BR0315778A - Compostos de 4-amino-1-(piridilmetil)piperidina substituìdos e compostos relacionados - Google Patents

Compostos de 4-amino-1-(piridilmetil)piperidina substituìdos e compostos relacionados

Info

Publication number
BR0315778A
BR0315778A BR0315778-4A BR0315778A BR0315778A BR 0315778 A BR0315778 A BR 0315778A BR 0315778 A BR0315778 A BR 0315778A BR 0315778 A BR0315778 A BR 0315778A
Authority
BR
Brazil
Prior art keywords
compounds
pyridylmethyl
amino
substituted
piperidine
Prior art date
Application number
BR0315778-4A
Other languages
English (en)
Inventor
Mathai Mammen
Richard Wilson
Yan Chen
Sarah Dunham
Adam Hughes
Craig Husfeld
Yu-Hua Ji
Trevor Mischki
Ioanna Stergiades
Li Li
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of BR0315778A publication Critical patent/BR0315778A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

"COMPOSTOS DE 4-AMINO-1-(PIRIDILMETIL)PIPERIDINA SUBSTITUìDOS E COMPOSTOS RELACIONADOS". Essa invenção fornece compostos de 4-amino-1(piridilmetil)piperidina e compostos relacionados e sais farmaceuticamente aceitáveis destes que são úteis como antagonistas do receptor muscarínico. Essa invenção também fornece composições farmacêuticas contendo tais compostos; processos e intermediários úteis para a preparação de tais compostos; e métodos para o tratamento de doença condições mediadas por receptores muscarínicos, tais como bexiga hiperativa, síndrome do cólon irritável e doença pulmonar obstrutiva crónica, usando tais compostos.
BR0315778-4A 2002-10-30 2003-10-29 Compostos de 4-amino-1-(piridilmetil)piperidina substituìdos e compostos relacionados BR0315778A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42222902P 2002-10-30 2002-10-30
US48648303P 2003-07-11 2003-07-11
PCT/US2003/034444 WO2004041806A2 (en) 2002-10-30 2003-10-29 Substituted 4-amino-1-(pyridylmethyl) piperidine as muscarinic receptor antagonists

Publications (1)

Publication Number Publication Date
BR0315778A true BR0315778A (pt) 2005-09-06

Family

ID=32314442

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0315778-4A BR0315778A (pt) 2002-10-30 2003-10-29 Compostos de 4-amino-1-(piridilmetil)piperidina substituìdos e compostos relacionados

Country Status (20)

Country Link
US (2) US7285564B2 (pt)
EP (1) EP1556372B1 (pt)
JP (2) JP4448492B2 (pt)
KR (1) KR20050061504A (pt)
AR (1) AR041855A1 (pt)
AT (1) ATE363482T1 (pt)
AU (1) AU2003285100A1 (pt)
BR (1) BR0315778A (pt)
CA (1) CA2500800A1 (pt)
DE (1) DE60314170T2 (pt)
EC (1) ECSP055762A (pt)
ES (1) ES2287543T3 (pt)
IS (1) IS7780A (pt)
MX (1) MXPA05004507A (pt)
NO (1) NO20052521L (pt)
PE (1) PE20040606A1 (pt)
PL (1) PL376716A1 (pt)
RU (1) RU2005116239A (pt)
TW (2) TW200800953A (pt)
WO (1) WO2004041806A2 (pt)

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TW200800953A (en) * 2002-10-30 2008-01-01 Theravance Inc Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine
TW200510298A (en) * 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
WO2005007645A1 (en) * 2003-07-11 2005-01-27 Theravance, Inc. Substituted 4-amino-1-benzylpiperidine compounds
PE20050973A1 (es) * 2003-10-29 2005-11-19 Theravance Inc Sales de acido naftalen-1,5-disulfonico de un compuesto de 4-amino-1-(piridilmetil)piperidina como antagonistas de receptores muscarinicos
EP1725525A1 (en) * 2004-03-11 2006-11-29 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
US7250414B2 (en) * 2004-03-11 2007-07-31 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
TW200540154A (en) * 2004-06-10 2005-12-16 Theravance Inc Crystalline form of a substituted pyrrolidine compound
TW200628465A (en) * 2004-10-28 2006-08-16 Theravance Inc Process for preparing substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
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EP1863490A2 (en) * 2005-03-28 2007-12-12 Vertex Pharmaceuticals Incorporated Muscarinic modulators
WO2008103426A1 (en) * 2007-02-23 2008-08-28 Theravance, Inc. Quaternary ammonium diphenylmethyl compounds useful as muscarinic receptor antagonists
WO2009153649A1 (en) * 2008-06-19 2009-12-23 Medichem, S.A. Process for preparing 3-substituted pyrrolidine compounds
EP2485595A4 (en) * 2009-10-07 2014-03-12 Merck Sharp & Dohme POLYTHERAPY USING BETA-3 ADRENERGIC RECEPTOR AGONIST AND ANTIMUSCARINIC AGENT
US20110281853A1 (en) 2010-05-12 2011-11-17 Rishi Arora Compositions and methods for treating or preventing atrial fibrillation
US9907767B2 (en) 2010-08-03 2018-03-06 Velicept Therapeutics, Inc. Pharmaceutical compositions and the treatment of overactive bladder
US9522129B2 (en) 2010-08-03 2016-12-20 Velicept Therapeutics, Inc. Pharmaceutical Combination
BR112013002511A2 (pt) * 2010-08-03 2017-06-27 Altherx Inc combinações de agonistas de receptores adrenérgicos beta - 3 e antagonistas receptores muscarínicos para tratamento da bexica hiperativa
AU2013216864A1 (en) * 2012-02-09 2014-09-11 Altherx, Inc. Combination of muscarinic receptor antagonists and beta- 3 adrenoceptor agonists for treating overactive bladder
KR20170086659A (ko) 2014-12-03 2017-07-26 벨리셉트 테라퓨틱스, 인크. 하부 요로 증상을 위한 변형 방출형 솔라베그론을 이용한 조성물 및 방법
CN108290824B (zh) 2015-10-23 2022-03-11 B3Ar治疗股份有限公司 索拉贝隆两性离子及其应用

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Also Published As

Publication number Publication date
NO20052521L (no) 2005-05-25
MXPA05004507A (es) 2005-10-18
WO2004041806A3 (en) 2004-08-05
CA2500800A1 (en) 2004-05-21
ES2287543T3 (es) 2007-12-16
TW200800953A (en) 2008-01-01
JP2010059214A (ja) 2010-03-18
US20080091034A1 (en) 2008-04-17
DE60314170D1 (de) 2007-07-12
EP1556372A2 (en) 2005-07-27
US8030502B2 (en) 2011-10-04
JP4448492B2 (ja) 2010-04-07
ECSP055762A (es) 2005-07-06
ATE363482T1 (de) 2007-06-15
IS7780A (is) 2005-03-31
EP1556372B1 (en) 2007-05-30
WO2004041806A2 (en) 2004-05-21
US20040122014A1 (en) 2004-06-24
JP2006512408A (ja) 2006-04-13
DE60314170T2 (de) 2008-01-24
AR041855A1 (es) 2005-06-01
KR20050061504A (ko) 2005-06-22
TW200418833A (en) 2004-10-01
PE20040606A1 (es) 2004-09-08
AU2003285100A1 (en) 2004-06-07
US7285564B2 (en) 2007-10-23
PL376716A1 (pl) 2006-01-09
RU2005116239A (ru) 2006-01-27
TWI295669B (en) 2008-04-11

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE 6A. E 7A.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2073 DE 28/09/2010.