BG64317B1 - Глюкокортикоид-селективни противовъзпалителни средства - Google Patents

Глюкокортикоид-селективни противовъзпалителни средства Download PDF

Info

Publication number
BG64317B1
BG64317B1 BG104719A BG10471900A BG64317B1 BG 64317 B1 BG64317 B1 BG 64317B1 BG 104719 A BG104719 A BG 104719A BG 10471900 A BG10471900 A BG 10471900A BG 64317 B1 BG64317 B1 BG 64317B1
Authority
BG
Bulgaria
Prior art keywords
dihydro
trimethyl
quinoline
methoxy
benzopyrano
Prior art date
Application number
BG104719A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG104719A (en
Inventor
Michael J. Coughlan
Steven W. Elmore
Michael E. Kort
Philip R. Kym
Jimmie L. Moore
John K. Pratt
Alan X. Wang
James P. Edwards
Todd K. Jones
Original Assignee
Abbott Laboratories
Ligand Pharmaceuticals,Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories, Ligand Pharmaceuticals,Inc filed Critical Abbott Laboratories
Publication of BG104719A publication Critical patent/BG104719A/xx
Publication of BG64317B1 publication Critical patent/BG64317B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BG104719A 1998-02-13 2000-08-28 Глюкокортикоид-селективни противовъзпалителни средства BG64317B1 (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2394798A 1998-02-13 1998-02-13
US24783199A 1999-02-10 1999-02-10
PCT/US1999/003127 WO1999041256A1 (en) 1998-02-13 1999-02-12 Glucocorticoid-selective anti-inflammatory agents

Publications (2)

Publication Number Publication Date
BG104719A BG104719A (en) 2001-05-31
BG64317B1 true BG64317B1 (bg) 2004-09-30

Family

ID=26697833

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104719A BG64317B1 (bg) 1998-02-13 2000-08-28 Глюкокортикоид-селективни противовъзпалителни средства

Country Status (21)

