BG63307B1 - Метод за получаване на сол на клавуланова киселина - Google Patents
Метод за получаване на сол на клавуланова киселина Download PDFInfo
- Publication number
- BG63307B1 BG63307B1 BG100765A BG10076596A BG63307B1 BG 63307 B1 BG63307 B1 BG 63307B1 BG 100765 A BG100765 A BG 100765A BG 10076596 A BG10076596 A BG 10076596A BG 63307 B1 BG63307 B1 BG 63307B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- clavulanic acid
- salt
- solution
- water
- organic solvent
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB9401969A GB9401969D0 (en) | 1994-02-02 | 1994-02-02 | Process |
PCT/GB1995/000191 WO1995021173A1 (en) | 1994-02-02 | 1995-01-31 | Process for the preparation of a salt of clavulanic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
BG100765A BG100765A (en) | 1997-09-30 |
BG63307B1 true BG63307B1 (bg) | 2001-09-28 |
Family
ID=10749727
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BG100765A BG63307B1 (bg) | 1994-02-02 | 1996-08-01 | Метод за получаване на сол на клавуланова киселина |
Country Status (32)
Country | Link |
---|---|
US (1) | US5965728A (fi) |
EP (1) | EP0741732B1 (fi) |
JP (1) | JP4074336B2 (fi) |
KR (1) | KR100388769B1 (fi) |
CN (1) | CN1065246C (fi) |
AP (1) | AP610A (fi) |
AT (1) | ATE202358T1 (fi) |
AU (1) | AU688849B2 (fi) |
BG (1) | BG63307B1 (fi) |
BR (1) | BR9506919A (fi) |
CA (1) | CA2182504C (fi) |
CZ (1) | CZ294005B6 (fi) |
DE (1) | DE69521415T2 (fi) |
DK (1) | DK0741732T3 (fi) |
ES (1) | ES2159626T3 (fi) |
FI (1) | FI111949B (fi) |
GB (1) | GB9401969D0 (fi) |
GR (1) | GR3036602T3 (fi) |
HK (1) | HK1012373A1 (fi) |
HU (1) | HU226597B1 (fi) |
MX (1) | MX9603204A (fi) |
NO (1) | NO314505B1 (fi) |
NZ (1) | NZ278927A (fi) |
OA (1) | OA10587A (fi) |
PL (1) | PL181451B1 (fi) |
PT (1) | PT741732E (fi) |
RO (1) | RO115730B1 (fi) |
RU (1) | RU2140418C1 (fi) |
SI (1) | SI0741732T1 (fi) |
SK (1) | SK282544B6 (fi) |
UA (1) | UA48944C2 (fi) |
WO (1) | WO1995021173A1 (fi) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AT400033B (de) | 1992-03-10 | 1995-09-25 | Biochemie Gmbh | Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben |
SI9400107A (en) | 1994-03-02 | 1995-10-31 | Lek Tovarna Farmacevtskih | New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804. |
GB9500977D0 (en) * | 1995-01-19 | 1995-03-08 | Smithkline Beecham Plc | Novel process |
SI9500134B (sl) | 1995-04-20 | 2004-04-30 | Lek, | Postopek za pripravo čistih alkalijskih soli klavulanske kisline |
GB9515809D0 (en) * | 1995-08-02 | 1995-10-04 | Smithkline Beecham Plc | Process |
AT403375B (de) * | 1995-11-15 | 1998-01-26 | Biochemie Gmbh | Verfahren zur fällung von alkalisalzen der clavulansäure |
US6414142B1 (en) | 1996-06-13 | 2002-07-02 | Smithkline Beecham Corporation | Process for preparing potassium clavulanate |
WO1998042858A1 (en) * | 1997-03-24 | 1998-10-01 | Cipan-Companhia Industrial Produtora De Antibióticos, S.A. | Process for the isolation of a pharmaceutically acceptable alkali metal salt of clavulanic acid |
PT867515E (pt) | 1997-03-24 | 2000-05-31 | Cipan Companhia Ind P De Antib | Processo para isolar um sal de acido clavulanico e de um metal alcalino farmaceuticamente aceitavel |
DZ2456A1 (fr) | 1997-04-04 | 2003-01-18 | Smithkline Beecham Plc | Procédé de préparation de sels de l'acide clavulanique. |
