BR0206730A - Processo para preparar uma composição de valproato de sódio não-higroscópica, composição farmacêutica não-higroscópia e seu uso - Google Patents

Processo para preparar uma composição de valproato de sódio não-higroscópica, composição farmacêutica não-higroscópia e seu uso

Info

Publication number
BR0206730A
BR0206730A BR0206730-7A BR0206730A BR0206730A BR 0206730 A BR0206730 A BR 0206730A BR 0206730 A BR0206730 A BR 0206730A BR 0206730 A BR0206730 A BR 0206730A
Authority
BR
Brazil
Prior art keywords
hygroscopic
composition
preparing
sodium valproate
pharmaceutical composition
Prior art date
Application number
BR0206730-7A
Other languages
English (en)
Inventor
Mohammed S Safadi
Maya Barder
Yechiel Golander
Avraham Yacobi
Daniel A Moros
Barrie Levitt
Michael Friedman
Original Assignee
Taro Pharmaceutical Ind L T D
Taro Pharmaceuticals L T D
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taro Pharmaceutical Ind L T D, Taro Pharmaceuticals L T D filed Critical Taro Pharmaceutical Ind L T D
Publication of BR0206730A publication Critical patent/BR0206730A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

"PROCESSO PARA PREPARAR UMA COMPOSIçãO DE VALPROATO DE SóDIO NãO-HIGROSCóPICA, COMPOSIçãO FARMACêUTICA NãO-HIGROSCóPICA E SEU USO". A presente invenção é direcionada a composições farmacêuticas orais não-higroscópicas de um sal de ácido valpróico, e processos para preparar tais composições. As composições farmacêuticas não-higroscópicas são preparadas misturando um sal higroscópico de ácido valpróico, um carbómero, e um aditivo não-higroscópico.
BR0206730-7A 2001-01-24 2002-01-24 Processo para preparar uma composição de valproato de sódio não-higroscópica, composição farmacêutica não-higroscópia e seu uso BR0206730A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/767,853 US20020143058A1 (en) 2001-01-24 2001-01-24 Process for preparing non-hygroscopic sodium valproate composition
PCT/US2002/002076 WO2002058666A2 (en) 2001-01-24 2002-01-24 Process for preparing non-hygroscopic sodium valproate composition

Publications (1)

Publication Number Publication Date
BR0206730A true BR0206730A (pt) 2004-02-10

Family

ID=25080780

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0206730-7A BR0206730A (pt) 2001-01-24 2002-01-24 Processo para preparar uma composição de valproato de sódio não-higroscópica, composição farmacêutica não-higroscópia e seu uso

Country Status (10)

Country Link
US (3) US20020143058A1 (pt)
EP (1) EP1353650A2 (pt)
JP (1) JP2004521890A (pt)
CN (1) CN1487827A (pt)
BR (1) BR0206730A (pt)
CA (1) CA2434226A1 (pt)
IL (1) IL156104A0 (pt)
MX (1) MXPA03006625A (pt)
RU (1) RU2003126177A (pt)
WO (1) WO2002058666A2 (pt)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0311642A (pt) * 2002-06-07 2005-03-01 Ranbaxy Lab Ltd Formulação de divalproex de sódio de liberação aumentada
US20040005357A1 (en) * 2002-07-03 2004-01-08 Sherman Bernard Charles Extended-release tablets comprising divalproex sodium
US20040091581A1 (en) * 2002-11-08 2004-05-13 Ghislaine Joly Starch/collagen casings for co-extruded food products
AU2003298010A1 (en) * 2002-12-19 2004-07-29 Pharmacia Corporation Non-hygroscopic formulation comprising a hydroscopic drug
EP1837020A1 (en) * 2006-03-24 2007-09-26 Bioalliance Pharma Mucosal bioadhesive slow release carrier for delivering active principles
PL204780B1 (pl) * 2006-06-02 2010-02-26 Zak & Lstrok Ady Farmaceutyczn Tabletka powlekana o przedłużonym uwalnianiu substancji aktywnej otrzymywana metodą bezpośredniego tabletkowania zawierająca indapamid albo jego farmaceutyczną sól oraz farmaceutycznie dopuszczalne wypełniacze, zastosowanie karbomeru do wytwarzania tabletki oraz sposób jej powlekania
WO2008033740A2 (en) * 2006-09-11 2008-03-20 Hydrogen Discoveries Inc. Mitigating hydrogen flux through solid and liquid barrier materials
PT2101733E (pt) * 2006-12-13 2012-10-30 Hoffmann La Roche Formulação de valganciclovir em pó
ES2674681T3 (es) * 2007-02-20 2018-07-03 Allergan Pharmaceuticals International Limited Composiciones estables de enzimas digestivas
US20100122747A1 (en) * 2007-09-10 2010-05-20 Hydrogen Discoveries, Inc. Composite Structures for Hydrogen Storage and Transfer
US20100204325A1 (en) * 2009-02-11 2010-08-12 Allergan, Inc. Valproic acid drug delivery systems and intraocular therapeutic uses thereof
EP2412369B1 (en) * 2009-03-27 2016-08-31 Toray Industries, Inc. Coated solid preparation
CN110448536A (zh) * 2019-08-23 2019-11-15 仁和堂药业有限公司 丙戊酸钠片剂及其加工工艺
CN113304117B (zh) * 2021-04-30 2023-05-12 山东京卫制药有限公司 一种丙戊酸钠缓释片的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5212326A (en) 1979-08-20 1993-05-18 Abbott Laboratories Sodium hydrogen divalproate oligomer
US4988731A (en) 1979-08-20 1991-01-29 Abbott Laboratories Sodium hydrogen divalproate oligomer
US4301176A (en) 1980-08-18 1981-11-17 Warner-Lambert Company Method of administering calcium valproate
IL72381A (en) 1983-07-20 1988-03-31 Sanofi Sa Pharmaceutical composition based on valproic acid
US5185159A (en) * 1983-07-20 1993-02-09 Sanofi Pharmaceutical composition based on valproic acid and a process for preparing it
US4913906B1 (en) * 1985-02-28 2000-06-06 Yissum Res Dev Co Controlled release dosage form of valproic acid
US4772540A (en) 1985-08-30 1988-09-20 Bar Ilan University Manufacture of microsieves and the resulting microsieves
EP0300111B1 (en) 1987-07-22 1991-10-16 Farvalsa AG A moisture stable solid valproic acid formulation and a method of preparing the same
GB8724763D0 (en) * 1987-10-22 1987-11-25 Aps Research Ltd Sustained-release formulations
EP0571973B1 (en) * 1992-05-29 2000-02-02 Nikken Chemicals Co., Ltd. Slow-release sodium valproate tablets
US6287598B1 (en) 1993-05-28 2001-09-11 Alza Corporation Method for providing sustained antiepileptic therapy

Also Published As

Publication number Publication date
JP2004521890A (ja) 2004-07-22
CA2434226A1 (en) 2002-08-01
US20030119872A1 (en) 2003-06-26
CN1487827A (zh) 2004-04-07
MXPA03006625A (es) 2004-11-12
IL156104A0 (en) 2003-12-23
US6752997B2 (en) 2004-06-22
US20040208927A1 (en) 2004-10-21
WO2002058666A3 (en) 2002-12-27
RU2003126177A (ru) 2005-01-10
US20020143058A1 (en) 2002-10-03
EP1353650A2 (en) 2003-10-22
WO2002058666A2 (en) 2002-08-01

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Legal Events

Date Code Title Description
B11A Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing
B11Y Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette]