BR0315867A - Composições e métodos para terapia transdérmica com oxibutinina - Google Patents
Composições e métodos para terapia transdérmica com oxibutininaInfo
- Publication number
- BR0315867A BR0315867A BR0315867-5A BR0315867A BR0315867A BR 0315867 A BR0315867 A BR 0315867A BR 0315867 A BR0315867 A BR 0315867A BR 0315867 A BR0315867 A BR 0315867A
- Authority
- BR
- Brazil
- Prior art keywords
- oxybutynin
- compositions
- therapy
- methods
- adverse drug
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00544—Plasters form or structure
- A61F2013/00646—Medication patches, e.g. transcutaneous
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Emergency Medicine (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Urology & Nephrology (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
"COMPOSIçõES E MéTODOS PARA TERAPIA TRANSDéRMICA COM OXIBUTININA". A presente invenção refere-se a composições e métodos para administrar oxibutinina enquanto minimiza a incidência e/ou gravidade de experiências adversas com droga associadas à terapia com oxibutinina. Em um aspecto, essas composições e métodos proporcionam uma menor concentração plasmática de metabólitos de oxibutinina, tal como N-desetiloxibutinina, que se presume estar contribuindo pelo menos em parte para algumas das experiências adversas com droga, enquanto mantém concentração plasmática de oxibutinina suficiente para beneficiar um indivíduo com terapia de oxibutinina. A invenção também se refere a isómeros de oxibutinina e seus metabólitos que satisfazem essas características de incidência e/ou gravidade minimizadas de experiências adversas com droga, e manutenção de terapia benéfica e eficaz para bexiga superativa. Em alguns aspectos, as composições poderão se apresentar na forma de um gel administrado topicamente de forma desobstruída ou livre.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/286,381 US7029694B2 (en) | 2000-04-26 | 2002-11-01 | Compositions and methods for transdermal oxybutynin therapy |
PCT/US2003/034654 WO2004041188A2 (en) | 2002-11-01 | 2003-10-31 | Compositions and methods for transdermal oxybutynin therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0315867A true BR0315867A (pt) | 2005-09-27 |
Family
ID=32312070
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0315867-5A BR0315867A (pt) | 2002-11-01 | 2003-10-31 | Composições e métodos para terapia transdérmica com oxibutinina |
Country Status (16)
Country | Link |
---|---|
US (1) | US7029694B2 (pt) |
EP (4) | EP2612629B1 (pt) |
JP (4) | JP2006513161A (pt) |
KR (4) | KR20110043725A (pt) |
CN (2) | CN101904812A (pt) |
AU (2) | AU2003287377B2 (pt) |
BR (1) | BR0315867A (pt) |
CA (2) | CA2504021C (pt) |
DK (1) | DK1565136T3 (pt) |
ES (2) | ES2764081T3 (pt) |
MX (1) | MXPA05004110A (pt) |
NO (2) | NO339626B1 (pt) |
NZ (2) | NZ586108A (pt) |
RU (1) | RU2311170C2 (pt) |
WO (1) | WO2004041188A2 (pt) |
ZA (1) | ZA200503316B (pt) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7179483B2 (en) * | 2000-04-26 | 2007-02-20 | Watson Pharmaceuticals, Inc. | Compositions and methods for transdermal oxybutynin therapy |
US7029694B2 (en) * | 2000-04-26 | 2006-04-18 | Watson Laboratories, Inc. | Compositions and methods for transdermal oxybutynin therapy |
US8980290B2 (en) | 2000-08-03 | 2015-03-17 | Antares Pharma Ipl Ag | Transdermal compositions for anticholinergic agents |
