DE68926274D1 - Rekombinante HBsAg Hybridpartikel, die morphologische Eigenschaften von HBsAg-Antigen haben und eine immunogene Sequenz enthalten, die neutralisierende Antikörper gegen HIV induziert oder die von diesen Antikörpern erkannt ist, Nukleotide Sequenzen, die diese Partikel codieren und sie enthaltende Impfstoffe - Google Patents

Rekombinante HBsAg Hybridpartikel, die morphologische Eigenschaften von HBsAg-Antigen haben und eine immunogene Sequenz enthalten, die neutralisierende Antikörper gegen HIV induziert oder die von diesen Antikörpern erkannt ist, Nukleotide Sequenzen, die diese Partikel codieren und sie enthaltende Impfstoffe

Info

Publication number
DE68926274D1
DE68926274D1 DE68926274T DE68926274T DE68926274D1 DE 68926274 D1 DE68926274 D1 DE 68926274D1 DE 68926274 T DE68926274 T DE 68926274T DE 68926274 T DE68926274 T DE 68926274T DE 68926274 D1 DE68926274 D1 DE 68926274D1
Authority
DE
Germany
Prior art keywords
particles
hbsag
amino acid
acid sequence
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68926274T
Other languages
English (en)
Inventor
Pierre Tiollais
Marie-Louise Michel
Maryline Mancini
Eliane Sobczak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Pasteur de Lille
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut Pasteur de Lille
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Pasteur de Lille, Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut Pasteur de Lille
Application granted granted Critical
Publication of DE68926274D1 publication Critical patent/DE68926274D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE68926274T 1988-07-29 1989-07-28 Rekombinante HBsAg Hybridpartikel, die morphologische Eigenschaften von HBsAg-Antigen haben und eine immunogene Sequenz enthalten, die neutralisierende Antikörper gegen HIV induziert oder die von diesen Antikörpern erkannt ist, Nukleotide Sequenzen, die diese Partikel codieren und sie enthaltende Impfstoffe Expired - Lifetime DE68926274D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8810336A FR2635532B1 (fr) 1988-07-29 1988-07-29 Particules hbsag recombinantes hybrides : caracteristiques morphologiques de l'antigene hbsag contenant 1 sequence immunogene induisant des anticorps neutralisants diriges contre hiv ou susceptible d'etre reconnue par de tels anticorps; sequences nucleotidiques codant pour de telles particules; vaccins les contenant

Publications (1)

Publication Number Publication Date
DE68926274D1 true DE68926274D1 (de) 1996-05-23

Family

ID=9368968

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68926274T Expired - Lifetime DE68926274D1 (de) 1988-07-29 1989-07-28 Rekombinante HBsAg Hybridpartikel, die morphologische Eigenschaften von HBsAg-Antigen haben und eine immunogene Sequenz enthalten, die neutralisierende Antikörper gegen HIV induziert oder die von diesen Antikörpern erkannt ist, Nukleotide Sequenzen, die diese Partikel codieren und sie enthaltende Impfstoffe

Country Status (7)

Country Link
EP (1) EP0354109B1 (de)
JP (1) JPH02211881A (de)
AT (1) ATE136933T1 (de)
DE (1) DE68926274D1 (de)
DK (1) DK373489A (de)
FR (1) FR2635532B1 (de)
PT (1) PT91316B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2025481A1 (en) * 1989-09-19 1991-03-20 Peter J. Kniskern Vaccine for aids and hepatitis b
EP0547689A2 (de) * 1991-12-18 1993-06-23 Merck & Co. Inc. Zyklisches HIV PND und T-Zell stimulierendes Epitop enthaltende synthetische Peptide
WO1993012815A1 (en) * 1991-12-27 1993-07-08 Gensci Limited Method for obtaining recombinant surface antigen of hepatitis b, antigen and vaccine based on it
EP0565794A1 (de) * 1992-04-14 1993-10-20 British Biotech Pharmaceuticals Limited Induktion von CTL-Antworten
IT1256575B (it) * 1992-12-10 1995-12-11 Cesalpino Andrea Fond Procedimento per la preparazione di immunogeni costituiti da antigeni esogeni capaci di generare non solo la risposta immune dei linfociti t helper,ma anche una efficace risposta dei linfociti t citotossici; e immunogeni cosi' ottenibili.
DE4405810A1 (de) 1994-02-23 1995-08-24 Behringwerke Ag Von einem Retrovirus aus der HIV-Gruppe abgeleitete Peptide und deren Verwendung
US5691447A (en) * 1995-03-24 1997-11-25 Tanox Biosystems, Inc. GC1q receptor, HIV-1 gp120 region binding thereto, and related peptides and targeting antibodies
EP1837017A3 (de) * 1997-01-22 2009-12-23 Eisai Inc. Mikropartikel zur Abgabe von Nukleinsäuren
FR2844514B1 (fr) 2002-09-16 2007-10-19 Neovacs Produit immunogene stable comprenant des heterocomplexes antigeniques, compositions les contenant et procede de preparation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3176404D1 (en) * 1980-04-22 1987-10-08 Pasteur Institut Vaccine against viral hepatitis b, method and transformed eucaryotic cells for the preparation of this vaccine
ATE70308T1 (de) * 1984-09-12 1991-12-15 Chiron Corp Hybridpartikel-immunogene.
CA1341482C (en) * 1984-10-31 2005-05-10 Paul A. Luciw Process for preparing fragments of aids-associated retroviruses
NZ215867A (en) * 1985-04-19 1989-10-27 Hoffmann La Roche Aids envelope protein, dna vectors and method of production
FR2581394B1 (fr) * 1985-05-02 1988-08-05 Grp Genie Genetique Particules ayant les proprietes immunogenes de l'antigene hbs et portant un site antigenique etranger aux epitopes portes par l'antigene hbs, vecteurs et cellules animales pour la production de telles particules et compositions contenant de telles particules pour la production de vaccins mixtes
EP0269520A3 (de) * 1986-11-21 1988-08-24 Institut Pasteur Zum Hervorrufen von AIDS geeignetes Retrovirus vom HIV-2-Typ sowie seine Antigen- und Nukleinsäurebestandteile
AU608294B2 (en) * 1987-01-16 1991-03-28 Institut Pasteur Peptides having immunological properties 2-hiv-2
EP0278940A3 (de) * 1987-01-30 1988-12-07 Smithkline Biologicals S.A. Hepatitis-B-Virus-Oberflächenantigene und sie enthaltende hybride Antigene

