HUP0104800A3 - Chromenone and chromanone derivatives as integrin inhibitors, process for producing the same and pharmaceutical compositions containing them - Google Patents
Chromenone and chromanone derivatives as integrin inhibitors, process for producing the same and pharmaceutical compositions containing themInfo
- Publication number
- HUP0104800A3 HUP0104800A3 HU0104800A HUP0104800A HUP0104800A3 HU P0104800 A3 HUP0104800 A3 HU P0104800A3 HU 0104800 A HU0104800 A HU 0104800A HU P0104800 A HUP0104800 A HU P0104800A HU P0104800 A3 HUP0104800 A3 HU P0104800A3
- Authority
- HU
- Hungary
- Prior art keywords
- chromenone
- producing
- pharmaceutical compositions
- same
- compositions containing
- Prior art date
Links
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N coumarin Chemical compound C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 title 2
- MSTDXOZUKAQDRL-UHFFFAOYSA-N 4-Chromanone Chemical class C1=CC=C2C(=O)CCOC2=C1 MSTDXOZUKAQDRL-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000006495 integrins Human genes 0.000 title 1
- 108010044426 integrins Proteins 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19850131A DE19850131A1 (en) | 1998-10-30 | 1998-10-30 | Chromenon and chromanone derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0104800A2 HUP0104800A2 (en) | 2002-07-29 |
| HUP0104800A3 true HUP0104800A3 (en) | 2003-12-29 |
Family
ID=7886203
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0104800A HUP0104800A3 (en) | 1998-10-30 | 1999-10-14 | Chromenone and chromanone derivatives as integrin inhibitors, process for producing the same and pharmaceutical compositions containing them |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6849646B1 (en) |
| EP (1) | EP1124824B1 (en) |
| JP (1) | JP4511734B2 (en) |
| KR (1) | KR20010080896A (en) |
| CN (1) | CN1150189C (en) |
| AR (1) | AR021029A1 (en) |
| AT (1) | ATE370944T1 (en) |
| AU (1) | AU754280B2 (en) |
| BR (1) | BR9914893A (en) |
| CA (1) | CA2348391C (en) |
| CZ (1) | CZ20011515A3 (en) |
| DE (2) | DE19850131A1 (en) |
| ES (1) | ES2292252T3 (en) |
| HU (1) | HUP0104800A3 (en) |
| ID (1) | ID28482A (en) |
| NO (1) | NO20012108L (en) |
| PL (1) | PL347246A1 (en) |
| RU (1) | RU2234505C2 (en) |
| SK (1) | SK5532001A3 (en) |
| WO (1) | WO2000026212A1 (en) |
| ZA (1) | ZA200104411B (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19842415A1 (en) | 1998-09-16 | 2000-03-23 | Merck Patent Gmbh | Pharmaceutical preparation for treating e.g. tumors, thrombosis or inflammation, contains cyclic pentapeptide integrin inhibitor and chemotherapeutic agent and/or angiogenesis inhibitor |
| US6972296B2 (en) | 1999-05-07 | 2005-12-06 | Encysive Pharmaceuticals Inc. | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors |
| CA2427334C (en) | 2000-11-01 | 2013-06-11 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Methods and compositions for the treatment of diseases of the eye |
| WO2002097116A2 (en) * | 2001-05-30 | 2002-12-05 | The Scripps Research Institute | Delivery system for nucleic acids |
| US20040198644A1 (en) * | 2001-08-01 | 2004-10-07 | Hans-Markus Bender | Integrin inhibitors for the treatment of eye diseases |
| AU2003208833A1 (en) * | 2002-02-14 | 2003-09-04 | Merck Patent Gmbh | Methods and compositions for the treatment of eye diseases |
| PL211300B1 (en) | 2002-04-17 | 2012-05-31 | Cytokinetics Inc | Compounds, compositions, and methods |
| WO2003105842A1 (en) * | 2002-06-13 | 2003-12-24 | Novuspharma S.P.A. | Derivatives of chromen-2-one as inhibitors of vegf production in mammalian cells |
| FR2841243B1 (en) * | 2002-06-19 | 2004-08-20 | Servier Lab | NOVEL 3- (4-OXO-4H-CHROMEN-2YL) - (1H) -QUINOLEIN- 4-ONES DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| DE60326248D1 (en) | 2002-07-17 | 2009-04-02 | Cytokinetics Inc | Compounds, compositions and methods for treating cellular proliferative disorders |
| DE10337863A1 (en) | 2003-08-18 | 2005-03-17 | Merck Patent Gmbh | Use of chromene-4-one derivatives |
| NZ590437A (en) * | 2008-06-25 | 2012-07-27 | Array Biopharma Inc | 6-substituted phenoxychroman carboxylic acid derivatives |
| WO2011156889A1 (en) * | 2010-06-14 | 2011-12-22 | Trt Pharma Inc. | Novel modulators of nrf2 and uses thereof |
