BG61039B1 - Метод за производство на клетъчна маса и/или ферментационни продукти при стерилни условия и устройство за осъществяването му - Google Patents
Метод за производство на клетъчна маса и/или ферментационни продукти при стерилни условия и устройство за осъществяването му Download PDFInfo
- Publication number
- BG61039B1 BG61039B1 BG96651A BG9665192A BG61039B1 BG 61039 B1 BG61039 B1 BG 61039B1 BG 96651 A BG96651 A BG 96651A BG 9665192 A BG9665192 A BG 9665192A BG 61039 B1 BG61039 B1 BG 61039B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- medium
- fermenter
- cell
- concentration
- culture
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 141
- 238000000855 fermentation Methods 0.000 title claims abstract description 58
- 230000004151 fermentation Effects 0.000 title claims abstract description 58
- 230000001413 cellular effect Effects 0.000 title claims 2
- 238000002360 preparation method Methods 0.000 title description 7
- 230000036961 partial effect Effects 0.000 claims abstract description 34
- 230000001954 sterilising effect Effects 0.000 claims abstract description 30
- 239000000203 mixture Substances 0.000 claims abstract description 28
- 235000015097 nutrients Nutrition 0.000 claims abstract description 24
- 230000001965 increasing effect Effects 0.000 claims abstract description 13
- 238000004113 cell culture Methods 0.000 claims abstract description 9
- 210000004027 cell Anatomy 0.000 claims abstract 16
- 210000004748 cultured cell Anatomy 0.000 claims abstract 2
- 239000002609 medium Substances 0.000 claims description 118
- 230000008569 process Effects 0.000 claims description 61
- 230000012010 growth Effects 0.000 claims description 57
- 238000004519 manufacturing process Methods 0.000 claims description 41
- 239000012141 concentrate Substances 0.000 claims description 35
- 239000001963 growth medium Substances 0.000 claims description 34
- 238000000926 separation method Methods 0.000 claims description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 27
- 238000009434 installation Methods 0.000 claims description 26
- 238000004659 sterilization and disinfection Methods 0.000 claims description 25
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 10
- 239000000523 sample Substances 0.000 claims description 10
- 230000003698 anagen phase Effects 0.000 claims description 9
- 238000001816 cooling Methods 0.000 claims description 9
- 238000011049 filling Methods 0.000 claims description 9
- 230000014759 maintenance of location Effects 0.000 claims description 7
- 229910052760 oxygen Inorganic materials 0.000 claims description 7
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 6
- 238000011081 inoculation Methods 0.000 claims description 6
- 239000001301 oxygen Substances 0.000 claims description 6
- 239000008223 sterile water Substances 0.000 claims description 6
- 241000894006 Bacteria Species 0.000 claims description 5
- 239000004310 lactic acid Substances 0.000 claims description 5
- 235000014655 lactic acid Nutrition 0.000 claims description 5
- 238000011068 loading method Methods 0.000 claims description 4
- 230000033228 biological regulation Effects 0.000 claims description 3
- 230000007613 environmental effect Effects 0.000 claims description 3
- 238000005119 centrifugation Methods 0.000 claims description 2
- 239000000654 additive Substances 0.000 claims 1
- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000002203 pretreatment Methods 0.000 claims 1
- 230000000306 recurrent effect Effects 0.000 claims 1
- 238000005507 spraying Methods 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 abstract description 27
- 230000007704 transition Effects 0.000 abstract description 11
- 230000001105 regulatory effect Effects 0.000 abstract description 8
- 238000011218 seed culture Methods 0.000 abstract description 2
- 239000000758 substrate Substances 0.000 description 77
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 49
- 239000008103 glucose Substances 0.000 description 49
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 35
