BG36199A3 - Method for preparing derivatives of 3- (1- piperidinylalkyl)- 4h- pyrido (1, 2- a) pyrimidin- 4- on - Google Patents

Method for preparing derivatives of 3- (1- piperidinylalkyl)- 4h- pyrido (1, 2- a) pyrimidin- 4- on

Info

Publication number
BG36199A3
BG36199A3 BG051433A BG5143381A BG36199A3 BG 36199 A3 BG36199 A3 BG 36199A3 BG 051433 A BG051433 A BG 051433A BG 5143381 A BG5143381 A BG 5143381A BG 36199 A3 BG36199 A3 BG 36199A3
Authority
BG
Bulgaria
Prior art keywords
piperidinylalkyl
pyrido
pyrimidin
preparing derivatives
preparing
Prior art date
Application number
BG051433A
Other languages
Bulgarian (bg)
English (en)
Inventor
Ludo Kennis
Josephus Mertens
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BG36199A3 publication Critical patent/BG36199A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BG051433A 1980-03-28 1981-03-27 Method for preparing derivatives of 3- (1- piperidinylalkyl)- 4h- pyrido (1, 2- a) pyrimidin- 4- on BG36199A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13484580A 1980-03-28 1980-03-28
US06/191,632 US4342870A (en) 1980-03-28 1980-09-29 Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives

Publications (1)

Publication Number Publication Date
BG36199A3 true BG36199A3 (en) 1984-09-14

Family

ID=26832744

Family Applications (1)

Application Number Title Priority Date Filing Date
BG051433A BG36199A3 (en) 1980-03-28 1981-03-27 Method for preparing derivatives of 3- (1- piperidinylalkyl)- 4h- pyrido (1, 2- a) pyrimidin- 4- on

Country Status (22)

