BR0113296A - Processo para a preparação de sais de peptìdeos, seu uso e preparações farmacêuticas contendo os sais de peptìdeos - Google Patents
Processo para a preparação de sais de peptìdeos, seu uso e preparações farmacêuticas contendo os sais de peptìdeosInfo
- Publication number
- BR0113296A BR0113296A BR0113296-2A BR0113296A BR0113296A BR 0113296 A BR0113296 A BR 0113296A BR 0113296 A BR0113296 A BR 0113296A BR 0113296 A BR0113296 A BR 0113296A
- Authority
- BR
- Brazil
- Prior art keywords
- peptide salts
- pharmaceutical preparations
- preparation
- preparations containing
- peptide
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 5
- 150000003839 salts Chemical class 0.000 title abstract 5
- 239000000825 pharmaceutical preparation Substances 0.000 title abstract 4
- 238000002360 preparation method Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- UCANQOXFIYWYIX-IDEADWEOSA-N (2S)-1-[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2R)-2-[[(2R)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-(carbamoylamino)pentanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]-N-[(2R)-1-amino-1-oxopropan-2-yl]pyrrolidine-2-carboxamide 4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid Chemical compound OC(=O)c1cc2ccccc2c(Cc2c(O)c(cc3ccccc23)C(O)=O)c1O.CC(C)C[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O.CC(C)C[C@H](NC(=O)[C@@H](CCCNC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](Cc1cccnc1)NC(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)[C@@H](Cc1ccc2ccccc2c1)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O UCANQOXFIYWYIX-IDEADWEOSA-N 0.000 abstract 1
- 101000904173 Homo sapiens Progonadoliberin-1 Proteins 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 102100024028 Progonadoliberin-1 Human genes 0.000 abstract 1
- 101000996723 Sus scrofa Gonadotropin-releasing hormone receptor Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- XLXSAKCOAKORKW-UHFFFAOYSA-N gonadorelin Chemical compound C1CCC(C(=O)NCC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 XLXSAKCOAKORKW-UHFFFAOYSA-N 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10040700A DE10040700A1 (de) | 2000-08-17 | 2000-08-17 | Salze von biologisch aktiven Peptiden, ihre Herstellung und Verwendung |
| PCT/EP2001/009219 WO2002014347A2 (de) | 2000-08-17 | 2001-08-09 | Verfahren zur herstellung von peptidsalzen, deren verwendung und die peptidsalze enthaltende pharmazeutische zubereitungen |
| CA002355573A CA2355573A1 (en) | 2000-08-17 | 2001-08-22 | Method for the synthesis of peptide salts, their use and the pharmaceutical preparations, containing peptide salts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0113296A true BR0113296A (pt) | 2003-07-15 |
Family
ID=27805895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0113296-2A BR0113296A (pt) | 2000-08-17 | 2001-08-09 | Processo para a preparação de sais de peptìdeos, seu uso e preparações farmacêuticas contendo os sais de peptìdeos |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6780972B2 (bg) |
| EP (1) | EP1309607B1 (bg) |
| JP (1) | JP2004506647A (bg) |
| CN (1) | CN1187369C (bg) |
| AR (1) | AR030371A1 (bg) |
| AT (1) | ATE280779T1 (bg) |
| AU (2) | AU1043902A (bg) |
| BG (1) | BG107612A (bg) |
| BR (1) | BR0113296A (bg) |
| CA (1) | CA2355573A1 (bg) |
| CZ (1) | CZ2003688A3 (bg) |
| DE (2) | DE10040700A1 (bg) |
| DK (1) | DK1309607T3 (bg) |
| EE (1) | EE200300065A (bg) |
| ES (1) | ES2230371T3 (bg) |
| HK (1) | HK1058366A1 (bg) |
| HU (1) | HUP0300738A3 (bg) |
| IL (1) | IL154150A0 (bg) |
| MX (1) | MXPA03001448A (bg) |
| NO (1) | NO20030618D0 (bg) |
| NZ (1) | NZ524023A (bg) |
| PL (1) | PL204496B1 (bg) |
| PT (1) | PT1309607E (bg) |
| RU (1) | RU2266296C2 (bg) |
| SI (1) | SI1309607T1 (bg) |
| SK (1) | SK3032003A3 (bg) |
| TW (1) | TWI236910B (bg) |
| UA (1) | UA74005C2 (bg) |
| WO (1) | WO2002014347A2 (bg) |
| ZA (1) | ZA200300777B (bg) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6828415B2 (en) * | 1993-02-19 | 2004-12-07 | Zentaris Gmbh | Oligopeptide lyophilisate, their preparation and use |
| US7098305B2 (en) * | 2001-09-06 | 2006-08-29 | Ardana Bioscience Limited | Sustained release of microcrystalline peptide suspensions |
| EP1674082A1 (de) | 2004-12-22 | 2006-06-28 | Zentaris GmbH | Verfahren zur Herstellung von sterilen Suspensionen oder Lyophilisaten schwerlöslicher basischer Peptidkomplexe, diese enthaltende pharmazeutische Formulierungen sowie ihre Verwendung als Arzneimittel |
| RU2525661C2 (ru) * | 2012-11-15 | 2014-08-20 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт вакцин и сывороток им. И.И. Мечникова" Российской академии медицинских наук (ФГБУ "НИИВС им. И.И. Мечникова" РАМН) | Способ получения высокотитражной антимикробной сыворотки для оценки антигенной активности противостафилококковых вакцин |
