BR0314475A - Substituìdos 4-(indazol-3-il) fenóis como ligandos de receptor de estrogênio (er) e seu uso no tratamento de doenças inflamatórias - Google Patents

Substituìdos 4-(indazol-3-il) fenóis como ligandos de receptor de estrogênio (er) e seu uso no tratamento de doenças inflamatórias

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Publication number
BR0314475A
BR0314475A BR0314475-5A BR0314475A BR0314475A BR 0314475 A BR0314475 A BR 0314475A BR 0314475 A BR0314475 A BR 0314475A BR 0314475 A BR0314475 A BR 0314475A
Authority
BR
Brazil
Prior art keywords
indazol
ligands
treatment
estrogen receptor
phenols
Prior art date
Application number
BR0314475-5A
Other languages
English (en)
Inventor
Robert John Steffan
Edward Martin Matelan
Mark Anthony Ashwell
William Ronald Solvibile
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of BR0314475A publication Critical patent/BR0314475A/pt

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    • A61K31/415—1,2-Diazoles
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Abstract

"SUBSTITUìDOS 4-(INDAZOL-3-IL)FENóIS COMO LIGANDOS DE RECEPTOR DE ESTROGêNIO (ER) E SEU USO NO TRATAMENTO DE DOENçAS INFLAMATóRIAS". Esta invenção fornece o composto de fórmulas I ou II, apresentando a estrutura em que R~ 1~, R~ 2~, R~ 3~, R~ 4~, R~ 5~, R~ 6~, R~ 7~, R~ 8~, e R~ 10~ estão de acordo com o que é definido na especificação ou seu sal farmaceuticamente aceitável, que são úteis para o tratamento do componente inflamatório de doenças e são particularmente úteis no tratamento de aterosclerose, infarto do miocárdio, falha congestiva do coração, doença inflamatória do intestino. Artrite, diabetes tipo II e doenças auto-imunes como esclerose múltipla e artrite reumatóide.
BR0314475-5A 2002-09-25 2003-09-24 Substituìdos 4-(indazol-3-il) fenóis como ligandos de receptor de estrogênio (er) e seu uso no tratamento de doenças inflamatórias BR0314475A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41393102P 2002-09-25 2002-09-25
PCT/US2003/030252 WO2004031159A1 (en) 2002-09-25 2003-09-24 Substituted 4-(indazol-3-yl)phenols as estrogen receptor (er) ligands and their use in the treatment of inflammatory diseases

Publications (1)

Publication Number Publication Date
BR0314475A true BR0314475A (pt) 2005-08-09

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BR0314475-5A BR0314475A (pt) 2002-09-25 2003-09-24 Substituìdos 4-(indazol-3-il) fenóis como ligandos de receptor de estrogênio (er) e seu uso no tratamento de doenças inflamatórias

Country Status (21)

