BR9914893A - Cromenona e derivados de cromanona como inibidores de integrina - Google Patents

Cromenona e derivados de cromanona como inibidores de integrina

Info

Publication number
BR9914893A
BR9914893A BR9914893-5A BR9914893A BR9914893A BR 9914893 A BR9914893 A BR 9914893A BR 9914893 A BR9914893 A BR 9914893A BR 9914893 A BR9914893 A BR 9914893A
Authority
BR
Brazil
Prior art keywords
integrin inhibitors
chromenone
chromanone derivatives
chromanone
derivatives
Prior art date
Application number
BR9914893-5A
Other languages
English (en)
Inventor
Claus Fittschen
Simon Goodman
Joachim Maerz
Peter Raddatz
Matthias Wiesner
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR9914893A publication Critical patent/BR9914893A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

Patente de Invenção: <B>"CROMENONA E DERIVADOS DE CROMANONA COMO INIBIDORES DE INTEGRINA"<D>. A invenção refere-se a compostos tendo a fórmula (I) em que R¹, R², R³, R^ 4^, R^ 5^, R^ 6^, R^ 8^, R^ 11^, Z, m e n possuem o significado citado na reivindicação 1 e seus sais e solvatos fisiologicamente aceitáveis, os quais podem ser usados como inibidores da integrina, especialmente na profilaxia e tratamento de doenças circulatórias, no caso de trombose, enfarte do miocárdio, doenças cardíacas coronarianas, arteriosclerose, osteoporose, processos patológicos causados ou propagados por angiogênese e na terapia de tumores.
BR9914893-5A 1998-10-30 1999-10-14 Cromenona e derivados de cromanona como inibidores de integrina BR9914893A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19850131A DE19850131A1 (de) 1998-10-30 1998-10-30 Chromenon- und Chromanonderivate
PCT/EP1999/007725 WO2000026212A1 (de) 1998-10-30 1999-10-14 Chromenon- und chromanonderivate als integrinhemmer

Publications (1)

Publication Number Publication Date
BR9914893A true BR9914893A (pt) 2001-07-17

Family

ID=7886203

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9914893-5A BR9914893A (pt) 1998-10-30 1999-10-14 Cromenona e derivados de cromanona como inibidores de integrina

Country Status (21)

