BR0013179A - Compostos de oxoazaeterociclila substituìda - Google Patents
Compostos de oxoazaeterociclila substituìdaInfo
- Publication number
- BR0013179A BR0013179A BR0013179-2A BR0013179A BR0013179A BR 0013179 A BR0013179 A BR 0013179A BR 0013179 A BR0013179 A BR 0013179A BR 0013179 A BR0013179 A BR 0013179A
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- oxoazaeterocyclyl
- factor
- substituted
- inhibiting
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 108010074860 Factor Xa Proteins 0.000 abstract 4
- 230000002401 inhibitory effect Effects 0.000 abstract 3
- 108010029144 Factor IIa Proteins 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
Abstract
Patente de Invenção: "COMPOSTOS DE OXOAZAETEROCICLILA SUBSTITUìDA". Esta invenção é direcionada aos compostos de oxoazaeterociclila que inibem o Fator Xa, aos compostos de oxoazaeterociclila que inibem tanto o Fator Xa como o Fator IIa, às composições farmacêuticas que compreendem estes compostos, aos intermediários úteis para preparar estes compostos, a um método de diretamente inibir o Fator Xa e a um método de diretamente inibir de forma simultânea o Fator Xa e o Fator IIa.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US36319699A | 1999-07-28 | 1999-07-28 | |
PCT/IB2000/001156 WO2001007436A2 (en) | 1999-07-28 | 2000-07-26 | Substituted oxoazaheterocyclyl compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0013179A true BR0013179A (pt) | 2002-04-02 |
Family
ID=23429232
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0013179-2A BR0013179A (pt) | 1999-07-28 | 2000-07-26 | Compostos de oxoazaeterociclila substituìda |
Country Status (25)
Country | Link |
---|---|
EP (1) | EP1208097B1 (pt) |
JP (1) | JP4829449B2 (pt) |
KR (1) | KR20020087041A (pt) |
CN (1) | CN1420882A (pt) |
AT (1) | ATE423113T1 (pt) |
AU (1) | AU773227B2 (pt) |
BG (1) | BG106340A (pt) |
BR (1) | BR0013179A (pt) |
CA (1) | CA2382755A1 (pt) |
CR (1) | CR6563A (pt) |
CZ (1) | CZ2002323A3 (pt) |
DE (1) | DE60041584D1 (pt) |
EE (1) | EE200200045A (pt) |
HK (1) | HK1054227A1 (pt) |
HR (1) | HRP20020076A2 (pt) |
HU (1) | HUP0203375A3 (pt) |
IL (2) | IL147495A0 (pt) |
MX (1) | MXPA02000888A (pt) |
NO (1) | NO20020214L (pt) |
PL (1) | PL354998A1 (pt) |
RU (1) | RU2002105011A (pt) |
SK (1) | SK1182002A3 (pt) |
TR (1) | TR200200225T2 (pt) |
WO (1) | WO2001007436A2 (pt) |
ZA (1) | ZA200200543B (pt) |
Families Citing this family (95)
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EA005893B1 (ru) | 2000-03-21 | 2005-06-30 | Смитклайн Бичам Корпорейшн | Ингибиторы протеаз |
AU2002211280A1 (en) * | 2000-09-29 | 2002-04-08 | Cor Therapeutics, Inc. | Piperazin-2-one amides as inhibitors of factor Xa |
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GB0112836D0 (en) | 2001-05-25 | 2001-07-18 | Smithkline Beecham Plc | Medicaments |
GB0114005D0 (en) | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
GB0114004D0 (en) | 2001-06-08 | 2001-08-01 | Glaxo Group Ltd | Chemical compounds |
HUP0401886A2 (hu) | 2001-07-02 | 2004-12-28 | Astrazeneca Ab, | Kemokin receptor aktivitás modulátorokként alkalmazható piperidinszármazékok, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
GB0120461D0 (en) | 2001-08-22 | 2001-10-17 | Astrazeneca Ab | Novel compounds |
AU2007229363B2 (en) * | 2001-08-24 | 2009-06-04 | University Of South Florida | Piperazinone Compounds as Anti-Tumor and Anti-Cancer Agents and the Methods of Treatment |
