BR0008760A - Genes pks da schizochytrium - Google Patents
Genes pks da schizochytriumInfo
- Publication number
- BR0008760A BR0008760A BR0008760-2A BR0008760A BR0008760A BR 0008760 A BR0008760 A BR 0008760A BR 0008760 A BR0008760 A BR 0008760A BR 0008760 A BR0008760 A BR 0008760A
- Authority
- BR
- Brazil
- Prior art keywords
- production
- genes
- pks
- long
- plants
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 6
- 241000233671 Schizochytrium Species 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 5
- 235000020978 long-chain polyunsaturated fatty acids Nutrition 0.000 abstract 3
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- DVSZKTAMJJTWFG-UHFFFAOYSA-N docosa-2,4,6,8,10,12-hexaenoic acid Chemical compound CCCCCCCCCC=CC=CC=CC=CC=CC=CC(O)=O DVSZKTAMJJTWFG-UHFFFAOYSA-N 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- 150000004665 fatty acids Chemical class 0.000 abstract 2
- 241000294598 Moritella marina Species 0.000 abstract 1
- 241000863432 Shewanella putrefaciens Species 0.000 abstract 1
- 108700019146 Transgenes Proteins 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
- MBMBGCFOFBJSGT-KUBAVDMBSA-N docosahexaenoic acid Natural products CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 abstract 1
- SBHCLVQMTBWHCD-UHFFFAOYSA-N icosa-2,4,6,8,10-pentaenoic acid Chemical compound CCCCCCCCCC=CC=CC=CC=CC=CC(O)=O SBHCLVQMTBWHCD-UHFFFAOYSA-N 0.000 abstract 1
- 238000011031 large-scale manufacturing process Methods 0.000 abstract 1
- 150000004668 long chain fatty acids Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 239000003921 oil Substances 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
- C12N15/8247—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine involving modified lipid metabolism, e.g. seed oil composition
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/28—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Vibrionaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6432—Eicosapentaenoic acids [EPA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
- C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
- C12P7/6434—Docosahexenoic acids [DHA]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6436—Fatty acid esters
- C12P7/6445—Glycerides
- C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/231,899 US6566583B1 (en) | 1997-06-04 | 1999-01-14 | Schizochytrium PKS genes |
| PCT/US2000/000956 WO2000042195A2 (en) | 1999-01-14 | 2000-01-14 | Schizochytrium pks genes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0008760A true BR0008760A (pt) | 2002-10-08 |
Family
ID=22871074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0008760-2A BR0008760A (pt) | 1999-01-14 | 2000-01-14 | Genes pks da schizochytrium |
Country Status (10)
| Country | Link |
|---|---|
| US (6) | US6566583B1 (cg-RX-API-DMAC7.html) |
| EP (4) | EP2333071A1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP2002534123A (cg-RX-API-DMAC7.html) |
| BR (1) | BR0008760A (cg-RX-API-DMAC7.html) |
| CA (1) | CA2359629C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2427017T3 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1041292A1 (cg-RX-API-DMAC7.html) |
| IL (4) | IL144269A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX252154B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2000042195A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (79)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6566583B1 (en) * | 1997-06-04 | 2003-05-20 | Daniel Facciotti | Schizochytrium PKS genes |
| DE60042730D1 (de) | 1999-01-05 | 2009-09-24 | Univ Boston | Verbessertes klonierungsverfahren |
| US8003772B2 (en) * | 1999-01-14 | 2011-08-23 | Martek Biosciences Corporation | Chimeric PUFA polyketide synthase systems and uses thereof |
