CY1110464T1 - Παραγωγα πυραζολοπυριδινης ως αναστολεις του βητα-αδρενεργικου υποδοχεα της κινασης1 - Google Patents
Παραγωγα πυραζολοπυριδινης ως αναστολεις του βητα-αδρενεργικου υποδοχεα της κινασης1Info
- Publication number
- CY1110464T1 CY1110464T1 CY20091100501T CY091100501T CY1110464T1 CY 1110464 T1 CY1110464 T1 CY 1110464T1 CY 20091100501 T CY20091100501 T CY 20091100501T CY 091100501 T CY091100501 T CY 091100501T CY 1110464 T1 CY1110464 T1 CY 1110464T1
- Authority
- CY
- Cyprus
- Prior art keywords
- beta
- adenergic
- pyrazolopyridine
- producers
- cells
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Addiction (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Η εφεύρεση αναφέρεται στα 6-αμιδο υποκατεστημένα παράγωγα πυραζολοπυριδίνης του χημικού τύπου (I) τα οποία είναι χρήσιμα ως αναστολείς του βητα- αδρενεργικού υποδοχέα κινάσης 1 (βARK-1), σε σκευάσματα που περιέχουν αυτού του είδους τις ενώσεις και στην χρήση τους για την θεραπεία και τη πρόληψη της χρόνιας καρδιακής ανεπάρκειας, της υπέρτασης, της ισχαιμίας του μυοκαρδίου και των μολύνσεων από τον ιό της ηπατίτιδας C (HCV), και για την πρόληψη του εθισμού στο όπιο.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05013774 | 2005-06-27 | ||
| EP06754324A EP1899333B1 (en) | 2005-06-27 | 2006-06-13 | Pyrazolopyridine derivatives as inhibitors of beta-adrenergic receptor kinase 1 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1110464T1 true CY1110464T1 (el) | 2015-04-29 |
Family
ID=35395578
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20091100501T CY1110464T1 (el) | 2005-06-27 | 2009-05-11 | Παραγωγα πυραζολοπυριδινης ως αναστολεις του βητα-αδρενεργικου υποδοχεα της κινασης1 |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US7910602B2 (el) |
| EP (1) | EP1899333B1 (el) |
| JP (1) | JP5010594B2 (el) |
| KR (1) | KR20080020638A (el) |
| CN (1) | CN101208340B (el) |
| AR (1) | AR054514A1 (el) |
| AT (1) | ATE423118T1 (el) |
| AU (1) | AU2006264044A1 (el) |
| BR (1) | BRPI0612320A2 (el) |
| CA (1) | CA2611296A1 (el) |
| CY (1) | CY1110464T1 (el) |
| DE (1) | DE602006005242D1 (el) |
| DK (1) | DK1899333T3 (el) |
| ES (1) | ES2322197T3 (el) |
| HR (1) | HRP20090244T2 (el) |
| IL (1) | IL188381A0 (el) |
| MA (1) | MA29498B1 (el) |
| MX (1) | MX2007015829A (el) |
| MY (1) | MY139016A (el) |
| NO (1) | NO20080392L (el) |
| NZ (1) | NZ564757A (el) |
| PL (1) | PL1899333T3 (el) |
| PT (1) | PT1899333E (el) |
| RS (1) | RS50821B (el) |
| RU (1) | RU2415855C2 (el) |
| SI (1) | SI1899333T1 (el) |
| TW (1) | TW200800982A (el) |
| UY (1) | UY29632A1 (el) |
| WO (1) | WO2007000241A1 (el) |
| ZA (1) | ZA200709853B (el) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200815438A (en) * | 2006-06-13 | 2008-04-01 | Bayer Schering Pharma Ag | Substituted pyrazolopyridines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same |
| JPWO2009107391A1 (ja) * | 2008-02-27 | 2011-06-30 | 武田薬品工業株式会社 | ６員芳香環含有化合物 |
| US9321787B2 (en) * | 2011-07-07 | 2016-04-26 | Sanofi | Carboxylic acid derivatives having an oxazolo[5,4-d]pyrimidine ring |
| US8889730B2 (en) | 2012-04-10 | 2014-11-18 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| US9394285B2 (en) | 2013-03-15 | 2016-07-19 | Pfizer Inc. | Indole and indazole compounds that activate AMPK |
