MXPA02009895A - Proteinas de fusion de antigeno de nucleo de hepatitis b. - Google Patents
Proteinas de fusion de antigeno de nucleo de hepatitis b.Info
- Publication number
- MXPA02009895A MXPA02009895A MXPA02009895A MXPA02009895A MXPA02009895A MX PA02009895 A MXPA02009895 A MX PA02009895A MX PA02009895 A MXPA02009895 A MX PA02009895A MX PA02009895 A MXPA02009895 A MX PA02009895A MX PA02009895 A MXPA02009895 A MX PA02009895A
- Authority
- MX
- Mexico
- Prior art keywords
- particles
- loop
- hbcag
- sequences
- core
- Prior art date
Links
- 101710132601 Capsid protein Proteins 0.000 title abstract 8
- 102000037865 fusion proteins Human genes 0.000 title 1
- 108020001507 fusion proteins Proteins 0.000 title 1
- 208000006454 hepatitis Diseases 0.000 title 1
- 231100000283 hepatitis Toxicity 0.000 title 1
- 239000002245 particle Substances 0.000 abstract 6
- 239000000539 dimer Substances 0.000 abstract 2
- 230000037431 insertion Effects 0.000 abstract 2
- 238000003780 insertion Methods 0.000 abstract 2
- 241000700721 Hepatitis B virus Species 0.000 abstract 1
- 210000000234 capsid Anatomy 0.000 abstract 1
- 210000000987 immune system Anatomy 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/02—Hepadnaviridae, e.g. hepatitis B virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/735—Fusion polypeptide containing domain for protein-protein interaction containing a domain for self-assembly, e.g. a viral coat protein (includes phage display)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La capsida del virus de hepatitis B (HBV) se elabora de una especie individual de proteina llamada el antigeno de nucleo (HBcAg) que se auto-ensambla en particulas. Las particulas son altamente inmunogenicas y son capaces de presentar epitopes heterologos al sistema inmunitario cuando los epitopes se insertan en una region expuesta en la superficie de las particulas llamada la "asa el". Los bloques de construccion estructural de las particulas son dimeros estrechamente asociados de HBcAg en los cuales las asas el adyacentes estan yuxtapuestas de forma cercana. Se propone que las secuencias insertadas en la asa el, se restrinjan conformacionalmente en las particulas ensambladas cuando se presentan en la proteina de nucleo monomerica. La invencion busca solucionar este problema al enlazar covalentemente proteinas de nucleo como copias en tandem, por ejemplo, como dimeros, de modo que se pueden hacer inserciones independientes en cada copia. Esto es particularmente util para la insercion de grandes secuencias en la asa el, debido a que permite que estas secuencias se inserten en solo una copia de la proteina de nucleo por repeticion en tandem, reduciendo de este modo las potenciales oposiciones conformacionales en el ensamble. De manera alternativa, se puede insertar una secuencia diferente en cada asa el de una repeticion en tandem, incrementando de esta manera la flexibilidad de las particulas de HBcAg como un sistema de distribucion de epitopes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP00107118 | 2000-04-07 | ||
PCT/GB2001/001607 WO2001077158A1 (en) | 2000-04-07 | 2001-04-09 | Hepatitis b core antigen fusion proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
MXPA02009895A true MXPA02009895A (es) | 2004-09-06 |
Family
ID=8168351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MXPA02009895A MXPA02009895A (es) | 2000-04-07 | 2001-04-09 | Proteinas de fusion de antigeno de nucleo de hepatitis b. |
Country Status (18)
Country | Link |
---|---|
US (1) | US7270821B2 (es) |
EP (1) | EP1268530B1 (es) |
JP (1) | JP4713809B2 (es) |
KR (1) | KR100808313B1 (es) |
CN (1) | CN100360556C (es) |
AP (1) | AP1836A (es) |
AT (1) | ATE336502T1 (es) |
AU (1) | AU784345B2 (es) |
BR (1) | BR0109919A (es) |
CA (1) | CA2405438C (es) |
DE (1) | DE60122300T2 (es) |
DK (1) | DK1268530T3 (es) |
EA (1) | EA200201077A1 (es) |
ES (1) | ES2269371T3 (es) |
MX (1) | MXPA02009895A (es) |
PT (1) | PT1268530E (es) |
