IL62494A - 2-alkyl-3-(4'-aroyl-and 4'-(indol-3"-yl)-piperidin-1'-alkyl)-4h-pyrido(1,2-a)pyrimidin-4-one derivatives,their preparation and pharmaceutical compositions containing them - Google Patents
2-alkyl-3-(4'-aroyl-and 4'-(indol-3"-yl)-piperidin-1'-alkyl)-4h-pyrido(1,2-a)pyrimidin-4-one derivatives,their preparation and pharmaceutical compositions containing themInfo
- Publication number
- IL62494A IL62494A IL62494A IL6249481A IL62494A IL 62494 A IL62494 A IL 62494A IL 62494 A IL62494 A IL 62494A IL 6249481 A IL6249481 A IL 6249481A IL 62494 A IL62494 A IL 62494A
- Authority
- IL
- Israel
- Prior art keywords
- alkyl
- aroyl
- pyrido
- indol
- pyrimidin
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13484580A | 1980-03-28 | 1980-03-28 | |
| US06/191,632 US4342870A (en) | 1980-03-28 | 1980-09-29 | Novel 3-(1-piperidinylalkyl)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL62494A0 IL62494A0 (en) | 1981-05-20 |
| IL62494A true IL62494A (en) | 1984-08-31 |
Family
ID=26832744
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL62494A IL62494A (en) | 1980-03-28 | 1981-03-26 | 2-alkyl-3-(4'-aroyl-and 4'-(indol-3"-yl)-piperidin-1'-alkyl)-4h-pyrido(1,2-a)pyrimidin-4-one derivatives,their preparation and pharmaceutical compositions containing them |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US4342870A (cs) |
| EP (1) | EP0037265B1 (cs) |
| AU (1) | AU537700B2 (cs) |
| BG (1) | BG36199A3 (cs) |
| CA (1) | CA1163994A (cs) |
| CS (1) | CS256366B2 (cs) |
| DE (1) | DE3168433D1 (cs) |
| DK (1) | DK159390C (cs) |
| ES (1) | ES8300763A1 (cs) |
| FI (1) | FI71737C (cs) |
| GR (1) | GR72488B (cs) |
| HU (1) | HU187329B (cs) |
| IE (1) | IE51319B1 (cs) |
| IL (1) | IL62494A (cs) |
| MA (1) | MA19107A1 (cs) |
| NO (1) | NO156752C (cs) |
| NZ (1) | NZ196522A (cs) |
| PH (1) | PH16530A (cs) |
| PT (1) | PT72740B (cs) |
| RO (1) | RO82508A (cs) |
| SU (1) | SU1068037A3 (cs) |
| YU (1) | YU43010B (cs) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4443451A (en) * | 1981-07-15 | 1984-04-17 | Janssen Pharmaceutica N.V. | Bicyclic pyrimidin-5-one derivatives |
| US4548938A (en) * | 1981-07-15 | 1985-10-22 | Janssen Pharmaceutica N.V. | 5-H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one compounds |
| US4355037A (en) * | 1981-11-12 | 1982-10-19 | Hoechst-Roussel Pharmaceuticals | 3-(4-Piperidyl)-1,2-benzisoxales |
| US4485107A (en) * | 1982-11-01 | 1984-11-27 | Janssen Pharmaceutica N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones |
| US4581171A (en) * | 1983-07-27 | 1986-04-08 | Janssen Pharmaceutica, N.V. | [[Bis(aryl)methylene]-1-piperidinyl]alkyl-pyrimidinones useful for treating psychotropic disorders |
| US4888426A (en) * | 1983-11-30 | 1989-12-19 | Janssen Pharmaceutica N.V. | 1-(5-methyl-furan-2-ylmethyl)-N-(4-piperidinyl)imidazo [4,5-6]pyridine-2-amine |
| US4695569A (en) * | 1983-11-30 | 1987-09-22 | Janssen Pharmaceutica N.V. | Bicyclic heterocyclyl containing N-(bicyclic heterocyclyl)-4-piperidinamines |
| PH23995A (en) * | 1984-01-09 | 1990-02-09 | Janssen Pharmaceutica Nv | 4((bicycle heterocyclyl)-methyl and hetero)piperidines |
| US4548939A (en) * | 1984-10-01 | 1985-10-22 | Janssen Pharmaceutica N. V. | 1H-Indol-3-yl containing 1,3-dimethyl-1H-purine-2,6-diones |
| US4804663A (en) * | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
| SG47757A1 (en) * | 1986-09-22 | 1998-04-17 | Janssen Pharmaceutica Nv | Serotonin antagonists for treating wounds |
| IL90879A0 (en) * | 1988-09-02 | 1990-02-09 | Janssen Pharmaceutica Nv | 3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them |