| US20070244192A1 (en) * | 1999-01-14 | 2007-10-18 | Martek Biosciences Corporation | Plant seed oils containing polyunsaturated fatty acids |
| US7217856B2 (en) * | 1999-01-14 | 2007-05-15 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US7211418B2 (en) * | 1999-01-14 | 2007-05-01 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| US7247461B2 (en) * | 1999-01-14 | 2007-07-24 | Martek Biosciences Corporation | Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof |
| US7271315B2 (en) * | 1999-01-14 | 2007-09-18 | Martek Biosciences Corporation | PUFA polyketide synthase systems and uses thereof |
| KR20080007279A (ko) | 2000-01-19 | 2008-01-17 | 마텍 바이오싸이언스스 코포레이션 | 무용매 추출 방법 |
| KR20070073986A (ko) | 2000-01-28 | 2007-07-10 | 마텍 바이오싸이언스스 코포레이션 | 발효기 내에서 진핵 미생물의 고밀도 배양에 의한고도불포화 지방산을 함유하는 지질의 증진된 생산 방법 |
| TWI337619B (en) | 2001-04-16 | 2011-02-21 | Martek Biosciences Corp | Pufa polyketide synthase systems and uses thereof |
| EP1531687A4 (en) | 2002-06-18 | 2006-11-15 | Martek Biosciences Corp | STABLE EMULSION OF LEN IN WATER SOLUTIONS AND METHOD FOR THE PRODUCTION THEREOF |
| AU2003296638B2 (en) | 2002-12-19 | 2009-06-11 | University Of Bristol | Method for the production of polyunsaturated fatty acids |
| CA2517253C (en) | 2003-02-27 | 2018-07-03 | Basf Plant Science Gmbh | Method for the production of polyunsaturated fatty acids |
| EP1619960A4 (en) * | 2003-03-07 | 2009-03-18 | Advanced Bionutrition Corp | FEED FORMULATION FOR LAND AND WATER RESIDENTS |
| ES2516641T3 (es) * | 2003-03-26 | 2014-10-31 | Dsm Ip Assets B.V. | Sistemas de policétido sintasa de AGPI y usos de los mismos |
| CA2868312A1 (en) | 2003-03-31 | 2004-10-14 | University Of Bristol | Novel plant acyltransferases specific for long-chained, multiply unsaturated fatty acids |
| US7646815B2 (en) * | 2003-07-15 | 2010-01-12 | Lsi Corporation | Intra estimation chroma mode 0 sub-block dependent prediction |
| US7208590B2 (en) * | 2003-07-15 | 2007-04-24 | Abbott Laboratories | Genes involved in polyketide synthase pathways and uses thereof |
| DE102004017370A1 (de) * | 2004-04-08 | 2005-10-27 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | PUFA-PKS Gene aus Ulkenia |
| DE102004017369A1 (de) * | 2004-04-08 | 2005-11-03 | Nutrinova Nutrition Specialties & Food Ingredients Gmbh | Screeningverfahren zur Identifizierung von PUFA-PKS in Proben |
| WO2005103253A1 (en) | 2004-04-22 | 2005-11-03 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| US7807849B2 (en) | 2004-04-22 | 2010-10-05 | Commonwealth Scientific And Industrial Research Organisation | Synthesis of long-chain polyunsaturated fatty acids by recombinant cells |
| EP1871883A1 (en) * | 2005-03-02 | 2008-01-02 | Metanomics GmbH | Process for the production of fine chemicals |
| EP2447356B1 (en) | 2005-06-07 | 2016-04-20 | DSM Nutritional Products AG | Eukaryotic microorganisms for producing lipids and antioxidants |
| EP1903883A4 (en) | 2005-07-01 | 2010-06-23 | Martek Biosciences Corp | OIL PRODUCT CONTAINING MULTIPLE UNSATURATED FATTY ACIDS AND ITS USES AND MANUFACTURING |
| JP4943678B2 (ja) * | 2005-08-01 | 2012-05-30 | 国立大学法人北海道大学 | 細胞の脂肪酸組成を改変する方法およびその利用 |
| EP1965658B2 (en) | 2005-11-18 | 2022-10-05 | Commonwealth Scientific and Industrial Research Organisation | Feedstuffs for aquaculture comprising stearidonic acid feedstuffs for aquaculture |
| MX340759B (es) * | 2006-03-15 | 2015-03-11 | Dsm Ip Assets B V * | Aceites de semillas vegetales que contienen ácidos grasos poli-insaturados. |
| MX295615B (es) * | 2006-04-11 | 2012-02-07 | Market Biosciences Corp | Productos alimenticios que comprenden acidos grasos poliinsaturados de cadena largay metodos para preparar los mismos. |
