AR039467A1 - Procedimiento para preparar gama-butirolactamas y gama-aminoacidos muy funcionalizados - Google Patents

Procedimiento para preparar gama-butirolactamas y gama-aminoacidos muy funcionalizados

Info

Publication number
AR039467A1
AR039467A1 ARP030101461A ARP030101461A AR039467A1 AR 039467 A1 AR039467 A1 AR 039467A1 AR P030101461 A ARP030101461 A AR P030101461A AR P030101461 A ARP030101461 A AR P030101461A AR 039467 A1 AR039467 A1 AR 039467A1
Authority
AR
Argentina
Prior art keywords
range
butirolactamas
aminoacidos
functioned
procedure
Prior art date
Application number
ARP030101461A
Other languages
English (en)
Original Assignee
Warner Lambert Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co filed Critical Warner Lambert Co
Publication of AR039467A1 publication Critical patent/AR039467A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
    • C07C229/18—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

La presente se refiere a un procedimiento para preparar yeta-butirolactamas y yeta- aminoácidos muy funcionalizados mediante aminación reductora de ácido mucohálico o sus derivados, y describe un procedimiento para preparar pregabalina, o ácido 3-aminometil-5-metiloctanoico, análogos del GABA con deseable actividad medicinal. Como lo indica la fórmula (1).
ARP030101461A 2002-04-30 2003-04-28 Procedimiento para preparar gama-butirolactamas y gama-aminoacidos muy funcionalizados AR039467A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37699102P 2002-04-30 2002-04-30

Publications (1)

Publication Number Publication Date
AR039467A1 true AR039467A1 (es) 2005-02-23

Family

ID=29401429

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP030101461A AR039467A1 (es) 2002-04-30 2003-04-28 Procedimiento para preparar gama-butirolactamas y gama-aminoacidos muy funcionalizados

Country Status (15)

