BG108874A - Изоструктурни псевдополиморфи на 9-деоксо-9а-а3а-метил-9а-хомоеритромицин а - Google Patents

Изоструктурни псевдополиморфи на 9-деоксо-9а-а3а-метил-9а-хомоеритромицин а

Info

Publication number
BG108874A
BG108874A BG108874A BG10887404A BG108874A BG 108874 A BG108874 A BG 108874A BG 108874 A BG108874 A BG 108874A BG 10887404 A BG10887404 A BG 10887404A BG 108874 A BG108874 A BG 108874A
Authority
BG
Bulgaria
Prior art keywords
deoxo
aza
methyl
homoerythromycin
isostructural
Prior art date
Application number
BG108874A
Other languages
English (en)
Inventor
Miljenko Dumic
Mladen Vinkovic
Marina Oresic
Ernest Mestrovic
Aleksandar Danilovski
Alojz Dumbovic
Zdravka Knezevic
Gorjana Lazarevski
Dominic Cincic
Darko Filic
Katica Lazaric
Dejan-Kresimir Bucar
Original Assignee
Pliva-Istrazivacki Institut D.O.O.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva-Istrazivacki Institut D.O.O. filed Critical Pliva-Istrazivacki Institut D.O.O.
Publication of BG108874A publication Critical patent/BG108874A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thermal Transfer Or Thermal Recording In General (AREA)
  • Non-Silver Salt Photosensitive Materials And Non-Silver Salt Photography (AREA)
  • Finger-Pressure Massage (AREA)
  • Instructional Devices (AREA)

Abstract

Изобретението се отнася до практически чисти изоструктурни псевдополиморфи на 9-деоксо-9а -аза-9а-метил-9а- хомоеритромицин А с формула, в която S означава органичен разтворител, който е най-малко частично смесим с вода, х означава 1, 1.25, 1.5 или 2; y означава 0, 0.5 или 1, псевдополиморфът се характеризира чрез моноклинна пространствена група Р 21 и средни параметри на единичната клетка, включващи кристални осoви дължини: а = 15.5 - 17.0 А, b = 15.5 - 17.0 А и с = 17.5 - 19.5 А, и ъглите между кристалните оси алфа = гама = 90 градуса и бета = 106 - 112 градуса. Изобретението се отнася и до методите за получаване на практически чисти псевдополиморфи с посочената формула, до фармацевтични състави, включващи тези псевдополиморфи, до метод за лечение на бактериални и протозойни инфекции исвързаните с възпаление заболявания чрез прилагане на фармацевтичен състав, съдържащ посочените псевдополиморфи.
BG108874A 2002-03-18 2004-09-14 Изоструктурни псевдополиморфи на 9-деоксо-9а-а3а-метил-9а-хомоеритромицин а BG108874A (bg)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HR20020231A HRP20020231A2 (en) 2002-03-18 2002-03-18 ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
US39361202P 2002-07-03 2002-07-03
US39470502P 2002-07-08 2002-07-08

Publications (1)

Publication Number Publication Date
BG108874A true BG108874A (bg) 2005-12-30

Family

ID=28045976

Family Applications (1)

Application Number Title Priority Date Filing Date
BG108874A BG108874A (bg) 2002-03-18 2004-09-14 Изоструктурни псевдополиморфи на 9-деоксо-9а-а3а-метил-9а-хомоеритромицин а

Country Status (23)

Country Link
US (1) US7569549B2 (bg)
EP (2) EP1485393B1 (bg)
JP (1) JP2005529082A (bg)
KR (1) KR20050002872A (bg)
CN (1) CN1642966A (bg)
AT (1) ATE440104T1 (bg)
AU (1) AU2003215779A1 (bg)
BG (1) BG108874A (bg)
BR (1) BR0308644A (bg)
CA (1) CA2479211A1 (bg)
DE (1) DE60328872D1 (bg)
EA (1) EA200401217A1 (bg)
ES (1) ES2331733T3 (bg)
HR (2) HRP20020231A2 (bg)
IL (1) IL163836A0 (bg)
IS (1) IS7449A (bg)
MX (1) MXPA04009009A (bg)
NO (1) NO20044341L (bg)
NZ (1) NZ535477A (bg)
PL (1) PL372468A1 (bg)
RS (1) RS82504A (bg)
TN (1) TNSN04166A1 (bg)
WO (1) WO2003077830A2 (bg)

Families Citing this family (12)

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Publication number Priority date Publication date Assignee Title
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
HRP20020614A2 (en) * 2002-07-22 2004-06-30 PLIVA-ISTRAŽIVAČKI INSTITUT d.o.o. Rhombic pseudopolymorph of 9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin a
DE602004019288D1 (de) 2003-07-24 2009-03-19 Pliva Hrvatska D O O Schnellösliches azithromycin in einzeldosisform
EP1878432A1 (en) * 2003-07-24 2008-01-16 Pliva - Research and Development Ltd. Single dose fast dissolving azithromycin
WO2005053652A1 (en) 2003-12-04 2005-06-16 Pfizer Products Inc. Multiparticulate crystalline drug compositions containing a poloxamer and a glyceride
BRPI0417360A (pt) * 2003-12-04 2007-03-13 Pfizer Prod Inc método para a preparação de multiparticulados farmacêuticos
EP1691786A1 (en) 2003-12-04 2006-08-23 Pfizer Products Inc. Multiparticulate compositions with improved stability
BRPI0417348A (pt) * 2003-12-04 2007-03-13 Pfizer Prod Inc processo de gelatinização por spray com utilização de uma extrusora para preparação de composições de droga cristalina multiparticulada contendo preferencialmente um poloxámero e um glicerìdeo
JP2007513146A (ja) * 2003-12-04 2007-05-24 ファイザー・プロダクツ・インク 液体系プロセスによるアジスロマイシンマルチパーティキュレート剤形
US6984403B2 (en) * 2003-12-04 2006-01-10 Pfizer Inc. Azithromycin dosage forms with reduced side effects
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation

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YU43006B (en) * 1981-03-06 1989-02-28 Pliva Pharm & Chem Works Process for preparing n-methyl-11-aza-10-deoxo-10-dihydro erythromycin and derivatives thereof
RU2066324C1 (ru) * 1987-07-09 1996-09-10 Пфайзер Инк. Кристаллический дигидрат азитромицина и способ его получения
HRP20020231A2 (en) 2002-03-18 2003-12-31 Pliva D D ISOSTRUCTURAL PSEUDOPOLYMORPHS OF 9-DEOXO-9a-AZA-9a-METHYL-9a-HOMOERYTHROMYCIN A
WO1994026758A1 (en) 1993-05-19 1994-11-24 Pfizer Inc. Intermediate for azithromycin
HRP940251B1 (en) 1994-04-15 1998-12-31 Stjepan Mutak Process for the preparation of azithromycin dihydrochloride
ES2122905B1 (es) * 1996-07-11 1999-11-16 Astur Pharma Sa Sintesis de 11,12-hidrogenoortoborato de 9-desoxo-9a-aza-11,12-desoxi-9a-metil-9a-homoeritromicina a. un procedimiento para la preparacion de 9-desoxo-9a-aza-9a-metil-9a-homoeritromicina a dihidrato (azitromicina dihidrato).
PT102130A (pt) 1998-03-13 1999-09-30 Hovione Sociedade Quimica S A Processo de preparacao de dihidrato de azitromicina
TW546302B (en) * 1998-05-08 2003-08-11 Biochemie Sa Improvements in macrolide production
CN1205338A (zh) 1998-05-08 1999-01-20 刘万忠 阿奇霉素水溶性盐的合成新方法及其在医药上的用途
CA2245398C (en) 1998-08-21 2002-01-29 Apotex Inc. Azithromycin monohydrate isopropanol clathrate and methods for the manufacture thereof
EP1484062A1 (en) * 1998-11-30 2004-12-08 Teva Pharmaceutical Industries Limited Crystalline azithromycin, process for manufacture and pharmaceutical compositions thereof
JP4703924B2 (ja) * 1999-06-29 2011-06-15 サンド・アクチエンゲゼルシヤフト マクロライド
ES2177373B1 (es) * 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
EP1246831B1 (en) * 2000-01-04 2008-03-05 Teva Pharmaceutical Industries Ltd. Preparation method of azithromycin dihydrate
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KR100491183B1 (ko) 2001-03-21 2005-05-25 한미약품 주식회사 아지트로마이신의 제조방법 및 이 방법에 사용되는9-데옥소-9에이-아자-9에이-호모에리트로마이신 에이의결정성 수화물
KR100431431B1 (ko) 2001-04-25 2004-05-14 한미약품 주식회사 아지트로마이신 수화물의 1,2-프로필렌글리콜 내포화합물,그의 제조방법 및 그의 약학적 조성물
HRP20010301A2 (en) 2001-04-27 2001-12-31 Pliva D D New therapeutic indication for azithromycin in the treatment of non-infective inflammatory diseases
US6861413B2 (en) * 2001-05-22 2005-03-01 Pfizer Inc. Stable non-dihydrate azithromycin oral suspensions
JP2004530703A (ja) * 2001-05-22 2004-10-07 ファイザー・プロダクツ・インク 結晶形アジスロマイシン
EP1455758A1 (en) * 2001-12-21 2004-09-15 Pfizer Products Inc. Directly compressible formulations of azithromycin
WO2003053399A2 (en) 2001-12-21 2003-07-03 Pfizer Products Inc. Methods for wet granulating azithromycin
BR0307331A (pt) 2002-02-01 2004-12-07 Pfizer Prod Inc Formulações granuladas a seco de azitromicina
ITMI20021209A1 (it) 2002-06-04 2003-12-04 Chemi Spa Processo di preparazione di azitromicina ad elevata purezza

Also Published As

Publication number Publication date
HRP20040858A2 (en) 2005-06-30
KR20050002872A (ko) 2005-01-10
BR0308644A (pt) 2005-01-25
EP1485393B1 (en) 2009-08-19
IS7449A (is) 2004-09-16
EA200401217A1 (ru) 2005-02-24
EP1485393A2 (en) 2004-12-15
AU2003215779A1 (en) 2003-09-29
TNSN04166A1 (en) 2007-03-12
US20040014951A1 (en) 2004-01-22
ES2331733T3 (es) 2010-01-14
MXPA04009009A (es) 2005-06-17
PL372468A1 (en) 2005-07-25
IL163836A0 (en) 2005-12-18
WO2003077830A2 (en) 2003-09-25
ATE440104T1 (de) 2009-09-15
DE60328872D1 (en) 2009-10-01
NZ535477A (en) 2006-11-30
US7569549B2 (en) 2009-08-04
CA2479211A1 (en) 2003-09-25
RS82504A (en) 2006-12-15
JP2005529082A (ja) 2005-09-29
NO20044341L (no) 2004-11-23
CN1642966A (zh) 2005-07-20
WO2003077830A3 (en) 2004-05-13
EP1627883A1 (en) 2006-02-22
HRP20020231A2 (en) 2003-12-31

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