Country Link
US (1) US6849646B1 (pt)
EP (1) EP1124824B1 (pt)
JP (1) JP4511734B2 (pt)
KR (1) KR20010080896A (pt)
CN (1) CN1150189C (pt)
AR (1) AR021029A1 (pt)
AT (1) ATE370944T1 (pt)
AU (1) AU754280B2 (pt)
BR (1) BR9914893A (pt)
CA (1) CA2348391C (pt)
CZ (1) CZ20011515A3 (pt)
DE (2) DE19850131A1 (pt)
ES (1) ES2292252T3 (pt)
HU (1) HUP0104800A3 (pt)
ID (1) ID28482A (pt)
NO (1) NO20012108D0 (pt)
PL (1) PL347246A1 (pt)
RU (1) RU2234505C2 (pt)
SK (1) SK5532001A3 (pt)
WO (1) WO2000026212A1 (pt)
ZA (1) ZA200104411B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19842415A1 (de) 1998-09-16 2000-03-23 Merck Patent Gmbh Pharmazeutische Zubereitung
US6972296B2 (en) 1999-05-07 2005-12-06 Encysive Pharmaceuticals Inc. Carboxylic acid derivatives that inhibit the binding of integrins to their receptors
BR0115077A (pt) * 2000-11-01 2003-12-23 Merck Patent Ges Mit Beschroen Métodos e composições para o tratamento de doenças dos olhos
CA2449054C (en) 2001-05-30 2011-01-04 The Scripps Research Institute Integrin targeting liposome for nucleic acid delivery
BR0211604A (pt) * 2001-08-01 2004-08-24 Merck Patent Gmbh Inibidores de integrina para o tratamento de doenças do olho
KR20040091002A (ko) * 2002-02-14 2004-10-27 메르크 파텐트 게엠베하 안질환을 치료하기 위한 방법 및 조성물
JP4664597B2 (ja) 2002-04-17 2011-04-06 サイトキネティクス・インコーポレーテッド 化合物、組成物および方法
US20060122387A1 (en) * 2002-06-13 2006-06-08 Cti Europe S.R.L. Derivatives of chromen-2-one as inhibitors of vegf production in mammalian cells
FR2841243B1 (fr) * 2002-06-19 2004-08-20 Servier Lab Nouveaux derives de 3-(4-oxo-4h-chromen-2yl)-(1h)-quinolein- 4-ones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AU2003252025A1 (en) 2002-07-17 2004-02-02 Cytokinetics, Inc. Compounds, compositions, and methods
DE10337863A1 (de) 2003-08-18 2005-03-17 Merck Patent Gmbh Verwendung von Chromen-4-on-Derivaten
DK2307397T3 (da) * 2008-06-25 2014-11-03 Array Biopharma Inc 6-substituerede phenoxychroman-carboxylsyrederivater
WO2011156889A1 (en) * 2010-06-14 2011-12-22 Trt Pharma Inc. Novel modulators of nrf2 and uses thereof
RU2612875C1 (ru) * 2015-12-14 2017-03-13 Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) Средство для ингибирования фермента тирозил-днк-фосфодиэстеразы 1 человека
CN112110902B (zh) * 2020-09-17 2021-12-07 江苏科技大学 1-脱氧野尻霉素-山奈酚化合物、中间体，制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL89840A (en) * 1988-04-06 1996-10-31 Lipha Substituted flavonoid compounds and salts thereof their preparation and pharmaceutical composition containing them
EP0459983A1 (en) * 1988-12-21 1991-12-11 PHARMACIA &amp; UPJOHN COMPANY Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
US5703075A (en) 1988-12-21 1997-12-30 Pharmacia & Upjohn Company Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
WO1991019707A2 (en) * 1990-06-20 1991-12-26 The Upjohn Company Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
FR2693196B1 (fr) * 1992-07-03 1994-12-23 Lipha Dérivés de benzopyranone ou de benzothiopyranone, procédé de préparation et composition pharmaceutique les contenant.
US5731324A (en) * 1993-07-22 1998-03-24 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
FR2717479B1 (fr) * 1994-03-18 1996-06-07 Pf Medicament Nouvelles 3-(omega-benzoylpipéridino) alcoyl)-4H-Benzopyran-4-ones, leur préparation et leur application en thérapeutique.

Also Published As

Publication number Publication date
RU2234505C2 (ru) 2004-08-20
EP1124824B1 (de) 2007-08-22
DE19850131A1 (de) 2000-05-04
DE59914471D1 (de) 2007-10-04
NO20012108L (no) 2001-04-27
HUP0104800A2 (hu) 2002-07-29
HUP0104800A3 (en) 2003-12-29
NO20012108D0 (no) 2001-04-27
CA2348391C (en) 2009-09-29
CZ20011515A3 (cs) 2001-08-15
AR021029A1 (es) 2002-06-12
ATE370944T1 (de) 2007-09-15
EP1124824A1 (de) 2001-08-22
JP4511734B2 (ja) 2010-07-28
PL347246A1 (en) 2002-03-25
AU6471699A (en) 2000-05-22
SK5532001A3 (en) 2001-12-03
CN1329610A (zh) 2002-01-02
ES2292252T3 (es) 2008-03-01
CA2348391A1 (en) 2000-05-11
ID28482A (id) 2001-05-31
US6849646B1 (en) 2005-02-01
CN1150189C (zh) 2004-05-19
WO2000026212A1 (de) 2000-05-11
KR20010080896A (ko) 2001-08-25
JP2002528544A (ja) 2002-09-03
ZA200104411B (en) 2002-08-29
AU754280B2 (en) 2002-11-14

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.