BG62964B1 - Нови таксоиди, получаването им и фармацевтични състави, които ги съдържат - Google Patents

Нови таксоиди, получаването им и фармацевтични състави, които ги съдържат Download PDF

Info

Publication number
BG62964B1
BG62964B1 BG101940A BG10194097A BG62964B1 BG 62964 B1 BG62964 B1 BG 62964B1 BG 101940 A BG101940 A BG 101940A BG 10194097 A BG10194097 A BG 10194097A BG 62964 B1 BG62964 B1 BG 62964B1
Authority
BG
Bulgaria
Prior art keywords
radical
carbon atoms
phenyl
alkyl
atoms
Prior art date
Application number
BG101940A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG101940A (en
Inventor
Herve Bouchard
Jean-Dominique Bourzat
Alain Commercon
Original Assignee
Rhone-Poulenc Rorer S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone-Poulenc Rorer S.A. filed Critical Rhone-Poulenc Rorer S.A.
Publication of BG101940A publication Critical patent/BG101940A/xx
Publication of BG62964B1 publication Critical patent/BG62964B1/bg

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D305/00Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines Containing Plant Substances (AREA)
BG101940A 1995-04-03 1997-10-03 Нови таксоиди, получаването им и фармацевтични състави, които ги съдържат BG62964B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9503868A FR2732342B1 (fr) 1995-04-03 1995-04-03 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR1996/000487 WO1996031493A1 (fr) 1995-04-03 1996-04-01 Nouveaux taxoïdes, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
BG101940A BG101940A (en) 1998-11-30
BG62964B1 true BG62964B1 (bg) 2000-12-29

Family

ID=9477663

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101940A BG62964B1 (bg) 1995-04-03 1997-10-03 Нови таксоиди, получаването им и фармацевтични състави, които ги съдържат

Country Status (32)

Country Link
US (1) US5959125A (de)
EP (1) EP0821680B1 (de)
JP (1) JPH11504004A (de)
KR (1) KR19980703520A (de)
CN (1) CN1073106C (de)
AP (1) AP784A (de)
AR (1) AR002730A1 (de)
AT (1) ATE195940T1 (de)
AU (1) AU703918B2 (de)
BG (1) BG62964B1 (de)
BR (1) BR9604799A (de)
CA (1) CA2214322C (de)
CZ (1) CZ287430B6 (de)
DE (1) DE69610085T2 (de)
DK (1) DK0821680T3 (de)
EA (1) EA000726B1 (de)
ES (1) ES2151155T3 (de)
FR (1) FR2732342B1 (de)
GE (1) GEP19991872B (de)
GR (1) GR3034203T3 (de)
HU (1) HUP9802042A3 (de)
IL (1) IL117760A (de)
MX (1) MX9707427A (de)
NO (1) NO974563L (de)
NZ (1) NZ305898A (de)
PL (1) PL322581A1 (de)
PT (1) PT821680E (de)
RO (1) RO115879B1 (de)
SK (1) SK282047B6 (de)
TW (1) TW347389B (de)
WO (1) WO1996031493A1 (de)
ZA (1) ZA962633B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
FR2764118B1 (fr) * 1997-05-30 2000-08-04 Thomson Csf Transistor bipolaire stabilise avec elements isolants electriques
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
JP2002543127A (ja) * 1999-05-03 2002-12-17 アベンテイス・フアルマ・ソシエテ・アノニム 脳内の異常な細胞の増殖を処置する方法
PL350028A1 (en) * 2000-02-02 2002-10-21 Univ Florida State Res Found C10 carbonate substituted taxanes as antitumor agents
US6649632B2 (en) * 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
US6596737B2 (en) * 2000-02-02 2003-07-22 Fsu Research Foundation, Inc. C10 carbamoyloxy substituted taxanes
JP2004339475A (ja) * 2003-02-03 2004-12-02 Merck Patent Gmbh フッ化物、オキシフッ化物、フルオロ硫化物および/またはオキシフルオロ硫化物に基づく真珠光沢顔料
CA2526278A1 (en) * 2003-05-20 2004-12-02 Aronex Pharmaceuticals, Inc. Combination chemotherapy comprising a liposomal platinum complex
PE20050693A1 (es) 2004-02-13 2005-09-27 Univ Florida State Res Found Taxanos sustituidos con esteres de ciclopentilo en c10
US20060189679A1 (en) * 2005-02-14 2006-08-24 Florida State University Research Foundation, Inc. C10 cyclopropyl ester substituted taxane compositions
JP2011517455A (ja) * 2008-03-31 2011-06-09 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド C(10)エチルエステルおよびc(10)シクロプロピルエステル置換タキサン

