BR0116539A - Derivados de piridona tendo uma atividade de ligação para o receptor 2 do tipo canabinóide - Google Patents
Derivados de piridona tendo uma atividade de ligação para o receptor 2 do tipo canabinóideInfo
- Publication number
- BR0116539A BR0116539A BR0116539-9A BR0116539A BR0116539A BR 0116539 A BR0116539 A BR 0116539A BR 0116539 A BR0116539 A BR 0116539A BR 0116539 A BR0116539 A BR 0116539A
- Authority
- BR
- Brazil
- Prior art keywords
- binding activity
- cannabinoid receptor
- pyridone derivatives
- alkyl
- formula
- Prior art date
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
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- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
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- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
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- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Abstract
"DERIVADOS DE PIRIDONA TENDO UMA ATIVIDADE DE LIGAçãO PARA O RECEPTOR 2 DO TIPO CANABINóIDE". Foi constatado que o composto tendo a atividade de ligação com o receptor de 2 de canabinóide representado pela fórmula (I): onde R^ 1^ é um grupo representado pela fórmula: -Y^ 1^-Y^ 2^-Y^ 3^-R^ a^ onde Y^ 1^ é uma ligação simples ou similar; Y^ 2^ é -C(=O)-NH- ou similar; Y^ 3^ é arila opcionalmente substituída ou similar; R^ 2^ é hidrogênio ou similar; R^ 3^ é alquila ou similar; R^ 4^ é alquila ou similar; R^ 5^ é alquila opcionalmente substituída ou similar; ou R^ 3^ e R^ 4^ tomados juntos com o átomo adjacente formam grupo cíclico ou similar.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2000400768 | 2000-12-28 | ||
PCT/JP2001/011427 WO2002053543A1 (fr) | 2000-12-28 | 2001-12-26 | Derive de pyridone ayant une affinite pour le recepteur cannabinoide de type 2 |
Publications (1)
Publication Number | Publication Date |
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BR0116539A true BR0116539A (pt) | 2003-09-23 |
Family
ID=18865293
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0116539-9A BR0116539A (pt) | 2000-12-28 | 2001-12-26 | Derivados de piridona tendo uma atividade de ligação para o receptor 2 do tipo canabinóide |
Country Status (15)
Country | Link |
---|---|
US (3) | US6977266B2 (pt) |
EP (1) | EP1357111B1 (pt) |
JP (2) | JP4137636B2 (pt) |
KR (2) | KR20030070082A (pt) |
CN (1) | CN100575345C (pt) |
AT (1) | ATE438624T1 (pt) |
BR (1) | BR0116539A (pt) |
CA (1) | CA2433158C (pt) |
CY (1) | CY1109514T1 (pt) |
DE (1) | DE60139506D1 (pt) |
DK (1) | DK1357111T3 (pt) |
ES (1) | ES2330719T3 (pt) |
PT (1) | PT1357111E (pt) |
TW (1) | TWI287004B (pt) |
WO (1) | WO2002053543A1 (pt) |
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-
2001
- 2001-12-26 BR BR0116539-9A patent/BR0116539A/pt not_active IP Right Cessation
- 2001-12-26 TW TW090132297A patent/TWI287004B/zh not_active IP Right Cessation
- 2001-12-26 KR KR10-2003-7008600A patent/KR20030070082A/ko not_active Application Discontinuation
- 2001-12-26 KR KR1020067006393A patent/KR100828982B1/ko not_active IP Right Cessation
- 2001-12-26 PT PT01272859T patent/PT1357111E/pt unknown
- 2001-12-26 CA CA2433158A patent/CA2433158C/en not_active Expired - Fee Related
- 2001-12-26 US US10/250,421 patent/US6977266B2/en not_active Expired - Fee Related
- 2001-12-26 EP EP01272859A patent/EP1357111B1/en not_active Expired - Lifetime
- 2001-12-26 CN CN01822847A patent/CN100575345C/zh not_active Expired - Fee Related
- 2001-12-26 ES ES01272859T patent/ES2330719T3/es not_active Expired - Lifetime
- 2001-12-26 AT AT01272859T patent/ATE438624T1/de active
- 2001-12-26 JP JP2002554662A patent/JP4137636B2/ja not_active Expired - Fee Related
- 2001-12-26 DE DE60139506T patent/DE60139506D1/de not_active Expired - Lifetime
- 2001-12-26 DK DK01272859T patent/DK1357111T3/da active
- 2001-12-26 WO PCT/JP2001/011427 patent/WO2002053543A1/ja not_active Application Discontinuation
-
2005
- 2005-06-29 US US11/168,640 patent/US7652141B2/en not_active Expired - Fee Related
-
2008
- 2008-01-31 JP JP2008021092A patent/JP2008169217A/ja active Pending
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2009
- 2009-09-02 US US12/585,057 patent/US8088924B2/en not_active Expired - Fee Related
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Also Published As
Publication number | Publication date |
---|---|
US20040082619A1 (en) | 2004-04-29 |
JP4137636B2 (ja) | 2008-08-20 |
KR20060033816A (ko) | 2006-04-19 |
US6977266B2 (en) | 2005-12-20 |
ES2330719T3 (es) | 2009-12-15 |
WO2002053543A1 (fr) | 2002-07-11 |
CN100575345C (zh) | 2009-12-30 |
CY1109514T1 (el) | 2014-08-13 |
DE60139506D1 (de) | 2009-09-17 |
CA2433158C (en) | 2011-05-10 |
PT1357111E (pt) | 2009-10-20 |
EP1357111A4 (en) | 2005-10-05 |
US20060052411A1 (en) | 2006-03-09 |
US8088924B2 (en) | 2012-01-03 |
EP1357111A1 (en) | 2003-10-29 |
JPWO2002053543A1 (ja) | 2004-05-13 |
US20100081686A1 (en) | 2010-04-01 |
CA2433158A1 (en) | 2002-07-11 |
EP1357111B1 (en) | 2009-08-05 |
KR20030070082A (ko) | 2003-08-27 |
TWI287004B (en) | 2007-09-21 |
US7652141B2 (en) | 2010-01-26 |
ATE438624T1 (de) | 2009-08-15 |
DK1357111T3 (da) | 2009-11-02 |
JP2008169217A (ja) | 2008-07-24 |
CN1492856A (zh) | 2004-04-28 |
KR100828982B1 (ko) | 2008-05-14 |
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