- 239000000047 product Substances 0.000 description 27
- 239000012071 phase Substances 0.000 description 26
- 238000003306 harvesting Methods 0.000 description 19
- 244000005700 microbiome Species 0.000 description 18
- 230000000737 periodic effect Effects 0.000 description 16
- 238000011146 sterile filtration Methods 0.000 description 15
- 238000004886 process control Methods 0.000 description 13
- 230000010261 cell growth Effects 0.000 description 11
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 10
- 239000002028 Biomass Substances 0.000 description 8
- 241001134659 Lactobacillus curvatus Species 0.000 description 8
- 230000009471 action Effects 0.000 description 8
- 239000012528 membrane Substances 0.000 description 8
- 239000000306 component Substances 0.000 description 7
- 230000009466 transformation Effects 0.000 description 7
- 238000010790 dilution Methods 0.000 description 6
- 239000012895 dilution Substances 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- 239000007789 gas Substances 0.000 description 6
- 238000005259 measurement Methods 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 238000012546 transfer Methods 0.000 description 6
- 238000010923 batch production Methods 0.000 description 5
- 230000008901 benefit Effects 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 238000010438 heat treatment Methods 0.000 description 5
- 239000012092 media component Substances 0.000 description 5
- 238000009331 sowing Methods 0.000 description 5
- 241000191965 Staphylococcus carnosus Species 0.000 description 4
- 230000008859 change Effects 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- 238000002474 experimental method Methods 0.000 description 4
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- 238000012423 maintenance Methods 0.000 description 4
- 230000002503 metabolic effect Effects 0.000 description 4
- 239000002207 metabolite Substances 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 230000002829 reductive effect Effects 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- 241000191953 Kocuria varians Species 0.000 description 3
- 241000186660 Lactobacillus Species 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 238000004140 cleaning Methods 0.000 description 3
- 239000000498 cooling water Substances 0.000 description 3
- XGZRAKBCYZIBKP-UHFFFAOYSA-L disodium;dihydroxide Chemical compound [OH-].[OH-].[Na+].[Na+] XGZRAKBCYZIBKP-UHFFFAOYSA-L 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 230000000977 initiatory effect Effects 0.000 description 3
- 229940039696 lactobacillus Drugs 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 241000192132 Leuconostoc Species 0.000 description 2
- 241000192041 Micrococcus Species 0.000 description 2
- 241000192001 Pediococcus Species 0.000 description 2
- 241000191996 Pediococcus pentosaceus Species 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 238000010924 continuous production Methods 0.000 description 2
- 230000003111 delayed effect Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000012737 fresh medium Substances 0.000 description 2
- 239000007791 liquid phase Substances 0.000 description 2
- 239000012533 medium component Substances 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 238000005192 partition Methods 0.000 description 2
- 238000004064 recycling Methods 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 239000013049 sediment Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 238000004448 titration Methods 0.000 description 2
- 230000007306 turnover Effects 0.000 description 2
- 241000589220 Acetobacter Species 0.000 description 1
- 241000193798 Aerococcus Species 0.000 description 1
- 241000607534 Aeromonas Species 0.000 description 1
- 101100340331 Arabidopsis thaliana IDM1 gene Proteins 0.000 description 1
- 241000589154 Azotobacter group Species 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000186000 Bifidobacterium Species 0.000 description 1
- 241000046135 Cedecea Species 0.000 description 1
