ES2151155T3 - NEW TAXOIDS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. - Google Patents
NEW TAXOIDS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM.Info
- Publication number
- ES2151155T3 ES2151155T3 ES96911009T ES96911009T ES2151155T3 ES 2151155 T3 ES2151155 T3 ES 2151155T3 ES 96911009 T ES96911009 T ES 96911009T ES 96911009 T ES96911009 T ES 96911009T ES 2151155 T3 ES2151155 T3 ES 2151155T3
- Authority
- ES
- Spain
- Prior art keywords
- radical
- general formula
- sub
- contain
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
NUEVOS TAXOIDES DE FORMULA GENERAL (I) EN LA QUE: R REPRESENTA UN RADICAL ALCOILO SUSTITUIDO O UN RADICAL ALCENILO, ALCINILO, CICLOALCOILO, CICLOALCENILO EVENTUALMENTE SUSTITUIDO, FENILO O UN RADICAL HETEROCICLICO AROMATICO O NO QUE TIENE 5 O 6 ESLABONES; Z REPRESENTA UN ATOMO DE HIDROGENO O UN RADICAL DE FORMULA GENERAL (II), EN LA QUE R SUB,1} REPRESENTA UN RADICAL BENZOILO, EVENTUALMENTE SUSTITUIDO, TENOILO O FUROILO O UN RADICAL R SUB,2} ICAL ALCOILO, ALCENILO, ALCINILO, CICLOALCOILO, CICLOALCENILO, BICICLOALCOILO, FENILO EVENTUALMENTE SUSTITUIDO O HETEROCICLILO, R SUB,3} REPRESENTA UN RADICAL ALCOILO, ALCENILO, ALCINILO, CICLOALCOILO, FENILO, NAFTILO O HETEROCICLICO AROMATICO. LOS NUEVOS PRODUCTOS DE FORMULA GENERAL (I) EN LA QUE Z REPRESENTA UN RADICAL DE FORMULA GENERAL (II) PRESENTAN UNA NOTABLE ACTIVIDAD ANTITUMORAL.NEW GENERAL FORMULA TAXOIDS (I) IN WHICH: R REPRESENTS A SUBSTITUTED RADICAL ALCOYL OR A RADICAL ALCHENYL, ALCINYL, EVENTUALLY SUBSTITUTED CYCLOALCENYL, PHENYL, OR A NON-AROMATIC HETERO-CYCLE-6 OR Z REPRESENTS A HYDROGEN ATOMO OR A RADICAL OF GENERAL FORMULA (II), IN WHICH R SUB, 1} REPRESENTS A RADICAL BENZOIL, EVENTUALLY SUBSTITUTED, TENOIL OR FUROIL, OR A RADICAL R SUB, 2} ICAL ALCOILO, ALCENILO, ALCINILO CYCLLOALCOYL, CYCLLOALCENYL, BICYCLOALCOYL, PHENYL EVENTUALLY SUBSTITUTED OR HETEROCICLYL, R SUB, 3} REPRESENTS A RADICAL ALCOYL, ALCYNYL, ALCINYL, CYCLOALCOYL, FENYL, NAPHTHYL OR HETHYL THE NEW PRODUCTS OF GENERAL FORMULA (I) IN WHICH Z REPRESENTS A RADICAL OF GENERAL FORMULA (II) PRESENT A REMARKABLE ANTI-TUMOR ACTIVITY.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9503868A FR2732342B1 (en) | 1995-04-03 | 1995-04-03 | NOVEL TAXOIDS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2151155T3 true ES2151155T3 (en) | 2000-12-16 |
Family
ID=9477663
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES96911009T Expired - Lifetime ES2151155T3 (en) | 1995-04-03 | 1996-04-01 | NEW TAXOIDS, THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM. |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US5959125A (en) |
| EP (1) | EP0821680B1 (en) |
| JP (1) | JPH11504004A (en) |
| KR (1) | KR19980703520A (en) |
| CN (1) | CN1073106C (en) |
| AP (1) | AP784A (en) |
| AR (1) | AR002730A1 (en) |
| AT (1) | ATE195940T1 (en) |
| AU (1) | AU703918B2 (en) |
| BG (1) | BG62964B1 (en) |
| BR (1) | BR9604799A (en) |
| CA (1) | CA2214322C (en) |
| CZ (1) | CZ287430B6 (en) |
| DE (1) | DE69610085T2 (en) |
| DK (1) | DK0821680T3 (en) |
| EA (1) | EA000726B1 (en) |
| ES (1) | ES2151155T3 (en) |
| FR (1) | FR2732342B1 (en) |
| GE (1) | GEP19991872B (en) |
| GR (1) | GR3034203T3 (en) |
| HU (1) | HUP9802042A3 (en) |
| IL (1) | IL117760A (en) |
| MX (1) | MX9707427A (en) |
| NO (1) | NO974563L (en) |
| NZ (1) | NZ305898A (en) |
| PL (1) | PL322581A1 (en) |
| PT (1) | PT821680E (en) |
| RO (1) | RO115879B1 (en) |
| SK (1) | SK282047B6 (en) |
| TW (1) | TW347389B (en) |
| WO (1) | WO1996031493A1 (en) |
| ZA (1) | ZA962633B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6495579B1 (en) | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
| FR2764118B1 (en) * | 1997-05-30 | 2000-08-04 | Thomson Csf | STABILIZED BIPOLAR TRANSISTOR WITH ELECTRICAL INSULATING ELEMENTS |
| US6156789A (en) * | 1998-03-17 | 2000-12-05 | Rhone-Poulenc Rorer S.A. | Method for treating abnormal cell proliferation in the brain |
| CA2365776A1 (en) * | 1999-05-03 | 2000-11-09 | Alain Renard | Method for treating abnormal cell proliferation in the brain |
