BR0109919A - Proteìna, partìcula, molécula de ácido nucleico, célula hospedeira, processo para produzir uma proteìna, composição farmacêutica, uso de uma proteìna, e, método de vacinação profilática ou terapêutica de um indivìduo - Google Patents

Proteìna, partìcula, molécula de ácido nucleico, célula hospedeira, processo para produzir uma proteìna, composição farmacêutica, uso de uma proteìna, e, método de vacinação profilática ou terapêutica de um indivìduo

Info

Publication number
BR0109919A
BR0109919A BR0109919-1A BR0109919A BR0109919A BR 0109919 A BR0109919 A BR 0109919A BR 0109919 A BR0109919 A BR 0109919A BR 0109919 A BR0109919 A BR 0109919A
Authority
BR
Brazil
Prior art keywords
protein
particles
loop
hbcag
sequences
Prior art date
Application number
BR0109919-1A
Other languages
English (en)
Inventor
Annick Gehin
Robert Gilbert
David Stuart
David Rowlands
Original Assignee
Univ Leeds Innovations Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leeds Innovations Ltd filed Critical Univ Leeds Innovations Ltd
Publication of BR0109919A publication Critical patent/BR0109919A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/02—Hepadnaviridae, e.g. hepatitis B virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

"PROTEìNA, PARTìCULA, MOLéCULA DE áCIDO NUCLEICO, CéLULA HOSPEDEIRA, PROCESSO PARA PRODUZIR UMA PROTEìNA, COMPOSIçãO FARMACêUTICA, USO DE UMA PROTEìNA, E, MéTODO DE VACINAçãO PROFILáTICA OU TERAPêUTICA DE UM INDIVìDUO". O capsídeo de vírus de hepatite (HBV) é feito de uma única espécie de proteína chamada antígeno de núcleo (HBcAg) que se auto-reúne em partículas. As partículas são altamente imunogenes e são capazes de apresentar epítopos heterólogos ao sistema imune quando os epítopos são inseridos na região exposta das partículas à superfície chamada "laço el". Os blocos de construção estruturais das partículas são dímeros estreitamente associados de HBcAg em que os laços el adjacentes são intimamente justapostos. Propõe-se que as seq³ências inseridas no laço el sejam conformacionalmente limitadas nas partículas reunidas quando elas são apresentadas na proteína de núcleo monomérica. A invenção procura resolver este problema por ligação covalente das proteínas de núcleo como cópias em tandem, por exemplo como dímeros, de modo que as inserções podem ser feitas independentemente em cada cópia. Isto é particularmente utilizável para inserção de seq³ências grandes no laço el porque permite que estas seq³ências sejam inseridas em apenas uma cópia da proteína de núcleo por repetição em tandem, assim reduzindo a probabilidade de choques conformacionais em potencial na reunião. Alternativamente, uma diferente seq³ência pode ser inserida em cada laço el de uma repetição em tandem, assim aumentando a flexibilidade de partículas HBcAg como um sistema de liberação de epítopo.
BR0109919-1A 2000-04-07 2001-04-09 Proteìna, partìcula, molécula de ácido nucleico, célula hospedeira, processo para produzir uma proteìna, composição farmacêutica, uso de uma proteìna, e, método de vacinação profilática ou terapêutica de um indivìduo BR0109919A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP00107118 2000-04-07
PCT/GB2001/001607 WO2001077158A1 (en) 2000-04-07 2001-04-09 Hepatitis b core antigen fusion proteins

Publications (1)

Publication Number Publication Date
BR0109919A true BR0109919A (pt) 2003-03-11

Family

ID=8168351

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0109919-1A BR0109919A (pt) 2000-04-07 2001-04-09 Proteìna, partìcula, molécula de ácido nucleico, célula hospedeira, processo para produzir uma proteìna, composição farmacêutica, uso de uma proteìna, e, método de vacinação profilática ou terapêutica de um indivìduo

Country Status (18)

Country Link
US (1) US7270821B2 (pt)
EP (1) EP1268530B1 (pt)
JP (1) JP4713809B2 (pt)
KR (1) KR100808313B1 (pt)
CN (1) CN100360556C (pt)
AP (1) AP1836A (pt)
AT (1) ATE336502T1 (pt)
AU (1) AU784345B2 (pt)
BR (1) BR0109919A (pt)
CA (1) CA2405438C (pt)
DE (1) DE60122300T2 (pt)
DK (1) DK1268530T3 (pt)
EA (1) EA200201077A1 (pt)
ES (1) ES2269371T3 (pt)
MX (1) MXPA02009895A (pt)
PT (1) PT1268530E (pt)
WO (1) WO2001077158A1 (pt)
ZA (1) ZA200208967B (pt)

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KR102237130B1 (ko) * 2012-12-11 2021-04-08 오시벡스 에스에이에스 향상된 특성을 갖는 변형된 코일드 코일 유형 단백질
CN105431457A (zh) * 2013-06-06 2016-03-23 大卫·J·罗兰 单结构域抗体展示
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Also Published As

Publication number Publication date
US20040223965A1 (en) 2004-11-11
US7270821B2 (en) 2007-09-18
CA2405438C (en) 2011-07-12
KR20030009429A (ko) 2003-01-29
DE60122300D1 (de) 2006-09-28
DK1268530T3 (da) 2006-11-13
AU784345B2 (en) 2006-03-16
CA2405438A1 (en) 2001-10-18
MXPA02009895A (es) 2004-09-06
ZA200208967B (en) 2003-10-08
CN1441807A (zh) 2003-09-10
KR100808313B1 (ko) 2008-02-27
AU4670601A (en) 2001-10-23
WO2001077158A1 (en) 2001-10-18
JP2003530123A (ja) 2003-10-14
CN100360556C (zh) 2008-01-09
DE60122300T2 (de) 2007-08-30
ES2269371T3 (es) 2007-04-01
EP1268530A1 (en) 2003-01-02
PT1268530E (pt) 2006-12-29
JP4713809B2 (ja) 2011-06-29
ATE336502T1 (de) 2006-09-15
EA200201077A1 (ru) 2003-04-24
EP1268530B1 (en) 2006-08-16
AP2002002658A0 (en) 2002-12-31
AP1836A (en) 2008-03-14

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