MXPA05004507A - 4-amino-1-(piridilmetil)piperidina sustituida como antagonista del receptor muscarinico. - Google Patents

4-amino-1-(piridilmetil)piperidina sustituida como antagonista del receptor muscarinico.

Info

Publication number
MXPA05004507A
MXPA05004507A MXPA05004507A MXPA05004507A MXPA05004507A MX PA05004507 A MXPA05004507 A MX PA05004507A MX PA05004507 A MXPA05004507 A MX PA05004507A MX PA05004507 A MXPA05004507 A MX PA05004507A MX PA05004507 A MXPA05004507 A MX PA05004507A
Authority
MX
Mexico
Prior art keywords
compounds
pyridylmethyl
piperidine
amino
receptor antagonists
Prior art date
Application number
MXPA05004507A
Other languages
English (en)
Inventor
Stergiades Ioanna
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of MXPA05004507A publication Critical patent/MXPA05004507A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Esta invencion proporciona la 4-amino-1-(piridilmetil) piperidina de la formula (I) y compuestos relacionados y sales farmaceuticamente aceptables de los mismos, los cuales son utiles como antagonistas de receptores muscarinicos. Esta invencion tambien proporciona composiciones farmaceuticas que contienen estos compuestos; procedimientos y productos intermediarios para preparar estos compuestos; y metodos para el tratamiento de condiciones de enfermedad mediadas por los receptores muscarinicos, tales como la vejiga hiperactiva, sindrome del intestino irritable y enfermedad pulmonar obstructiva, cronica, utilizando estos compuestos.
MXPA05004507A 2002-10-30 2003-10-29 4-amino-1-(piridilmetil)piperidina sustituida como antagonista del receptor muscarinico. MXPA05004507A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42222902P 2002-10-30 2002-10-30
US48648303P 2003-07-11 2003-07-11
PCT/US2003/034444 WO2004041806A2 (en) 2002-10-30 2003-10-29 Substituted 4-amino-1-(pyridylmethyl) piperidine as muscarinic receptor antagonists

Publications (1)

Publication Number Publication Date
MXPA05004507A true MXPA05004507A (es) 2005-10-18

Family

ID=32314442

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05004507A MXPA05004507A (es) 2002-10-30 2003-10-29 4-amino-1-(piridilmetil)piperidina sustituida como antagonista del receptor muscarinico.

Country Status (20)