Country Link
US (1) US4342870A (cs)
EP (1) EP0037265B1 (cs)
AU (1) AU537700B2 (cs)
BG (1) BG36199A3 (cs)
CA (1) CA1163994A (cs)
CS (1) CS256366B2 (cs)
DE (1) DE3168433D1 (cs)
DK (1) DK159390C (cs)
ES (1) ES8300763A1 (cs)
FI (1) FI71737C (cs)
GR (1) GR72488B (cs)
HU (1) HU187329B (cs)
IE (1) IE51319B1 (cs)
IL (1) IL62494A (cs)
MA (1) MA19107A1 (cs)
NO (1) NO156752C (cs)
NZ (1) NZ196522A (cs)
PH (1) PH16530A (cs)
PT (1) PT72740B (cs)
RO (1) RO82508A (cs)
SU (1) SU1068037A3 (cs)
YU (1) YU43010B (cs)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
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US4443451A (en) 1981-07-15 1984-04-17 Janssen Pharmaceutica N.V. Bicyclic pyrimidin-5-one derivatives
US4548938A (en) * 1981-07-15 1985-10-22 Janssen Pharmaceutica N.V. 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds
US4355037A (en) * 1981-11-12 1982-10-19 Hoechst-Roussel Pharmaceuticals 3-(4-Piperidyl)-1,2-benzisoxales
US4485107A (en) * 1982-11-01 1984-11-27 Janssen Pharmaceutica N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones
US4581171A (en) * 1983-07-27 1986-04-08 Janssen Pharmaceutica, N.V. [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders
US4888426A (en) * 1983-11-30 1989-12-19 Janssen Pharmaceutica N.V. 1-(5-methyl-furan-2-ylmethyl)-N-(4-piperidinyl)imidazo [4,5-6]pyridine-2-amine
US4695569A (en) * 1983-11-30 1987-09-22 Janssen Pharmaceutica N.V. Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4548939A (en) * 1984-10-01 1985-10-22 Janssen Pharmaceutica N. V. 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones
US4804663A (en) * 1985-03-27 1989-02-14 Janssen Pharmaceutica N.V. 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles
EP0268309B1 (en) * 1986-09-22 1996-12-11 Janssen Pharmaceutica N.V. Serotonin antagonists for treating wounds
IL90879A0 (en) * 1988-09-02 1990-02-09 Janssen Pharmaceutica Nv 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
CA2000786C (en) * 1988-11-07 1999-01-26 Cornelus G. M. Janssen 3-piperidinyl-1,2-benzisoxazoles
WO1990006303A1 (en) * 1988-12-02 1990-06-14 Pfizer Inc. Arylpiperidine derivatives
JPH04504263A (ja) * 1989-03-23 1992-07-30 マリンクロッド・インコーポレイテッド 放射性沃素又は臭素標識ピペリジン化合物、並びに上記化合物の及び上記化合物を含む組成物の製法
DE4138756A1 (de) * 1991-11-26 1993-05-27 Troponwerke Gmbh & Co Kg Kombination mit neuroprotektiver wirkung
US5266571A (en) * 1992-01-09 1993-11-30 Amer Moh Samir Treatment of hemorrhoids with 5-HT2 antagonists
FI943727A0 (fi) * 1992-02-13 1994-08-12 Merrell Dow Pharma Piperidinyylitiasyklisiä johdannaisia
AU669196B2 (en) * 1992-07-13 1996-05-30 Janssen Pharmaceutica N.V. Novel 4-(3-benzofuranyl)piperidinyl and 4-(3-benzothienyl)piperidinyl derivatives and pharmaceutical compositions containing them
DK0729357T3 (da) 1993-11-19 2005-06-06 Janssen Pharmaceutica Nv Mikroindkapslede 1,2-benzazoler
ES2085234B1 (es) * 1994-02-24 1997-01-16 Vita Invest Sa Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen.
TW421649B (en) * 1995-01-31 2001-02-11 Janssen Pharmaceutica Nv 4-(1H-indol-1yl)-1-piperidinyl derivatives
US5753664A (en) * 1995-03-16 1998-05-19 Takeda Chemical Industries, Ltd. Heterocyclic compounds, their production and use
CN100390146C (zh) * 2002-11-13 2008-05-28 斯索恩有限公司 制备利培酮的方法和用于该方法的中间体
EP1615924A1 (en) * 2003-04-22 2006-01-18 Synthon B.V. Water soluble salts of risperidone
ES2842289T3 (es) * 2008-02-29 2021-07-13 Vm Therapeutics Llc Compuestos para tratar el síndrome del dolor y otros trastornos
KR102137087B1 (ko) 2012-02-10 2020-07-24 피티씨 테라퓨틱스, 인크. 척수성 근위축증을 치료하기 위한 화합물
WO2013130689A1 (en) 2012-03-01 2013-09-06 Ptc Therapeutics, Inc. Compounds for treating spinal muscular atrophy
JP6219921B2 (ja) 2012-03-23 2017-10-25 ピーティーシー セラピューティクス， インコーポレイテッド 脊髄性筋委縮症を処置するための化合物
WO2014143915A1 (en) * 2013-03-15 2014-09-18 Vm Therapeutics Llc Novel crystalline forms
WO2015105657A1 (en) 2013-12-19 2015-07-16 Ptc Therapeutics, Inc. Methods for modulating the amount of rna transcripts
WO2016196386A1 (en) 2015-05-30 2016-12-08 Ptc Therapeutics, Inc. Methods for modulating rna splicing
KR102488323B1 (ko) 2015-12-10 2023-01-12 피티씨 테라퓨틱스, 인크. 헌팅턴병 치료 또는 개선을 위한 조성물
AU2017363369A1 (en) 2016-11-28 2019-05-30 Ptc Therapeutics, Inc Methods for modulating RNA splicing
US11407753B2 (en) 2017-06-05 2022-08-09 Ptc Therapeutics, Inc. Compounds for treating Huntington's disease
BR112019026508A2 (pt) 2017-06-14 2020-07-14 Ptc Therapeutics, Inc. métodos para modificar o splicing do rna
CN111163838B (zh) 2017-06-28 2023-03-28 Ptc医疗公司 用于治疗亨廷顿氏病的方法
CN111182898B (zh) 2017-06-28 2024-04-16 Ptc医疗公司 用于治疗亨廷顿氏病的方法
CA3094703A1 (en) 2018-03-27 2019-10-03 Ptc Therapeutics, Inc. Compounds for treating huntington's disease
WO2020005882A1 (en) 2018-06-27 2020-01-02 Ptc Therapeutics, Inc. Heteroaryl compounds for treating huntington's disease
SG11202012869SA (en) 2018-06-27 2021-01-28 Ptc Therapeutics Inc Heteroaryl compounds for treating huntington's disease
US11858941B2 (en) 2018-06-27 2024-01-02 Ptc Therapeutics, Inc. Heterocyclic and heteroaryl compounds for treating Huntington's disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3412094A (en) * 1967-06-21 1968-11-19 Searle & Co 5-alkyl-2-amino-4-azido-6-phenylpyrimidines and congeners
US3960863A (en) * 1974-06-25 1976-06-01 Sankyo Company Limited Pyrido[1,2-a]pyrimidinone derivatives
JPS5146497A (en) * 1974-10-19 1976-04-20 Masato Aiura Hobuban
JPS525795A (en) * 1975-06-28 1977-01-17 Sankyo Co Ltd Preparation of tetrahydro pyridopyrimidinone derivatives
HU173438B (hu) * 1975-11-27 1979-05-28 Chinoin Gyogyszer Es Vegyeszet Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom

Also Published As

Publication number Publication date
DK159390B (da) 1990-10-08
FI71737C (fi) 1987-02-09
YU43010B (en) 1989-02-28
FI810956L (fi) 1981-09-29
IL62494A0 (en) 1981-05-20
RO82508A (ro) 1983-09-26
NO156752C (no) 1987-11-18
NO811058L (no) 1981-09-29
EP0037265A1 (en) 1981-10-07
GR72488B (cs) 1983-11-14
NZ196522A (en) 1985-10-11
RO82508B (ro) 1983-08-30
IL62494A (en) 1984-08-31
CA1163994A (en) 1984-03-20
SU1068037A3 (ru) 1984-01-15
EP0037265B1 (en) 1985-01-23
AU6842981A (en) 1981-10-01
AU537700B2 (en) 1984-07-05
CS256366B2 (en) 1988-04-15
PH16530A (en) 1983-11-10
US4342870A (en) 1982-08-03
DK138281A (da) 1981-09-29
PT72740B (en) 1982-11-16
DE3168433D1 (de) 1985-03-07
FI71737B (fi) 1986-10-31
NO156752B (no) 1987-08-10
IE51319B1 (en) 1986-12-10
IE810706L (en) 1981-09-28
YU81081A (en) 1983-12-31
MA19107A1 (fr) 1981-10-01
ES500814A0 (es) 1982-11-01
HU187329B (en) 1985-12-28
ES8300763A1 (es) 1982-11-01
DK159390C (da) 1991-03-04
PT72740A (en) 1981-04-01

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