US20070225379A1 (en) * | 2001-08-03 | 2007-09-27 | Carrara Dario Norberto R | Transdermal delivery of systemically active central nervous system drugs |
US20040198706A1 (en) * | 2003-03-11 | 2004-10-07 | Carrara Dario Norberto R. | Methods and formulations for transdermal or transmucosal application of active agents |
US7198801B2 (en) * | 2000-08-03 | 2007-04-03 | Antares Pharma Ipl Ag | Formulations for transdermal or transmucosal application |
AU2001282064B2 (en) * | 2000-08-03 | 2007-02-01 | Antares Pharma Ipl Ag | Novel composition for transdermal and/or transmucosal administration of active compounds that ensures adequate therapeutic levels |
US8846039B2 (en) * | 2002-04-26 | 2014-09-30 | Asan Laboratories Company (Cayman), Limited | Method for ameliorating pruritus |
US6809118B2 (en) * | 2002-07-25 | 2004-10-26 | Yih-Lin Chung | Methods for therapy of radiation cutaneous syndrome |
US20060275370A1 (en) * | 2002-07-25 | 2006-12-07 | Yih-Lin Chung | Method and compositions for treatment of epithelial damage |
US8163764B2 (en) * | 2002-04-26 | 2012-04-24 | Asan Laboratories Company (Cayman) Limited | Skincare methods |
US8946295B2 (en) * | 2002-07-25 | 2015-02-03 | Sunny Pharmtech Inc. | Histone hyperacetylating agents for promoting wound healing and preventing scar formation |
US7101566B2 (en) * | 2002-06-28 | 2006-09-05 | Ethicon, Inc. | Polymer coated microparticles for sustained release |
AU2003272517A1 (en) * | 2002-09-13 | 2004-04-30 | Zicam, Llc. | Compositions to reduce congestion and methods for application thereof to the nasal membrane |
ES2285457T3 (es) * | 2003-05-07 | 2007-11-16 | Firmenich Sa | Perfume rociable con una tenacidad mejorada. |
DE10340428B4 (de) * | 2003-09-02 | 2015-02-12 | Acino Ag | Opioides Analgetikum enthaltende transdermale Formulierung |
TW200512013A (en) * | 2003-09-18 | 2005-04-01 | Orient Europharma Co Ltd | Gel formulation of oxybutynin hydrochloride |
AU2004283431B2 (en) * | 2003-10-10 | 2009-09-10 | Antares Pharma Ipl Ag | Transdermal pharmaceutical formulation for minimizing skin residues |
US7425340B2 (en) * | 2004-05-07 | 2008-09-16 | Antares Pharma Ipl Ag | Permeation enhancing compositions for anticholinergic agents |
WO2007124250A2 (en) | 2006-04-21 | 2007-11-01 | Antares Pharma Ipl Ag | Methods of treating hot flashes with formulations for transdermal or transmucosal application |
US8067399B2 (en) | 2005-05-27 | 2011-11-29 | Antares Pharma Ipl Ag | Method and apparatus for transdermal or transmucosal application of testosterone |
JP5815915B2 (ja) * | 2005-10-11 | 2015-11-17 | ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション | 過活動膀胱障害の治療のためのスフィンゴミエリンリポソーム |
EP1951186A4 (en) | 2005-10-19 | 2009-11-04 | Menni Menashe Zinger | METHODS FOR TREATING HYPERHIDROSIS |
WO2008067991A2 (en) * | 2006-12-08 | 2008-06-12 | Antares Pharma Ipl Ag | Skin-friendly drug complexes for transdermal administration |
WO2009150408A2 (en) * | 2008-06-13 | 2009-12-17 | Summit Corporation Plc | Topical antimuscarinic formulations |
CA2730847A1 (en) * | 2008-07-14 | 2010-01-21 | Otonomy, Inc. | Controlled-release apoptosis modulating compositions and methods for the treatment of otic disorders |
US20100016450A1 (en) * | 2008-07-21 | 2010-01-21 | Otonomy, Inc. | Controlled release delivery devices for the treatment of otic disorders |