Also Published As

Publication number Publication date
PT91316A (pt) 1990-02-08
EP0354109A1 (de) 1990-02-07
FR2635532B1 (fr) 1992-05-22
JPH02211881A (ja) 1990-08-23
PT91316B (pt) 1995-08-09
DK373489D0 (da) 1989-07-28
EP0354109B1 (de) 1996-04-17
DK373489A (da) 1990-01-30
FR2635532A1 (fr) 1990-02-23
ATE136933T1 (de) 1996-05-15

Similar Documents

Publication Publication Date Title
LU91388I2 (en) Papillomavirus (humain types 16,18).
ATE295895T1 (de) Genetischer impfstoff gegen den immunschwäche virus
ATE97164T1 (de) Rekombinantes vaccinia-virus mva.
ES8500322A1 (es) Un metodo de modificar un virus para conferirle una nueva funcion biologica.
DE69233607D1 (de) Peptide, die die zytotoxische T-Lymphozyte Antwort gegen Hepatitis-B-Virus induzieren
DE69434954D1 (de) Peptide zum Induzieren einer Antwort der zytotoxischen T-Lymphozyten gerichtet gegen das Hepatitis-B-Virus
DE68926274D1 (de) Rekombinante HBsAg Hybridpartikel, die morphologische Eigenschaften von HBsAg-Antigen haben und eine immunogene Sequenz enthalten, die neutralisierende Antikörper gegen HIV induziert oder die von diesen Antikörpern erkannt ist, Nukleotide Sequenzen, die diese Partikel codieren und sie enthaltende Impfstoffe
ATE118822T1 (de) Rekombinanter, fremde gene enthaltender menschlicher cytomegalovirus und seine verwendung.
ATE134195T1 (de) Peptidfragmente von hiv
DE3585578D1 (de) Hepatitisoberflaechenantigenpartikelvakzin.
EP0236977A3 (de) Impfstoffe gegen Rindervirus-Diarrhoe und Schweine-Cholera
ATE102650T1 (de) Mutanten des infektioesen bovinen rhinotracheitisvirus, vakzine die sie enthalten, verfahren zu ihrer herstellung und ihrer verwendung.
FI885296A (fi) Rekombinant hiv-2 polypeptid.
DE69101646D1 (de) Vakzine gegen Coccidiose.
KR950005326A (ko) 재조합 아데노바이러스 백신
KR960701208A (ko) 바이러스 단백질에 의해 면역 반응을 자극하는 방법(stimulation of immune response by viral protein)
ES2062990T3 (es) Vacunas, que contienen la proteina f del virus del sida.
DK257887A (da) Fremgangsmaade til fremstilling af hbcag i gaer og plasmid til brug ved udoevelse af fremgangsmaaden
EP0496787A4 (en) Novel infectious bursal disease virus
ATE111485T1 (de) Peptidbehandlung von hartnäckigen infektionskrankheiten.
Gerin et al. Recombinant DNA and synthetic peptide approaches to HBV vaccine development: Immunogenicity and protective efficacy in chimpanzees.
Panicali Development of live recombinant vaccines using genetically engineered vaccinia viruses.
Zuckerman Immunization Against Hepatitis B
TH4070EX (th) ลำดับ dna ที่มีรหัสของเซอร์เฟสแอนติเจนโปรตีน p31 ที่ดัดแปลงของไวรัสเฮพพาทิทิส บี

Legal Events

Date Code Title Description
8332 No legal effect for de