AR023496A1 - Derivados del dibenzoazuleno, sus enantiomeros o diastereomeros, un procedimiento para su preparacion, el empleo de los mismos como sustancias activasterapeuticas y para preparar un medicamento, las composiciones farmaceuticas que los contienen, y un procedimiento para preparar estas composicionesfa - Google Patents
Derivados del dibenzoazuleno, sus enantiomeros o diastereomeros, un procedimiento para su preparacion, el empleo de los mismos como sustancias activasterapeuticas y para preparar un medicamento, las composiciones farmaceuticas que los contienen, y un procedimiento para preparar estas composicionesfaInfo
- Publication number
- AR023496A1 AR023496A1 ARP000101738A ARP000101738A AR023496A1 AR 023496 A1 AR023496 A1 AR 023496A1 AR P000101738 A ARP000101738 A AR P000101738A AR P000101738 A ARP000101738 A AR P000101738A AR 023496 A1 AR023496 A1 AR 023496A1
- Authority
- AR
- Argentina
- Prior art keywords
- atoms
- trisubstituted
- mono
- hal
- alkyl
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical compound C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000126 substance Substances 0.000 title 1
- 125000004429 atom Chemical group 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 230000001131 transforming effect Effects 0.000 abstract 3
- 101100294115 Caenorhabditis elegans nhr-4 gene Proteins 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001409 amidines Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
- 125000006239 protecting group Chemical group 0.000 abstract 1
- 238000003797 solvolysis reaction Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Virology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Abstract
Derivados del dibenzoazuleno de formula (1) en donde R1 representa OR4, NHR4 o NA2; R2 representa H, Hal, NO2, NHR4, NA2, OR4, SO3R4, SO2R4 o SR4; R3representa NH2, H2N-C-(=NH) o H2N-(C=NH)-NH, en donde los grupos de amino primarios también pueden estar protegidos con grupos protectores de aminoconvencionales, o R5-NH-; R4 representa H, A, Ar o aralk; R5 representa un heterociclo de uno o más nucleos y con 1 a 4 átomos de N, O y/o S, el cual puede noestar sustituido o estar mono, di o trisustituido con Hal, A, -CO-A, OA, CN, COOA, CONH2, NO2, =NH o =O; A representa alquilo de 1 a 15 átomos de C ocicloalquilo de 3 a 15 átomos de C que se encuentra no sustituido o mono, di o trisustituido con R6, y en el cual uno, dos o tres grupos metileno pueden estarreemplazados por N, O y/o S; R6 representa Hal, NO2, NHA, NA2, OA, fenoxi, CO-A, SO3A, CN, NHCOA, COOA, CONA2 o SO2A; A representa H o alquilo de 1a 6 átomos de C; A representa alquilo de 1 a 6 átomos de C; Ar representa un sistema de anillo aromático de uno o dos nucleos con 0, 1, 2, 3 o 4 átomos de N,O y/o S, el cual se encuentra no sustituido o mono, di o trisustituido con alquilo de 1 a 6 átomos de C y/o R6; Aralk representa aralquileno de 7 a 14 átomosde C que se encuentra no sustituido o mono, di o trisustituido con R6, y en el cual uno, dos o tres grupos metileno pueden estar reemplazados por N, O y/o S;Hal representa F, Cl, Br o I; m, n representan independientemente 0, 1, 2, 3 o 4, las sales aceptables desde el punto devista fisiologico y los solvatos deestos compuestos. Un procedimiento para preparar los compuestos de formula (1) y sus sales y solvatos, en el cual a) se libera un compuesto de formula (1) deuno de sus derivados funcionales por tratamiento con un agente de solvolisis o hidrogenolisis, o b) se transforma un resto R1, R2 y/o R3 en otro resto R1, R2y/o R3, ya sea, por ejemplo i) transformando un grupo amino en un grupo guanidino por reaccion con un agente de amidinacion, ii) saponificando un éster, iii)reduciendo un ácido carboxílico a un alcohol, iv) transformando una hidroxiamidina en una amidina por hidrogenacion, y/o se transforma una base o un ácido de
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19916837A DE19916837A1 (de) | 1999-04-14 | 1999-04-14 | Dibenzoazulenderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR023496A1 true AR023496A1 (es) | 2002-09-04 |
Family
ID=7904536
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000101738A AR023496A1 (es) | 1999-04-14 | 2000-04-14 | Derivados del dibenzoazuleno, sus enantiomeros o diastereomeros, un procedimiento para su preparacion, el empleo de los mismos como sustancias activasterapeuticas y para preparar un medicamento, las composiciones farmaceuticas que los contienen, y un procedimiento para preparar estas composicionesfa |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US6521646B1 (es) |