CN101564377A (zh) * | 2009-04-24 | 2009-10-28 | 杭州锐思医药科技有限公司 | 奥昔布宁透皮凝胶及其制备方法 |
US8920392B2 (en) * | 2009-05-05 | 2014-12-30 | Watson Laboratories, Inc. | Method for treating overactive bladders and a device for storage and administration of topical oxybutynin compositions |
EP2473161B1 (en) | 2009-08-31 | 2017-05-17 | Dr. Reddy's Laboratories Ltd. | Topical formulations comprising a steroid |
CN102309447A (zh) * | 2010-07-06 | 2012-01-11 | 上海现代药物制剂工程研究中心有限公司 | 含盐酸奥昔布宁的自粘性喷雾透皮组合物及制备方法 |
US11083696B2 (en) * | 2011-09-21 | 2021-08-10 | University College Cardiff Consultants Limited | Dispersion anaesthetic device |
US20140271796A1 (en) * | 2011-10-26 | 2014-09-18 | Hisamitsu Pharmaceutical Co., Inc. | Oxybutynin-containing transdermal absorption preparation |
KR20140121487A (ko) | 2012-03-14 | 2014-10-15 | 반다 파마슈티칼즈, 인코퍼레이티드. | 정신적 질환의 치료 용도를 위한 일로페리돈 대사물질 |
CN102614108B (zh) * | 2012-04-16 | 2013-10-16 | 上海现代药物制剂工程研究中心有限公司 | 含奥昔布宁的立方水质液晶凝胶经皮吸收制剂及其制法 |
US20160184431A1 (en) | 2014-03-11 | 2016-06-30 | Promius Pharma Llc | Topical compositions comprising a corticosteroid |
CA2973372A1 (en) | 2015-01-09 | 2016-07-14 | Chase Pharmaceuticals Corporation | Oxybutynin transdermal therapeutic system combination |
US10525132B2 (en) * | 2015-04-30 | 2020-01-07 | Hisamitsu Pharmaceutical Co., Inc. | External agent for treating hyperhidrosis |
JP6564927B2 (ja) * | 2016-02-25 | 2019-08-21 | 久光製薬株式会社 | 外用液剤 |
WO2018063876A1 (en) * | 2016-09-30 | 2018-04-05 | Alpha To Omega Pharmaceutical Consultants, Inc. | Transdermal and/or topical delivery systems comprising cetirizine dihydrochloride |
US11033511B2 (en) * | 2017-08-01 | 2021-06-15 | Hisamitsu Pharmaceutical Co., Inc. | Pharmaceutical patch |
WO2022045200A1 (ja) * | 2020-08-28 | 2022-03-03 | 久光製薬株式会社 | 多汗症治療用の外用液剤 |
Family Cites Families (68)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US147236A (en) * | 1874-02-10 | Improvement in devices for riveting the teeth of saws | ||
US161044A (en) * | 1875-03-23 | Improvement in combined shovels and ash-pan lifters | ||
US2909462A (en) | 1955-12-08 | 1959-10-20 | Bristol Myers Co | Acrylic acid polymer laxative compositions |
US5736577A (en) | 1995-01-31 | 1998-04-07 | Sepracor, Inc. | Methods and compositions for treating urinary incontinence using optically pure (S)-oxybutynin |
US4405616A (en) | 1975-06-19 | 1983-09-20 | Nelson Research & Development Company | Penetration enhancers for transdermal drug delivery of systemic agents |
US4316893A (en) | 1975-06-19 | 1982-02-23 | Nelson Research & Development Co. | Vehicle composition containing 1-substituted azacycloalkan-2-ones |
US3989816A (en) | 1975-06-19 | 1976-11-02 | Nelson Research & Development Company | Vehicle composition containing 1-substituted azacycloheptan-2-ones |
JPS6025045B2 (ja) | 1980-03-19 | 1985-06-15 | 製鉄化学工業株式会社 | 塩水吸収能のすぐれたアクリル酸重合体の製造方法 |
US4557934A (en) | 1983-06-21 | 1985-12-10 | The Procter & Gamble Company | Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one |
JPS60100516A (ja) | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
US4959217A (en) | 1986-05-22 | 1990-09-25 | Syntex (U.S.A.) Inc. | Delayed/sustained release of macromolecules |
US5028430A (en) | 1987-05-08 | 1991-07-02 | Syntex (U.S.A.) Inc. | Delivery systems for the controlled administration of LHRH analogs |
