BR0111538A - Derivados de 1,3,8-triaza-espiro 4,5!decan-4-ona como antogonistas de receptor de neurocinina - Google Patents
Derivados de 1,3,8-triaza-espiro 4,5!decan-4-ona como antogonistas de receptor de neurocininaInfo
- Publication number
- BR0111538A BR0111538A BR0111538-3A BR0111538A BR0111538A BR 0111538 A BR0111538 A BR 0111538A BR 0111538 A BR0111538 A BR 0111538A BR 0111538 A BR0111538 A BR 0111538A
- Authority
- BR
- Brazil
- Prior art keywords
- lower alkyl
- hydrogen
- halogen
- phenyl
- triaza
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/02—Suppositories; Bougies; Bases therefor; Ovules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
"DERIVADOS DE 1,3,8-TRIAZA-ESPIRO'4,5!DECAN-4-ONA COMO ANTAGONISTAS DE RECEPTOR DE NEUROCININA". A invenção refere-se a compostos da fórmula (I) em que R^ 1^ é hidrogênio, alquila inferior, alquenila inferior, fenila ou os seguintes grupos -(CH~ 2~)~ m~,-heterocíclicos não aromáticos, que estão opcionalmente substituídos por alquila inferior, ou é -(CH~ 2~)~ m~-heteroarila, que está opcionalmente substituída por um ou dois substituintes selecionados do grupo que consiste de alquila inferior, alcóxi inferior, halogênio, CF~ 3~, benzila ou ciano, ou é -(CH~ 2~)~ m~-C(O)-NRR', -(CH~ 2~)~ m~-C(O)-alquila inferior, -(CH~ 2~)~ m~-C(O)-O-alquila inferior, -(CH~ 2~)~ m~-O-alquila inferior, -(CH~ 2~)~ m~-CH[C(O)-O-alquila inforior]~ 2~, -(CH~ 2~)~ m~-CH(OH)-CH~ 2~-O-fenila, -(CH~ 2~)~ m~-CH(CF~ 3~)OH, -(CH~ 2~)~ m~-OH, -(CH~ 2~)~ m~-CN, -(CH~ 2~)~ m~-NRR', -(CH~ 2~)~ m~-cicloalquila ou -(CH~ 2~)~ m~-CHF~ 2~; R^ 2^ é hidrogênio, alquila inferior, halogênio ou alcóxi inferior; R^ 3^ é alquila inferior, alcóxi inferior, halogênio ou CF~ 3~ R,R' são iguais ou diferentes e são hidrogênio ou alquila inferior; x é >N-, >C= ou >CH-; X^ 1^/X^ 2^ são independentemente entre si hidrogênio, hidróxi ou alcóxi inferior ou podem ser juntos um grupo oxo; Y^ 1^/Y^ 2^ são independentemente entre si hidrogênio, alquila inferior, -(CH~ 2~)~ m~-fenila ou podem ser juntos um grupo oxo; Z é uma ligação, -CH~ 2~- ou -C(O)-; m é 0, 1, 2, 3 ou 4; n é 2 ou 3; n^ 1^ é 0, 1 ou 2; e a seus sais de adição ácidos farmaceuticamente aceitáveis. Os compostos descritos têm uma boa afinidade para o receptor de NK1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00112285 | 2000-06-08 | ||
PCT/EP2001/006305 WO2001094346A1 (en) | 2000-06-08 | 2001-06-01 | 1,3,8-TRIAZA-SPIRO'4,5!DECAN-4-ONE DERIVATIVES AS NEUROKININ RECEPTOR ANTAGONISTS |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0111538A true BR0111538A (pt) | 2003-07-01 |
Family
ID=8168940
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0111538-3A BR0111538A (pt) | 2000-06-08 | 2001-06-01 | Derivados de 1,3,8-triaza-espiro 4,5!decan-4-ona como antogonistas de receptor de neurocinina |
Country Status (17)
Country | Link |
---|---|
US (1) | US6482829B2 (pt) |
EP (1) | EP1292596B1 (pt) |
JP (1) | JP4245348B2 (pt) |
KR (1) | KR100518198B1 (pt) |
CN (1) | CN1261433C (pt) |
AR (1) | AR028683A1 (pt) |
AT (1) | ATE381565T1 (pt) |
AU (2) | AU2001267513B2 (pt) |
BR (1) | BR0111538A (pt) |
CA (1) | CA2411716C (pt) |
DE (1) | DE60131971T2 (pt) |
ES (1) | ES2296761T3 (pt) |