DE60234354D1 (de) * | 2001-08-24 | 2009-12-24 | Univ Yale | Piperazinon-verbindungen als antitumorale und krebsbekämpfende mittel |
GB0122503D0 (en) | 2001-09-18 | 2001-11-07 | Astrazeneca Ab | Chemical compounds |
EP1314733A1 (en) | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indole-2-carboxamides as factor Xa inhibitors |
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SE0200844D0 (sv) | 2002-03-19 | 2002-03-19 | Astrazeneca Ab | Chemical compounds |
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AU2003231359B2 (en) | 2002-04-16 | 2009-04-30 | Teijin Limited | Piperidine derivatives having CCR3 antagonism |
CA2483504A1 (en) | 2002-04-25 | 2003-11-06 | Teijin Limited | 4,4-(disubstituted)piperidine derivatives with ccr3 antagonism |
TW200409637A (en) | 2002-06-26 | 2004-06-16 | Glaxo Group Ltd | Compounds |
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US7358268B2 (en) | 2002-12-04 | 2008-04-15 | Sanofi-Aventis Deutschland Gmbh | Imidazole derivatives as factor Xa inhibitors |
ATE443699T1 (de) * | 2002-12-06 | 2009-10-15 | Purdue Research Foundation | Pyridine zur behandlung von verletztemsäugetiernervengewebe |
US8729107B2 (en) | 2002-12-06 | 2014-05-20 | Purdue Research Foundation | Pyridines for treating injured mammalian nerve tissue |
US7429581B2 (en) | 2002-12-23 | 2008-09-30 | Sanofi-Aventis Deutschland Gmbh | Pyrazole-derivatives as factor Xa inhibitors |
US8044206B2 (en) | 2003-03-07 | 2011-10-25 | Astellas Pharma Inc. | Nitrogen—containing heterocyclic derivatives having 2,6-disubstituted styryl |
SE0300957D0 (sv) | 2003-04-01 | 2003-04-01 | Astrazeneca Ab | Chemical compounds |
US7741341B2 (en) | 2003-05-19 | 2010-06-22 | Sanofi-Aventis Deutschland Gmbh | Benzimidazole-derivatives as factor Xa inhibitors |
US7317027B2 (en) | 2003-05-19 | 2008-01-08 | Sanofi-Aventis Deutschland Gmbh | Azaindole-derivatives as factor Xa inhibitors |
US7223780B2 (en) | 2003-05-19 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Triazole-derivatives as blood clotting enzyme factor Xa inhibitors |
EP1479675A1 (en) | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Indazole-derivatives as factor Xa inhibitors |
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CN104610257B (zh) * | 2015-02-14 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | 一类含酰胺结构的FXa抑制剂、制备方法及其用途 |
CN104610258B (zh) * | 2015-02-14 | 2016-03-30 | 佛山市赛维斯医药科技有限公司 | 一类含酰胺和甲氧苯结构的FXa抑制剂、制备方法及其用途 |
CN104557928B (zh) * | 2015-02-14 | 2016-08-24 | 佛山市赛维斯医药科技有限公司 | 一种含二环酰胺结构凝血因子Xa抑制剂、其制备方法及其用途 |
CN104672235B (zh) * | 2015-02-14 | 2016-02-17 | 佛山市赛维斯医药科技有限公司 | 一类含双酰胺基和烷氧苯基结构的FXa抑制剂及其用途 |
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CN104650082B (zh) * | 2015-02-14 | 2016-06-01 | 佛山市赛维斯医药科技有限公司 | 一类凝血因子Xa抑制剂、制备方法及其用途 |
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EA201890152A1 (ru) | 2015-06-26 | 2018-08-31 | Такеда Фармасьютикал Компани Лимитед | Производные 2,3-дигидро-4h-1,3-бензоксазин-4-онов в качестве модуляторов холинергического мускаринового m1 рецептора |
BR112018000728A2 (pt) | 2015-07-15 | 2018-09-04 | Axovant Sciences Gmbh | resumo método para a profilaxia e/ou tratamento de alucinações visuais em um sujeito com necessidade do mesmo |
EP3366679B1 (en) * | 2015-10-20 | 2021-03-24 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
WO2018082964A1 (en) | 2016-11-04 | 2018-05-11 | Basf Se | Process for the production of pyridazinyl-amides in a one-pot synthesis |
