AR041378A1 - 4- (indazol-3 il) fenoles substituidos - Google Patents

4- (indazol-3 il) fenoles substituidos

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Publication number
AR041378A1
AR041378A1 ARP030103479A ARP030103479A AR041378A1 AR 041378 A1 AR041378 A1 AR 041378A1 AR P030103479 A ARP030103479 A AR P030103479A AR P030103479 A ARP030103479 A AR P030103479A AR 041378 A1 AR041378 A1 AR 041378A1
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AR
Argentina
Prior art keywords
co2r11
alkyl
arylalkyl
alkenyl
aryl
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Application number
ARP030103479A
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English (en)
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Wyeth Corp
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Publication date
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Publication of AR041378A1 publication Critical patent/AR041378A1/es

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    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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Abstract

Se presentan compuestos 4-(indazol-3-il)fenoles sustituidos como ligandos al receptor de estrógenos y las sales farmacéuticamente aceptable de los mismos que son útiles para el tratamiento del componente inflamatorio de enfermedades y sonparticularmente eficaces en el tratamiento de ateroesclerosis, infartación de miocardio, paro cardíaco congestivo, enfermedad intestinal inflamatoria, diabetes tipo II, y enfermedades autoinmunes tales como esclerosis múltiple y artritisreumatoidea. Reivindicación 1: Un compuesto de las fórmulas (1) o (2) que tiene la estructura en las cuales R1 es H, alquilo de C1-6, alquenilo de C2-7, cicloalquilo de C3-8, cicloalquenilo de C4-8, arilo de C6-20, arilalquilo de C7-26, o un anilloo sistema anular heterocíclico saturado, insaturado o parcialmente insaturado de 4-14 átomos, que contiene 1-4 heteroátomos seleccionados del grupo de N, O y S; R2, R3, R4 y R5 son cada uno, independientemente, H, alquilo de C1-6, alquenilo de C2-7,hidroxilo, alcoxilo de C1-6, ariloxilo de C6-20, halógeno, trifluormetilo, -CN, -NO2, -CHO, o -CO2R11; R6, R7, R8 y R9 son cada uno, independientemente, H, alquilo de C1-6, alquenilo de C2-7, hidroxilo, alcoxilo de C1-6, ariloxilo de C6-20,halógeno, trifluormetilo, -CO2R11, arilo de C6-20, arilalquilo de C7-26, o un anillo o sistema anular heterocíclico saturado, insaturado o parcialmente insaturado de 4-14 átomos, que contiene 1-4 heteroátomos seleccionados del grupo de N, O, y S;R10 es H, -CO2R11, -CONHR11, -P(=O)(OH)OR11, o -CO(CH2)nCH(NHR12)-CO2R; R11 es H, alquilo de C1-6, arilo de C6-20, o arilalquilo de C7-26; R12 es H o -CO2R11; n = 0-3, o una sal farmacéuticamente aceptable del mismo.
ARP030103479A 2002-09-25 2003-09-24 4- (indazol-3 il) fenoles substituidos AR041378A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41393102P 2002-09-25 2002-09-25

Publications (1)

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AR041378A1 true AR041378A1 (es) 2005-05-11

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ARP030103479A AR041378A1 (es) 2002-09-25 2003-09-24 4- (indazol-3 il) fenoles substituidos

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US (2) US7241791B2 (es)
EP (1) EP1542976B1 (es)
JP (1) JP4459813B2 (es)
KR (1) KR20050053702A (es)
CN (2) CN101054364A (es)
AR (1) AR041378A1 (es)
AT (1) ATE422202T1 (es)
AU (1) AU2003276940A1 (es)
BR (1) BR0314475A (es)
CA (1) CA2499736A1 (es)
CR (1) CR7769A (es)
DE (1) DE60326077D1 (es)
DK (1) DK1542976T3 (es)
EC (1) ECSP055704A (es)
ES (1) ES2319519T3 (es)
MX (1) MXPA05003275A (es)
NO (1) NO20051942L (es)
RU (1) RU2005109387A (es)
TW (1) TW200409759A (es)
WO (1) WO2004031159A1 (es)
ZA (1) ZA200502462B (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100439341C (zh) * 2002-12-02 2008-12-03 弗·哈夫曼-拉罗切有限公司 作为促肾上腺皮质激素释放因子拮抗剂的吲唑衍生物
JP2005089457A (ja) * 2003-09-03 2005-04-07 Yung Shin Pharmaceutical Industry Co Ltd 骨成長を促進するまたは骨吸収を阻害するための薬剤組成物
EP1704856A4 (en) * 2003-12-26 2009-08-19 Kyowa Hakko Kirin Co Ltd PROTEIN INHIBITOR OF THE HSP90 FAMILY
TW200605886A (en) * 2004-08-03 2006-02-16 Wyeth Corp Indazoles useful in treating cardiovascular diseases
DE102004039280A1 (de) * 2004-08-13 2006-02-23 Merck Patent Gmbh 1,5-Diphenyl-pyrazole
KR20070051877A (ko) 2004-09-02 2007-05-18 와이어쓰 사이토킨 조절제로서의 페난트리딘 카보닐 페놀
EP1647549A1 (en) * 2004-10-14 2006-04-19 Laboratoire Theramex Indazoles, benzisoxazoles and benzisothiazoles as estrogenic agents
US7601847B2 (en) * 2004-10-26 2009-10-13 Wyeth Preparation and purification of 4-(indazol-3-yl)phenols
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