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US (2) US7241791B2 (pt)
EP (1) EP1542976B1 (pt)
JP (1) JP4459813B2 (pt)
KR (1) KR20050053702A (pt)
CN (2) CN1321984C (pt)
AR (1) AR041378A1 (pt)
AT (1) ATE422202T1 (pt)
AU (1) AU2003276940A1 (pt)
BR (1) BR0314475A (pt)
CA (1) CA2499736A1 (pt)
CR (1) CR7769A (pt)
DE (1) DE60326077D1 (pt)
DK (1) DK1542976T3 (pt)
EC (1) ECSP055704A (pt)
ES (1) ES2319519T3 (pt)
MX (1) MXPA05003275A (pt)
NO (1) NO20051942L (pt)
RU (1) RU2005109387A (pt)
TW (1) TW200409759A (pt)
WO (1) WO2004031159A1 (pt)
ZA (1) ZA200502462B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2507074A1 (en) * 2002-12-02 2004-06-17 F. Hoffmann-La Roche Ag Indazole derivatives as crf antagonists
JP2005089457A (ja) * 2003-09-03 2005-04-07 Yung Shin Pharmaceutical Industry Co Ltd 骨成長を促進するまたは骨吸収を阻害するための薬剤組成物
JPWO2005063222A1 (ja) * 2003-12-26 2007-07-19 協和醗酵工業株式会社 Ｈｓｐ９０ファミリー蛋白質阻害剤
CN101213194A (zh) 2004-08-03 2008-07-02 惠氏公司 可用于治疗心血管疾病的吲唑化合物
DE102004039280A1 (de) * 2004-08-13 2006-02-23 Merck Patent Gmbh 1,5-Diphenyl-pyrazole
EP1784391A1 (en) * 2004-09-02 2007-05-16 Wyeth Phenanthridine carbonyl phenols as cytokine expression modulators
EP1647549A1 (en) 2004-10-14 2006-04-19 Laboratoire Theramex Indazoles, benzisoxazoles and benzisothiazoles as estrogenic agents
US7601847B2 (en) * 2004-10-26 2009-10-13 Wyeth Preparation and purification of 4-(indazol-3-yl)phenols
TW200621237A (en) * 2004-11-01 2006-07-01 Wyeth Corp [(1-h-indazol-3-yl)methyl]phenols and (hydroxyphenyl)(1h-indazol-3-yl)methanones
CN100516049C (zh) * 2004-11-16 2009-07-22 永信药品工业股份有限公司 抗血管生成药n2-(取代的芳基甲基)-3-(取代的苯基)吲唑的合成
MX2007008495A (es) * 2005-01-19 2007-09-14 Wyeth Corp Estructura receptora de estrogenos.
EP2644587A3 (en) 2006-09-12 2013-10-23 Gilead Sciences, Inc. Process and intermediates for preparing integrase inhibitors
EP2184987A4 (en) * 2007-07-31 2011-09-28 Burnham Inst Medical Research BIDENTATE COMPOUNDS AS KINASE INHIBITORS
AR068403A1 (es) 2007-09-11 2009-11-18 Gilead Sciences Inc Proceso e intermediarios para la preparacion de inhibidores de integrasa
CA2728098A1 (en) * 2008-07-17 2010-01-21 Asahi Kasei Pharma Corporation Pyrazole-containing tricyclic compounds as_antagonits of an ep1 receptor
US20110229471A1 (en) 2008-11-26 2011-09-22 Cedars-Sinai Medical Center Methods of determining responsiveness to anti-tnf alpha therapy in inflammatory bowel disease
WO2010075579A2 (en) 2008-12-24 2010-07-01 Cedars-Sinai Medical Center Methods of predicting medically refractive ulcerative colitis (mr-uc) requiring colectomy
TWI476188B (zh) 2010-05-27 2015-03-11 Ube Industries 新穎吲唑衍生物或其鹽及其製造中間體、以及使用其之抗氧化劑
SG11201500812QA (en) 2012-08-03 2015-04-29 Gilead Sciences Inc Process and intermediates for preparing integrase inhibitors
JP2014133739A (ja) * 2012-12-12 2014-07-24 Dainippon Sumitomo Pharma Co Ltd インダゾール誘導体またはピロロピリジン誘導体からなる医薬
EP2978440B1 (en) 2013-03-27 2019-10-02 Cedars-Sinai Medical Center Treating fibrosis by inhibiting tl1a and diagnosing fibrosis by detecting il31ra
WO2015010108A1 (en) 2013-07-19 2015-01-22 Cedars-Sinai Medical Center Signature of tl1a (tnfsf15) signaling pathway
KR102412146B1 (ko) * 2015-02-11 2022-06-22 주식회사 아이엔테라퓨틱스 소디움 채널 차단제
US11186872B2 (en) 2016-03-17 2021-11-30 Cedars-Sinai Medical Center Methods of diagnosing inflammatory bowel disease through RNASET2
CN106511350A (zh) * 2016-09-26 2017-03-22 张德芳 6‑羟基‑7‑芳甲酰基喹啉酮类化合物在治疗溃疡性结肠炎中的应用
WO2018188590A1 (en) * 2017-04-11 2018-10-18 Sunshine Lake Pharma Co., Ltd. Fluorine-substituted indazole compounds and uses thereof
WO2019226936A1 (en) * 2018-05-23 2019-11-28 The Board Of Trustees Of The University Of Illinois Estrogen receptor beta ligands for the prevention and treatment of multiple sclerosis (ms) and other demyelinating, inflammatory and neurodegenerative diseases

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01180878A (ja) 1988-01-11 1989-07-18 Yoshitomi Pharmaceut Ind Ltd 縮合ピラゾール化合物
JPH027066A (ja) 1988-06-27 1990-01-11 Hitachi Chem Co Ltd 電子写真感光体
DK181190D0 (da) 1990-07-30 1990-07-30 Lundbeck & Co As H 3-aryl-indol- eller 3-aryl-indazolderivater
JPH05331168A (ja) 1992-05-29 1993-12-14 Yoshitomi Pharmaceut Ind Ltd Ｎ−オキシドを有する新規な縮合型ピラゾール化合物
WO1994007865A1 (en) 1992-09-29 1994-04-14 Yoshitomi Pharmaceutical Industries, Ltd. Carboxylic ester compound
JPH06206872A (ja) 1992-10-06 1994-07-26 Yoshitomi Pharmaceut Ind Ltd 縮合型ピラゾール化合物
CA2190708A1 (en) * 1995-12-08 1997-06-09 Johannes Aebi Aminoalkyl substituted benzo-heterocyclic compounds
US6080773A (en) 1997-10-14 2000-06-27 Akzo Nobel, N.V. Benzylamine derivatives which are useful in treating psychiatric disorders
JP4324988B2 (ja) * 1997-12-17 2009-09-02 東洋紡績株式会社 発毛誘導剤および発毛方法
US6897231B2 (en) * 2000-07-31 2005-05-24 Signal Pharmaceuticals, Inc. Indazole derivatives as JNK inhibitors and compositions and methods related thereto
US7045539B2 (en) 2000-12-22 2006-05-16 Astrazeneca Ab Therapeutic benzoxazole compounds
EP1380576B1 (en) * 2001-04-16 2009-11-25 Eisai R&D Management Co., Ltd. 1h-indazole compounds inhibiting jnk
UA83620C2 (ru) 2001-12-05 2008-08-11 Уайт Замещенные бензоксазолы и их аналоги как эстрогенные агенты
US6774248B2 (en) 2001-12-18 2004-08-10 Wyeth Substituted 2-phenyl benzofurans as estrogenic agents
US20040002524A1 (en) 2002-06-24 2004-01-01 Richard Chesworth Benzimidazole compounds and their use as estrogen agonists/antagonists
CN101213194A (zh) * 2004-08-03 2008-07-02 惠氏公司 可用于治疗心血管疾病的吲唑化合物

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