CN104650081B - 凝血因子Xa抑制剂、制备方法及其用途 - Google Patents
凝血因子Xa抑制剂、制备方法及其用途 Download PDFInfo
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- CN104650081B CN104650081B CN201510082596.9A CN201510082596A CN104650081B CN 104650081 B CN104650081 B CN 104650081B CN 201510082596 A CN201510082596 A CN 201510082596A CN 104650081 B CN104650081 B CN 104650081B
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- QKMIGHKYVLIYNV-BVSLBCMMSA-N CCCCCN([C@@H](CC)CCNC([C@H]1CC[C@H](C)CC1)=O)C(c1ccc(C2CC2)[s]1)=O Chemical compound CCCCCN([C@@H](CC)CCNC([C@H]1CC[C@H](C)CC1)=O)C(c1ccc(C2CC2)[s]1)=O QKMIGHKYVLIYNV-BVSLBCMMSA-N 0.000 description 1
- FBPPAKZMNZNGFA-MISYRCLQSA-N CCN(C[C@H](CCC1)CCN1C(c1ccc(C)[s]1)=O)C([C@H]1CC[C@H](C)CC1)=O Chemical compound CCN(C[C@H](CCC1)CCN1C(c1ccc(C)[s]1)=O)C([C@H]1CC[C@H](C)CC1)=O FBPPAKZMNZNGFA-MISYRCLQSA-N 0.000 description 1
- SEBFUPSMJCZZJX-NMIHRBCNSA-N C[C@H](CC1)CC[C@@H]1C(N(C[C@H]1CCC2)C[C@@H]1N2C(c1ccc(C2CCCCC2)[s]1)=O)=O Chemical compound C[C@H](CC1)CC[C@@H]1C(N(C[C@H]1CCC2)C[C@@H]1N2C(c1ccc(C2CCCCC2)[s]1)=O)=O SEBFUPSMJCZZJX-NMIHRBCNSA-N 0.000 description 1
- AITYAJUOLMKZKD-VQHPVUNQSA-N C[C@H](CC1)CC[C@@H]1C(N(C[C@H]1CCC2)C[C@@H]1N2C(c1ccc[s]1)=O)=O Chemical compound C[C@H](CC1)CC[C@@H]1C(N(C[C@H]1CCC2)C[C@@H]1N2C(c1ccc[s]1)=O)=O AITYAJUOLMKZKD-VQHPVUNQSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
化合物 | IC50(nM) |
Edoxaban | 3.9 |
实施例1化合物 | 1.8 |
实施例2化合物 | 6.5 |
实施例3化合物 | 3.0 |
实施例4化合物 | 4.2 |
实施例5化合物 | 4.7 |
Claims (3)
Priority Applications (1)
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CN201510082596.9A CN104650081B (zh) | 2015-02-14 | 2015-02-14 | 凝血因子Xa抑制剂、制备方法及其用途 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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CN201510082596.9A CN104650081B (zh) | 2015-02-14 | 2015-02-14 | 凝血因子Xa抑制剂、制备方法及其用途 |
Publications (2)
Publication Number | Publication Date |
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CN104650081A CN104650081A (zh) | 2015-05-27 |
CN104650081B true CN104650081B (zh) | 2016-06-01 |
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CN201510082596.9A Active CN104650081B (zh) | 2015-02-14 | 2015-02-14 | 凝血因子Xa抑制剂、制备方法及其用途 |
Country Status (1)
Country | Link |
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CN (1) | CN104650081B (zh) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1420882A (zh) * | 1999-07-28 | 2003-05-28 | 阿温蒂斯药物公司 | 取代的氧代氮杂杂环基化合物 |
CN101163700A (zh) * | 2005-03-31 | 2008-04-16 | 第一三共株式会社 | 三胺衍生物 |
CN101223167A (zh) * | 2005-07-15 | 2008-07-16 | 弗·哈夫曼-拉罗切有限公司 | 新的杂芳基稠合的环状胺 |
-
2015
- 2015-02-14 CN CN201510082596.9A patent/CN104650081B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1420882A (zh) * | 1999-07-28 | 2003-05-28 | 阿温蒂斯药物公司 | 取代的氧代氮杂杂环基化合物 |
CN101163700A (zh) * | 2005-03-31 | 2008-04-16 | 第一三共株式会社 | 三胺衍生物 |
CN101223167A (zh) * | 2005-07-15 | 2008-07-16 | 弗·哈夫曼-拉罗切有限公司 | 新的杂芳基稠合的环状胺 |
Also Published As
Publication number | Publication date |
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CN104650081A (zh) | 2015-05-27 |
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PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Blood clotting factor Xa inhibitor, as well as preparation method and application thereof Effective date of registration: 20170816 Granted publication date: 20160601 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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Date of cancellation: 20190604 Granted publication date: 20160601 Pledgee: Guangdong Nanhai Rural Commercial Bank branch branch of Limited by Share Ltd Pledgor: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. Registration number: 2017990000756 |
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Effective date of registration: 20191014 Address after: No.118, block B, high tech entrepreneurship service center, Tongling Economic Development Zone, Anhui Province Patentee after: Tongwei Technology Co., Ltd. Tongling City Address before: Chancheng district has 528000 Taiwan public in Guangdong province Foshan City No. 32 first floor 1636, shop No. 1637 Patentee before: FOSHAN SAIWEISI PHARMACEUTICAL TECHNOLOGY CO., LTD. |