US5641504A (en) | 1988-06-09 | 1997-06-24 | Alza Corporation | Skin permeation enhancer compositions using glycerol monolinoleate |
EP0481007B1 (en) | 1989-06-07 | 1997-01-22 | BAZZANO, Gail S | SLOW RELEASE VEHICLES FOR MINIMIZING SKIN IRRITANCY OF TOPICAL COMPOSITIONS containing retinoids |
US5922342A (en) | 1990-10-01 | 1999-07-13 | Pharmacia & Upjohn Company | Lateral edge coated controlled release pharmaceutical compositions |
US5152997A (en) | 1990-12-11 | 1992-10-06 | Theratech, Inc. | Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels |
US5164190A (en) | 1990-12-11 | 1992-11-17 | Theratech, Inc. | Subsaturated transdermal drug delivery device exhibiting enhanced drug flux |
US5212199A (en) | 1991-05-17 | 1993-05-18 | Theratech, Inc. | Sorbitan esters as skin permeation enhancers |
US5227169A (en) | 1991-05-17 | 1993-07-13 | Theratech, Inc. | Sorbitan esters as skin permeation enhancers |
MX9202350A (es) | 1991-05-20 | 1992-11-01 | Alza Corp | Composiciones de incrementador de penetracion a la piel que usan monolinoleato de glicerol. |
AU670777B2 (en) | 1992-04-16 | 1996-08-01 | Ortho Pharmaceutical Corporation | Aqueous gel vehicles for retinoids |
JP3786684B2 (ja) | 1992-05-13 | 2006-06-14 | アルザ・コーポレーション | オキシブチニンの経皮投与 |
US5900250A (en) | 1992-05-13 | 1999-05-04 | Alza Corporation | Monoglyceride/lactate ester permeation enhancer for oxybutnin |
US5534496A (en) | 1992-07-07 | 1996-07-09 | University Of Southern California | Methods and compositions to enhance epithelial drug transport |
JP3190441B2 (ja) * | 1992-07-20 | 2001-07-23 | エーザイ株式会社 | 塩酸アゼラスチンを含有する安定な製剤 |
JP3277342B2 (ja) | 1992-09-02 | 2002-04-22 | 武田薬品工業株式会社 | 徐放性マイクロカプセルの製造法 |
US5747065A (en) | 1993-09-29 | 1998-05-05 | Lee; Eun Soo | Monoglyceride/lactate ester permeation enhancer for oxybutynin |
WO1995024172A1 (en) | 1994-03-07 | 1995-09-14 | Theratech, Inc. | Drug-containing adhesive composite transdermal delivery device |
ZA954599B (en) | 1994-06-07 | 1996-01-26 | Allergan Inc | Stable gel formulation for topical treatment of skin conditions |
NL9401051A (nl) * | 1994-06-24 | 1996-02-01 | Stichting Tech Wetenschapp | Microfoon op basis van fluidum-stroommeting en akoestische generator gebaseerd daarop. |
US5840338A (en) | 1994-07-18 | 1998-11-24 | Roos; Eric J. | Loading of biologically active solutes into polymer gels |
US5635203A (en) | 1994-09-29 | 1997-06-03 | Alza Corporation | Transdermal device having decreased delamination |
WO1996011022A1 (fr) | 1994-10-05 | 1996-04-18 | Hisamitsu Pharmaceutical Co., Inc. | Constituants de composition medicamenteuse comprenant des derives de o-toluidine n-substituee et preparation absorbable par voie cutanee |
US5516808A (en) | 1994-10-27 | 1996-05-14 | Sawaya; Assad S. | Topical cellulose pharmaceutical formulation |
US5582838A (en) | 1994-12-22 | 1996-12-10 | Merck & Co., Inc. | Controlled release drug suspension delivery device |
US5562917A (en) | 1994-12-23 | 1996-10-08 | Pentech Pharmaceuticals, Inc. | Transdermal administration of apomorphine |
US5532278A (en) | 1995-01-31 | 1996-07-02 | Sepracor, Inc. | Methods and compositions for treating urinary incontinence using optically pure (S)-oxybutynin |
US5677346A (en) | 1995-01-31 | 1997-10-14 | Sepracor, Inc. | Treating urinary incontinence using (S)-desethyloxybutynin |
DE19511698C1 (de) | 1995-03-30 | 1996-08-22 | Schober Werkzeug & Maschbau | Vorrichtung zum Verbinden einer Siegelfolie mit einer Materialbahn |