| PL2034973T5 (pl) | 2006-06-22 | 2023-02-20 | Dsm Ip Assets B.V. | Kapsułkowane kompozycje nietrwałych związków i sposoby ich wytwarzania |
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| SG10201501004UA (en) | 2006-08-29 | 2015-04-29 | Dsm Ip Assets Bv | USE OF DPA(n-6) OILS IN INFANT FORMULA |
| CA2675026A1 (en) * | 2007-01-12 | 2008-07-24 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms |
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| US11248244B2 (en) * | 2017-05-10 | 2022-02-15 | Nanjing University Of Technology | Schizochytrium limacinum strain, building method therefor and application thereof |
| US11866788B2 (en) | 2018-05-08 | 2024-01-09 | Sanford Burnham Prebys Medical Discovery Institute | Role of PVT1 in the diagnosis and treatment of MYC-driven cancer |
| JPWO2020032261A1 (ja) * | 2018-08-10 | 2021-08-10 | 協和発酵バイオ株式会社 | エイコサペンタエン酸を生産する微生物及びエイコサペンタエン酸の製造法 |
| WO2020032258A1 (ja) * | 2018-08-10 | 2020-02-13 | 協和発酵バイオ株式会社 | 多価不飽和脂肪酸を生産する微生物及び多価不飽和脂肪酸の製造法 |
| EP4031253B1 (en) * | 2019-09-19 | 2025-11-05 | Sanford Burnham Prebys Medical Discovery Institute | Methods and compositions for treating myc-driven cancers |
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1999
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- 2000-01-14 JP JP2000593752A patent/JP2002534123A/ja not_active Withdrawn
- 2000-01-14 BR BR0008760-2A patent/BR0008760A/pt active Search and Examination
- 2000-01-14 EP EP10010708A patent/EP2333071A1/en not_active Withdrawn
- 2000-01-14 EP EP10010710A patent/EP2333073A1/en not_active Withdrawn
- 2000-01-14 EP EP00904357A patent/EP1147197A2/en not_active Ceased
- 2000-01-14 IL IL14426900A patent/IL144269A0/xx unknown
- 2000-01-14 WO PCT/US2000/000956 patent/WO2000042195A2/en not_active Ceased
- 2000-01-14 EP EP10010709.3A patent/EP2333072B1/en not_active Expired - Lifetime
- 2000-01-14 MX MXPA01007153 patent/MX252154B/es active IP Right Grant
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- 2002-12-27 US US10/331,061 patent/US7214853B2/en not_active Expired - Lifetime
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- 2007-06-28 US US11/770,474 patent/US7897844B2/en not_active Expired - Fee Related
- 2007-11-07 JP JP2007289187A patent/JP2008099697A/ja not_active Withdrawn
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- 2013-02-21 IL IL224871A patent/IL224871A/en not_active IP Right Cessation
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| JP2002534123A (ja) | 2002-10-15 |
| US20090098622A1 (en) | 2009-04-16 |
| WO2000042195A2 (en) | 2000-07-20 |
| MXPA01007153A (es) | 2003-07-21 |
| CA2359629C (en) | 2015-02-24 |
| IL144269A (en) | 2010-04-15 |
| JP2008099697A (ja) | 2008-05-01 |
| ES2427017T3 (es) | 2013-10-28 |
| US20030101486A1 (en) | 2003-05-29 |
| IL224871A (en) | 2017-11-30 |
| IL188590A0 (en) | 2008-04-13 |
| EP2333072A1 (en) | 2011-06-15 |
| US20080148433A1 (en) | 2008-06-19 |
| US20110250342A1 (en) | 2011-10-13 |
| CA2359629A1 (en) | 2000-07-20 |
| WO2000042195A3 (en) | 2000-09-28 |
| US6566583B1 (en) | 2003-05-20 |
| US7214853B2 (en) | 2007-05-08 |
| IL144269A0 (en) | 2002-05-23 |
| IL188590A (en) | 2013-06-27 |
| HK1041292A1 (zh) | 2002-07-05 |
| EP1147197A2 (en) | 2001-10-24 |
| US20140053299A1 (en) | 2014-02-20 |
| EP2333073A1 (en) | 2011-06-15 |
| WO2000042195B1 (en) | 2000-11-09 |
| EP2333072B1 (en) | 2013-06-19 |
| HK1159166A1 (en) | 2012-07-27 |
| US7897844B2 (en) | 2011-03-01 |
| US8829274B2 (en) | 2014-09-09 |
| JP2010252811A (ja) | 2010-11-11 |
| EP2333071A1 (en) | 2011-06-15 |
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