BG65680B1 - Използване на ет743 за лечение на рак - Google Patents

Използване на ет743 за лечение на рак Download PDF

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Publication number
BG65680B1
BG65680B1 BG106171A BG10617101A BG65680B1 BG 65680 B1 BG65680 B1 BG 65680B1 BG 106171 A BG106171 A BG 106171A BG 10617101 A BG10617101 A BG 10617101A BG 65680 B1 BG65680 B1 BG 65680B1
Authority
BG
Bulgaria
Prior art keywords
use according
cancer
administered
ecteinascidin
patients
Prior art date
Application number
BG106171A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG106171A (en
Inventor
Angela Bowman
Jean MISSET
Esteban Cvitkovic
George Demetri
Cecilia Guzman
Jose Jimeno
Chris Twelves
HOFF Daniel VON
Lazaro Luis Lopez
Original Assignee
Pharma Mar S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9911183.3A external-priority patent/GB9911183D0/en
Priority claimed from GBGB9911346.6A external-priority patent/GB9911346D0/en
Priority claimed from GBGB9918534.0A external-priority patent/GB9918534D0/en
Priority claimed from GBGB9927005.0A external-priority patent/GB9927005D0/en
Priority claimed from GBGB9927106.6A external-priority patent/GB9927106D0/en
Priority claimed from GB0007637A external-priority patent/GB0007637D0/en
Application filed by Pharma Mar S.A. filed Critical Pharma Mar S.A.
Publication of BG106171A publication Critical patent/BG106171A/xx
Publication of BG65680B1 publication Critical patent/BG65680B1/bg

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995Pyrazines or piperazines forming part of bridged ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
BG106171A 1999-05-13 2001-12-03 Използване на ет743 за лечение на рак BG65680B1 (bg)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GBGB9911183.3A GB9911183D0 (en) 1999-05-13 1999-05-13 Treatment of cancers
GBGB9911346.6A GB9911346D0 (en) 1999-05-14 1999-05-14 Treatment of cancers
GBGB9918534.0A GB9918534D0 (en) 1999-08-05 1999-08-05 Treatment of cancers
GBGB9927005.0A GB9927005D0 (en) 1999-11-15 1999-11-15 Treatment of cancers
GBGB9927106.6A GB9927106D0 (en) 1999-11-16 1999-11-16 Cancer treatment
GB0007637A GB0007637D0 (en) 2000-03-29 2000-03-29 Antitumour compound

Publications (2)

Publication Number Publication Date
BG106171A BG106171A (en) 2002-06-28
BG65680B1 true BG65680B1 (bg) 2009-06-30

Family

ID=27546594

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106171A BG65680B1 (bg) 1999-05-13 2001-12-03 Използване на ет743 за лечение на рак

Country Status (32)