US5601839A (en) | 1995-04-26 | 1997-02-11 | Theratech, Inc. | Triacetin as a penetration enhancer for transdermal delivery of a basic drug |
US5912268A (en) | 1995-05-22 | 1999-06-15 | Alza Corporation | Dosage form and method for treating incontinence |
US5674895A (en) | 1995-05-22 | 1997-10-07 | Alza Corporation | Dosage form comprising oxybutynin |
US5759583A (en) | 1995-08-30 | 1998-06-02 | Syntex (U.S.A.) Inc. | Sustained release poly (lactic/glycolic) matrices |
JP4176832B2 (ja) | 1996-02-02 | 2008-11-05 | インターシア セラピューティクス, インコーポレイティド | 移植可能な系を用いる活性剤の持続投与 |
JPH09255565A (ja) * | 1996-03-26 | 1997-09-30 | Daikyo Yakuhin Kogyo Kk | 皮膚局所麻酔用ヒドロゲルパッチ |
US6096339A (en) | 1997-04-04 | 2000-08-01 | Alza Corporation | Dosage form, process of making and using same |
IT1283102B1 (it) | 1996-06-06 | 1998-04-07 | Permatec Nv | Composizione terapeutica per la somministrazione transdermica di un principio attivo estrogeno o progestinico o di loro miscele |
US5783208A (en) | 1996-07-19 | 1998-07-21 | Theratech, Inc. | Transdermal drug delivery matrix for coadministering estradiol and another steroid |
US5762953A (en) | 1996-08-22 | 1998-06-09 | Theratech, Inc. | Transdermal propentofylline compositions for the treatment of Alzheimers disease |
US5985317A (en) | 1996-09-06 | 1999-11-16 | Theratech, Inc. | Pressure sensitive adhesive matrix patches for transdermal delivery of salts of pharmaceutical agents |
WO1998018416A1 (en) | 1996-10-30 | 1998-05-07 | Theratech, Inc. | Fatty acid esters of glycolic acid and its salts as permeation enhancers |
US6203817B1 (en) | 1997-02-19 | 2001-03-20 | Alza Corporation | Reduction of skin reactions caused by transdermal drug delivery |
DK0973499T3 (da) | 1997-03-31 | 2003-11-17 | Alza Corp | Implanterbart diffusionsafgivelsessystem |
EP0971641A4 (en) | 1997-04-03 | 2003-08-13 | Point Biomedical Corp | SYSTEM FOR THE ADMINISTRATION OF AN INTRAVESICAL MEDICINAL PRODUCT |
JP4138910B2 (ja) * | 1997-07-02 | 2008-08-27 | 帝國製薬株式会社 | 経皮吸収性が良好で且つ皮膚刺激性の少ない塩酸アゼラスチン含有経皮製剤 |
US5905391A (en) | 1997-07-14 | 1999-05-18 | Intel Corporation | Master-slave delay locked loop for accurate delay or non-periodic signals |
US5948433A (en) | 1997-08-21 | 1999-09-07 | Bertek, Inc. | Transdermal patch |
KR100648536B1 (ko) | 1997-11-10 | 2006-11-24 | 셀러지 파마세우티칼스, 인크 | 침투 보강 및 자극 감소를 위한 계 |
DE29823343U1 (de) | 1998-03-20 | 1999-07-15 | Schwarz Pharma Ag, 40789 Monheim | Transdermales Therapeutisches System (TTS) Oxybutynin enthaltend |
AR018321A1 (es) | 1998-03-26 | 2001-11-14 | Alza Corp | Una forma de dosificacion de liberacion prolongada que comprende oxibutinina y los usos de la oxibutinina y de la forma de dosificacion de liberacionprolongada. |
FR2779438B1 (fr) | 1998-06-03 | 2004-12-24 | Jean Marc Aiache | Gel stable, son procede de preparation, et compositions pharmaceutiques le comprenant |
WO2001017472A1 (en) * | 1999-09-08 | 2001-03-15 | Watson Pharmaceuticals, Inc. | Using quaternary ammonium salts for transdermal drug delivery |
US6562368B2 (en) | 1999-12-16 | 2003-05-13 | Dermatrends, Inc. | Transdermal administration of oxybutynin using hydroxide-releasing agents as permeation enhancers |
US7029694B2 (en) * | 2000-04-26 | 2006-04-18 | Watson Laboratories, Inc. | Compositions and methods for transdermal oxybutynin therapy |
