B2 (en) * 2002-12-19 2005-11-08 Acusphere, Inc. Methods and apparatus for making particles using spray dryer and in-line jet mill
US7511079B2 (en) * 2003-03-24 2009-03-31 Baxter International Inc. Methods and apparatuses for the comminution and stabilization of small particles
US7485283B2 (en) * 2004-04-28 2009-02-03 Lantheus Medical Imaging Contrast agents for myocardial perfusion imaging

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