- 241000588923 Citrobacter Species 0.000 description 1
- 241000193403 Clostridium Species 0.000 description 1
- 241000192093 Deinococcus Species 0.000 description 1
- 241000607473 Edwardsiella <enterobacteria> Species 0.000 description 1
- 241000588914 Enterobacter Species 0.000 description 1
- 241000588698 Erwinia Species 0.000 description 1
- 241000588722 Escherichia Species 0.000 description 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 230000005526 G1 to G0 transition Effects 0.000 description 1
- 241000193789 Gemella Species 0.000 description 1
- 241000589236 Gluconobacter Species 0.000 description 1
- 241000588731 Hafnia Species 0.000 description 1
- 241000205035 Halobacteriaceae Species 0.000 description 1
- 241000588748 Klebsiella Species 0.000 description 1
- 241000588752 Kluyvera Species 0.000 description 1
- 241000589246 Legionellaceae Species 0.000 description 1
- 241000588656 Neisseriaceae Species 0.000 description 1
- 241001622836 Obesumbacterium Species 0.000 description 1
- 241000191998 Pediococcus acidilactici Species 0.000 description 1
- 241000206591 Peptococcus Species 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 241000588768 Providencia Species 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 241001633102 Rhizobiaceae Species 0.000 description 1
- 241000192031 Ruminococcus Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000192023 Sarcina Species 0.000 description 1
- 241000607720 Serratia Species 0.000 description 1
- 241000204117 Sporolactobacillus Species 0.000 description 1
- 241000186547 Sporosarcina Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241000607598 Vibrio Species 0.000 description 1
- 241000607757 Xenorhabdus Species 0.000 description 1
- 241000607734 Yersinia <bacteria> Species 0.000 description 1
- 241000588901 Zymomonas Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000006978 adaptation Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 238000003320 cell separation method Methods 0.000 description 1
- 238000005352 clarification Methods 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000011437 continuous method Methods 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 238000011010 flushing procedure Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000007792 gaseous phase Substances 0.000 description 1
- CJNBYAVZURUTKZ-UHFFFAOYSA-N hafnium(IV) oxide Inorganic materials O=[Hf]=O CJNBYAVZURUTKZ-UHFFFAOYSA-N 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000004941 influx Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 235000021231 nutrient uptake Nutrition 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000009722 regulation of fermentation Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000003971 tillage Methods 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/10—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by centrifugation ; Cyclones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M1/00—Apparatus for enzymology or microbiology
- C12M1/36—Apparatus for enzymology or microbiology including condition or time responsive control, e.g. automatically controlled fermentors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/26—Means for regulation, monitoring, measurement or control, e.g. flow regulation of pH
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
- C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
- C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/813—Continuous fermentation
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Sustainable Development (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4037325A DE4037325A1 (de) | 1990-11-23 | 1990-11-23 | Verfahren zur erzeugung von zellmasse und/oder fermentierungsprodukten unter sterilen bedingungen sowie vorrichtung zur durchfuehrung des verfahrens |
| PCT/EP1991/002189 WO1992009683A1 (fr) | 1990-11-23 | 1991-11-21 | Procede et dispositif de production de masses cellulaires et/ou de produits de fermentation dans des conditions steriles et dispositif pour mettre en ×uvre ce procede |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG96651A BG96651A (bg) | 1993-12-24 |