AU5378201A (en) * | 2000-04-26 | 2001-11-07 | Watson Pharmaceuticals Inc | Minimizing adverse experience associated with oxybutynin therapy |
US6545046B2 (en) | 2000-08-30 | 2003-04-08 | Theramax Inc. | Method for enhanced delivery of oxybutynin and compositions thereof |
JP5039252B2 (ja) * | 2000-08-31 | 2012-10-03 | ユニメッド ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 性機能低下を治療するための医薬組成物及び方法 |
US9875202B2 (en) | 2015-03-09 | 2018-01-23 | Nordic Semiconductor Asa | Peripheral communication system with shortcut path |
-
2002
- 2002-11-01 US US10/286,381 patent/US7029694B2/en not_active Expired - Lifetime
-
2003
- 2003-10-31 ES ES13159680T patent/ES2764081T3/es not_active Expired - Lifetime
- 2003-10-31 JP JP2004550327A patent/JP2006513161A/ja not_active Withdrawn
- 2003-10-31 AU AU2003287377A patent/AU2003287377B2/en not_active Expired
- 2003-10-31 CN CN2010102423125A patent/CN101904812A/zh active Pending
- 2003-10-31 EP EP13159680.1A patent/EP2612629B1/en not_active Expired - Lifetime
- 2003-10-31 BR BR0315867-5A patent/BR0315867A/pt not_active Application Discontinuation
- 2003-10-31 EP EP13159679.3A patent/EP2606865A1/en not_active Withdrawn
- 2003-10-31 RU RU2005116678/15A patent/RU2311170C2/ru not_active IP Right Cessation
- 2003-10-31 WO PCT/US2003/034654 patent/WO2004041188A2/en active Application Filing
- 2003-10-31 EP EP03781610.5A patent/EP1565136B1/en not_active Expired - Lifetime
- 2003-10-31 NZ NZ586108A patent/NZ586108A/en not_active IP Right Cessation
- 2003-10-31 DK DK03781610T patent/DK1565136T3/da active
- 2003-10-31 KR KR1020117004676A patent/KR20110043725A/ko active Search and Examination
- 2003-10-31 CN CNA2003801023284A patent/CN1708269A/zh active Pending
- 2003-10-31 EP EP19208494.5A patent/EP3659562A1/en active Pending
- 2003-10-31 KR KR1020057007551A patent/KR20050061588A/ko not_active Application Discontinuation
- 2003-10-31 KR KR1020127008065A patent/KR20120038026A/ko active Search and Examination
- 2003-10-31 CA CA2504021A patent/CA2504021C/en not_active Expired - Lifetime
- 2003-10-31 MX MXPA05004110A patent/MXPA05004110A/es active IP Right Grant
- 2003-10-31 CA CA2718277A patent/CA2718277C/en not_active Expired - Lifetime
- 2003-10-31 KR KR1020137004607A patent/KR20130026510A/ko not_active Application Discontinuation
- 2003-10-31 ES ES03781610.5T patent/ES2532495T3/es not_active Expired - Lifetime
- 2003-10-31 NZ NZ539562A patent/NZ539562A/en not_active IP Right Cessation
-
2005
- 2005-04-25 ZA ZA200503316A patent/ZA200503316B/en unknown
- 2005-05-31 NO NO20052625A patent/NO339626B1/no not_active IP Right Cessation
-
2010
- 2010-02-05 AU AU2010200418A patent/AU2010200418B2/en not_active Expired
-
2011
- 2011-09-20 JP JP2011204430A patent/JP5770582B2/ja not_active Expired - Lifetime
-
2015
- 2015-02-26 JP JP2015036485A patent/JP6118358B2/ja not_active Expired - Lifetime
-
2016
- 2016-09-26 JP JP2016187360A patent/JP6209263B2/ja not_active Expired - Lifetime
- 2016-12-01 NO NO20161918A patent/NO343756B1/no not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR0315867A (pt) | Composições e métodos para terapia transdérmica com oxibutinina | |
MX342305B (es) | Minimizacion de experiencias adversas asociadas con la terapia con oxibutinina. | |
BRPI0517481A (pt) | método para tratar, controlar ou evitar uma doença ou distúrbio parasìtico protozoário, e, composição farmacêutica | |