Country Link
US (1) US8119638B2 (cg-RX-API-DMAC7.html)
EP (3) EP1716853B9 (cg-RX-API-DMAC7.html)
JP (2) JP2002544231A (cg-RX-API-DMAC7.html)
KR (1) KR20020019914A (cg-RX-API-DMAC7.html)
CN (2) CN1360503A (cg-RX-API-DMAC7.html)
AR (1) AR028476A1 (cg-RX-API-DMAC7.html)
AT (3) ATE375795T1 (cg-RX-API-DMAC7.html)
AU (2) AU777417B2 (cg-RX-API-DMAC7.html)
BG (1) BG65680B1 (cg-RX-API-DMAC7.html)
BR (1) BR0010531A (cg-RX-API-DMAC7.html)
CA (1) CA2373794C (cg-RX-API-DMAC7.html)
CY (4) CY1105818T1 (cg-RX-API-DMAC7.html)
CZ (1) CZ301482B6 (cg-RX-API-DMAC7.html)
DE (4) DE60045720D1 (cg-RX-API-DMAC7.html)
DK (3) DK1702618T3 (cg-RX-API-DMAC7.html)
ES (2) ES2272279T3 (cg-RX-API-DMAC7.html)
FR (1) FR08C0013I2 (cg-RX-API-DMAC7.html)
HU (2) HU229866B1 (cg-RX-API-DMAC7.html)
IL (2) IL146434A0 (cg-RX-API-DMAC7.html)
LU (1) LU91418I2 (cg-RX-API-DMAC7.html)
MX (1) MXPA01011562A (cg-RX-API-DMAC7.html)
MY (1) MY164077A (cg-RX-API-DMAC7.html)
NL (1) NL300337I2 (cg-RX-API-DMAC7.html)
NO (2) NO324564B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ515423A (cg-RX-API-DMAC7.html)
PL (1) PL198185B1 (cg-RX-API-DMAC7.html)
PT (3) PT1176964E (cg-RX-API-DMAC7.html)
SI (3) SI1702618T1 (cg-RX-API-DMAC7.html)
SK (1) SK287580B6 (cg-RX-API-DMAC7.html)
TR (1) TR200103819T2 (cg-RX-API-DMAC7.html)
UA (1) UA74782C2 (cg-RX-API-DMAC7.html)
WO (1) WO2000069441A1 (cg-RX-API-DMAC7.html)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY164077A (en) 1999-05-13 2017-11-30 Pharma Mar Sa Compositions and uses of et743 for treating cancer
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
CN100374162C (zh) * 2000-11-06 2008-03-12 法马马有限公司 海鞘素-743在制备用于治疗肿瘤的药剂中的应用
GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
KR20050038578A (ko) * 2001-10-19 2005-04-27 파르마 마르, 에스.에이. 항종양성 화합물의 암치료에 있어서의 향상된 용도
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
WO2005049031A1 (en) * 2003-11-13 2005-06-02 Pharma Mar, S.A.U. Combination
US20080255132A1 (en) * 2003-11-14 2008-10-16 Eric Rowinsky Combination Therapy Comprising the Use of Et-743 and Paclitaxel for Treating Cancer
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
US20080293725A1 (en) * 2004-07-09 2008-11-27 Rafael Rosell Costa Prognostic Molecular Markers
JP4554684B2 (ja) * 2004-10-26 2010-09-29 ファルマ・マル・エス・アー, ソシエダッド・ユニペルソナル 抗癌治療
KR101188691B1 (ko) * 2004-10-29 2012-10-09 파르마 마르 에스.에이. 엑티나시딘 및 디사카라이드를 포함하는 제제
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
EP2023931A2 (en) * 2006-05-12 2009-02-18 Pharma Mar S.A. Anticancer treatments with a combination of docetaxel and ecteinascidin
JP2011500046A (ja) * 2007-10-19 2011-01-06 ファルマ・マール・ソシエダード・アノニマ Et−743治療のための予後分子マーカー
HK1244713A1 (zh) * 2016-02-04 2018-08-17 江苏恒瑞医药股份有限公司 一种曲贝替定的可注射胃肠外用药物组合物及其制备方法
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
WO2020239478A1 (en) 2019-05-28 2020-12-03 Pharma Mar, S.A. Trabectedin for treating sarcomas based on genomic markers
CN112574234B (zh) * 2019-09-27 2022-05-24 江苏恒瑞医药股份有限公司 一种海鞘素衍生物的制备方法
BR112022020812A2 (pt) 2020-04-15 2022-11-29 Ever Valinject Gmbh Composição farmacêutica compreendendo trabectedina e um aminoacido, formulação liofilizada e uma solução de injeção intravenosa compreendendo dita composição
EP3960177A1 (en) * 2020-08-26 2022-03-02 Anturec Pharmaceuticals GmbH Composition comprising ttf-ngr for use in treating soft-tissue sarcoma
US12303506B2 (en) 2022-01-20 2025-05-20 Extrovis Ag Trabectedin composition

Citations (4)

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Publication number Priority date Publication date Assignee Title
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US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds

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MXPA02011319A (es) * 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
EP1356097A2 (en) * 2000-08-11 2003-10-29 City of Hope The anti-neoplastic agent et-743 inhibits trans activation by sxr
CN100374162C (zh) * 2000-11-06 2008-03-12 法马马有限公司 海鞘素-743在制备用于治疗肿瘤的药剂中的应用
EP1360337A1 (en) 2001-02-09 2003-11-12 The Regents Of The University Of California Ecteinascidin family compounds: compositions and methods
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KR20050038578A (ko) 2001-10-19 2005-04-27 파르마 마르, 에스.에이. 항종양성 화합물의 암치료에 있어서의 향상된 용도
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GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
WO2005049031A1 (en) 2003-11-13 2005-06-02 Pharma Mar, S.A.U. Combination
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
US20080255132A1 (en) * 2003-11-14 2008-10-16 Eric Rowinsky Combination Therapy Comprising the Use of Et-743 and Paclitaxel for Treating Cancer
US20080293725A1 (en) * 2004-07-09 2008-11-27 Rafael Rosell Costa Prognostic Molecular Markers
CA2583464A1 (en) 2004-09-29 2006-04-06 Pharma Mar S.A., Sociedad Unipersonal Ecteinascidin compounds as anti -inflammatory agents
JP4554684B2 (ja) * 2004-10-26 2010-09-29 ファルマ・マル・エス・アー, ソシエダッド・ユニペルソナル 抗癌治療
KR101188691B1 (ko) * 2004-10-29 2012-10-09 파르마 마르 에스.에이. 엑티나시딘 및 디사카라이드를 포함하는 제제
JP2009517403A (ja) * 2005-11-25 2009-04-30 ユニバーシティー オブ メディシン アンド デンティストリー オブ ニュージャージー Parp−1阻害剤の使用
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Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5089273A (en) * 1986-06-09 1992-02-18 Board Of Trustees Of The University Of Illinois Ecteinascidins 729, 743, 745, 759A, 759B and 770
US5256663A (en) * 1986-06-09 1993-10-26 The Board Of Trustees Of The University Of Illinois Compositions comprising ecteinascidins and a method of treating herpes simplex virus infections therewith
US5478932A (en) * 1993-12-02 1995-12-26 The Board Of Trustees Of The University Of Illinois Ecteinascidins
US5654426A (en) * 1993-12-02 1997-08-05 Univ Illinois Ecteinascidins
US5721362A (en) * 1996-09-18 1998-02-24 President And Fellows Of Harvard College Process for producing ecteinascidin compounds