SI1412078T1 (sl) | 2001-08-02 | 2009-04-30 | Lg Life Sciences Ltd Lg Twin T | Postopki za pripravo amino-zaščitenih derivatov 4-aminometilen-pirolidin-3-ona, gemifloksacina ali njegove soli |
JP2019527214A (ja) | 2016-07-14 | 2019-09-26 | アカオジェン インコーポレイテッド | 細菌感染症の処置における使用のためのセフチブテンとクラブラン酸の組み合わせ |
CN108822134B (zh) * | 2018-04-25 | 2021-06-25 | 国药集团威奇达药业有限公司 | 克拉维酸叔丁胺盐的制备方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1508977A (en) * | 1974-04-20 | 1978-04-26 | Beecham Group Ltd | Beta-lactam antibiotic from streptomyces clavuligerus |
GB1563103A (en) * | 1975-10-13 | 1980-03-19 | Beecham Group Ltd | Process for the preparation of clavulanic acid |
DE3063683D1 (en) * | 1979-08-24 | 1983-07-14 | Beecham Group Plc | Amine salt of clavulanic acid, its preparation and use |
GB8404749D0 (en) * | 1984-02-23 | 1984-03-28 | Atomic Energy Authority Uk | Fluidic contactor |
-
1994
- 1994-02-02 GB GB9401969A patent/GB9401969D0/en active Pending
-
1995
- 1995-01-31 CZ CZ19962294A patent/CZ294005B6/cs not_active IP Right Cessation
- 1995-01-31 AU AU15412/95A patent/AU688849B2/en not_active Ceased
- 1995-01-31 DE DE69521415T patent/DE69521415T2/de not_active Expired - Lifetime
- 1995-01-31 PL PL95315782A patent/PL181451B1/pl not_active IP Right Cessation
- 1995-01-31 AP APAP/P/1996/000838A patent/AP610A/en active
- 1995-01-31 UA UA96083392A patent/UA48944C2/uk unknown
- 1995-01-31 EP EP95907075A patent/EP0741732B1/en not_active Expired - Lifetime
- 1995-01-31 SI SI9530525T patent/SI0741732T1/xx unknown
- 1995-01-31 RU RU96117347A patent/RU2140418C1/ru not_active IP Right Cessation
- 1995-01-31 BR BR9506919A patent/BR9506919A/pt not_active Application Discontinuation
- 1995-01-31 KR KR1019960704202A patent/KR100388769B1/ko not_active IP Right Cessation
- 1995-01-31 MX MX9603204A patent/MX9603204A/es not_active IP Right Cessation
- 1995-01-31 NZ NZ278927A patent/NZ278927A/en not_active IP Right Cessation
- 1995-01-31 JP JP52044595A patent/JP4074336B2/ja not_active Expired - Fee Related
- 1995-01-31 CN CN95192179A patent/CN1065246C/zh not_active Expired - Fee Related
- 1995-01-31 US US08/663,158 patent/US5965728A/en not_active Expired - Lifetime
- 1995-01-31 ES ES95907075T patent/ES2159626T3/es not_active Expired - Lifetime
- 1995-01-31 PT PT95907075T patent/PT741732E/pt unknown
- 1995-01-31 DK DK95907075T patent/DK0741732T3/da active
- 1995-01-31 RO RO96-01582A patent/RO115730B1/ro unknown
- 1995-01-31 HU HU9602128A patent/HU226597B1/hu not_active IP Right Cessation
- 1995-01-31 WO PCT/GB1995/000191 patent/WO1995021173A1/en active IP Right Grant
- 1995-01-31 SK SK1003-96A patent/SK282544B6/sk not_active IP Right Cessation
- 1995-01-31 AT AT95907075T patent/ATE202358T1/de not_active IP Right Cessation
- 1995-01-31 CA CA002182504A patent/CA2182504C/en not_active Expired - Fee Related
-
1996
- 1996-08-01 BG BG100765A patent/BG63307B1/bg unknown
- 1996-08-01 NO NO19963217A patent/NO314505B1/no not_active IP Right Cessation
- 1996-08-01 FI FI963050A patent/FI111949B/fi active
- 1996-08-02 OA OA60872A patent/OA10587A/en unknown
-
1998
- 1998-12-16 HK HK98113569A patent/HK1012373A1/xx not_active IP Right Cessation
-
2001
- 2001-09-12 GR GR20010401463T patent/GR3036602T3/el not_active IP Right Cessation
Also Published As
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