MX2020009246A (es) | Uso del inhibidor de pcsk9 para disminuir el riesgo cardiovascular. | |
BRPI0507895A (pt) | composição para o tratamento de insuficiências venosas crÈnicas, compreendendo um extrato de folhas de videira-vermelha e um agente antiinflamatório | |
BRPI0507189A (pt) | uso combinado de um agonista de glp-1 e compostos de gastrina | |
BR0307975A (pt) | Métodos para reduzir cronicamente a inflamação patológica em um paciente e para determinar a eficácia de um regime de administração crÈnica para tratar inflamação patológica em um indivìduo, composição e terapia combinada para tratamento crÈnico de inflamação patológica em um paciente e uso de um inibidor de alfa-4-integrina | |
NO20056252L (no) | Terapeutiske og profylaktiske metoder for neuromuskulaere lidelser | |
AR044007A1 (es) | Metodos para el tratamiento de la enfermedad de parkinson | |
MX2009013989A (es) | Terapia en combinacion para depresion. | |
BR0013122A (pt) | Ciclobenzaprina para tratamento de distúrbio de ansiedade generalizado e composições de ciclobenzaprina | |
BRPI0515600A (pt) | formas farmacêuticas opióides tendo cmédia e auc em estado estável proporcionais à dose e cmax de dose única inferior ao proporcional à dose | |
CU23821A3 (es) | Composición farmacéutica que comprende una difenilurea sustituida con omega-carboxiarilo para el tratamiento del cáncer | |
BR0209948A (pt) | Inibidores de fator inibitório de migração de macrófago e métodos para identificar os mesmos | |
BR112013010021A2 (pt) | combinações farmacêuticas para o tratamento de distúrbios metabólicos. | |
BRPI0508254A (pt) | métodos e composições para o tratamento ou prevenção de distúrbios psiquiátricos com inibidores de cox-2 sozinhos e em combinação com agentes antidepressivos | |
BR9914419A (pt) | Terapia para melhoria da percepção | |
BRPI0517650A (pt) | uso de ranolazina em combinação com pelo menos um agente de remodelamento para reversão de remodelamento ventricular esquerdo no tratamento de insuficiência cardìaca | |
BR112014027884A2 (pt) | combinações farmacêuticas para tratamento de distúrbios metabólicos | |
AR053928A1 (es) | Metodos reactivos para el tratamiento de trastornos inflamatorios | |
BR112021018973A2 (pt) | Formulação de combinação tripla de baixa dose | |
CL2016001707A1 (es) | Tratamiento de trastornos congnitivos con (r)-7-cloro-n-(quinuclidin-3-il) benzo(b)tiofeno-2-carboxamida y sales farmacéuticamente aceptables de la misma (div. sol. 1178-11). | |
BRPI0411665A (pt) | uso de agomelatina ou de um seu sal farmaceuticamente aceitável, composição farmacêutica ou kit, e, métodos para o tratamento de doenças ou distúrbios responsivos a um inibidor da recaptação de serotonina e para aumentar e/ou proporcionar inìcio mais rápido do efeito terapêutico de um inibidor da recaptação de serotonina | |
BR112014030777A2 (pt) | método e composição para aliviar sintomas de tumor | |
BR112012024936A2 (pt) | uso de diacereína ou de um sal, um análogo, uma prodroga, ou um metabólito ativo farmaceuticamente aceitável do mesmo |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
B15K | Others concerning applications: alteration of classification |
Free format text: A CLASSIFICACAO ANTERIOR ERA: A61F 13/00 Ipc: A61K 9/00 (2006.01), A61K 31/216 (2006.01), A61P 1 |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |