BR0309743A - Processo para a preparação de gama-butirolactamas e gama-aminoácidos altamente funcionalizados - Google Patents
Processo para a preparação de gama-butirolactamas e gama-aminoácidos altamente funcionalizadosInfo
- Publication number
- BR0309743A BR0309743A BR0309743-9A BR0309743A BR0309743A BR 0309743 A BR0309743 A BR 0309743A BR 0309743 A BR0309743 A BR 0309743A BR 0309743 A BR0309743 A BR 0309743A
- Authority
- BR
- Brazil
- Prior art keywords
- gamma
- butyrolactams
- preparation
- amino acids
- highly functionalized
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/18—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
"PROCESSO PARA A PREPARAçãO DE GAMA-BUTIROLACTAMAS E GAMA-AMINOáCIDOS ALTAMENTE FUNCIONALIZADOS". A presente invenção refere-se a um processo para a preparação de <sym>-butirolactamas e <sym>-aminoácidos altamente funcionalizados por aminação redutiva de ácido muco-hálico ou dos seus derivados, e descreve um processo para a preparação de pregabalina ou ácido 3-aminometil-5-metil-octanóico, análogos de GABA com atividade medicinal desejável (Fórmula I).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37699102P | 2002-04-30 | 2002-04-30 | |
PCT/IB2003/001646 WO2003093220A1 (en) | 2002-04-30 | 2003-04-17 | Process for preparing highly functionalized y-butyrolactams and y-amino acids |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0309743A true BR0309743A (pt) | 2005-02-09 |
Family
ID=29401429
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0309743-9A BR0309743A (pt) | 2002-04-30 | 2003-04-17 | Processo para a preparação de gama-butirolactamas e gama-aminoácidos altamente funcionalizados |
Country Status (15)
Country | Link |
---|---|
US (2) | US20030225149A1 (pt) |
EP (1) | EP1499583A1 (pt) |
JP (1) | JP2005523932A (pt) |
KR (1) | KR20040106415A (pt) |
CN (1) | CN1649827A (pt) |
AR (1) | AR039467A1 (pt) |
AU (1) | AU2003219425A1 (pt) |
BR (1) | BR0309743A (pt) |
CA (1) | CA2483830A1 (pt) |
IL (1) | IL164781A0 (pt) |
MX (1) | MXPA04010771A (pt) |
PL (1) | PL373296A1 (pt) |
RU (1) | RU2004131840A (pt) |
TW (1) | TW200400929A (pt) |
WO (1) | WO2003093220A1 (pt) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100491282B1 (ko) | 1996-07-24 | 2005-05-24 | 워너-램버트 캄파니 엘엘씨 | 통증 치료용 이소부틸가바 및 그의 유도체 |
AU2005256945B2 (en) * | 2004-06-21 | 2008-11-13 | Upjohn Us 1 Llc | Preparation of pregabalin and related compounds |
DK1773902T3 (en) * | 2004-08-04 | 2018-02-05 | Foam Supplies Inc | REACTIVITY DIFFERENCE AND CATALYSTS DEGREE IN POLYURETHAN |
CN101160281A (zh) * | 2005-04-06 | 2008-04-09 | 特瓦制药工业有限公司 | 结晶形态的普瑞巴林 |
WO2006110783A2 (en) * | 2005-04-11 | 2006-10-19 | Teva Pharmaceutical Industries Ltd. | Process for making (s)-pregabalin |
US7488846B2 (en) * | 2005-04-11 | 2009-02-10 | Teva Pharmaceuical Industries Ltd. | Pregabalin free of lactam and a process for preparation thereof |
CA2604624A1 (en) * | 2005-05-10 | 2006-11-16 | Teva Pharmaceutical Industries Ltd. | Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid |
JP2008505980A (ja) * | 2005-05-10 | 2008-02-28 | テバ ファーマシューティカル インダストリーズ リミティド | イソブチルグルタル酸を有さないプレガバリン及びその調製方法 |
ATE486841T1 (de) * | 2005-05-10 | 2010-11-15 | Teva Pharma | Verfahren zur herstellung von pregabalin und salzen daraus |
CZ297970B6 (cs) * | 2005-08-10 | 2007-05-09 | Zentiva, A. S | Zpusob výroby (S)-3-(aminomethyl)-5-methyl-hexanové kyseliny (pregabalinu) |
EP1841726B1 (en) * | 2005-09-19 | 2012-10-31 | Teva Pharmaceutical Industries Ltd | An asymmetric synthesis of (s)-(+)-3-(aminomethyl)-5-methylhexanoic acid |
WO2007127309A2 (en) * | 2006-04-24 | 2007-11-08 | Teva Pharmaceutical Industries Ltd. | Processes for the synthesis of 3-isobutylglutaric acid |
TW200815323A (en) * | 2006-05-24 | 2008-04-01 | Teva Pharma | Processes for the preparation of R-(+)-3-(carbamoylmethyl)-5-methylhexanoic acid and salts thereof |
BRPI0702897A2 (pt) * | 2006-05-31 | 2011-03-15 | Teva Pharmaceutical Ind Ltda | processo para preparar um intermediário de pregabalina |
WO2007143152A2 (en) * | 2006-05-31 | 2007-12-13 | Teva Pharmaceutical Industries Ltd. | Preparation of (s)-pregabalin-nitrile |
BRPI0803092A2 (pt) * | 2007-03-22 | 2011-08-30 | Teva Pharma | sìntese de (s)-(+)-3-(aminometil)-5-metil ácido hexanóico, (s)-pregabalina |
WO2008127646A2 (en) * | 2007-04-11 | 2008-10-23 | Dsm Ip Assets B.V. | Transaminase-based processes for preparation of pregabalin |
ES2551552T3 (es) * | 2007-06-05 | 2015-11-19 | Akzo Nobel Coatings International B.V. | Composición de revestimiento curable por radiación derivada de aceites vegetales epoxidados |
US20090137842A1 (en) * | 2007-10-03 | 2009-05-28 | Vollerner Yuri | Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof |
JP2011507941A (ja) * | 2007-12-26 | 2011-03-10 | ジェネリクス・(ユーケー)・リミテッド | プレガバリンの製造方法 |
JP2010043063A (ja) | 2008-05-09 | 2010-02-25 | Agency For Science Technology & Research | 川崎病の診断及び治療 |
US20100087525A1 (en) * | 2008-06-23 | 2010-04-08 | Lilach Hedvati | Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester |
MX2011009154A (es) | 2009-03-05 | 2011-10-10 | Akzo Nobel Coatings Int Bv | Polioles de aceite con funcion de hidroxilo y composiciones de recubrimiento preparadas de polioles de aceite con funcion de hidroxilo. |
WO2011086565A1 (en) * | 2010-01-15 | 2011-07-21 | Lupin Limited | Method for preparation of enantiomerically enriched and/or racemic gamma-amino acids |
WO2012089655A2 (en) | 2010-12-28 | 2012-07-05 | Akzo Nobel Coatings International B.V. | Radiation curable coating compositions for metal |
GB201121317D0 (en) | 2011-12-09 | 2012-01-25 | Syngenta Ltd | Herbicidal compounds |
RU2605418C2 (ru) | 2011-12-21 | 2016-12-20 | Акцо Нобель Коатингс Интернэшнл Б.В. | Покрывные композиции на основе растворителей |
KR102025208B1 (ko) | 2011-12-21 | 2019-09-25 | 아크조노벨코팅스인터내셔널비.브이. | 수성 코팅 조성물 |
CN107746834A (zh) * | 2013-03-27 | 2018-03-02 | 辉瑞爱尔兰制药公司 | 用于制备普瑞巴林的方法和中间体 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3935210A (en) * | 1971-07-29 | 1976-01-27 | Sandoz, Inc. | Preparation of 1-aryl-4,5-dihalo-pyridazone-6 |
SK283281B6 (sk) * | 1992-05-20 | 2003-05-02 | Northwestern University | Deriváty gamaaminomaslovej kyseliny, spôsoby a medziprodukty na ich výrobu, ich použitie a farmaceutické prostriedky |
DZ2770A1 (fr) * | 1998-04-17 | 2003-12-01 | Lilly Co Eli | Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4. |
JP2002520277A (ja) * | 1998-07-09 | 2002-07-09 | ワーナー−ランバート・カンパニー | 不眠症を治療する方法 |
OA11962A (en) * | 1999-06-10 | 2006-04-17 | Warner Lambert Co | Mono-and disubstituted 3-propyl gamma-aminobutyricacids. |
-
2003
- 2003-02-13 US US10/365,430 patent/US20030225149A1/en not_active Abandoned
- 2003-04-17 KR KR10-2004-7017412A patent/KR20040106415A/ko not_active Application Discontinuation
- 2003-04-17 CN CNA038096412A patent/CN1649827A/zh active Pending
- 2003-04-17 RU RU2004131840/04A patent/RU2004131840A/ru not_active Application Discontinuation
- 2003-04-17 AU AU2003219425A patent/AU2003219425A1/en not_active Abandoned
- 2003-04-17 WO PCT/IB2003/001646 patent/WO2003093220A1/en not_active Application Discontinuation
- 2003-04-17 PL PL03373296A patent/PL373296A1/xx not_active Application Discontinuation
- 2003-04-17 MX MXPA04010771A patent/MXPA04010771A/es not_active Application Discontinuation
- 2003-04-17 CA CA002483830A patent/CA2483830A1/en not_active Abandoned
- 2003-04-17 BR BR0309743-9A patent/BR0309743A/pt not_active IP Right Cessation
- 2003-04-17 EP EP03715236A patent/EP1499583A1/en not_active Withdrawn
- 2003-04-17 JP JP2004501360A patent/JP2005523932A/ja not_active Withdrawn
- 2003-04-23 US US10/421,350 patent/US6924377B2/en not_active Expired - Fee Related
- 2003-04-28 AR ARP030101461A patent/AR039467A1/es unknown
- 2003-04-29 TW TW092110024A patent/TW200400929A/zh unknown
-
2004
- 2004-10-21 IL IL16478104A patent/IL164781A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AR039467A1 (es) | 2005-02-23 |
PL373296A1 (en) | 2005-08-22 |
AU2003219425A1 (en) | 2003-11-17 |
WO2003093220A1 (en) | 2003-11-13 |
RU2004131840A (ru) | 2005-05-27 |
MXPA04010771A (es) | 2005-03-07 |
US20030236415A1 (en) | 2003-12-25 |
JP2005523932A (ja) | 2005-08-11 |
CN1649827A (zh) | 2005-08-03 |
CA2483830A1 (en) | 2003-11-13 |
EP1499583A1 (en) | 2005-01-26 |
IL164781A0 (en) | 2005-12-18 |
KR20040106415A (ko) | 2004-12-17 |
TW200400929A (en) | 2004-01-16 |
US6924377B2 (en) | 2005-08-02 |
US20030225149A1 (en) | 2003-12-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A E 7A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2051 DE 27/04/2010. |
|
B08J | Incorrect entry in the gazette republished [chapter 8.10 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 2105 DE 10/05/2011. TEXTO CORRETO: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2055 DE 25/05/2010. |