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2211861T3 (es) * 1992-07-01 2004-07-16 Bristol-Myers Squibb Company 7,8-ciclopropataxanos de accion antitumoral.
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
IL107950A (en) * 1992-12-15 2001-04-30 Upjohn Co b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them

Also Published As

Publication number Publication date
SK282047B6 (sk) 2001-10-08
DE69610085T2 (de) 2001-01-11
JPH11504004A (ja) 1999-04-06
CN1073106C (zh) 2001-10-17
EP0821680A1 (de) 1998-02-04
ES2151155T3 (es) 2000-12-16
HUP9802042A2 (hu) 2000-06-28
PL322581A1 (en) 1998-02-02
CN1179777A (zh) 1998-04-22
HUP9802042A3 (en) 2001-02-28
BG101940A (en) 1998-11-30
GR3034203T3 (en) 2000-11-30
ATE195940T1 (de) 2000-09-15
MX9707427A (es) 1998-02-28
AU5402896A (en) 1996-10-23
EP0821680B1 (de) 2000-08-30
DK0821680T3 (da) 2000-11-20
FR2732342A1 (fr) 1996-10-04
SK133397A3 (en) 1998-02-04
NO974563L (no) 1997-11-24
RO115879B1 (ro) 2000-07-28
FR2732342B1 (fr) 1997-04-30
NZ305898A (en) 1998-12-23
NO974563D0 (no) 1997-10-02
PT821680E (pt) 2000-12-29
AU703918B2 (en) 1999-04-01
EA199700288A1 (ru) 1998-04-30
IL117760A0 (en) 1996-08-04
EA000726B1 (ru) 2000-02-28
AP9701094A0 (en) 1997-10-31
WO1996031493A1 (fr) 1996-10-10
AR002730A1 (es) 1998-04-29
CA2214322A1 (fr) 1996-10-10
BR9604799A (pt) 1999-04-06
GEP19991872B (en) 1999-12-06
IL117760A (en) 2001-11-25
US5959125A (en) 1999-09-28
CZ310997A3 (cs) 1998-01-14
DE69610085D1 (de) 2000-10-05
ZA962633B (en) 1996-10-07
CZ287430B6 (en) 2000-11-15
AP784A (en) 1999-11-22
TW347389B (en) 1998-12-11
CA2214322C (fr) 2007-01-30
KR19980703520A (ko) 1998-11-05

Similar Documents

Publication Publication Date Title
AP753A (en) Novel taxoids, preparation thereof and pharmaceutical compositions containing same.
US5847170A (en) Taxoids, their preparation and pharmaceutical compositions containing them
RU2139864C1 (ru) Таксоиды, способы их получения, промежуточные соединения и фармацевтическая композиция
BG63204B1 (bg) Нови таксоиди, получаването им и фармацевтични състави, които ги съдържат
BG62964B1 (bg) Нови таксоиди, получаването им и фармацевтични състави, които ги съдържат
AP1023A (en) Taxoids, preparation thereof and pharmaceutical compositions containing same.
SK68195A3 (en) Taxane derivatives, method of their preparation and pharmaceutical agents containing these derivatives
US6372780B2 (en) Methods of treating cell lines expressing multidrug resistance P-glycoprotein
US5840931A (en) Taxoids, their preparation and pharmaceutical compositions containing them
MXPA97007427A (en) New taxoids, its preparation and the pharmaceutical compositions that contain them
US5968931A (en) Taxoids, preparation thereof and pharmaceutical compositions containing same
RU2144920C1 (ru) Таксоиды, способ их получения и фармацевтическая композиция на их основе
MXPA97002742A (en) New taxoids, its preparation and the pharmaceutical compositions that contain them