BG49275A3 - Метод за получаване на заместени диазабицикло алкилхинолин карбонови киселини - Google Patents

Метод за получаване на заместени диазабицикло алкилхинолин карбонови киселини

Info

Publication number
BG49275A3
BG49275A3 BG076465A BG7646586A BG49275A3 BG 49275 A3 BG49275 A3 BG 49275A3 BG 076465 A BG076465 A BG 076465A BG 7646586 A BG7646586 A BG 7646586A BG 49275 A3 BG49275 A3 BG 49275A3
Authority
BG
Bulgaria
Prior art keywords
general formula
alkyl
carbon
attached
diazobicycloalkylchinolin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
BG076465A
Other languages
English (en)
Inventor
Martin JEFSON
Paul MCGUIRK
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of BG49275A3 publication Critical patent/BG49275A3/bg
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Materials For Photolithography (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Методът намира приложение във фармацевтичната промишленост за получаване на бактерицидни средства с висока антибактериална ективност. Съединенията имат обща формула в която r1 означава водород, фармацевтично приемлив катион или /с1-с6/ алкил; а означава сн или сf; у означава /с1-с3/ алкил, /с1-с3/ халогеналкил, циклопропил, винил, n-метиламино, р-флуорфенил; а въглерод и, взет заедно с у и въглерода и азота, към които а и у са прикрепени, образува 6-членен пръстен, който може да съдържа кислород и към който може да бъде прикрепен r3, означаващ метил или метилен, а r2 означава диазабициклоалкил с вътрешен мост. Методът се състои във взаимодействие на съответно заместена с халоген хинолинкарбонова киселина със съединение с обща формула r2н, в която r2 има значенията, посочени по-горе, и незадължително превръщане на полученото съединение с обща формула i в присъединителна с киселина сол. 3 претенции
BG076465A 1985-09-18 1986-09-18 Метод за получаване на заместени диазабицикло алкилхинолин карбонови киселини Active BG49275A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US77747185A 1985-09-18 1985-09-18

Publications (1)

Publication Number Publication Date
BG49275A3 true BG49275A3 (bg) 1991-09-16

Family

ID=25110350

Family Applications (2)

Application Number Title Priority Date Filing Date
BG076465A Active BG49275A3 (bg) 1985-09-18 1986-09-18 Метод за получаване на заместени диазабицикло алкилхинолин карбонови киселини
BG096080A BG61091B2 (bg) 1985-09-18 1992-03-17 Антибактериални заместени мостови-диазабициклоалкил хинолон карбоксилови киселини

Family Applications After (1)

Application Number Title Priority Date Filing Date
BG096080A BG61091B2 (bg) 1985-09-18 1992-03-17 Антибактериални заместени мостови-диазабициклоалкил хинолон карбоксилови киселини

Country Status (42)

Country Link
US (3) US4775668A (bg)
EP (1) EP0215650B1 (bg)
JP (1) JPH0798819B2 (bg)
KR (1) KR870000961B1 (bg)
CN (1) CN1014789B (bg)
AT (1) ATE72245T1 (bg)
AU (1) AU576302B2 (bg)
BG (2) BG49275A3 (bg)
CA (1) CA1340734C (bg)
CY (1) CY1774A (bg)
CZ (1) CZ277825B6 (bg)
DD (1) DD259190A5 (bg)
DE (2) DE3683711D1 (bg)
DK (1) DK171276B1 (bg)
EG (1) EG18184A (bg)
ES (1) ES2001428A6 (bg)
FI (1) FI87565C (bg)
GR (1) GR862363B (bg)
HK (1) HK132795A (bg)
HU (1) HU200462B (bg)
IE (1) IE58966B1 (bg)
IL (1) IL80033A (bg)
IN (1) IN166416B (bg)
LU (1) LU90356I2 (bg)
MA (1) MA20770A1 (bg)
MW (1) MW5886A1 (bg)
MX (1) MX173358B (bg)
MY (1) MY102518A (bg)
NO (1) NO170335C (bg)
NZ (1) NZ217614A (bg)
OA (1) OA08410A (bg)
PH (2) PH24048A (bg)
PL (1) PL149987B1 (bg)
PT (1) PT83388B (bg)
SG (1) SG28094G (bg)
SK (1) SK667886A3 (bg)
SU (1) SU1482531A3 (bg)
UA (1) UA6340A1 (bg)
YU (1) YU45024B (bg)
ZA (1) ZA867063B (bg)
ZM (1) ZM8586A1 (bg)
ZW (1) ZW19386A1 (bg)

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Also Published As

Publication number Publication date
YU161786A (en) 1987-10-31
MX173358B (es) 1994-02-23
EP0215650A3 (en) 1987-12-02
HK132795A (en) 1995-09-01
DK445886D0 (da) 1986-09-17
FI87565C (fi) 1993-01-25
MY102518A (en) 1992-07-31
US5091383A (en) 1992-02-25
FI87565B (fi) 1992-10-15
KR870000961B1 (ko) 1987-05-14
PL261410A1 (en) 1987-11-16
PT83388B (pt) 1989-05-12
IL80033A (en) 1992-05-25
EP0215650B1 (en) 1992-01-29
GR862363B (en) 1987-01-19
ES2001428A6 (es) 1988-05-16
IL80033A0 (en) 1986-12-31
PH25338A (en) 1991-04-30
FI863756A0 (fi) 1986-09-17
EP0215650A2 (en) 1987-03-25
PL149987B1 (en) 1990-04-30
PH24048A (en) 1990-03-05
DE19675019I2 (de) 2004-01-29
DK171276B1 (da) 1996-08-19
SK278605B6 (en) 1997-11-05
NO863718D0 (no) 1986-09-17
ATE72245T1 (de) 1992-02-15
AU576302B2 (en) 1988-08-18
OA08410A (fr) 1988-06-30
PT83388A (en) 1986-10-01
BG61091B2 (bg) 1996-10-31
MW5886A1 (en) 1987-12-09
ZM8586A1 (en) 1987-03-27
NZ217614A (en) 1989-11-28
UA6340A1 (uk) 1994-12-29
NO170335B (no) 1992-06-29
IE862479L (en) 1987-03-18
HU200462B (en) 1990-06-28
SU1482531A3 (ru) 1989-05-23
DD259190A5 (de) 1988-08-17
MA20770A1 (fr) 1987-04-01
CA1340734C (en) 1999-09-14
CN1014789B (zh) 1991-11-20
SK667886A3 (en) 1997-11-05
CZ667886A3 (en) 1993-02-17
SG28094G (en) 1994-10-28
EG18184A (en) 1992-12-30
DE3683711D1 (de) 1992-03-12
KR870003106A (ko) 1987-04-15
FI863756A (fi) 1987-03-19
DK445886A (da) 1987-05-27
IN166416B (bg) 1990-05-05
CY1774A (en) 1995-10-20
YU45024B (en) 1991-06-30
LU90356I2 (fr) 1999-04-26
ZA867063B (en) 1988-04-27
US4861779A (en) 1989-08-29
CZ277825B6 (en) 1993-06-16
IE58966B1 (en) 1993-12-01
HUT43070A (en) 1987-09-28
US4775668A (en) 1988-10-04
AU6276886A (en) 1987-03-19
CN86106385A (zh) 1987-06-03
JPH0798819B2 (ja) 1995-10-25
JPS62103083A (ja) 1987-05-13
ZW19386A1 (en) 1986-12-10
NO863718L (no) 1987-03-19
NO170335C (no) 1992-10-07
MX3751A (es) 1993-09-01

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