| CN107056894B (zh) * | 2017-05-26 | 2021-07-20 | 济南康和医药科技有限公司 | 一种片段法固相合成醋酸加尼瑞克的方法 |
| EP3590526A1 (en) * | 2018-07-05 | 2020-01-08 | Antev Limited | A lyophilization process and a teverelix-tfa lyophilizate obtained thereby |
| CN114249800B (zh) * | 2020-09-22 | 2024-07-26 | 深圳市星银医药有限公司 | 一种双羟萘酸多肽药物的制备方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4431635A (en) * | 1979-06-13 | 1984-02-14 | Coy David Howard | LH-RH Antagonists |
| EP0041286B1 (en) * | 1980-06-02 | 1984-08-15 | Andrew Victor Schally | Lh-rh antagonists |
| US4800191A (en) * | 1987-07-17 | 1989-01-24 | Schally Andrew Victor | LHRH antagonists |
| DE4305225A1 (de) * | 1993-02-19 | 1994-08-25 | Asta Medica Ag | Neues Herstellverfahren für Cetrorelix Lyophilisat |
| EP0626170A3 (en) * | 1993-05-10 | 1996-03-27 | Sandoz Ltd | Stabilization of pharmacoligically active compounds in controlled release compositions. |
| CA2178592C (en) * | 1993-12-09 | 2009-07-28 | Jurgen Engel | Long-acting injection suspensions and a process for their preparation |
| DE4342092B4 (de) * | 1993-12-09 | 2007-01-11 | Zentaris Gmbh | Langwirkende Injektionssuspension und Verfahren zur Herstellung |
| US6054432A (en) * | 1996-09-12 | 2000-04-25 | Asta Medica Aktiengesellschaft | Means for treating prostate hypertrophy and prostate cancer |
| BR9906903A (pt) * | 1998-01-16 | 2000-12-12 | Takeda Chemical Industries Ltd | Composição com liberação sustentada, processos para produzir a mesma, para suprimir a brusca liberação inicial da susbtância bioativa de uma composição com liberação sustentada e para aumentar a eficiência da inclusão da substância bioativa em uma composição com liberação sustentada, produto farmacêutico, agente para prevenir ou tratar câncer prostático, hipertrofia prostática, endometriose, histeromioma, metrofibroma, puberdade precoce, dismenorréia, ou câncer do seio, ou um contraceptivo, e, composto |
-
2000
- 2000-08-17 DE DE10040700A patent/DE10040700A1/de not_active Withdrawn
-
2001
- 2001-08-09 PL PL359495A patent/PL204496B1/pl not_active IP Right Cessation
- 2001-08-09 HU HU0300738A patent/HUP0300738A3/hu unknown
- 2001-08-09 JP JP2002519484A patent/JP2004506647A/ja active Pending
- 2001-08-09 EE EEP200300065A patent/EE200300065A/xx unknown
- 2001-08-09 AT AT01978273T patent/ATE280779T1/de not_active IP Right Cessation
- 2001-08-09 AU AU1043902A patent/AU1043902A/xx active Pending
- 2001-08-09 IL IL15415001A patent/IL154150A0/xx not_active IP Right Cessation
- 2001-08-09 MX MXPA03001448A patent/MXPA03001448A/es active IP Right Grant
- 2001-08-09 RU RU2003107560/04A patent/RU2266296C2/ru not_active IP Right Cessation
- 2001-08-09 CN CNB018142192A patent/CN1187369C/zh not_active Expired - Fee Related
- 2001-08-09 NZ NZ524023A patent/NZ524023A/en unknown
- 2001-08-09 AU AU2002210439A patent/AU2002210439B2/en not_active Ceased
- 2001-08-09 EP EP01978273A patent/EP1309607B1/de not_active Expired - Lifetime
- 2001-08-09 PT PT01978273T patent/PT1309607E/pt unknown
- 2001-08-09 SI SI200130237T patent/SI1309607T1/xx unknown
- 2001-08-09 WO PCT/EP2001/009219 patent/WO2002014347A2/de active IP Right Grant
- 2001-08-09 DE DE50104316T patent/DE50104316D1/de not_active Expired - Lifetime
- 2001-08-09 DK DK01978273T patent/DK1309607T3/da active
- 2001-08-09 CZ CZ2003688A patent/CZ2003688A3/cs unknown
- 2001-08-09 SK SK303-2003A patent/SK3032003A3/sk not_active Application Discontinuation
- 2001-08-09 ES ES01978273T patent/ES2230371T3/es not_active Expired - Lifetime
- 2001-08-09 BR BR0113296-2A patent/BR0113296A/pt not_active IP Right Cessation
- 2001-08-16 AR ARP010103935A patent/AR030371A1/es active IP Right Grant
- 2001-08-17 TW TW090120293A patent/TWI236910B/zh active
- 2001-08-22 CA CA002355573A patent/CA2355573A1/en not_active Abandoned
- 2001-08-24 US US09/939,532 patent/US6780972B2/en not_active Expired - Fee Related
- 2001-09-08 UA UA2003032260A patent/UA74005C2/uk unknown
-
2003
- 2003-01-29 ZA ZA200300777A patent/ZA200300777B/xx unknown
- 2003-02-07 NO NO20030618A patent/NO20030618D0/no unknown
- 2003-03-06 BG BG107612A patent/BG107612A/bg unknown
-
2004
- 2004-02-13 HK HK04101030A patent/HK1058366A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B25A | Requested transfer of rights approved |
Owner name: BLITZ F02-570 GMBH (DE) Free format text: TRANSFERIDO POR FUSAO DE: ZENTARIS AG |
|
| B25D | Requested change of name of applicant approved |
Owner name: ZENTARIS GMBH (DE) Free format text: ALTERADO DE: BLITZ F02-570 GMBH |
|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B25G | Requested change of headquarter approved |
Owner name: ZENTARIS GMBH (DE) Free format text: SEDE ALTERADA CONFORME PETICAO NO 020060058923-RJ DE 27.04.2006. |
|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 10A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2156 DE 02/05/2012. |