Also Published As

Publication number Publication date
PT1702618E (pt) 2008-01-11
LU91418I2 (fr) 2008-05-13
BR0010531A (pt) 2002-06-04
FR08C0013I2 (fr) 2009-10-30
HUP0201187A2 (en) 2002-09-28
SI1716853T1 (sl) 2011-10-28
IL146434A (en) 2008-03-20
SI1176964T1 (sl) 2007-02-28
EP1716853A2 (en) 2006-11-02
DE60030554T8 (de) 2008-01-10
PT1176964E (pt) 2007-01-31
IL146434A0 (en) 2002-07-25
JP5777562B2 (ja) 2015-09-09
NO2008005I1 (no) 2008-06-09
EP1716853B9 (en) 2011-09-28
NO2008005I2 (cg-RX-API-DMAC7.html) 2010-09-27
CA2373794C (en) 2005-10-11
NO20015516D0 (no) 2001-11-12
CY1105818T1 (el) 2011-02-02
PT1716853E (pt) 2011-05-12
CN1360503A (zh) 2002-07-24
US20070275942A1 (en) 2007-11-29
DK1176964T3 (da) 2007-01-15
CY1112753T1 (el) 2016-02-10
CN1679631A (zh) 2005-10-12
AU777417B2 (en) 2004-10-14
TR200103819T2 (tr) 2002-04-22
MXPA01011562A (es) 2002-07-30
CA2373794A1 (en) 2000-11-23
EP1702618A3 (en) 2006-12-27
EP1702618A2 (en) 2006-09-20
LU91418I9 (cg-RX-API-DMAC7.html) 2019-01-02
WO2000069441A1 (en) 2000-11-23
BG106171A (en) 2002-06-28
AU2005200180B9 (en) 2008-05-29
CY2008007I2 (el) 2009-11-04
EP1702618B1 (en) 2007-10-17
DE60036826D1 (de) 2007-11-29
HUS1500001I1 (hu) 2016-08-29
PL352931A1 (en) 2003-09-22
SK287580B6 (sk) 2011-03-04
MY164077A (en) 2017-11-30
JP2012149095A (ja) 2012-08-09
DE60030554T2 (de) 2007-09-13
HU229866B1 (en) 2014-10-28
ES2272279T3 (es) 2007-05-01
DK1702618T3 (da) 2008-02-25
AU2005200180B2 (en) 2007-12-13
SI1702618T1 (sl) 2008-02-29
EP1716853B1 (en) 2011-03-09
EP1716853A3 (en) 2006-11-15
ES2294756T3 (es) 2008-04-01
DE60036826T2 (de) 2008-08-28
NL300337I1 (nl) 2008-05-01
EP1176964B8 (en) 2007-10-10
DE60045720D1 (de) 2011-04-21
KR20020019914A (ko) 2002-03-13
NL300337I2 (nl) 2008-09-01
FR08C0013I1 (cg-RX-API-DMAC7.html) 2008-05-30
NZ515423A (en) 2004-04-30
DE122008000013I1 (de) 2008-08-07
CZ20014081A3 (cs) 2002-11-13
PL198185B1 (pl) 2008-06-30
CZ301482B6 (cs) 2010-03-17
EP1176964A1 (en) 2002-02-06
CN100477993C (zh) 2009-04-15
CY2008007I1 (el) 2009-11-04
JP2002544231A (ja) 2002-12-24
AU2005200180A1 (en) 2005-02-10
DE60030554D1 (de) 2006-10-19
DK1716853T3 (da) 2011-06-27
ATE375795T1 (de) 2007-11-15
NO20015516L (no) 2002-01-11
ATE338552T1 (de) 2006-09-15
NO324564B1 (no) 2007-11-19
ATE500830T1 (de) 2011-03-15
UA74782C2 (uk) 2006-02-15
CY1107143T1 (el) 2010-07-28
HUP0201187A3 (en) 2002-11-28
US8119638B2 (en) 2012-02-21
AR028476A1 (es) 2003-05-14
EP1176964B1 (en) 2006-09-06
SK16442001A3 (sk) 2002-03-05
AU4597500A (en) 2000-12-05

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