| GB201410815D0 (en) * | 2014-06-17 | 2014-07-30 | Ucb Biopharma Sprl And Katholieke Universiteit Leuven | Therapeutic agents |
| JP2022505707A (ja) * | 2018-10-24 | 2022-01-14 | ブリストル－マイヤーズ スクイブ カンパニー | 置換インドールおよびインダゾール化合物 |
| CN112912382B (zh) | 2018-10-24 | 2024-07-02 | 百时美施贵宝公司 | 经取代的吲哚二聚体化合物 |
| WO2024137671A1 (en) * | 2022-12-20 | 2024-06-27 | Exelixis, Inc. | Compounds that inhibit pkmyt1 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1043998B1 (en) * | 1997-12-13 | 2007-03-07 | Bristol-Myers Squibb Company | USE OF PYRAZOLO [3,4-b] PYRIDINE AS CYCLIN DEPENDANT KINASE INHIBITORS |
| JP2002020386A (ja) * | 2000-07-07 | 2002-01-23 | Ono Pharmaceut Co Ltd | ピラゾロピリジン誘導体 |
| WO2003068773A1 (en) * | 2002-02-12 | 2003-08-21 | Glaxo Group Limited | Pyrazolopyridine derivatives |
| EP1537106A1 (en) * | 2002-08-07 | 2005-06-08 | Mitsubishi Pharma Corporation | Dihydropyrazolopyridine compounds |
| JP4814783B2 (ja) * | 2003-02-27 | 2011-11-16 | パラウ ファルマ、 ソシエダッド アノニマ | ピラゾロピリジン誘導体 |
-
2006
- 2006-06-13 DK DK06754324T patent/DK1899333T3/da active
- 2006-06-13 JP JP2008518660A patent/JP5010594B2/ja not_active Expired - Fee Related
- 2006-06-13 SI SI200630284T patent/SI1899333T1/sl unknown
- 2006-06-13 WO PCT/EP2006/005649 patent/WO2007000241A1/en active Application Filing
- 2006-06-13 ES ES06754324T patent/ES2322197T3/es active Active
- 2006-06-13 AT AT06754324T patent/ATE423118T1/de not_active IP Right Cessation
- 2006-06-13 PL PL06754324T patent/PL1899333T3/pl unknown
- 2006-06-13 RU RU2008102970/04A patent/RU2415855C2/ru not_active IP Right Cessation
- 2006-06-13 MX MX2007015829A patent/MX2007015829A/es active IP Right Grant
- 2006-06-13 EP EP06754324A patent/EP1899333B1/en active Active
- 2006-06-13 NZ NZ564757A patent/NZ564757A/en not_active IP Right Cessation
- 2006-06-13 DE DE602006005242T patent/DE602006005242D1/de active Active
- 2006-06-13 RS RSP-2009/0165A patent/RS50821B/sr unknown
- 2006-06-13 CN CN200680023397XA patent/CN101208340B/zh not_active Expired - Fee Related
- 2006-06-13 KR KR1020077030289A patent/KR20080020638A/ko not_active Application Discontinuation
- 2006-06-13 CA CA002611296A patent/CA2611296A1/en not_active Abandoned
- 2006-06-13 AU AU2006264044A patent/AU2006264044A1/en not_active Abandoned
- 2006-06-13 BR BRPI0612320-1A patent/BRPI0612320A2/pt not_active IP Right Cessation
- 2006-06-13 PT PT06754324T patent/PT1899333E/pt unknown
- 2006-06-23 AR ARP060102721A patent/AR054514A1/es not_active Application Discontinuation
- 2006-06-23 TW TW095122584A patent/TW200800982A/zh unknown
- 2006-06-26 MY MYPI20063009A patent/MY139016A/en unknown
- 2006-06-27 UY UY29632A patent/UY29632A1/es not_active Application Discontinuation
-
2007
- 2007-11-15 ZA ZA200709853A patent/ZA200709853B/xx unknown
- 2007-11-30 MA MA30441A patent/MA29498B1/fr unknown
- 2007-12-20 US US11/961,282 patent/US7910602B2/en not_active Expired - Fee Related
- 2007-12-24 IL IL188381A patent/IL188381A0/en unknown
-
2008
- 2008-01-21 NO NO20080392A patent/NO20080392L/no not_active Application Discontinuation
-
2009
- 2009-04-24 HR HR20090244T patent/HRP20090244T2/xx unknown
- 2009-05-11 CY CY20091100501T patent/CY1110464T1/el unknown
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