| BG61039B1 true BG61039B1 (bg) | 1996-09-30 |
Family
ID=6418808
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG96651A BG61039B1 (bg) | 1990-11-23 | 1992-07-20 | Метод за производство на клетъчна маса и/или ферментационни продукти при стерилни условия и устройство за осъществяването му |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5981260A (fr) |
| EP (1) | EP0487867B1 (fr) |
| JP (1) | JPH05503635A (fr) |
| KR (1) | KR920703786A (fr) |
| AT (1) | ATE138684T1 (fr) |
| AU (1) | AU672745B2 (fr) |
| BG (1) | BG61039B1 (fr) |
| BR (1) | BR9106024A (fr) |
| CA (1) | CA2074466C (fr) |
| CZ (1) | CZ283799B6 (fr) |
| DE (2) | DE4037325A1 (fr) |
| DK (1) | DK0487867T3 (fr) |
| ES (1) | ES2090199T3 (fr) |
| FI (1) | FI101083B (fr) |
| HU (1) | HUT65380A (fr) |
| NO (1) | NO303230B1 (fr) |
| WO (1) | WO1992009683A1 (fr) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1080761C (zh) * | 1993-12-24 | 2002-03-13 | Basf公司 | 2－酮基－l－古洛糖酸的改良性生产方法 |
| DE9419230U1 (de) * | 1994-12-02 | 1995-03-09 | Forschungszentrum Jülich GmbH, 52428 Jülich | Anordnung für fed-batch-Prozeßuntersuchungen in einer Schüttelkolbenserie |
| FI100338B (fi) * | 1995-07-18 | 1997-11-14 | Danisco Sugar Finland Oy | Menetelmä puhtaan maitohapon valmistamiseksi |
| DE19718608A1 (de) * | 1997-05-02 | 1998-11-05 | Ireks Gmbh | Verfahren zur Herstellung von Milchsäure |
| US7879593B2 (en) * | 1999-12-16 | 2011-02-01 | Whiteman G Robert | Fermentation systems, methods and apparatus |
| US20020117445A1 (en) * | 1999-12-16 | 2002-08-29 | Whiteman G. Robert | Fermentation systems, methods, and apparatus |
| US9969633B2 (en) * | 1999-12-16 | 2018-05-15 | Robert Whiteman | Systems and methods for treating oil, fat and grease in collection systems |
| DE60124780T2 (de) * | 2000-12-20 | 2007-10-11 | Bayer Pharmaceuticals Corp., West Haven | Vorrichtung und verfahren zur serienvermehrung von säugerzellen zum animpfen |
| JP3958089B2 (ja) * | 2002-03-26 | 2007-08-15 | 有限会社新世紀発酵研究所 | 嫌気性菌の連続培養法 |
| US7081361B2 (en) * | 2003-08-07 | 2006-07-25 | Nch Corporation | Biomass generator |
| US7635586B2 (en) * | 2003-11-26 | 2009-12-22 | Broadley-James Corporation | Integrated bio-reactor monitor and control system |
| US7435581B2 (en) | 2003-11-26 | 2008-10-14 | Broadley-James Corporation | Integrated bio-reactor monitor and control system |
| US20080305213A1 (en) | 2007-06-11 | 2008-12-11 | Kerry Group Services International, Ltd. | Method and composition for preparing cured meat products |
| EP2398887A1 (fr) * | 2009-02-18 | 2011-12-28 | Universiti Sains Malaysia | Système de fermentation à l'état solide |
| US8551762B2 (en) | 2009-07-07 | 2013-10-08 | Nch Corporation | System and apparatus for feeding, solubilizing, growing and discharging a biological material |
| US8961893B2 (en) | 2009-07-07 | 2015-02-24 | Nch Corporation | Automated chemical diluter system having disposable components |
| SI3202785T1 (sl) | 2009-10-26 | 2024-08-30 | F. Hoffmann-La Roche Ag | Postopek za proizvodnjo glikoziliranega imunoglobulina |
| US8940520B2 (en) | 2010-05-20 | 2015-01-27 | Pond Biofuels Inc. | Process for growing biomass by modulating inputs to reaction zone based on changes to exhaust supply |
| US8889400B2 (en) | 2010-05-20 | 2014-11-18 | Pond Biofuels Inc. | Diluting exhaust gas being supplied to bioreactor |
| US20120156669A1 (en) | 2010-05-20 | 2012-06-21 | Pond Biofuels Inc. | Biomass Production |
| US8969067B2 (en) | 2010-05-20 | 2015-03-03 | Pond Biofuels Inc. | Process for growing biomass by modulating supply of gas to reaction zone |
| US11512278B2 (en) | 2010-05-20 | 2022-11-29 | Pond Technologies Inc. | Biomass production |
| US20120276633A1 (en) | 2011-04-27 | 2012-11-01 | Pond Biofuels Inc. | Supplying treated exhaust gases for effecting growth of phototrophic biomass |
| US9534261B2 (en) | 2012-10-24 | 2017-01-03 | Pond Biofuels Inc. | Recovering off-gas from photobioreactor |