| CA2000786C (en) * | 1988-11-07 | 1999-01-26 | Cornelus G. M. Janssen | 3-piperidinyl-1,2-benzisoxazoles |
| HU207310B (en) * | 1988-12-02 | 1993-03-29 | Pfizer | Process for producing aryl-piperidine derivatives |
| EP0460118A1 (en) * | 1989-03-23 | 1991-12-11 | Mallinckrodt International Corporation | Radioactive iodine- or bromine labelled piperidine compound as well as method of preparing same and composition comprising said compound |
| DE4138756A1 (de) * | 1991-11-26 | 1993-05-27 | Troponwerke Gmbh & Co Kg | Kombination mit neuroprotektiver wirkung |
| US5266571A (en) * | 1992-01-09 | 1993-11-30 | Amer Moh Samir | Treatment of hemorrhoids with 5-HT2 antagonists |
| ATE206119T1 (de) * | 1992-02-13 | 2001-10-15 | Merrell Pharma Inc | Thiacyclische piperidinylderivate |
| KR100251892B1 (ko) * | 1992-07-13 | 2000-09-01 | 디르크 반테 | 신규한 4-(3-벤조푸라닐)피페리디닐 및 4-(3-벤조티에닐)피페리디닐 유도체 및 이들을 함유하는 약제학적 조성물 |
| CZ293764B6 (cs) | 1993-11-19 | 2004-07-14 | Janssen Pharmaceutica N. V. | Farmaceutický prostředek s dostatečným a dlouhodobým uvolňováním léčiva, biodegradovatelné a biokompatibilní mikročástice, způsob jejich výroby a použití |
| ES2085234B1 (es) * | 1994-02-24 | 1997-01-16 | Vita Invest Sa | Agente activo sobre el sistema nervioso central, procedimiento para su preparacion y composiciones farmaceuticas que lo contienen. |
| TW421649B (en) * | 1995-01-31 | 2001-02-11 | Janssen Pharmaceutica Nv | 4-(1H-indol-1yl)-1-piperidinyl derivatives |
| US5753664A (en) * | 1995-03-16 | 1998-05-19 | Takeda Chemical Industries, Ltd. | Heterocyclic compounds, their production and use |
| WO2004043923A1 (en) * | 2002-11-13 | 2004-05-27 | Synthon B.V. | Process for making risperidone and intermediates therefor |
| WO2004094415A1 (en) * | 2003-04-22 | 2004-11-04 | Synthon B.V. | Risperidone monohydrochloride |
| EP2252608A4 (en) | 2008-02-29 | 2012-10-03 | Vm Discovery Inc | METHOD FOR TREATING PAIN SYNDROME AND OTHER SUFFERING |
| DK2812004T3 (en) | 2012-02-10 | 2018-10-15 | Ptc Therapeutics Inc | COMPOUNDS FOR TREATMENT OF SPINAL MUSCLE DROPHY |
| EA029155B1 (ru) | 2012-03-01 | 2018-02-28 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Соединения для лечения спинальной мышечной атрофии |
| EA028382B1 (ru) | 2012-03-23 | 2017-11-30 | ПиТиСи ТЕРАПЬЮТИКС, ИНК. | Соединения для лечения спинальной мышечной атрофии |
| US9724348B2 (en) | 2013-03-15 | 2017-08-08 | Vm Therapeutics Llc | Crystalline forms |
| EP3082820B1 (en) | 2013-12-19 | 2022-07-20 | PTC Therapeutics, Inc. | Methods for modulating the amount of rna transcripts |
| US10668171B2 (en) | 2015-05-30 | 2020-06-02 | Ptc Therapeutics, Inc. | Methods for modulating RNA splicing |
| SI3386511T1 (sl) | 2015-12-10 | 2021-09-30 | Ptc Therapeutics, Inc. | Postopki za zdravljenje Huntingtonove bolezni |
| EA201991309A1 (ru) | 2016-11-28 | 2019-11-29 | Способы модуляции сплайсинга рнк | |
| CN111065626B (zh) | 2017-06-05 | 2024-09-27 | Ptc医疗公司 | 用于治疗亨廷顿氏舞蹈病的化合物 |
| JP2020523365A (ja) | 2017-06-14 | 2020-08-06 | ピーティーシー セラピューティクス，インコーポレーテッド | Ｒｎａスプライシングを改変する方法 |
| WO2019005993A1 (en) | 2017-06-28 | 2019-01-03 | Ptc Therapeutics, Inc. | METHODS OF TREATING HUNTINGTON'S DISEASE |
| CN111182898B (zh) | 2017-06-28 | 2024-04-16 | Ptc医疗公司 | 用于治疗亨廷顿氏病的方法 |
| US12103926B2 (en) | 2018-03-27 | 2024-10-01 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| US11685746B2 (en) | 2018-06-27 | 2023-06-27 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating Huntington's disease |
| US12139499B2 (en) | 2018-06-27 | 2024-11-12 | Ptc Therapeutics, Inc. | Heteroaryl compounds for treating Huntington's disease |
