BR0009690A - Derivados de dibenzoazuleno para o tratamento de trombose, osteoporose e arteriosclerose - Google Patents
Derivados de dibenzoazuleno para o tratamento de trombose, osteoporose e arterioscleroseInfo
- Publication number
- BR0009690A BR0009690A BR0009690-3A BR0009690A BR0009690A BR 0009690 A BR0009690 A BR 0009690A BR 0009690 A BR0009690 A BR 0009690A BR 0009690 A BR0009690 A BR 0009690A
- Authority
- BR
- Brazil
- Prior art keywords
- arteriosclerosis
- thrombosis
- osteoporosis
- treatment
- derivatives
- Prior art date
Links
- 206010003210 Arteriosclerosis Diseases 0.000 title abstract 3
- 208000001132 Osteoporosis Diseases 0.000 title abstract 3
- 208000007536 Thrombosis Diseases 0.000 title abstract 3
- 208000011775 arteriosclerosis disease Diseases 0.000 title abstract 3
- 238000011282 treatment Methods 0.000 title abstract 3
- 239000000126 substance Substances 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000033115 angiogenesis Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 102000006495 integrins Human genes 0.000 abstract 1
- 108010044426 integrins Proteins 0.000 abstract 1
- 208000010125 myocardial infarction Diseases 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 230000000644 propagated effect Effects 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyridine Compounds (AREA)
Abstract
Patente de Invenção: "DERIVADOS DE DIBENZOAZULENO PARA O TRATAMENTO DE TROMBOSE, OSTEOPOROSE E ARTERIOSCLEROSE". A presente invenção refere-se a compostos de fórmula (I) em que R^ 1^, R^ 2^ e R^ 3^ m e n são definidos conforme a reivindicação 1 e a seus sais e solvatos fisiologicamente aceitáveis. As substâncias inventivas são usadas como substâncias inibidoras de integrina, especialmente na profilaxia e tratamento de distúrbios cardiovasculares, tromboses, enfarto cardíaco, distúrbios coronários, arteriosclerose, osteoporose, em condições patológicas que são provocadas ou propagadas pela angiogênese e na terapia do tumor.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19916837A DE19916837A1 (de) | 1999-04-14 | 1999-04-14 | Dibenzoazulenderivate |
PCT/EP2000/002925 WO2000063178A1 (de) | 1999-04-14 | 2000-04-01 | Dibenzoazulenderivate zur behandlung von thrombose, osteoporose, arteriosklerose |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0009690A true BR0009690A (pt) | 2002-01-08 |
Family
ID=7904536
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0009690-3A BR0009690A (pt) | 1999-04-14 | 2000-04-01 | Derivados de dibenzoazuleno para o tratamento de trombose, osteoporose e arteriosclerose |
Country Status (19)
Country | Link |
---|---|
US (1) | US6521646B1 (pt) |
EP (1) | EP1169306A1 (pt) |
JP (1) | JP2002542231A (pt) |
KR (1) | KR20010102570A (pt) |
CN (1) | CN1345312A (pt) |
AR (1) | AR023496A1 (pt) |
AU (1) | AU3817400A (pt) |
BR (1) | BR0009690A (pt) |
CA (1) | CA2367359A1 (pt) |
CZ (1) | CZ20013704A3 (pt) |
DE (1) | DE19916837A1 (pt) |
HU (1) | HUP0200643A3 (pt) |
MX (1) | MXPA01010294A (pt) |
NO (1) | NO20014976L (pt) |
PL (1) | PL350354A1 (pt) |
RU (1) | RU2001129708A (pt) |
SK (1) | SK14342001A3 (pt) |
WO (1) | WO2000063178A1 (pt) |
ZA (1) | ZA200109343B (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2806082B1 (fr) * | 2000-03-07 | 2002-05-17 | Adir | Nouveaux composes bicycliques antagonistes des recepteurs de la vitronectine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2002002577A1 (en) * | 2000-06-30 | 2002-01-10 | Dow Global Technology Inc. | Polycyclic, fused ring compounds, metal complexes and polymerization process |