| DE102018120885B4 (de) * | 2018-08-27 | 2020-06-18 | Sartorius Stedim Biotech Gmbh | Vorrichtung und Verfahren zur kontrollierten Zuführung von Substrat |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3591455A (en) * | 1968-02-14 | 1971-07-06 | Nalco Chemical Co | Continuous microbial process |
| DE1953430A1 (de) * | 1968-10-25 | 1970-04-30 | Tanabe Seiyaku Co | Verfahren zur kontinuierlichen Fermentation mit Hilfe von aeroben Mikroorganismen |
| GB1290444A (fr) * | 1970-02-02 | 1972-09-27 | ||
| US3857757A (en) * | 1972-11-30 | 1974-12-31 | Gen Electric | Means for the oxygen/temperature control of aerobic fermentations |
| US4105804A (en) * | 1973-01-31 | 1978-08-08 | Gyozo Terui | Method for separation of bacteria cells from culture broth |
| US3956482A (en) * | 1973-06-25 | 1976-05-11 | W. R. Grace & Co. | Milk production |
| FR2259903A1 (en) * | 1974-02-05 | 1975-08-29 | Univ Moskovsk | Continuous propagation of micro-organisms in a closed circuit - with accurately controlled process parameters and uniformity in operation |
| GB1545766A (en) * | 1975-07-22 | 1979-05-16 | Novo Industri As | Process for the production of a glucose isomerase product by fermentation |
| GB1514425A (en) * | 1976-02-20 | 1978-06-14 | Gist Brocades Nv | Vinegar production and other fermentation processes |
| CH621363A5 (fr) * | 1976-05-18 | 1981-01-30 | Mueller Hans Dr Ing Fa | |
| US4167450A (en) * | 1977-07-13 | 1979-09-11 | University Of New Hampshire | Method and apparatus for the production of secondary metabolites by the maintenance-state cultivation of microorganisms |
| US4357424A (en) * | 1979-12-13 | 1982-11-02 | Sim-Chem Limited | Process for the continuous production of fermentation alcohol |
| DE3171017D1 (en) * | 1980-08-19 | 1985-07-25 | Ici Plc | Fermentation process |
| US4342835A (en) * | 1980-10-03 | 1982-08-03 | Provesta Corporation | Fermentation process and apparatus |
| DE3049381A1 (de) * | 1980-12-29 | 1982-07-29 | Rudolf 8034 Germering Schanze | Verfahren zur herstellung von ammoniumlactat enthaltenden mischungen, waessriges ammoniumlactat und vorrichtung zur durchfuehrung des verfahrens |
| FR2505359B1 (fr) * | 1981-05-08 | 1985-07-05 | Air Liquide | Procede et installation de fabrication de microorganismes |
| US4399223A (en) * | 1981-07-07 | 1983-08-16 | Phillips Petroleum Company | Cellular product separation |
| SU1024514A1 (ru) * | 1981-07-28 | 1983-06-23 | Всесоюзный Научно-Исследовательский Биотехнический Институт | Способ культивировани водородных бактерий |
| DE3323205A1 (de) * | 1983-06-28 | 1985-01-17 | Carl Schleicher & Schuell Gmbh & Co Kg, 3352 Einbeck | Einrichtung u. kontinuierliches verfahren zur filtration, sterilisation von fermentationsloesungen, kultur von mikroorganismen sowie fuer die fraktinierung von komponenten unterschiedlicher molekulargewichte auf membranen |
| CA1232050A (fr) * | 1984-02-28 | 1988-01-26 | James A. Zeitlin | Systeme regulateur de fermentation |
| US4680267A (en) * | 1985-03-01 | 1987-07-14 | New Brunswick Scientific Company, Inc. | Fermentor control system |
| FR2611742B1 (fr) * | 1987-03-02 | 1990-01-05 | Lyonnaise Eaux | Procede de production de cultures enrichies en microorganismes et/ou en metabolites resultant de ces cultures, appareillage pour la mise en oeuvre de ce procede et application de ce dernier, notamment a l'ensemencement et au reensemencement des nitrificateurs et bassins de traitement des eaux |
| DE3733748A1 (de) * | 1987-10-06 | 1989-04-20 | Westphal Kg Georg | Verfahren zur gewinnung von ethanol und biomasse aus vergorener maische |
| CA1293217C (fr) * | 1987-11-09 | 1991-12-17 | Sooyoung Stanford Lee | Fermentation a rythme de croissance controle |
| US4885241A (en) * | 1988-10-13 | 1989-12-05 | University Of Queensland | Ethanol production by zymomonas cultured in yeast-conditioned media |
| US4985355A (en) * | 1988-10-13 | 1991-01-15 | University Of Queensland | Ethanol production by zymomonas cultured in yeast-conditioned media |
-
1990
- 1990-11-23 DE DE4037325A patent/DE4037325A1/de active Granted
-
1991
- 1991-10-07 DK DK91117048.8T patent/DK0487867T3/da active