Country Link
US (2) US7285564B2 (es)
EP (1) EP1556372B1 (es)
JP (2) JP4448492B2 (es)
KR (1) KR20050061504A (es)
AR (1) AR041855A1 (es)
AT (1) ATE363482T1 (es)
AU (1) AU2003285100A1 (es)
BR (1) BR0315778A (es)
CA (1) CA2500800A1 (es)
DE (1) DE60314170T2 (es)
EC (1) ECSP055762A (es)
ES (1) ES2287543T3 (es)
IS (1) IS7780A (es)
MX (1) MXPA05004507A (es)
NO (1) NO20052521L (es)
PE (1) PE20040606A1 (es)
PL (1) PL376716A1 (es)
RU (1) RU2005116239A (es)
TW (2) TW200800953A (es)
WO (1) WO2004041806A2 (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200800953A (en) * 2002-10-30 2008-01-01 Theravance Inc Intermediates for preparing substituted 4-amino-1-(pyridylmethyl) piperidine
TW200510298A (en) 2003-06-13 2005-03-16 Theravance Inc Substituted pyrrolidine and related compounds
US7368463B2 (en) * 2003-07-11 2008-05-06 Theravance, Inc. Substituted 4-amino-1-benzylpiperidine compounds
PE20050973A1 (es) * 2003-10-29 2005-11-19 Theravance Inc Sales de acido naftalen-1,5-disulfonico de un compuesto de 4-amino-1-(piridilmetil)piperidina como antagonistas de receptores muscarinicos
WO2005087722A1 (en) * 2004-03-11 2005-09-22 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
EP1723142A1 (en) * 2004-03-11 2006-11-22 Theravance, Inc. Diphenylmethyl compounds useful as muscarinic receptor antagonists
TW200540154A (en) * 2004-06-10 2005-12-16 Theravance Inc Crystalline form of a substituted pyrrolidine compound
TW200628465A (en) * 2004-10-28 2006-08-16 Theravance Inc Process for preparing substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
US7880007B2 (en) * 2004-11-29 2011-02-01 Vertex Pharmaceuticals Incorporated Bicyclic substituted phenyl piperidine modulators of muscarinic receptors
EP1863490A2 (en) * 2005-03-28 2007-12-12 Vertex Pharmaceuticals Incorporated Muscarinic modulators
BRPI0807615A8 (pt) * 2007-02-23 2017-12-05 Theravance Inc Compostos de difenilmetil amônico quaternário úteis como antagonistas de receptor muscarínico
WO2009153649A1 (en) * 2008-06-19 2009-12-23 Medichem, S.A. Process for preparing 3-substituted pyrrolidine compounds
NZ599233A (en) * 2009-10-07 2013-04-26 Merck Sharp & Dohme Combination therapy using a beta 3 adrenergic receptor agonist and an antimuscarinic agent
WO2011143457A2 (en) 2010-05-12 2011-11-17 Northwestern University Compositions and methods for treating or preventing atrial fibrillation
US9907767B2 (en) 2010-08-03 2018-03-06 Velicept Therapeutics, Inc. Pharmaceutical compositions and the treatment of overactive bladder
MX353105B (es) 2010-08-03 2017-12-19 Velicept Therapeutics Inc Combinaciones de agonistas del receptor beta-3-adrenergico y antagonistas del receptor muscarinico para tratar vejiga hiperactiva.
US9522129B2 (en) 2010-08-03 2016-12-20 Velicept Therapeutics, Inc. Pharmaceutical Combination
EP2811989A1 (en) * 2012-02-09 2014-12-17 Altherx Inc. Combination of muscarinic receptor antagonists and beta- 3 adrenoceptor agonists for treating overactive bladder
AU2015358378A1 (en) 2014-12-03 2017-06-29 Velicept Therapeutics, Inc. Compositions and methods of using modified release solabegron for lower urinary tract symptoms
PT3365321T (pt) 2015-10-23 2024-01-12 B3Ar Therapeutics Inc Zwiterião de solabegron e suas utilizações

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TW200628465A (en) 2004-10-28 2006-08-16 Theravance Inc Process for preparing substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds

Also Published As

Publication number Publication date
JP4448492B2 (ja) 2010-04-07
US7285564B2 (en) 2007-10-23
US20040122014A1 (en) 2004-06-24
BR0315778A (pt) 2005-09-06
ECSP055762A (es) 2005-07-06
KR20050061504A (ko) 2005-06-22
TW200418833A (en) 2004-10-01
NO20052521L (no) 2005-05-25
PL376716A1 (pl) 2006-01-09
US20080091034A1 (en) 2008-04-17
ES2287543T3 (es) 2007-12-16
EP1556372B1 (en) 2007-05-30
PE20040606A1 (es) 2004-09-08
IS7780A (is) 2005-03-31
TW200800953A (en) 2008-01-01
WO2004041806A2 (en) 2004-05-21
DE60314170D1 (de) 2007-07-12
JP2010059214A (ja) 2010-03-18
ATE363482T1 (de) 2007-06-15
US8030502B2 (en) 2011-10-04
RU2005116239A (ru) 2006-01-27
TWI295669B (en) 2008-04-11
AR041855A1 (es) 2005-06-01
AU2003285100A1 (en) 2004-06-07
DE60314170T2 (de) 2008-01-24
CA2500800A1 (en) 2004-05-21
WO2004041806A3 (en) 2004-08-05
JP2006512408A (ja) 2006-04-13
EP1556372A2 (en) 2005-07-27

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