| RU2612875C1 (en) * | 2015-12-14 | 2017-03-13 | Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) | Means for human tyrosyl-dna-phosphodiesterase 1 enzyme inhibition |
| CN112110902B (en) * | 2020-09-17 | 2021-12-07 | 江苏科技大学 | 1-deoxynojirimycin-kaempferol compound, intermediate, preparation method and application |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA21528A1 (en) * | 1988-04-06 | 1989-12-31 | Lipha | SUBSTITUTE COMPONENTS OF FLAVONOIDE, THEIR SALTS, THEIR MANUFACTURES AND PRODUCTS CONTAINING THESE MATERIALS. |
| US5703075A (en) | 1988-12-21 | 1997-12-30 | Pharmacia & Upjohn Company | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones |
| JPH04502322A (en) * | 1988-12-21 | 1992-04-23 | ジ・アップジョン・カンパニー | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazin-4-ones |
| CA2081577A1 (en) | 1990-06-20 | 1991-12-21 | Ronald B. Gammill | Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1, 3-benzoxazine-4-ones |
| FR2693196B1 (en) * | 1992-07-03 | 1994-12-23 | Lipha | Benzopyranone or benzothiopyranone derivatives, process for their preparation and pharmaceutical composition containing them. |
| US5731324A (en) * | 1993-07-22 | 1998-03-24 | Eli Lilly And Company | Glycoprotein IIb/IIIa antagonists |
| FR2717479B1 (en) * | 1994-03-18 | 1996-06-07 | Pf Medicament | News 3- (omega-benzoylpiperidino) alcoyl) -4H-Benzopyran-4-ones, their preparation and their therapeutic application. |
-
1998
- 1998-10-30 DE DE19850131A patent/DE19850131A1/en not_active Withdrawn
-
1999
- 1999-10-14 CA CA002348391A patent/CA2348391C/en not_active Expired - Fee Related
- 1999-10-14 PL PL99347246A patent/PL347246A1/en unknown
- 1999-10-14 WO PCT/EP1999/007725 patent/WO2000026212A1/en active IP Right Grant
- 1999-10-14 ES ES99952566T patent/ES2292252T3/en not_active Expired - Lifetime
- 1999-10-14 SK SK553-2001A patent/SK5532001A3/en unknown
- 1999-10-14 ID IDW00200101018A patent/ID28482A/en unknown
- 1999-10-14 KR KR1020017005079A patent/KR20010080896A/en not_active Application Discontinuation
- 1999-10-14 BR BR9914893-5A patent/BR9914893A/en not_active IP Right Cessation
- 1999-10-14 CN CNB998142344A patent/CN1150189C/en not_active Expired - Fee Related
- 1999-10-14 RU RU2001114188/04A patent/RU2234505C2/en not_active IP Right Cessation
- 1999-10-14 AT AT99952566T patent/ATE370944T1/en not_active IP Right Cessation
- 1999-10-14 JP JP2000579600A patent/JP4511734B2/en not_active Expired - Fee Related
- 1999-10-14 HU HU0104800A patent/HUP0104800A3/en unknown
- 1999-10-14 EP EP99952566A patent/EP1124824B1/en not_active Expired - Lifetime
- 1999-10-14 AU AU64716/99A patent/AU754280B2/en not_active Ceased
- 1999-10-14 DE DE59914471T patent/DE59914471D1/en not_active Expired - Lifetime
- 1999-10-14 US US09/830,285 patent/US6849646B1/en not_active Expired - Fee Related
- 1999-10-14 CZ CZ20011515A patent/CZ20011515A3/en unknown
- 1999-10-29 AR ARP990105483A patent/AR021029A1/en not_active Application Discontinuation
-
2001
- 2001-04-27 NO NO20012108A patent/NO20012108L/en not_active Application Discontinuation
- 2001-05-29 ZA ZA200104411A patent/ZA200104411B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000026212A1 (en) | 2000-05-11 |
| NO20012108D0 (en) | 2001-04-27 |
| ATE370944T1 (en) | 2007-09-15 |
| JP4511734B2 (en) | 2010-07-28 |
| EP1124824A1 (en) | 2001-08-22 |
| NO20012108L (en) | 2001-04-27 |
| ZA200104411B (en) | 2002-08-29 |
| CA2348391C (en) | 2009-09-29 |
| CZ20011515A3 (en) | 2001-08-15 |
| ES2292252T3 (en) | 2008-03-01 |
| JP2002528544A (en) | 2002-09-03 |
| DE59914471D1 (en) | 2007-10-04 |
| CN1150189C (en) | 2004-05-19 |
| EP1124824B1 (en) | 2007-08-22 |
| ID28482A (en) | 2001-05-31 |
| PL347246A1 (en) | 2002-03-25 |
| CN1329610A (en) | 2002-01-02 |
| AU754280B2 (en) | 2002-11-14 |
| AU6471699A (en) | 2000-05-22 |
| BR9914893A (en) | 2001-07-17 |
| US6849646B1 (en) | 2005-02-01 |
| AR021029A1 (en) | 2002-06-12 |
| RU2234505C2 (en) | 2004-08-20 |
| DE19850131A1 (en) | 2000-05-04 |
| CA2348391A1 (en) | 2000-05-11 |
| HUP0104800A2 (en) | 2002-07-29 |
| SK5532001A3 (en) | 2001-12-03 |
| KR20010080896A (en) | 2001-08-25 |
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