| EP (1) | EP1169306A1 (es) |
| JP (1) | JP2002542231A (es) |
| KR (1) | KR20010102570A (es) |
| CN (1) | CN1345312A (es) |
| AR (1) | AR023496A1 (es) |
| AU (1) | AU3817400A (es) |
| BR (1) | BR0009690A (es) |
| CA (1) | CA2367359A1 (es) |
| CZ (1) | CZ20013704A3 (es) |
| DE (1) | DE19916837A1 (es) |
| HU (1) | HUP0200643A3 (es) |
| MX (1) | MXPA01010294A (es) |
| NO (1) | NO20014976L (es) |
| PL (1) | PL350354A1 (es) |
| RU (1) | RU2001129708A (es) |
| SK (1) | SK14342001A3 (es) |
| WO (1) | WO2000063178A1 (es) |
| ZA (1) | ZA200109343B (es) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2806082B1 (fr) * | 2000-03-07 | 2002-05-17 | Adir | Nouveaux composes bicycliques antagonistes des recepteurs de la vitronectine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP4964389B2 (ja) * | 2000-06-30 | 2012-06-27 | ダウ グローバル テクノロジーズ エルエルシー | 多環式、縮合環化合物、金属錯体及び重合方法 |
| US20050107350A1 (en) * | 2003-08-22 | 2005-05-19 | Pharmacia Corporation | Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith |
| KR101224368B1 (ko) | 2004-06-04 | 2013-01-22 | 더 스크립스 리서치 인스티튜트 | 혈관신생 질환 치료용 조성물 및 방법 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3795709A (en) * | 1968-02-07 | 1974-03-05 | Sandoz Ag | Benzobenzazulenes |
| ES2148742T3 (es) * | 1995-03-09 | 2000-10-16 | Ortho Pharma Corp | Dibenz(a,f)azulenos sustituidos y procedimientos de preparacion. |
| EP0910563B1 (en) * | 1995-06-29 | 2003-05-02 | Smithkline Beecham Corporation | Integrin receptor antagonists |
| EA002271B1 (ru) * | 1996-03-20 | 2002-02-28 | Хехст Марион Руссель | ТРИЦИКЛИЧЕСКИЕ СОЕДИНЕНИЯ, ОБЛАДАЮЩИЕ АКТИВНОСТЬЮ В ОТНОШЕНИИ ИНТЕГРИНОВ, В ЧАСТНОСТИ В ОТНОШЕНИИ ИНТЕГРИНА АЛЬФАvБЕТА 3, СПОСОБ ИХ ПОЛУЧЕНИЯ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ, ИСПОЛЬЗУЕМЫЕ В ЭТОМ СПОСОБЕ, ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ МЕДИКАМЕНТОВ И СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ |
| CO4920232A1 (es) * | 1997-01-08 | 2000-05-29 | Smithkline Beecham Corp | Acidos aceticos dibenzo [a,d] cicloheptano con actividad antagonista del receptor de vitronectin |
-
1999
- 1999-04-14 DE DE19916837A patent/DE19916837A1/de not_active Withdrawn
-
2000
- 2000-04-01 RU RU2001129708/04A patent/RU2001129708A/ru unknown
- 2000-04-01 CA CA002367359A patent/CA2367359A1/en not_active Abandoned
- 2000-04-01 AU AU38174/00A patent/AU3817400A/en not_active Abandoned
- 2000-04-01 JP JP2000612271A patent/JP2002542231A/ja active Pending
- 2000-04-01 PL PL00350354A patent/PL350354A1/xx unknown
- 2000-04-01 WO PCT/EP2000/002925 patent/WO2000063178A1/de not_active Application Discontinuation
- 2000-04-01 HU HU0200643A patent/HUP0200643A3/hu unknown
- 2000-04-01 KR KR1020017011575A patent/KR20010102570A/ko not_active Application Discontinuation
- 2000-04-01 US US09/958,812 patent/US6521646B1/en not_active Expired - Fee Related
- 2000-04-01 CZ CZ20013704A patent/CZ20013704A3/cs unknown
- 2000-04-01 MX MXPA01010294A patent/MXPA01010294A/es unknown
- 2000-04-01 BR BR0009690-3A patent/BR0009690A/pt not_active Application Discontinuation
- 2000-04-01 EP EP00917037A patent/EP1169306A1/de not_active Withdrawn
- 2000-04-01 CN CN00805748A patent/CN1345312A/zh active Pending
- 2000-04-01 SK SK1434-2001A patent/SK14342001A3/sk unknown
- 2000-04-14 AR ARP000101738A patent/AR023496A1/es unknown
-
2001
- 2001-10-12 NO NO20014976A patent/NO20014976L/no not_active Application Discontinuation
- 2001-11-13 ZA ZA200109343A patent/ZA200109343B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0200643A3 (en) | 2003-10-28 |
| HUP0200643A2 (hu) | 2002-07-29 |
| ZA200109343B (en) | 2003-04-30 |
| MXPA01010294A (es) | 2002-05-06 |
| CZ20013704A3 (cs) | 2002-02-13 |
| US6521646B1 (en) | 2003-02-18 |
| EP1169306A1 (de) | 2002-01-09 |
| NO20014976D0 (no) | 2001-10-12 |
| WO2000063178A1 (de) | 2000-10-26 |
| DE19916837A1 (de) | 2000-10-19 |
| SK14342001A3 (sk) | 2002-04-04 |
| NO20014976L (no) | 2001-10-12 |
| BR0009690A (pt) | 2002-01-08 |
| JP2002542231A (ja) | 2002-12-10 |
| AU3817400A (en) | 2000-11-02 |
| PL350354A1 (en) | 2002-12-02 |
| CA2367359A1 (en) | 2000-10-26 |
| RU2001129708A (ru) | 2004-02-27 |
| CN1345312A (zh) | 2002-04-17 |
| KR20010102570A (ko) | 2001-11-15 |
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