WO (1) | WO2001077158A1 (es) |
ZA (1) | ZA200208967B (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1218514B1 (en) * | 1999-10-08 | 2006-04-26 | Celltech Pharma Europe Limited | Designing immunogens |
US7094409B2 (en) | 2001-01-19 | 2006-08-22 | Cytos Biotechnology Ag | Antigen arrays for treatment of allergic eosinophilic diseases |
US7128911B2 (en) | 2001-01-19 | 2006-10-31 | Cytos Biotechnology Ag | Antigen arrays for treatment of bone disease |
ATE447967T1 (de) | 2001-09-14 | 2009-11-15 | Cytos Biotechnology Ag | Verpackung von immunstimulierendem cpg in virusähnlichen partikeln: herstellungsverfahren und verwendung |
KR100465643B1 (ko) * | 2001-09-28 | 2005-01-13 | (주) 에이프로젠 | 비형 간염 바이러스 프리에쓰1 항원 유래의 에피토프 태그및 이에 대한 항체를 이용한 폴리펩티드의 검출 및 정제방법 |
US7115266B2 (en) | 2001-10-05 | 2006-10-03 | Cytos Biotechnology Ag | Angiotensin peptide-carrier conjugates and uses thereof |
BR0213117A (pt) | 2001-10-05 | 2004-09-21 | Cytos Biotechnology Ag | Conjugados peptìdeo angiotensina-veìculo e seus usos |
EP1523334A2 (en) | 2002-07-18 | 2005-04-20 | Cytos Biotechnology AG | Hapten-carrier conjugates and uses thereof |
DE60336902D1 (de) | 2002-07-19 | 2011-06-09 | Cytos Biotechnology Ag | Impfstoffzusammensetzungen enthaltende amyloid beta 1-6 antigenarrays |
US7537767B2 (en) | 2003-03-26 | 2009-05-26 | Cytis Biotechnology Ag | Melan-A- carrier conjugates |
WO2004085635A1 (en) | 2003-03-26 | 2004-10-07 | Cytos Biotechnology Ag | Melan-a peptide analogue-virus-like-particle conjugates |
CN100537762C (zh) * | 2004-06-24 | 2009-09-09 | 中国人民解放军军事医学科学院野战输血研究所 | 一种嵌合型病毒样颗粒疫苗载体蛋白及其制备方法与应用 |
KR100687653B1 (ko) * | 2005-05-13 | 2007-02-27 | 유기현 | 스타-델타 결선용 전자개폐기의 제어방법 |
EP2185195A2 (en) | 2007-08-16 | 2010-05-19 | Tripep Ab | Immunogen platform |
WO2009130588A2 (en) * | 2008-04-22 | 2009-10-29 | Tripep Ab | Immunogen platform |
DK2376108T3 (en) | 2008-12-09 | 2017-04-24 | Pfizer Vaccines Llc | IgE CH3 peptide vaccine |
WO2011013034A1 (en) | 2009-07-30 | 2011-02-03 | Pfizer Vaccines Llc | Antigenic tau peptides and uses thereof |
RU2538162C2 (ru) | 2009-09-03 | 2015-01-10 | Пфайзер Вэксинс ЭлЭлСи | Вакцина против pcsk9 |
GB0918679D0 (en) * | 2009-10-23 | 2009-12-09 | Iqur Ltd | Influenza vaccine |
JP6199036B2 (ja) * | 2010-03-16 | 2017-09-20 | バイオエヌテック アーゲーBioNTech AG | 自己タンパク質に対する体液性免疫応答に関わる腫瘍ワクチン接種 |
CA2800774A1 (en) | 2010-06-07 | 2011-12-15 | Pfizer Vaccines Llc | Ige ch3 peptide vaccine |
WO2012131504A1 (en) | 2011-03-02 | 2012-10-04 | Pfizer Inc. | Pcsk9 vaccine |
CN102199217B (zh) * | 2011-04-01 | 2013-03-27 | 中国人民解放军第三军医大学 | 乙型肝炎病毒多表位融合蛋白及其制备方法和应用 |
ES2668672T3 (es) | 2011-04-15 | 2018-05-21 | Osaka University | Vacuna de ADN |
EP2891497B1 (en) * | 2012-08-31 | 2020-07-01 | Osaka University | Dna vaccine containing vegf-specific epitope and/or angiopoietin-2-specific epitope |
EP2931896B1 (en) * | 2012-12-11 | 2019-01-16 | Osivax SAS | Modified coiled coil type proteins having improved properties |
CA2914555A1 (en) * | 2013-06-06 | 2014-12-11 | David J Rowlands | Single domain antibody display |
CN104341506A (zh) * | 2013-07-30 | 2015-02-11 | 复旦大学 | 一种重组融合蛋白及其用途 |
EP3104877B1 (en) | 2014-02-11 | 2020-01-22 | The USA, as represented by The Secretary, Department of Health and Human Services | Pcsk9 vaccine and methods of using the same |
GB201402890D0 (en) * | 2014-02-18 | 2014-04-02 | Iqur Ltd | Vaccines based on hepatitis B Core antigens |
GB201421692D0 (en) * | 2014-12-05 | 2015-01-21 | Iquar Ltd | Vaccines based on hepatitis B core antigens |
GB201505041D0 (en) * | 2015-03-25 | 2015-05-06 | Iqur Ltd | Vaccines based on hepatitis B core antigens |
BR112019009221A2 (pt) | 2016-11-11 | 2019-07-16 | Fraunhofer Usa Inc | proteína de fusão, método para produzir a proteína, composição, partícula semelhante a vírus, método para produzir partículas semelhantes a vírus, e método para induzir uma resposta imunológica em um sujeito |