Country Link
US (2) US20030225149A1 (es)
EP (1) EP1499583A1 (es)
JP (1) JP2005523932A (es)
KR (1) KR20040106415A (es)
CN (1) CN1649827A (es)
AR (1) AR039467A1 (es)
AU (1) AU2003219425A1 (es)
BR (1) BR0309743A (es)
CA (1) CA2483830A1 (es)
IL (1) IL164781A0 (es)
MX (1) MXPA04010771A (es)
PL (1) PL373296A1 (es)
RU (1) RU2004131840A (es)
TW (1) TW200400929A (es)
WO (1) WO2003093220A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU228426B1 (hu) 1996-07-24 2013-03-28 Warner Lambert Co Izobutil-gaba és származékai alkalmazása fájdalom kezelésére alkalmas gyógyszer elõállítására
DE602005018965D1 (de) * 2004-06-21 2010-03-04 Warner Lambert Co Herstellung von pregabalin und verwandten verbindungen
DK1773902T3 (en) 2004-08-04 2018-02-05 Foam Supplies Inc REACTIVITY DIFFERENCE AND CATALYSTS DEGREE IN POLYURETHAN
CA2603129A1 (en) * 2005-04-06 2006-10-12 Teva Pharmaceutical Industries Ltd. Crystalline forms of pregabalin
MX2007012606A (es) * 2005-04-11 2008-01-11 Teva Pharma Proceso para elaborar (s)-pregabalina.
US7488846B2 (en) * 2005-04-11 2009-02-10 Teva Pharmaceuical Industries Ltd. Pregabalin free of lactam and a process for preparation thereof
CA2604624A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
CA2604602A1 (en) * 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Method for the preparation of pregabalin and salts thereof
WO2006122255A1 (en) 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabalin free of isobutylglutaric acid and a process for preparation thereof
CZ297970B6 (cs) * 2005-08-10 2007-05-09 Zentiva, A. S Zpusob výroby (S)-3-(aminomethyl)-5-methyl-hexanové kyseliny (pregabalinu)
KR20080034205A (ko) * 2005-09-19 2008-04-18 테바 파마슈티컬 인더스트리즈 리미티드 (ｓ)-프레가발린의 신규한 합성을 위한 주요 중간체인 키랄3-카르바모일메틸-5-메틸 헥산산
BRPI0702865A2 (pt) * 2006-04-24 2012-08-07 Teva Pharma processos para preparaÇço do Ácido 3-isobutilglutÁrico e de (s)- pregabalin, a partir de combinaÇÕes de composiÇÕes com fàrmulas especÍficas para uso na dita preparaÇço
EP2019817A2 (en) * 2006-05-24 2009-02-04 Teva Pharmaceutical Industries Ltd. Processes for the preparation of r-(+)-3-(carbamoyl methyl)-5-methylhexanoic acid and salts thereof
US20080015385A1 (en) * 2006-05-31 2008-01-17 Lilach Hedvati Preparation of (S)-pregabalin-nitrile
EP2071032A3 (en) * 2006-05-31 2009-07-08 Teva Pharmaceutical Industries Ltd The use of enzymatic resolution for the preparation of intermediates of pregabalin
MX2008014759A (es) * 2007-03-22 2009-03-09 Teva Pharma Sintesis del acido (s)-(+)-3-(aminometil)-5-metil hexanoico.
WO2008127646A2 (en) * 2007-04-11 2008-10-23 Dsm Ip Assets B.V. Transaminase-based processes for preparation of pregabalin
MY162330A (en) * 2007-06-05 2017-05-31 Akzo Nobel Coatings Inc Radiation curable coating composition derived from epoxidized vegetable oils
US20090137842A1 (en) * 2007-10-03 2009-05-28 Vollerner Yuri Pregabalin -4-eliminate, pregabalin 5-eliminate, their use as reference marker and standard, and method to produce pregabalin containing low levels thereof
AU2008339583A1 (en) * 2007-12-26 2009-07-02 Generics [Uk] Limited Processes to pregabalin
JP2010043063A (ja) 2008-05-09 2010-02-25 Agency For Science Technology & Research 川崎病の診断及び治療
US20100087525A1 (en) * 2008-06-23 2010-04-08 Lilach Hedvati Stereoselective enzymatic synthesis of (s) or (r)-iso-butyl-glutaric ester
RU2539981C2 (ru) 2009-03-05 2015-01-27 Акцо Нобель Коатингс Интернэшнл Б.В. Привитые акриловые сополимеры масляных полиолов с гидроксильными функциональными группами
WO2011086565A1 (en) * 2010-01-15 2011-07-21 Lupin Limited Method for preparation of enantiomerically enriched and/or racemic gamma-amino acids
US20130280544A1 (en) 2010-12-28 2013-10-24 Akzo Nobel Coatings International B.V. Radiation curable coating compositions for metal
GB201121317D0 (en) 2011-12-09 2012-01-25 Syngenta Ltd Herbicidal compounds
KR102019726B1 (ko) 2011-12-21 2019-09-09 아크조노벨코팅스인터내셔널비.브이. 용제형 코팅 조성물
ES2629692T3 (es) 2011-12-21 2017-08-14 Akzo Nobel Coatings International B.V. Composiciones de revestimiento basadas en agua
HUE034834T2 (en) * 2013-03-27 2018-03-28 Pfizer Ireland Pharmaceuticals Procedure for Pregabalin Production and Intermediates

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3935210A (en) 1971-07-29 1976-01-27 Sandoz, Inc. Preparation of 1-aryl-4,5-dihalo-pyridazone-6
HU222776B1 (hu) * 1992-05-20 2003-10-28 Northwestern University (S)-(+)-4-amino-3-(2-metil-propil)-butánsav előállításának új hexánsav- és butándisav-származék köztitermékei és ezek előállítása
DZ2770A1 (fr) 1998-04-17 2003-12-01 Lilly Co Eli Procédé de préparation de 1h-indol-3 glyoxamides substituées en position 4.
CA2333024C (en) 1998-07-09 2002-03-26 Warner-Lambert Company Method for the treatment of insomnia
ATE419231T1 (de) * 1999-06-10 2009-01-15 Warner Lambert Co Mono-substituierte 3-propyl-gamma- aminobuttersäure

Also Published As

Publication number Publication date
PL373296A1 (en) 2005-08-22
AU2003219425A1 (en) 2003-11-17
WO2003093220A1 (en) 2003-11-13
CN1649827A (zh) 2005-08-03
US6924377B2 (en) 2005-08-02
TW200400929A (en) 2004-01-16
US20030225149A1 (en) 2003-12-04
BR0309743A (pt) 2005-02-09
RU2004131840A (ru) 2005-05-27
JP2005523932A (ja) 2005-08-11
CA2483830A1 (en) 2003-11-13
US20030236415A1 (en) 2003-12-25
MXPA04010771A (es) 2005-03-07
KR20040106415A (ko) 2004-12-17
IL164781A0 (en) 2005-12-18
EP1499583A1 (en) 2005-01-26

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