MX (1) | MXPA02012001A (pt) |
PE (1) | PE20020298A1 (pt) |
UY (1) | UY26754A1 (pt) |
WO (1) | WO2001094346A1 (pt) |
ZA (1) | ZA200209488B (pt) |
Families Citing this family (51)
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US7081463B2 (en) * | 2002-09-09 | 2006-07-25 | Janssen Pharmaceutica N.V. | Hydroxy alkyl substituted 1,3,8-Triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1receptor mediated disorders |
US7498323B2 (en) * | 2003-04-18 | 2009-03-03 | Ono Pharmaceuticals Co., Ltd. | Spiro-piperidine compounds and medicinal use thereof |
ES2359707T3 (es) * | 2004-01-08 | 2011-05-26 | F. Hoffmann-La Roche Ag | Derivados de diaza-espiropiperidina. |
JO2676B1 (en) * | 2004-04-06 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Derivatives of second-aza-spiro- (5,4) -dikan and their use as antihistamines |
JO2527B1 (en) * | 2004-04-06 | 2010-03-17 | شركة جانسين فارماسوتيكا ان. في | Derivatives of second-aza-Spiro- (5,5) -andecan and their use as antihistamines |
EP1790639B1 (en) | 2004-08-27 | 2014-03-26 | Ono Pharmaceutical Co., Ltd. | Spirocyclic compounds and their use as cxcr4-antagonists |
JP2008515956A (ja) * | 2004-10-12 | 2008-05-15 | ノボ ノルディスク アクティーゼルスカブ | 11β−ヒドロキシステロイドデヒドロゲナーゼ1型活性スピロ化合物 |
KR20070094666A (ko) | 2005-02-25 | 2007-09-20 | 에프. 호프만-라 로슈 아게 | 약제 물질 분산성이 향상된 정제 |
KR101355064B1 (ko) * | 2005-03-03 | 2014-01-24 | 얀센 파마슈티카 엔.브이. | 치환된 옥사-디아자-스피로-[5.5]-운데카논 유도체 및뉴로키닌 길항제로서의 이의 용도 |
CA2599186C (en) * | 2005-03-08 | 2014-12-09 | Janssen Pharmaceutica N.V. | Diaza-spiro-[4.4]-nonane derivatives as neurokinin (nk1) antagonists |
US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
BRPI0617271A2 (pt) * | 2005-10-11 | 2011-07-19 | Intermune Inc | inibidores de replicação viral |
US8053431B2 (en) * | 2005-11-01 | 2011-11-08 | High Point Pharmaceuticals, Llc | Pharmaceutical use of substituted amides |
CA2627306A1 (en) * | 2005-11-01 | 2007-05-10 | Transtech Pharma, Inc. | Pharmaceutical use of substituted amides |
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GB0601402D0 (en) * | 2006-01-24 | 2006-03-08 | Syngenta Participations Ag | Chemical Compounds |
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US20110003856A1 (en) * | 2007-02-23 | 2011-01-06 | Soren Ebdrup | N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase |
JP2010519242A (ja) * | 2007-02-23 | 2010-06-03 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | 新規化合物 |
JP2010520864A (ja) * | 2007-03-09 | 2010-06-17 | ハイ ポイント ファーマシューティカルズ,リミティド ライアビリティ カンパニー | ヒドロキシステロイドデヒドロゲナーゼインヒビターとしてのインドール−及びベンズイミダゾールアミド類 |
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EP2152081B1 (en) * | 2007-04-11 | 2012-10-24 | High Point Pharmaceuticals, LLC | Novel compounds |
ES2393230T3 (es) * | 2007-04-24 | 2012-12-19 | High Point Pharmaceuticals, Llc | Uso farmacéutico de amidas sustituidas |
CA2703635C (en) | 2007-10-26 | 2017-06-27 | Michael E. Jung | Diarylhydantoin compounds as androgen receptor modulators |
US7981904B2 (en) * | 2008-03-20 | 2011-07-19 | Takeda Pharmaceutical Company Limited | Acetyl CoA carboxylase inhibitors |
US20100076003A1 (en) * | 2008-09-19 | 2010-03-25 | Kathleen Battista | 5-oxazolidin-2-one substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful as orl-1 receptor modulators |