- 1991-10-07 ES ES91117048T patent/ES2090199T3/es not_active Expired - Lifetime
- 1991-10-07 AT AT91117048T patent/ATE138684T1/de not_active IP Right Cessation
- 1991-10-07 EP EP91117048A patent/EP0487867B1/fr not_active Expired - Lifetime
- 1991-10-07 DE DE59107860T patent/DE59107860D1/de not_active Expired - Lifetime
- 1991-11-21 BR BR919106024A patent/BR9106024A/pt not_active Application Discontinuation
- 1991-11-21 CA CA002074466A patent/CA2074466C/fr not_active Expired - Lifetime
- 1991-11-21 CZ CS921883A patent/CZ283799B6/cs unknown
- 1991-11-21 AU AU89466/91A patent/AU672745B2/en not_active Ceased
- 1991-11-21 WO PCT/EP1991/002189 patent/WO1992009683A1/fr active IP Right Grant
- 1991-11-21 US US07/795,899 patent/US5981260A/en not_active Expired - Lifetime
- 1991-11-21 HU HU9202189A patent/HUT65380A/hu unknown
- 1991-11-21 KR KR1019920701770A patent/KR920703786A/ko not_active Application Discontinuation
- 1991-11-21 JP JP3518666A patent/JPH05503635A/ja active Pending
-
1992
- 1992-05-13 FI FI922172A patent/FI101083B/fi active
- 1992-07-20 BG BG96651A patent/BG61039B1/bg unknown
- 1992-07-21 NO NO922887A patent/NO303230B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US5981260A (en) | 1999-11-09 |
| ATE138684T1 (de) | 1996-06-15 |
| EP0487867A1 (fr) | 1992-06-03 |
| NO922887L (no) | 1992-09-11 |
| EP0487867B1 (fr) | 1996-05-29 |
| DE4037325C2 (fr) | 1993-08-19 |
| NO922887D0 (no) | 1992-07-21 |
| DK0487867T3 (da) | 1996-10-07 |
| HU9202189D0 (en) | 1992-12-28 |
| AU8946691A (en) | 1992-06-25 |
| KR920703786A (ko) | 1992-12-18 |
| FI922172A (fi) | 1992-05-24 |
| CA2074466C (fr) | 2007-07-03 |
| BR9106024A (pt) | 1993-03-02 |
| CZ283799B6 (cs) | 1998-06-17 |
| JPH05503635A (ja) | 1993-06-17 |
| WO1992009683A1 (fr) | 1992-06-11 |
| CA2074466A1 (fr) | 1992-05-24 |
| BG96651A (bg) | 1993-12-24 |
| FI101083B (fi) | 1998-04-15 |
| FI922172A0 (fi) | 1992-05-13 |
| AU672745B2 (en) | 1996-10-17 |
| ES2090199T3 (es) | 1996-10-16 |
| DE4037325A1 (de) | 1992-05-27 |
| NO303230B1 (no) | 1998-06-15 |
| HUT65380A (en) | 1994-05-02 |
| DE59107860D1 (de) | 1996-07-04 |
| CS188392A3 (en) | 1992-12-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BG61039B1 (bg) | Метод за производство на клетъчна маса и/или ферментационни продукти при стерилни условия и устройство за осъществяването му | |
| JPWO2007032265A1 (ja) | アルコール生産細菌の連続培養装置及びその方法 | |
| CN201850276U (zh) | 乳酸菌的微滤膜偶联高密度培养装置 | |
| EP2678436B1 (fr) | Procédé de prévention d'infection bactérienne dans un procédé de fermentation | |
| KR20020034944A (ko) | 발효 공정의 최적화 | |
| JP2011092041A (ja) | エタノール生産微生物の連続培養発酵装置 | |
| CN115074220B (zh) | 一种模块化微生物菌剂培养及自动投加装置 | |
| CN109295118B (zh) | 一种丙酸杆菌的循环发酵方法 | |
| CN111893145A (zh) | 一种赖氨酸智能生物发酵新方法 | |
| CN101586133B (zh) | 阿维菌素批发酵优化工艺 | |
| O'Beirne et al. | The utilisation of glucose/acetate mixtures by Escherichia coli W3110 under aerobic growth conditions | |
| Yarovenko | Principles of the continuous alcohol and butanolacetone fermentation processes | |
| CN104946501B (zh) | 一种醋酸发酵扩培酸蒸工艺及系统 | |
| RU2105059C1 (ru) | Способ получения биомассы и устройство для его осуществления | |
| US20140141469A1 (en) | Methods of producing human hemoglobin in a bioreactor | |
| KR20150094722A (ko) | 폐수 처리로부터 나온 바이오매스에 대한 배치 공급식 공정에서 폴리히드록시알카노에이트(pha)의 생산성 증가 방법 | |
| EP3674392A1 (fr) | Procédé et appareil pour la croissance des microorganismes et son utilisation | |
| CN107058415A (zh) | 一种添加海藻糖酶提高谷氨酸发酵糖酸转化率的方法 | |
| US20240174970A1 (en) | Method for operating a bioprocess installation | |
| CN215209390U (zh) | 一种霉菌种子培养罐 | |
| US20230357816A1 (en) | Method and apparatus for the utilization of zero fiber and other side streams | |
| CN109777721B (zh) | 一种工程菌用连续发酵系统及发酵工艺 | |
| Östberg | Production of succinic acid by Actinobacillus succinogenes in attached-growth bioreactors and dynamic modelling of biofilm formation | |
| Fleming et al. | The fermenter in research and development | |
| BR102020024262A2 (pt) | Processo fermentativo, dispositivo para fermentação e kombucha |