CN110343707B (zh) * | 2019-05-30 | 2021-06-15 | 中国科学院生物物理研究所 | 基于乙肝核心抗原的hsv分型用蛋白、试剂盒及方法和应用 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2480780B1 (fr) * | 1980-04-22 | 1985-12-06 | Pasteur Institut | Procede de transformation de cellules, notamment eucaryotes, par un adn circulaire tel que celui du virus de l'hepatite b et preparations contenant les produits d'expression desdits adn |
JP2514033B2 (ja) * | 1987-05-20 | 1996-07-10 | 財団法人 癌研究会 | B型肝炎ウィルスの複製を可能とする新規な培養細胞 |
NZ235315A (en) * | 1989-09-19 | 1991-09-25 | Wellcome Found | Chimaeric hepadnavirus core antigen proteins and their construction |
US5723129A (en) * | 1991-10-16 | 1998-03-03 | University Of Saskatchewan | GnRH-leukotoxin chimeras |
JPH06279500A (ja) * | 1992-09-30 | 1994-10-04 | Imuno Japan:Kk | HBc融合蛋白粒子およびその製造方法 |
AU2540897A (en) | 1996-03-21 | 1997-10-10 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Methods and compositions of chimeric polypeptides for tumor antigen vaccines |
US20030021804A1 (en) * | 1997-01-21 | 2003-01-30 | Philip Needleman | Immunological process for increasing the hdl cholestrol concentration |
US6172216B1 (en) * | 1998-10-07 | 2001-01-09 | Isis Pharmaceuticals Inc. | Antisense modulation of BCL-X expression |
US6180343B1 (en) * | 1998-10-08 | 2001-01-30 | Rigel Pharmaceuticals, Inc. | Green fluorescent protein fusions with random peptides |
EP1218514B1 (en) * | 1999-10-08 | 2006-04-26 | Celltech Pharma Europe Limited | Designing immunogens |
US20040054139A1 (en) * | 2000-06-22 | 2004-03-18 | Mark Page | Modification of hepatitis b core antigen |
US7351413B2 (en) * | 2002-02-21 | 2008-04-01 | Lorantis, Limited | Stabilized HBc chimer particles as immunogens for chronic hepatitis |
-
2001
- 2001-04-09 US US10/240,917 patent/US7270821B2/en not_active Expired - Fee Related
- 2001-04-09 BR BR0109919-1A patent/BR0109919A/pt not_active IP Right Cessation
- 2001-04-09 MX MXPA02009895A patent/MXPA02009895A/es active IP Right Grant
- 2001-04-09 KR KR1020027013451A patent/KR100808313B1/ko not_active IP Right Cessation
- 2001-04-09 EP EP01919645A patent/EP1268530B1/en not_active Expired - Lifetime
- 2001-04-09 AT AT01919645T patent/ATE336502T1/de active
- 2001-04-09 EA EA200201077A patent/EA200201077A1/ru unknown
- 2001-04-09 DE DE60122300T patent/DE60122300T2/de not_active Expired - Lifetime
- 2001-04-09 WO PCT/GB2001/001607 patent/WO2001077158A1/en active IP Right Grant
- 2001-04-09 CA CA2405438A patent/CA2405438C/en not_active Expired - Fee Related
- 2001-04-09 CN CNB018106889A patent/CN100360556C/zh not_active Expired - Fee Related
- 2001-04-09 PT PT01919645T patent/PT1268530E/pt unknown
- 2001-04-09 JP JP2001575628A patent/JP4713809B2/ja not_active Expired - Fee Related
- 2001-04-09 ES ES01919645T patent/ES2269371T3/es not_active Expired - Lifetime
- 2001-04-09 AP APAP/P/2002/002658A patent/AP1836A/en active
- 2001-04-09 DK DK01919645T patent/DK1268530T3/da active
- 2001-04-09 AU AU46706/01A patent/AU784345B2/en not_active Ceased
-
2002
- 2002-11-05 ZA ZA200208967A patent/ZA200208967B/en unknown
Also Published As
Publication number | Publication date |
---|---|
ES2269371T3 (es) | 2007-04-01 |
AP2002002658A0 (en) | 2002-12-31 |
AU4670601A (en) | 2001-10-23 |
EP1268530A1 (en) | 2003-01-02 |
US20040223965A1 (en) | 2004-11-11 |
US7270821B2 (en) | 2007-09-18 |
DE60122300D1 (de) | 2006-09-28 |
CA2405438C (en) | 2011-07-12 |
EP1268530B1 (en) | 2006-08-16 |
KR20030009429A (ko) | 2003-01-29 |
CA2405438A1 (en) | 2001-10-18 |
JP2003530123A (ja) | 2003-10-14 |
AU784345B2 (en) | 2006-03-16 |
CN100360556C (zh) | 2008-01-09 |
ZA200208967B (en) | 2003-10-08 |
KR100808313B1 (ko) | 2008-02-27 |
BR0109919A (pt) | 2003-03-11 |
WO2001077158A1 (en) | 2001-10-18 |
EA200201077A1 (ru) | 2003-04-24 |
JP4713809B2 (ja) | 2011-06-29 |
AP1836A (en) | 2008-03-14 |
DE60122300T2 (de) | 2007-08-30 |
DK1268530T3 (da) | 2006-11-13 |
PT1268530E (pt) | 2006-12-29 |
ATE336502T1 (de) | 2006-09-15 |
CN1441807A (zh) | 2003-09-10 |
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