BRPI0517650A - uso de ranolazina em combinação com pelo menos um agente de remodelamento para reversão de remodelamento ventricular esquerdo no tratamento de insuficiência cardìaca - Google Patents
uso de ranolazina em combinação com pelo menos um agente de remodelamento para reversão de remodelamento ventricular esquerdo no tratamento de insuficiência cardìacaInfo
- Publication number
- BRPI0517650A BRPI0517650A BRPI0517650-6A BRPI0517650A BRPI0517650A BR PI0517650 A BRPI0517650 A BR PI0517650A BR PI0517650 A BRPI0517650 A BR PI0517650A BR PI0517650 A BRPI0517650 A BR PI0517650A
- Authority
- BR
- Brazil
- Prior art keywords
- remodeling
- ranolazine
- heart failure
- reversal
- combination
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
USO DE RANOLAZINA EM COMBINAçáO COM PELO MENOS UM AGENTE DE REMODELAMENTO PARA REVERSAO DE REMODELAMENTO VENTRICULAR ESQUERDO NO TRATAMENTO DE INSUFICIêNCIA CARDìACA. A presente invenção se refere a um método de reversão do remodelamento do ventrículo esquerdo através de administração combinada de quantidades terapeuticamente eficazes de ranolazina e pelo menos um agente de coremodelamento, o qual pode ser um inibidor de ACE, um ARB ou um beta-bloqueador. O método encontra utilidade no tratamento de insuficiência cardíaca. A presente invenção também se refere à formulações farmacêuticas que são adequadas para tal administração combinada.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62615404P | 2004-11-09 | 2004-11-09 | |
PCT/US2005/040824 WO2006053161A1 (en) | 2004-11-09 | 2005-11-09 | Use ranolazine in combination with at least one remodeling agent for reversing left ventricular remodeling in the treatment of heart failure |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0517650A true BRPI0517650A (pt) | 2008-10-14 |
Family
ID=35892429
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0517650-6A BRPI0517650A (pt) | 2004-11-09 | 2005-11-09 | uso de ranolazina em combinação com pelo menos um agente de remodelamento para reversão de remodelamento ventricular esquerdo no tratamento de insuficiência cardìaca |
Country Status (15)
Country | Link |
---|---|
US (2) | US20060111361A1 (pt) |
EP (1) | EP1809289A1 (pt) |
JP (1) | JP2008519770A (pt) |
KR (1) | KR20070084063A (pt) |
CN (1) | CN101072562A (pt) |
AU (1) | AU2005304421A1 (pt) |
BR (1) | BRPI0517650A (pt) |
CA (1) | CA2586840A1 (pt) |
IL (1) | IL183056A0 (pt) |
MX (1) | MX2007005367A (pt) |
NO (1) | NO20072934L (pt) |
RU (1) | RU2007121707A (pt) |
SG (1) | SG156681A1 (pt) |
WO (1) | WO2006053161A1 (pt) |
ZA (1) | ZA200703697B (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2332540A1 (en) * | 2002-05-21 | 2011-06-15 | Cv Therapeutics, Inc. | Administration of ranolazine for the treatment of diabetes |
US9782258B2 (en) * | 2006-09-08 | 2017-10-10 | The Regents Of The University Of California | Intramyocardial patterning for global cardiac resizing and reshaping |
JP2010514696A (ja) * | 2006-12-21 | 2010-05-06 | ギリアード・パロ・アルト・インコーポレイテッド | 心血管症状の低減 |
US20090111826A1 (en) * | 2007-02-13 | 2009-04-30 | Louis Lange | Use of ranolazine for the treatment of cardiovascular diseases |
US20080214555A1 (en) * | 2007-02-13 | 2008-09-04 | Markus Jerling | Use of ranolazine for the treatment of cardiovascular diseases |
WO2008101008A1 (en) * | 2007-02-13 | 2008-08-21 | Cv Therapeutics, Inc. | Use of ranolazine for the treatment of coronary microvascular diseases |