Country Link
EP (1) EP1053239B1 (hu)
JP (1) JP2002503665A (hu)
KR (1) KR20010040935A (hu)
CN (1) CN1119348C (hu)
AT (1) ATE230749T1 (hu)
AU (1) AU766441B2 (hu)
BG (1) BG64317B1 (hu)
BR (1) BR9907788A (hu)
CA (1) CA2320943A1 (hu)
DE (1) DE69904804T2 (hu)
DK (1) DK1053239T3 (hu)
ES (1) ES2192035T3 (hu)
HK (1) HK1033308A1 (hu)
HU (1) HUP0100460A3 (hu)
IL (1) IL137508A0 (hu)
NO (1) NO20004053L (hu)
NZ (1) NZ506013A (hu)
PL (1) PL193323B1 (hu)
SK (1) SK284689B6 (hu)
TR (1) TR200003094T2 (hu)
WO (1) WO1999041256A1 (hu)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6506766B1 (en) * 1998-02-13 2003-01-14 Abbott Laboratories Glucocortiocoid-selective antinflammatory agents
CO5180649A1 (es) * 1999-09-01 2002-07-30 Abbott Lab Antagonistas de los receptores de los glucocorticoides para el tratamiento de la diabetes para el tratamiento de la diabetes
US6329534B1 (en) 1999-09-01 2001-12-11 Abbott Laboratories Glucocorticoid receptor antagonists for treatment of diabetes
US6593480B2 (en) 1999-09-01 2003-07-15 Abbott Laboratories Glucocorticoid receptor antagonists for treatment of diabetes
US6436986B1 (en) 1999-09-01 2002-08-20 Abbott Laboratories Glucocorticoid receptor antagonists for treatment of diabetes
EP1201660B1 (en) 2000-10-30 2005-08-31 Pfizer Products Inc. Glucocorticoid receptor modulators
WO2003002548A1 (en) * 2001-06-29 2003-01-09 Abbott Laboratories A process for the preparation of chiral glucocorticoid receptor agents
US6608216B2 (en) 2001-06-29 2003-08-19 Abbott Laboratories Process for the preparation of chiral glucocorticoid receptor agents
US6518430B1 (en) 2001-09-21 2003-02-11 Abbott Laboratories Process for the preparation of 5-(substituted)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-F]quinolines and derivatives thereof
US6960581B2 (en) 2002-01-14 2005-11-01 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical formulations, and uses thereof
PT1490062E (pt) 2002-03-26 2008-01-30 Boehringer Ingelheim Pharma Miméticos de glucocorticóides, métodos para a sua preparação, composições farmacêuticas e suas utilizações
CA2477764A1 (en) 2002-03-26 2003-10-09 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
AU2003221706B2 (en) 2002-04-11 2008-02-28 Merck Sharp & Dohme Corp. 1H-Benzo[F]indazol-5-YL derivatives as selective glucocorticoid receptor modulators
US7186864B2 (en) 2002-05-29 2007-03-06 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
US7074806B2 (en) 2002-06-06 2006-07-11 Boehringer Ingelheim Pharmaceuticals, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
ATE403648T1 (de) 2002-08-21 2008-08-15 Boehringer Ingelheim Pharma Substituierte dihydrochinoline als glucocorticoid-mmimetika,verfahren zu deren herstellung, pharmazeutische zubereitungen und deren verwendung
MXPA05003800A (es) 2002-10-11 2005-06-08 Ligand Pharm Inc 5-(1¦,1¦-cicloalquil/alquenil)metiliden 1,2-dihidro-5h- cromeno[3,4f]quinolinas como compuestos moduladores de receptor de progesterona selectivos.
MXPA05003721A (es) * 2002-10-11 2005-06-17 Ligand Pharm Inc Derivados de 5-cicloalquenilo-5h-cromeno[3,4-f]quinolina como compuestos moduladores, selectivos de receptores de progesterona.
DE20301728U1 (de) 2002-10-11 2004-03-11 Ligand Pharmaceuticals, Inc., San Diego 5-substituierte 7,9-Difluor-5H-Chromeno(3,4-f) -Chinolin-Verbindungen als selektive Progesteronrezeptormodulator-Verbindungen
CA2512257A1 (en) 2003-01-03 2004-07-29 Boehringer Ingelheim Pharmaceuticals, Inc. 1-propanol and 1-propylamine derivatives and their use as glucocorticoid ligands
US20070088042A1 (en) 2004-09-09 2007-04-19 Meissner Robert S Fluorinated 4-azasteroid derivatives as androgen receptor modulators
US7235662B2 (en) 2003-06-11 2007-06-26 Bristol-Myers Squibb Company Modulators of the glucocorticoid receptor and method
US8097606B2 (en) 2003-07-23 2012-01-17 Corcept Therapeutics, Inc. Antiglucocorticoids for the treatment of catatonia
UY28526A1 (es) 2003-09-24 2005-04-29 Boehringer Ingelheim Pharma Miméticos de glucocorticoides, métodos de preparación composiciones farmacéuticas y usos de los mismos
ATE366726T1 (de) 2003-10-16 2007-08-15 Boehringer Ingelheim Pharma Stereoselektive synthese bestimmter trifluormethylsubstituierter alkohole
US7795272B2 (en) 2004-03-13 2010-09-14 Boehringer Ingelheim Pharmaceutical, Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof
EP1836166B1 (en) 2004-12-27 2009-06-17 Boehringer Ingelheim Pharmaceuticals Inc. Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof
CN102229562B (zh) * 2005-09-14 2013-11-13 参天制药株式会社 具有糖皮质激素受体结合活性的1,2-二氢喹啉衍生物
MX2011013679A (es) 2009-06-16 2012-01-20 Schering Corp Esteroides de heteroarilo [3.2-c] novedosos como agonistas de receptor de glucocorticoide composiciones y uso de los mismos.
CA2769563A1 (en) 2009-07-31 2011-02-10 Cadila Healthcare Limited Novel compounds as modulators of glucocorticoid receptors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0800519T3 (da) * 1994-12-22 2004-03-01 Ligand Pharm Inc Steroidreceptormodulatorforbindelser og fremgangsmåder

Also Published As

Publication number Publication date
EP1053239A1 (en) 2000-11-22
WO1999041256A1 (en) 1999-08-19
SK284689B6 (sk) 2005-09-08
NO20004053L (no) 2000-09-11
DK1053239T3 (da) 2003-04-22
IL137508A0 (en) 2001-07-24
PL343018A1 (en) 2001-07-30
PL193323B1 (pl) 2007-02-28
AU766441B2 (en) 2003-10-16
BR9907788A (pt) 2001-10-30
JP2002503665A (ja) 2002-02-05
CA2320943A1 (en) 1999-09-19
DE69904804D1 (de) 2003-02-13
DE69904804T2 (de) 2003-11-06
HUP0100460A2 (hu) 2001-09-28
CN1296486A (zh) 2001-05-23
HUP0100460A3 (en) 2003-03-28
KR20010040935A (ko) 2001-05-15
SK11972000A3 (sk) 2001-08-06
CN1119348C (zh) 2003-08-27
ES2192035T3 (es) 2003-09-16
NO20004053D0 (no) 2000-08-11
EP1053239B1 (en) 2003-01-08
BG104719A (en) 2001-05-31
TR200003094T2 (tr) 2001-01-22
HK1033308A1 (en) 2001-08-24
AU2677399A (en) 1999-08-30
NZ506013A (en) 2003-03-28
ATE230749T1 (de) 2003-01-15

Similar Documents

Publication Publication Date Title
BG64317B1 (bg) Глюкокортикоид-селективни противовъзпалителни средства
US6506766B1 (en) Glucocortiocoid-selective antinflammatory agents
CN111032034B (zh) 螺环化合物及其制造和使用方法
EP3686196B1 (en) Polycyclic compound acting as ido inhibitor and/or ido-hdac dual inhibitor
EP2041142B1 (de) Spirocyclische azaindol-derivate
AU760511B2 (en) Glucocorticoid-selective antiinflammatory agents
SG192248A1 (en) Pyrrolopyrazine-spirocyclic piperidine amides as modulators of ion channels
RO120136B1 (ro) Derivaţi de benzazepină, compoziţie farmaceutică şi utilizarea acestora pentru tratamentul bolii alzheimer şi a trisomiei
TW200808808A (en) Antagonists of the vanilloid receptor subtype 1 (VR1) and uses thereof
EA027113B1 (ru) Регуляторы пути комплемента и их применение
CN109516982A (zh) μ-阿片受体激动剂及其制备方法和在医药领域的应用
JP2023539194A (ja) Ａｐｏｌ１の阻害剤およびこれを使用する方法
EP0989987A1 (en) Spiro-azacyclic derivatives and their use as therapeutic agents
AU2014300629A1 (en) Chromane and chromene derivatives and their use as CRAC modulators
KR20180109871A (ko) 아졸로 치환된 피리딘 화합물
TW214547B (hu)
AU2013240007A1 (en) Schweinfurthin analogues
KR0182296B1 (ko) 헥사하이드로피롤로[2,3-b]인돌-카바메이트, -우레아, -아미드 및 관련 화합물과 이를 함유하는 약제학적 조성물
AU2015255181A1 (en) Spiro-cyclic amine derivatives as s1p modulators
CZ20002893A3 (cs) Glukokortikoidně selektivní protizánětlivé látky
MXPA00007944A (en) Glucocorticoid-selective anti-inflammatory agents
US12103915B2 (en) TEAD inhibitors and methods of uses thereof
CA2362272A1 (en) Spirocyclic ketones and their use as tachykinin antagonists
KR100768245B1 (ko) 신규한 갈란타민 유도체 및 유사체
WO2023141593A2 (en) Process for synthesis of galbulimima alkaloid 18 and compounds useful as opioid receptor antagonists and agonists