| IL279688B2 (en) | 2018-06-27 | 2025-01-01 | Ptc Therapeutics Inc | Heterocyclic and heteroaryl compounds for the treatment of Huntington's disease |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3412094A (en) * | 1967-06-21 | 1968-11-19 | Searle & Co | 5-alkyl-2-amino-4-azido-6-phenylpyrimidines and congeners |
| US3960863A (en) * | 1974-06-25 | 1976-06-01 | Sankyo Company Limited | Pyrido[1,2-a]pyrimidinone derivatives |
| JPS5146497A (en) * | 1974-10-19 | 1976-04-20 | Masato Aiura | Hobuban |
| JPS525795A (en) * | 1975-06-28 | 1977-01-17 | Sankyo Co Ltd | Preparation of tetrahydro pyridopyrimidinone derivatives |
| HU173438B (hu) * | 1975-11-27 | 1979-05-28 | Chinoin Gyogyszer Es Vegyeszet | Sposob poluchenija novykh proizvodnykh 4-okso-1,6,7,8-/tetragidro-4h-pirido/1,2/pirimidina s zaderzhivajuhhejj vozgoranie aktivnot'ju i protivosvertivajuhhem effektom |
-
1980
- 1980-09-29 US US06/191,632 patent/US4342870A/en not_active Expired - Lifetime
-
1981
- 1981-03-03 GR GR64291A patent/GR72488B/el unknown
- 1981-03-04 CA CA000372258A patent/CA1163994A/en not_active Expired
- 1981-03-17 AU AU68429/81A patent/AU537700B2/en not_active Ceased
- 1981-03-17 NZ NZ196522A patent/NZ196522A/en unknown
- 1981-03-21 MA MA19313A patent/MA19107A1/fr unknown
- 1981-03-24 SU SU813261927A patent/SU1068037A3/ru active
- 1981-03-24 CS CS812134A patent/CS256366B2/cs unknown
- 1981-03-26 DK DK138281A patent/DK159390C/da not_active IP Right Cessation
- 1981-03-26 PH PH25429A patent/PH16530A/en unknown
- 1981-03-26 IL IL62494A patent/IL62494A/xx unknown
- 1981-03-26 PT PT72740A patent/PT72740B/pt not_active IP Right Cessation
- 1981-03-27 BG BG051433A patent/BG36199A3/xx unknown
- 1981-03-27 HU HU81783A patent/HU187329B/hu not_active IP Right Cessation
- 1981-03-27 ES ES500814A patent/ES8300763A1/es not_active Expired
- 1981-03-27 YU YU810/81A patent/YU43010B/xx unknown
- 1981-03-27 NO NO811058A patent/NO156752C/no unknown
- 1981-03-27 EP EP81301335A patent/EP0037265B1/en not_active Expired
- 1981-03-27 IE IE706/81A patent/IE51319B1/en not_active IP Right Cessation
- 1981-03-27 DE DE8181301335T patent/DE3168433D1/de not_active Expired
- 1981-03-27 FI FI810956A patent/FI71737C/fi not_active IP Right Cessation
- 1981-03-28 RO RO81103848A patent/RO82508A/ro unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL62494A0 (en) | 1981-05-20 |
| EP0037265B1 (en) | 1985-01-23 |
| ES500814A0 (es) | 1982-11-01 |
| EP0037265A1 (en) | 1981-10-07 |
| YU43010B (en) | 1989-02-28 |
| ES8300763A1 (es) | 1982-11-01 |
| AU537700B2 (en) | 1984-07-05 |
| FI71737C (fi) | 1987-02-09 |
| YU81081A (en) | 1983-12-31 |
| NZ196522A (en) | 1985-10-11 |
| MA19107A1 (fr) | 1981-10-01 |
| GR72488B (cs) | 1983-11-14 |
| DK159390C (da) | 1991-03-04 |
| NO156752C (no) | 1987-11-18 |
| BG36199A3 (en) | 1984-09-14 |
| FI71737B (fi) | 1986-10-31 |
| RO82508B (ro) | 1983-08-30 |
| PT72740B (en) | 1982-11-16 |
| CS256366B2 (en) | 1988-04-15 |
| DK159390B (da) | 1990-10-08 |
| PH16530A (en) | 1983-11-10 |
| US4342870A (en) | 1982-08-03 |
| PT72740A (en) | 1981-04-01 |
| NO156752B (no) | 1987-08-10 |
| DE3168433D1 (de) | 1985-03-07 |
| DK138281A (da) | 1981-09-29 |
| SU1068037A3 (ru) | 1984-01-15 |
| RO82508A (ro) | 1983-09-26 |
| HU187329B (en) | 1985-12-28 |
| IE810706L (en) | 1981-09-28 |
| FI810956L (fi) | 1981-09-29 |
| CA1163994A (en) | 1984-03-20 |
| IE51319B1 (en) | 1986-12-10 |
| NO811058L (no) | 1981-09-29 |
| AU6842981A (en) | 1981-10-01 |
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