EA199700288A1 - Таксоиды, способы их получения и фармацевтическая композиция на их основе - Google Patents
Таксоиды, способы их получения и фармацевтическая композиция на их основеInfo
- Publication number
- EA199700288A1 EA199700288A1 EA199700288A EA199700288A EA199700288A1 EA 199700288 A1 EA199700288 A1 EA 199700288A1 EA 199700288 A EA199700288 A EA 199700288A EA 199700288 A EA199700288 A EA 199700288A EA 199700288 A1 EA199700288 A1 EA 199700288A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- radical
- general formula
- alkynyl
- cycloalkyl
- alkenyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Изобретение относится к новым таксоидам общей формулы (I)в которой R означает замещенный алкильный радикал или алкенильный, алкинильный, циклоалкильный, возможно, замещенный циклоалкенильный, фенильный радикал или ароматический или нет гетероциклический пяти- или шестичленный радикал; Z означает атом водорода или радикал общей формулы (II)в которой Rозначает, возможно, замещенный бензоильный радикал, или теноильный радикал, или фуроильный радикал, или радикал R-O-CO-, в котором Rозначает алкильный, алкенильный, алкинильный, циклоалкильный, циклоалкенильный, бициклоалкильный, возможно, замещенный фенильный или гетероциклический радикал; R- означает алкильный, алкенильный, алкинильный, циклоалкильный, фенильный, нафтильный или ароматический гетероциклиический радикал. Новые продукты общей формулы (I), в которой Z означает радикал общей формулы (II), обладают противоопухолевой активностью.Международная заявка была опубликована вместе с отчетом о международном поиске.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9503868A FR2732342B1 (fr) | 1995-04-03 | 1995-04-03 | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
PCT/FR1996/000487 WO1996031493A1 (fr) | 1995-04-03 | 1996-04-01 | Nouveaux taxoïdes, leur preparation et les compositions pharmaceutiques qui les contiennent |
Publications (2)
Publication Number | Publication Date |
---|---|
EA199700288A1 true EA199700288A1 (ru) | 1998-04-30 |
EA000726B1 EA000726B1 (ru) | 2000-02-28 |
Family
ID=9477663
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA199700288A EA000726B1 (ru) | 1995-04-03 | 1996-04-01 | Таксоиды, способы их получения и фармацевтическая композиция на их основе |
Country Status (32)
Country | Link |
---|---|
US (1) | US5959125A (ru) |
EP (1) | EP0821680B1 (ru) |
JP (1) | JPH11504004A (ru) |
KR (1) | KR19980703520A (ru) |
CN (1) | CN1073106C (ru) |
AP (1) | AP784A (ru) |
AR (1) | AR002730A1 (ru) |
AT (1) | ATE195940T1 (ru) |
AU (1) | AU703918B2 (ru) |
BG (1) | BG62964B1 (ru) |
BR (1) | BR9604799A (ru) |
CA (1) | CA2214322C (ru) |
CZ (1) | CZ287430B6 (ru) |
DE (1) | DE69610085T2 (ru) |
DK (1) | DK0821680T3 (ru) |
EA (1) | EA000726B1 (ru) |
ES (1) | ES2151155T3 (ru) |
FR (1) | FR2732342B1 (ru) |
GE (1) | GEP19991872B (ru) |
GR (1) | GR3034203T3 (ru) |
HU (1) | HUP9802042A3 (ru) |
IL (1) | IL117760A (ru) |
MX (1) | MX9707427A (ru) |
NO (1) | NO974563L (ru) |
NZ (1) | NZ305898A (ru) |
PL (1) | PL322581A1 (ru) |
PT (1) | PT821680E (ru) |
RO (1) | RO115879B1 (ru) |
SK (1) | SK282047B6 (ru) |
TW (1) | TW347389B (ru) |
WO (1) | WO1996031493A1 (ru) |
ZA (1) | ZA962633B (ru) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6495579B1 (en) | 1996-12-02 | 2002-12-17 | Angiotech Pharmaceuticals, Inc. | Method for treating multiple sclerosis |
FR2764118B1 (fr) * | 1997-05-30 | 2000-08-04 | Thomson Csf | Transistor bipolaire stabilise avec elements isolants electriques |
US6156789A (en) * | 1998-03-17 | 2000-12-05 | Rhone-Poulenc Rorer S.A. | Method for treating abnormal cell proliferation in the brain |
EP1176957A1 (en) * | 1999-05-03 | 2002-02-06 | Aventis Pharma S.A. | Method for treating abnormal cell proliferation in the brain |
JP2003522171A (ja) | 2000-02-02 | 2003-07-22 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | 抗腫瘍剤としてのc10カーボネート置換タキサン |