EP2117550A1 (en) * | 2007-02-13 | 2009-11-18 | CV Therapeutics Inc. | Use of ranolazine for the treatment of non-coronary microvascular diseases |
US20080233191A1 (en) * | 2007-03-22 | 2008-09-25 | Brent Blackburn | Use of ranolazine for elevated brain-type natriuretic peptide |
JP2010523264A (ja) * | 2007-04-11 | 2010-07-15 | ヘンリー フォード ヘルス システム | 心臓の静脈系を用いた心臓の修復、リサイジング、およびリシェイピング |
CA2689633A1 (en) * | 2007-05-31 | 2008-12-11 | Cv Therapeutics, Inc. | Use of ranolazine for elevated brain-type natriuretic peptide |
WO2008154033A2 (en) * | 2007-06-11 | 2008-12-18 | Symphony Medical, Inc. | Cardiac patterning for improving diastolic function |
US20090012103A1 (en) * | 2007-07-05 | 2009-01-08 | Matthew Abelman | Substituted heterocyclic compounds |
JP2012526848A (ja) * | 2009-05-14 | 2012-11-01 | ギリアード サイエンシーズ, インコーポレイテッド | Cns障害の治療のためのラノラジン |
CA3130908A1 (en) | 2009-06-30 | 2010-12-30 | Mallinckrodt Hospital Products IP Limited | Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE223218T1 (de) * | 1989-06-23 | 2002-09-15 | Syntex Llc | Ranolazin und verwandte piperazine zum schutz der skelettmuskulatur |
US20030077229A1 (en) * | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing cardiovascular or renal drugs |
AU8026200A (en) * | 1999-10-19 | 2001-04-30 | Board Of Regents, The University Of Texas System | Treatment of heart disease with cox-2 inhibitors |
JP2004505886A (ja) * | 2000-02-18 | 2004-02-26 | スィーヴィー セラピューティクス インコーポレイテッド | 鬱血性心不全の処置における部分的な脂肪酸酸化阻害剤 |
WO2002007716A2 (en) * | 2000-07-21 | 2002-01-31 | Cv Therapeutics, Inc. | Method for treating angina |
US20030220344A1 (en) * | 2002-04-04 | 2003-11-27 | Luiz Belardinelli | Method of treating arrhythmias |
-
2005
- 2005-11-09 AU AU2005304421A patent/AU2005304421A1/en not_active Abandoned
- 2005-11-09 MX MX2007005367A patent/MX2007005367A/es unknown
- 2005-11-09 EP EP05826116A patent/EP1809289A1/en not_active Withdrawn
- 2005-11-09 BR BRPI0517650-6A patent/BRPI0517650A/pt not_active IP Right Cessation
- 2005-11-09 SG SG200907097-0A patent/SG156681A1/en unknown
- 2005-11-09 CA CA002586840A patent/CA2586840A1/en not_active Abandoned
- 2005-11-09 JP JP2007540416A patent/JP2008519770A/ja not_active Withdrawn
- 2005-11-09 CN CNA2005800380175A patent/CN101072562A/zh active Pending
- 2005-11-09 WO PCT/US2005/040824 patent/WO2006053161A1/en active Application Filing
- 2005-11-09 KR KR1020077010435A patent/KR20070084063A/ko not_active Application Discontinuation
- 2005-11-09 RU RU2007121707/14A patent/RU2007121707A/ru not_active Application Discontinuation
- 2005-11-09 US US11/271,168 patent/US20060111361A1/en not_active Abandoned
-
2007
- 2007-05-08 ZA ZA200703697A patent/ZA200703697B/xx unknown
- 2007-05-08 IL IL183056A patent/IL183056A0/en unknown
- 2007-06-08 NO NO20072934A patent/NO20072934L/no not_active Application Discontinuation
-
2009
- 2009-02-26 US US12/393,952 patent/US20090176772A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
WO2006053161A1 (en) | 2006-05-18 |
AU2005304421A1 (en) | 2006-05-18 |
US20060111361A1 (en) | 2006-05-25 |
ZA200703697B (en) | 2008-09-25 |
CA2586840A1 (en) | 2006-05-18 |
NO20072934L (no) | 2007-08-08 |
IL183056A0 (en) | 2007-10-31 |
JP2008519770A (ja) | 2008-06-12 |
WO2006053161A8 (en) | 2006-09-14 |
CN101072562A (zh) | 2007-11-14 |
MX2007005367A (es) | 2007-06-18 |
RU2007121707A (ru) | 2008-12-20 |
EP1809289A1 (en) | 2007-07-25 |
KR20070084063A (ko) | 2007-08-24 |
SG156681A1 (en) | 2009-11-26 |
US20090176772A1 (en) | 2009-07-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2160 DE 29/05/2012. |