US11560372B2 (en) | 2017-04-18 | 2023-01-24 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds useful as modulators of acetylcholine receptors |
EP3618847B1 (en) | 2017-05-05 | 2021-04-07 | Zealand Pharma A/S | Gap junction intercellular communication modulators and their use for the treatment of diabetic eye disease |
CN110054619A (zh) * | 2018-01-18 | 2019-07-26 | 西北农林科技大学 | 新型二酮哌嗪类组蛋白去乙酰化酶抑制剂 |
BR112020020663A2 (pt) | 2018-04-10 | 2021-01-12 | Bayer Aktiengesellschaft | Derivados de oxadiazolina |
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SK102495A3 (en) * | 1993-02-22 | 1997-01-08 | Merck & Co Inc | Fibrinogen receptor antagonists and pharmaceutical agents containing them |
US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
US5612353A (en) * | 1995-06-07 | 1997-03-18 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Substituted (sulfinic acid, sulfonic acid, sulfonylamino or sulfinylamino) N-[(aminoiminomethyl)phenylalkyl]-azaheterocyclylamide compounds |
UA56197C2 (uk) * | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
NZ500354A (en) * | 1997-04-14 | 2001-11-30 | Cor Therapeutics Inc | Cyclic diaza compounds as selective factor Xa inhibitors for treating thrombotic related disorders |
CA2318351A1 (en) * | 1997-12-26 | 1999-07-08 | Hidemitsu Nishida | Aromatic compounds having cyclic amino or salts thereof |
EA200000768A1 (ru) * | 1998-01-27 | 2001-06-25 | Эвентис Фармасьютикалз Продактс Инк. | ЗАМЕЩЕННЫЕ ОКСОАЗАГЕТЕРОЦИКЛИЧЕСКИЕ ИНГИБИТОРЫ ФАКТОРА Ха |
WO1999040075A1 (fr) * | 1998-02-05 | 1999-08-12 | Takeda Chemical Industries, Ltd. | Derives de sulfamide, leur procede de production et leur utilisation |
JP2000204081A (ja) * | 1998-02-05 | 2000-07-25 | Takeda Chem Ind Ltd | スルホンアミド誘導体、その製造法及び用途 |
JP2003529531A (ja) * | 1998-11-25 | 2003-10-07 | アヴェンティス ファーマシューティカルズ インコーポレイテッド | 置換オキソアザへテロシクリルXa因子阻害剤 |
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- 2000-07-26 TR TR2002/00225T patent/TR200200225T2/xx unknown
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- 2000-07-26 CN CN00810877A patent/CN1420882A/zh active Pending
- 2000-07-26 SK SK118-2002A patent/SK1182002A3/sk unknown
- 2000-07-26 WO PCT/IB2000/001156 patent/WO2001007436A2/en active Search and Examination
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NO20020214L (no) | 2002-04-02 |
EE200200045A (et) | 2003-06-16 |
EP1208097A2 (en) | 2002-05-29 |
CA2382755A1 (en) | 2001-02-01 |
BG106340A (en) | 2002-10-31 |
CZ2002323A3 (cs) | 2002-05-15 |
DE60041584D1 (de) | 2009-04-02 |
WO2001007436A2 (en) | 2001-02-01 |
CR6563A (es) | 2008-11-25 |
HRP20020076A2 (en) | 2003-12-31 |
JP2003508353A (ja) | 2003-03-04 |
EP1208097B1 (en) | 2009-02-18 |
ZA200200543B (en) | 2003-08-27 |
ATE423113T1 (de) | 2009-03-15 |
AU773227B2 (en) | 2004-05-20 |
TR200200225T2 (tr) | 2002-06-21 |
NO20020214D0 (no) | 2002-01-15 |
IL147495A (en) | 2007-07-24 |
AU6462800A (en) | 2001-02-13 |
RU2002105011A (ru) | 2004-01-20 |
IL147495A0 (en) | 2002-08-14 |
HUP0203375A3 (en) | 2005-03-29 |
HK1054227A1 (zh) | 2003-11-21 |
JP4829449B2 (ja) | 2011-12-07 |
SK1182002A3 (en) | 2002-11-06 |
WO2001007436A3 (en) | 2001-08-23 |
CN1420882A (zh) | 2003-05-28 |
PL354998A1 (en) | 2004-03-22 |
MXPA02000888A (es) | 2002-07-30 |
HUP0203375A2 (hu) | 2002-12-28 |
KR20020087041A (ko) | 2002-11-21 |
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