JP2012530136A (ja) | 2009-06-16 | 2012-11-29 | メルク・シャープ・エンド・ドーム・コーポレイション | 置換−1,3,8−トリアザスピロ[4.5]デカン−2,4−ジオン |
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EP2760447A4 (en) | 2011-09-30 | 2015-10-21 | Univ Vanderbilt | ANTIVIRAL THERAPIES WITH D PHOSPHOLIPASE INHIBITORS |
KR20210013342A (ko) | 2012-09-26 | 2021-02-03 | 아라곤 파마슈티컬스, 인코포레이티드 | 비전이성 거세 저항성 전립선암 치료용 항안드로겐 |
JOP20200097A1 (ar) | 2013-01-15 | 2017-06-16 | Aragon Pharmaceuticals Inc | معدل مستقبل أندروجين واستخداماته |
TW201712012A (zh) | 2015-06-16 | 2017-04-01 | 美國禮來大藥廠 | 2-側氧基-1,3,8-三氮雜螺[4.5]癸-3-基羧酸衍生物 |
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TWI726969B (zh) | 2016-01-11 | 2021-05-11 | 比利時商健生藥品公司 | 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物 |
CN108884096B (zh) | 2016-02-08 | 2022-03-22 | 豪夫迈·罗氏有限公司 | 作为ddr1抑制剂的螺二氢吲哚酮 |
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2001
- 2001-05-21 US US09/861,795 patent/US6482829B2/en not_active Expired - Fee Related
- 2001-06-01 MX MXPA02012001A patent/MXPA02012001A/es active IP Right Grant
- 2001-06-01 JP JP2002501895A patent/JP4245348B2/ja not_active Expired - Fee Related
- 2001-06-01 EP EP01945242A patent/EP1292596B1/en not_active Expired - Lifetime
- 2001-06-01 CA CA2411716A patent/CA2411716C/en not_active Expired - Fee Related
- 2001-06-01 BR BR0111538-3A patent/BR0111538A/pt not_active IP Right Cessation
- 2001-06-01 KR KR10-2002-7016671A patent/KR100518198B1/ko not_active IP Right Cessation
- 2001-06-01 DE DE60131971T patent/DE60131971T2/de not_active Expired - Lifetime
- 2001-06-01 AT AT01945242T patent/ATE381565T1/de not_active IP Right Cessation
- 2001-06-01 ES ES01945242T patent/ES2296761T3/es not_active Expired - Lifetime
- 2001-06-01 AU AU2001267513A patent/AU2001267513B2/en not_active Ceased
- 2001-06-01 AU AU6751301A patent/AU6751301A/xx active Pending
- 2001-06-01 WO PCT/EP2001/006305 patent/WO2001094346A1/en active IP Right Grant
- 2001-06-01 CN CNB018109403A patent/CN1261433C/zh not_active Expired - Fee Related
- 2001-06-06 AR ARP010102690A patent/AR028683A1/es unknown
- 2001-06-07 UY UY26754A patent/UY26754A1/es not_active Application Discontinuation
- 2001-06-07 PE PE2001000533A patent/PE20020298A1/es not_active Application Discontinuation
-
2002
- 2002-11-21 ZA ZA200209488A patent/ZA200209488B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2411716C (en) | 2010-06-22 |
UY26754A1 (es) | 2001-12-28 |
MXPA02012001A (es) | 2003-04-22 |
AR028683A1 (es) | 2003-05-21 |
KR20030016283A (ko) | 2003-02-26 |
WO2001094346A1 (en) | 2001-12-13 |
US6482829B2 (en) | 2002-11-19 |
EP1292596A1 (en) | 2003-03-19 |
DE60131971T2 (de) | 2008-12-04 |
DE60131971D1 (de) | 2008-01-31 |
AU2001267513B2 (en) | 2006-03-16 |
CN1436188A (zh) | 2003-08-13 |
EP1292596B1 (en) | 2007-12-19 |
JP2003535863A (ja) | 2003-12-02 |
ES2296761T3 (es) | 2008-05-01 |
KR100518198B1 (ko) | 2005-10-04 |
JP4245348B2 (ja) | 2009-03-25 |
AU6751301A (en) | 2001-12-17 |
CA2411716A1 (en) | 2001-12-13 |
ZA200209488B (en) | 2004-02-23 |
CN1261433C (zh) | 2006-06-28 |
PE20020298A1 (es) | 2002-04-17 |
ATE381565T1 (de) | 2008-01-15 |
US20020006932A1 (en) | 2002-01-17 |
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