US6649632B2 (en) * | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
NZ514407A (en) * | 2000-02-02 | 2004-12-24 | Univ Florida State Res Found | C10 carbamoyloxy substituted taxanes as antitumor agents |
JP2004339475A (ja) * | 2003-02-03 | 2004-12-02 | Merck Patent Gmbh | フッ化物、オキシフッ化物、フルオロ硫化物および/またはオキシフルオロ硫化物に基づく真珠光沢顔料 |
CA2526278A1 (en) * | 2003-05-20 | 2004-12-02 | Aronex Pharmaceuticals, Inc. | Combination chemotherapy comprising a liposomal platinum complex |
HN2005000054A (es) | 2004-02-13 | 2009-02-18 | Florida State University Foundation Inc | Taxanos sustituidos con esteres de ciclopentilo en c10 |
AU2006214498A1 (en) * | 2005-02-14 | 2006-08-24 | Florida State University Research Foundation, Inc. | C10 cyclopropyl ester substituted taxane compositions |
JP2011517455A (ja) * | 2008-03-31 | 2011-06-09 | フロリダ・ステイト・ユニバーシティ・リサーチ・ファウンデイション・インコーポレイテッド | C(10)エチルエステルおよびc(10)シクロプロピルエステル置換タキサン |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO302520B1 (no) * | 1992-07-01 | 1998-03-16 | Bristol Myers Squibb Co | Fluortaxoler, mellomprodukt til fremstilling derav, samt farmasöytisk preparat inneholdende dem |
US5254580A (en) * | 1993-01-19 | 1993-10-19 | Bristol-Myers Squibb Company | 7,8-cyclopropataxanes |
FR2698871B1 (fr) * | 1992-12-09 | 1995-02-24 | Rhone Poulenc Rorer Sa | Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
IL107950A (en) * | 1992-12-15 | 2001-04-30 | Upjohn Co | b 7, b 8 - Matano - Taxols, their preparation and pharmaceutical preparations against malignant tumors containing them |
-
1995
- 1995-04-03 FR FR9503868A patent/FR2732342B1/fr not_active Expired - Fee Related
-
1996
- 1996-04-01 TW TW085103805A patent/TW347389B/zh active
- 1996-04-01 ES ES96911009T patent/ES2151155T3/es not_active Expired - Lifetime
- 1996-04-01 MX MX9707427A patent/MX9707427A/es not_active IP Right Cessation
- 1996-04-01 NZ NZ305898A patent/NZ305898A/xx unknown
- 1996-04-01 AP APAP/P/1997/001094A patent/AP784A/en active
- 1996-04-01 AU AU54028/96A patent/AU703918B2/en not_active Ceased
- 1996-04-01 BR BR9604799A patent/BR9604799A/pt not_active Application Discontinuation
- 1996-04-01 DE DE69610085T patent/DE69610085T2/de not_active Expired - Fee Related
- 1996-04-01 CN CN96192946A patent/CN1073106C/zh not_active Expired - Fee Related
- 1996-04-01 GE GEAP19963965A patent/GEP19991872B/en unknown
- 1996-04-01 SK SK1333-97A patent/SK282047B6/sk unknown
- 1996-04-01 KR KR1019970706924A patent/KR19980703520A/ko not_active Application Discontinuation
- 1996-04-01 US US08/930,561 patent/US5959125A/en not_active Expired - Fee Related
- 1996-04-01 IL IL11776096A patent/IL117760A/en not_active IP Right Cessation
- 1996-04-01 RO RO97-01817A patent/RO115879B1/ro unknown
- 1996-04-01 CA CA002214322A patent/CA2214322C/fr not_active Expired - Fee Related
- 1996-04-01 PT PT96911009T patent/PT821680E/pt unknown
- 1996-04-01 HU HU9802042A patent/HUP9802042A3/hu unknown
- 1996-04-01 DK DK96911009T patent/DK0821680T3/da active
- 1996-04-01 EA EA199700288A patent/EA000726B1/ru not_active IP Right Cessation
- 1996-04-01 CZ CZ19973109A patent/CZ287430B6/cs not_active IP Right Cessation
- 1996-04-01 AT AT96911009T patent/ATE195940T1/de not_active IP Right Cessation
- 1996-04-01 PL PL96322581A patent/PL322581A1/xx unknown
- 1996-04-01 JP JP8530026A patent/JPH11504004A/ja not_active Ceased
- 1996-04-01 EP EP96911009A patent/EP0821680B1/fr not_active Expired - Lifetime
- 1996-04-01 WO PCT/FR1996/000487 patent/WO1996031493A1/fr not_active Application Discontinuation
- 1996-04-02 ZA ZA962633A patent/ZA962633B/xx unknown
- 1996-04-03 AR ARP960102049A patent/AR002730A1/es not_active Application Discontinuation
-
1997
- 1997-10-02 NO NO974563A patent/NO974563L/no not_active Application Discontinuation
- 1997-10-03 BG BG101940A patent/BG62964B1/bg unknown
-
2000
- 2000-08-31 GR GR20000400100T patent/GR3034203T3/el not_active IP Right Cessation
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |