ES2151155T3 - Nuevos taxoides, su preparacion y las composiciones farmaceuticas que les contienen. - Google Patents

Nuevos taxoides, su preparacion y las composiciones farmaceuticas que les contienen.

Info

Publication number
ES2151155T3
ES2151155T3 ES96911009T ES96911009T ES2151155T3 ES 2151155 T3 ES2151155 T3 ES 2151155T3 ES 96911009 T ES96911009 T ES 96911009T ES 96911009 T ES96911009 T ES 96911009T ES 2151155 T3 ES2151155 T3 ES 2151155T3
Authority
ES
Spain
Prior art keywords
radical
general formula
sub
contain
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96911009T
Other languages
English (en)
Inventor
Herve Bouchard
Jean-Dominique Bourzat
Alain Commercon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Application granted granted Critical
Publication of ES2151155T3 publication Critical patent/ES2151155T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

NUEVOS TAXOIDES DE FORMULA GENERAL (I) EN LA QUE: R REPRESENTA UN RADICAL ALCOILO SUSTITUIDO O UN RADICAL ALCENILO, ALCINILO, CICLOALCOILO, CICLOALCENILO EVENTUALMENTE SUSTITUIDO, FENILO O UN RADICAL HETEROCICLICO AROMATICO O NO QUE TIENE 5 O 6 ESLABONES; Z REPRESENTA UN ATOMO DE HIDROGENO O UN RADICAL DE FORMULA GENERAL (II), EN LA QUE R SUB,1} REPRESENTA UN RADICAL BENZOILO, EVENTUALMENTE SUSTITUIDO, TENOILO O FUROILO O UN RADICAL R SUB,2} ICAL ALCOILO, ALCENILO, ALCINILO, CICLOALCOILO, CICLOALCENILO, BICICLOALCOILO, FENILO EVENTUALMENTE SUSTITUIDO O HETEROCICLILO, R SUB,3} REPRESENTA UN RADICAL ALCOILO, ALCENILO, ALCINILO, CICLOALCOILO, FENILO, NAFTILO O HETEROCICLICO AROMATICO. LOS NUEVOS PRODUCTOS DE FORMULA GENERAL (I) EN LA QUE Z REPRESENTA UN RADICAL DE FORMULA GENERAL (II) PRESENTAN UNA NOTABLE ACTIVIDAD ANTITUMORAL.
ES96911009T 1995-04-03 1996-04-01 Nuevos taxoides, su preparacion y las composiciones farmaceuticas que les contienen. Expired - Lifetime ES2151155T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9503868A FR2732342B1 (fr) 1995-04-03 1995-04-03 Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
ES2151155T3 true ES2151155T3 (es) 2000-12-16

Family

ID=9477663

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96911009T Expired - Lifetime ES2151155T3 (es) 1995-04-03 1996-04-01 Nuevos taxoides, su preparacion y las composiciones farmaceuticas que les contienen.

Country Status (32)

Country Link
US (1) US5959125A (es)
EP (1) EP0821680B1 (es)
JP (1) JPH11504004A (es)
KR (1) KR19980703520A (es)
CN (1) CN1073106C (es)
AP (1) AP784A (es)
AR (1) AR002730A1 (es)
AT (1) ATE195940T1 (es)
AU (1) AU703918B2 (es)
BG (1) BG62964B1 (es)
BR (1) BR9604799A (es)
CA (1) CA2214322C (es)
CZ (1) CZ287430B6 (es)
DE (1) DE69610085T2 (es)
DK (1) DK0821680T3 (es)
EA (1) EA000726B1 (es)
ES (1) ES2151155T3 (es)
FR (1) FR2732342B1 (es)
GE (1) GEP19991872B (es)
GR (1) GR3034203T3 (es)
HU (1) HUP9802042A3 (es)
IL (1) IL117760A (es)
MX (1) MX9707427A (es)
NO (1) NO974563L (es)
NZ (1) NZ305898A (es)
PL (1) PL322581A1 (es)
PT (1) PT821680E (es)
RO (1) RO115879B1 (es)
SK (1) SK282047B6 (es)
TW (1) TW347389B (es)
WO (1) WO1996031493A1 (es)
ZA (1) ZA962633B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6495579B1 (en) 1996-12-02 2002-12-17 Angiotech Pharmaceuticals, Inc. Method for treating multiple sclerosis
FR2764118B1 (fr) * 1997-05-30 2000-08-04 Thomson Csf Transistor bipolaire stabilise avec elements isolants electriques
US6156789A (en) * 1998-03-17 2000-12-05 Rhone-Poulenc Rorer S.A. Method for treating abnormal cell proliferation in the brain
CA2365776A1 (en) * 1999-05-03 2000-11-09 Alain Renard Method for treating abnormal cell proliferation in the brain
US6649632B2 (en) 2000-02-02 2003-11-18 Fsu Research Foundation, Inc. C10 ester substituted taxanes
CA2368151A1 (en) 2000-02-02 2001-08-09 Florida State University Research Foundation, Inc. C10 carbonate substituted taxanes as antitumor agents
JP2003522173A (ja) * 2000-02-02 2003-07-22 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド 抗腫瘍剤としてのｃ１０カルバモイルオキシ置換タキサン
JP2004339475A (ja) * 2003-02-03 2004-12-02 Merck Patent Gmbh フッ化物、オキシフッ化物、フルオロ硫化物および／またはオキシフルオロ硫化物に基づく真珠光沢顔料
EP1663153A4 (en) * 2003-05-20 2011-01-05 Aronex Pharmaceuticals Inc COMBINATION SCHEMOTHERAPY WITH A LIPOSOMAL PLATINUM COMPLEX
HN2005000054A (es) * 2004-02-13 2009-02-18 Florida State University Foundation Inc Taxanos sustituidos con esteres de ciclopentilo en c10
MX2007009748A (es) * 2005-02-14 2007-09-26 Univ Florida State Res Found Composiciones de taxano sustituidas con esteres ciclopropilicos en c10.
JP2011517455A (ja) * 2008-03-31 2011-06-09 フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド Ｃ（１０）エチルエステルおよびｃ（１０）シクロプロピルエステル置換タキサン

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5254580A (en) * 1993-01-19 1993-10-19 Bristol-Myers Squibb Company 7,8-cyclopropataxanes
AU656475B2 (en) * 1992-07-01 1995-02-02 Bristol-Myers Squibb Company Fluoro taxols
FR2698871B1 (fr) * 1992-12-09 1995-02-24 Rhone Poulenc Rorer Sa Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent.
IL107950A (en) * 1992-12-15 2001-04-30 Upjohn Co b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them

Also Published As

Publication number Publication date
AP784A (en) 1999-11-22
CA2214322A1 (fr) 1996-10-10
NO974563D0 (no) 1997-10-02
IL117760A0 (en) 1996-08-04
FR2732342A1 (fr) 1996-10-04
CA2214322C (fr) 2007-01-30
EP0821680A1 (fr) 1998-02-04
AP9701094A0 (en) 1997-10-31
AR002730A1 (es) 1998-04-29
WO1996031493A1 (fr) 1996-10-10
GR3034203T3 (en) 2000-11-30
ZA962633B (en) 1996-10-07
KR19980703520A (ko) 1998-11-05
CN1179777A (zh) 1998-04-22
SK282047B6 (sk) 2001-10-08
CZ310997A3 (cs) 1998-01-14
CN1073106C (zh) 2001-10-17
DK0821680T3 (da) 2000-11-20
HUP9802042A3 (en) 2001-02-28
EP0821680B1 (fr) 2000-08-30
AU703918B2 (en) 1999-04-01
MX9707427A (es) 1998-02-28
BR9604799A (pt) 1999-04-06
HUP9802042A2 (hu) 2000-06-28
NZ305898A (en) 1998-12-23
SK133397A3 (en) 1998-02-04
DE69610085T2 (de) 2001-01-11
US5959125A (en) 1999-09-28
EA199700288A1 (ru) 1998-04-30
TW347389B (en) 1998-12-11
GEP19991872B (en) 1999-12-06
JPH11504004A (ja) 1999-04-06
PL322581A1 (en) 1998-02-02
IL117760A (en) 2001-11-25
DE69610085D1 (de) 2000-10-05
BG62964B1 (bg) 2000-12-29
AU5402896A (en) 1996-10-23
NO974563L (no) 1997-11-24
PT821680E (pt) 2000-12-29
EA000726B1 (ru) 2000-02-28
ATE195940T1 (de) 2000-09-15
BG101940A (en) 1998-11-30
FR2732342B1 (fr) 1997-04-30
CZ287430B6 (en) 2000-11-15
RO115879B1 (ro) 2000-07-28

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