| CZ20013405A3 (en) * | 2000-02-02 | 2002-03-13 | Florida State University Research Foundation, Inc. | C10 carbonate substituted taxanes functioning as antitumor agents |
| ATE401325T1 (en) * | 2000-02-02 | 2008-08-15 | Univ Florida State Res Found | C10-CARBAMOYLOXY SUBSTITUTED TAXANES AS ANTI-TUMOR AGENTS |
| US6649632B2 (en) | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
| JP2004339475A (en) * | 2003-02-03 | 2004-12-02 | Merck Patent Gmbh | Pearlescent pigment based on fluoride, oxyfluoride, fluorosulfide and/or oxyfluorosulfide |
| CA2526278A1 (en) * | 2003-05-20 | 2004-12-02 | Aronex Pharmaceuticals, Inc. | Combination chemotherapy comprising a liposomal platinum complex |
| HN2005000054A (en) | 2004-02-13 | 2009-02-18 | Florida State University Foundation Inc | REPLACED TAXANS WITH CYCLOPENTILO ESTERS IN C10 |
| WO2006088767A2 (en) * | 2005-02-14 | 2006-08-24 | Florida State University Research Foundation, Inc. | C10 cyclopropyl ester substituted taxane compositions |
| JP2011517455A (en) * | 2008-03-31 | 2011-06-09 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | C (10) ethyl ester and C (10) cyclopropyl ester substituted taxanes |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0577082B1 (en) * | 1992-07-01 | 1996-04-10 | Bristol-Myers Squibb Company | Fluoro taxols with antitumor activity |
| US5254580A (en) * | 1993-01-19 | 1993-10-19 | Bristol-Myers Squibb Company | 7,8-cyclopropataxanes |
| FR2698871B1 (en) * | 1992-12-09 | 1995-02-24 | Rhone Poulenc Rorer Sa | New taxoids, their preparation and the pharmaceutical compositions containing them. |
| IL107950A (en) * | 1992-12-15 | 2001-04-30 | Upjohn Co | 7β, 8β - METHANO-TAXOLS, THEIR PREPARATION AND ANTINEOPLASTIC PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
-
1995
- 1995-04-03 FR FR9503868A patent/FR2732342B1/en not_active Expired - Fee Related
-
1996
- 1996-04-01 US US08/930,561 patent/US5959125A/en not_active Expired - Fee Related
- 1996-04-01 AP APAP/P/1997/001094A patent/AP784A/en active
- 1996-04-01 DE DE69610085T patent/DE69610085T2/en not_active Expired - Fee Related
- 1996-04-01 AT AT96911009T patent/ATE195940T1/en not_active IP Right Cessation
- 1996-04-01 JP JP8530026A patent/JPH11504004A/en not_active Ceased
- 1996-04-01 IL IL11776096A patent/IL117760A/en not_active IP Right Cessation
- 1996-04-01 CN CN96192946A patent/CN1073106C/en not_active Expired - Fee Related
- 1996-04-01 HU HU9802042A patent/HUP9802042A3/en unknown
- 1996-04-01 PT PT96911009T patent/PT821680E/en unknown
- 1996-04-01 MX MX9707427A patent/MX9707427A/en not_active IP Right Cessation
- 1996-04-01 EA EA199700288A patent/EA000726B1/en not_active IP Right Cessation
- 1996-04-01 KR KR1019970706924A patent/KR19980703520A/en not_active Application Discontinuation
- 1996-04-01 WO PCT/FR1996/000487 patent/WO1996031493A1/en not_active Application Discontinuation
- 1996-04-01 EP EP96911009A patent/EP0821680B1/en not_active Expired - Lifetime
- 1996-04-01 RO RO97-01817A patent/RO115879B1/en unknown
- 1996-04-01 SK SK1333-97A patent/SK282047B6/en unknown
- 1996-04-01 BR BR9604799A patent/BR9604799A/en not_active Application Discontinuation
- 1996-04-01 GE GEAP19963965A patent/GEP19991872B/en unknown
- 1996-04-01 NZ NZ305898A patent/NZ305898A/en unknown
- 1996-04-01 TW TW085103805A patent/TW347389B/en active
- 1996-04-01 CA CA002214322A patent/CA2214322C/en not_active Expired - Fee Related
- 1996-04-01 AU AU54028/96A patent/AU703918B2/en not_active Ceased
- 1996-04-01 DK DK96911009T patent/DK0821680T3/en active
- 1996-04-01 CZ CZ19973109A patent/CZ287430B6/en not_active IP Right Cessation
- 1996-04-01 ES ES96911009T patent/ES2151155T3/en not_active Expired - Lifetime
- 1996-04-01 PL PL96322581A patent/PL322581A1/en unknown
- 1996-04-02 ZA ZA962633A patent/ZA962633B/en unknown
- 1996-04-03 AR ARP960102049A patent/AR002730A1/en not_active Application Discontinuation
-
1997
- 1997-10-02 NO NO974563A patent/NO974563L/en not_active Application Discontinuation
- 1997-10-03 BG BG101940A patent/BG62964B1/en unknown
-
2000
- 2000-08-31 GR GR20000400100T patent/GR3034203T3/en not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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