US20050107350A1 (en) * | 2003-08-22 | 2005-05-19 | Pharmacia Corporation | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith |
AU2005249586B2 (en) | 2004-06-04 | 2010-12-23 | The Scripps Research Institute | Compositions and methods for treatment of neovascular diseases |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3795709A (en) * | 1968-02-07 | 1974-03-05 | Sandoz Ag | Benzobenzazulenes |
ATE193878T1 (de) * | 1995-03-09 | 2000-06-15 | Ortho Pharma Corp | Substituierte dibenz(a,f)azulene und verfahren zu ihrer herstellung |
DK0910563T3 (da) * | 1995-06-29 | 2003-09-01 | Smithkline Beecham Corp | Integrinreceptorantagonister |
GEP20012516B (en) * | 1996-03-20 | 2001-08-27 | Genentech Inc | Tricyclic Compounds Having Activity Specific for Integring, Particularly , avB3 Integrins, Method for Preparation the Same as Drugs and Pharmaceutical Composition Containing Same |
CO4920232A1 (es) * | 1997-01-08 | 2000-05-29 | Smithkline Beecham Corp | Acidos aceticos dibenzo [a,d] cicloheptano con actividad antagonista del receptor de vitronectin |
-
1999
- 1999-04-14 DE DE19916837A patent/DE19916837A1/de not_active Withdrawn
-
2000
- 2000-04-01 MX MXPA01010294A patent/MXPA01010294A/es unknown
- 2000-04-01 SK SK1434-2001A patent/SK14342001A3/sk unknown
- 2000-04-01 CZ CZ20013704A patent/CZ20013704A3/cs unknown
- 2000-04-01 RU RU2001129708/04A patent/RU2001129708A/ru unknown
- 2000-04-01 JP JP2000612271A patent/JP2002542231A/ja active Pending
- 2000-04-01 BR BR0009690-3A patent/BR0009690A/pt not_active Application Discontinuation
- 2000-04-01 HU HU0200643A patent/HUP0200643A3/hu unknown
- 2000-04-01 AU AU38174/00A patent/AU3817400A/en not_active Abandoned
- 2000-04-01 WO PCT/EP2000/002925 patent/WO2000063178A1/de not_active Application Discontinuation
- 2000-04-01 CA CA002367359A patent/CA2367359A1/en not_active Abandoned
- 2000-04-01 KR KR1020017011575A patent/KR20010102570A/ko not_active Application Discontinuation
- 2000-04-01 US US09/958,812 patent/US6521646B1/en not_active Expired - Fee Related
- 2000-04-01 EP EP00917037A patent/EP1169306A1/de not_active Withdrawn
- 2000-04-01 CN CN00805748A patent/CN1345312A/zh active Pending
- 2000-04-01 PL PL00350354A patent/PL350354A1/xx unknown
- 2000-04-14 AR ARP000101738A patent/AR023496A1/es unknown
-
2001
- 2001-10-12 NO NO20014976A patent/NO20014976L/no not_active Application Discontinuation
- 2001-11-13 ZA ZA200109343A patent/ZA200109343B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
JP2002542231A (ja) | 2002-12-10 |
KR20010102570A (ko) | 2001-11-15 |
WO2000063178A1 (de) | 2000-10-26 |
MXPA01010294A (es) | 2002-05-06 |
RU2001129708A (ru) | 2004-02-27 |
HUP0200643A2 (hu) | 2002-07-29 |
NO20014976D0 (no) | 2001-10-12 |
SK14342001A3 (sk) | 2002-04-04 |
EP1169306A1 (de) | 2002-01-09 |
PL350354A1 (en) | 2002-12-02 |
AR023496A1 (es) | 2002-09-04 |
AU3817400A (en) | 2000-11-02 |
DE19916837A1 (de) | 2000-10-19 |
CA2367359A1 (en) | 2000-10-26 |
CN1345312A (zh) | 2002-04-17 |
HUP0200643A3 (en) | 2003-10-28 |
NO20014976L (no) | 2001-10-12 |
US6521646B1 (en) | 2003-02-18 |
ZA200109343B (en) | 2003-04-30 |
CZ20013704A3 (cs) | 2002-02-13 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |