BR0317168A - Composto ou uma forma farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos de reduzir condutância de cálcio de um receptor de capsaicina celular, e de inibir ligação de ligante vanilóide a um receptor de capsaicina, métodos de tratar uma condição responsiva à modulação de receptor de capsaicina, dor, coceira, tosse ou soluços, incontinência urinária, de promover perda de peso em paciente, e de determinar a presença ou ausência de receptor de capsaicina em uma amostra, preparação farmacêutica embalada, e, uso de um composto - Google Patents

Composto ou uma forma farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos de reduzir condutância de cálcio de um receptor de capsaicina celular, e de inibir ligação de ligante vanilóide a um receptor de capsaicina, métodos de tratar uma condição responsiva à modulação de receptor de capsaicina, dor, coceira, tosse ou soluços, incontinência urinária, de promover perda de peso em paciente, e de determinar a presença ou ausência de receptor de capsaicina em uma amostra, preparação farmacêutica embalada, e, uso de um composto

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Publication number
BR0317168A
BR0317168A BR0317168-0A BR0317168A BR0317168A BR 0317168 A BR0317168 A BR 0317168A BR 0317168 A BR0317168 A BR 0317168A BR 0317168 A BR0317168 A BR 0317168A
Authority
BR
Brazil
Prior art keywords
capsaicin receptor
methods
compound
receptor
itching
Prior art date
Application number
BR0317168-0A
Other languages
English (en)
Inventor
Rajagopal Bakthavatchalam
Charles A Blum
Harry Brielmann
Timothy M Caldwell
Stephane Delombaert
Kevin J Hodgetts
Xiaozhang Zheng
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of BR0317168A publication Critical patent/BR0317168A/pt

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Abstract

"COMPOSTO OU UMA FORMA FARMACEUTICAMENTE ACEITáVEL DO MESMO, COMPOSIçãO FARMACêUTICA, MéTODOS DE REDUZIR CONDUTâNCIA DE CáLCIO DE UM RECEPTOR DE CAPSAICINA CELULAR, E DE INIBIR LIGAçãO DE LIGANTE VANILóIDE A UM RECEPTOR DE CAPSAICINA, MéTODOS DE TRATAR UMA CONDIçãO RESPONSIVA à MODULAçãO DE RECEPTOR DE CAPSAICINA, DOR, COCEIRA, TOSSE OU SOLUçOS, INCONTINêNCIA URINáRIA, DE PROMOVER PERDA DE PESO EM UM PACIENTE, E DE DETERMINAR A PRESENçA OU AUSêNCIA DE RECEPTOR DE CAPSAICINA EM UMA AMOSTRA, PREPARAçãO FARMACêUTICA EMBALADA, E, USO DE UM COMPOSTO". Proporciona-se determinados análogos de quinazolin-4-ilamina com substituição em 2. Referidos compostos são ligantes que podem ser usados para modular atividade de receptor especifico in vivo ou in vitro, e são particularmente úteis no tratamento de condições associadas com ativação patológica de receptor em humanos, animais de companhia domesticados e animais de criação. Proporciona-se composições farmacêuticas e métodos para utilizar os mesmos no tratamento de referidos distúrbios, bem como métodos para utilizar referidos ligantes para estudos de localização de receptor.
BR0317168-0A 2002-12-13 2003-12-12 Composto ou uma forma farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos de reduzir condutância de cálcio de um receptor de capsaicina celular, e de inibir ligação de ligante vanilóide a um receptor de capsaicina, métodos de tratar uma condição responsiva à modulação de receptor de capsaicina, dor, coceira, tosse ou soluços, incontinência urinária, de promover perda de peso em paciente, e de determinar a presença ou ausência de receptor de capsaicina em uma amostra, preparação farmacêutica embalada, e, uso de um composto BR0317168A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43313902P 2002-12-13 2002-12-13
PCT/US2003/039606 WO2004055003A1 (en) 2002-12-13 2003-12-12 2-substituted quinazolin-4-ylamine analogues as capsaicin receptor modulators

Publications (1)

Publication Number Publication Date
BR0317168A true BR0317168A (pt) 2005-11-01

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BR0317168-0A BR0317168A (pt) 2002-12-13 2003-12-12 Composto ou uma forma farmaceuticamente aceitável do mesmo, composição farmacêutica, métodos de reduzir condutância de cálcio de um receptor de capsaicina celular, e de inibir ligação de ligante vanilóide a um receptor de capsaicina, métodos de tratar uma condição responsiva à modulação de receptor de capsaicina, dor, coceira, tosse ou soluços, incontinência urinária, de promover perda de peso em paciente, e de determinar a presença ou ausência de receptor de capsaicina em uma amostra, preparação farmacêutica embalada, e, uso de um composto

Country Status (13)

Country Link
US (2) US20040156869A1 (pt)
EP (2) EP1569925A1 (pt)
JP (2) JP2006515847A (pt)
KR (1) KR20050084292A (pt)
CN (1) CN1726205A (pt)
AR (1) AR042461A1 (pt)
AU (2) AU2003300898A1 (pt)
BR (1) BR0317168A (pt)
CA (2) CA2509233A1 (pt)
MX (1) MXPA05006123A (pt)
PE (1) PE20040935A1 (pt)
TW (1) TW200418480A (pt)
WO (2) WO2004055003A1 (pt)

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ES2400339T3 (es) 2002-07-15 2013-04-09 Symphony Evolution, Inc. Compuestos, composiciones farmacéuticas de los mismos y su uso en el tratamiento del cáncer
WO2004054582A1 (en) * 2002-12-13 2004-07-01 Neurogen Corporation Combination therapy for the treatment of pain
WO2004055003A1 (en) * 2002-12-13 2004-07-01 Neurogen Corporation 2-substituted quinazolin-4-ylamine analogues as capsaicin receptor modulators
DE602004007141T2 (de) * 2003-07-10 2007-10-11 Neurogen Corp., Branford Aryl-substituierte Benzo(D)isothiazol-3-Ylamin Analoga als Capsaicinrezeptormodulatoren
TW200510373A (en) 2003-07-14 2005-03-16 Neurogen Corp Substituted quinolin-4-ylamine analogues
US7329664B2 (en) * 2003-07-16 2008-02-12 Neurogen Corporation Substituted (7-pyridyl-4-phenylamino-quinazolin-2-yl)-methanol analogues
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