BG107411A - Near infrared fluorescent contrast agent and fluorescence imaging - Google Patents

Near infrared fluorescent contrast agent and fluorescence imaging

Info

Publication number
BG107411A
BG107411A BG107411/2002A BG74112002A BG107411A BG 107411 A BG107411 A BG 107411A BG 107411/2002 A BG107411/2002 A BG 107411/2002A BG 74112002 A BG74112002 A BG 74112002A BG 107411 A BG107411 A BG 107411A
Authority
BG
Bulgaria
Prior art keywords
contrast agent
near infrared
fluorescence imaging
infrared fluorescent
fluorescent contrast
Prior art date
Application number
BG107411/2002A
Other languages
Bulgarian (bg)
English (en)
Inventor
Naoto Miwa
Michihito Inagaki
Hiroaki Eguchi
Masafumi Okumura
Yoshio Inagaki
Toru Harada
Original Assignee
Schering Aktiengesellschaft
Fuji Photo Film Co.,Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft, Fuji Photo Film Co.,Ltd filed Critical Schering Aktiengesellschaft
Publication of BG107411A publication Critical patent/BG107411A/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0016—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being a halogen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0025—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through an oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0033—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through a sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0041—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through a nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/06—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups three >CH- groups, e.g. carbocyanines
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/80—Fluorescent dyes, e.g. rhodamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Eye Examination Apparatus (AREA)
  • Transforming Light Signals Into Electric Signals (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
BG107411/2002A 1998-09-18 2001-03-13 Near infrared fluorescent contrast agent and fluorescence imaging BG107411A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10283301A JP2000095758A (ja) 1998-09-18 1998-09-18 近赤外蛍光造影剤および蛍光造影方法
PCT/EP1999/007088 WO2000016810A1 (en) 1998-09-18 1999-09-16 Near infrared fluorescent contrast agent and fluorescence imaging

Publications (1)

Publication Number Publication Date
BG107411A true BG107411A (en) 2004-06-30

Family

ID=17663691

Family Applications (3)

Application Number Title Priority Date Filing Date
BG107411/2002A BG107411A (en) 1998-09-18 2001-03-13 Near infrared fluorescent contrast agent and fluorescence imaging
BG107411A BG65173B1 (bg) 1998-09-18 2001-03-13 Флуоресцентно контрастно средство за близка инфрачервена област на спектъра и флуоресцентно изобразяване
BG105337A BG65172B1 (bg) 1998-09-18 2001-03-13 Флуоресцентно контрастно средство за близка инфрачервена област на спектъра и флуоресцентно изобразяване

Family Applications After (2)

Application Number Title Priority Date Filing Date
BG107411A BG65173B1 (bg) 1998-09-18 2001-03-13 Флуоресцентно контрастно средство за близка инфрачервена област на спектъра и флуоресцентно изобразяване
BG105337A BG65172B1 (bg) 1998-09-18 2001-03-13 Флуоресцентно контрастно средство за близка инфрачервена област на спектъра и флуоресцентно изобразяване

Country Status (30)

Country Link
US (1) US7488468B1 (hu)
EP (1) EP1113822B1 (hu)
JP (2) JP2000095758A (hu)
KR (2) KR100585370B1 (hu)
CN (2) CN1196497C (hu)
AT (1) ATE248608T1 (hu)
AU (1) AU763991B2 (hu)
BG (3) BG107411A (hu)
BR (1) BR9913849A (hu)
CA (1) CA2344315A1 (hu)
DE (1) DE69911034T2 (hu)
DK (1) DK1113822T3 (hu)
EA (2) EA005070B1 (hu)
EE (1) EE200100162A (hu)
ES (1) ES2207338T3 (hu)
HK (1) HK1042855B (hu)
HU (1) HUP0103503A3 (hu)
ID (1) ID29455A (hu)
IL (2) IL141656A0 (hu)
MX (1) MXPA01002194A (hu)
NO (2) NO322559B1 (hu)
NZ (1) NZ510019A (hu)
PL (1) PL193411B1 (hu)
PT (1) PT1113822E (hu)
RS (1) RS50203B (hu)
SK (1) SK3742001A3 (hu)
TR (1) TR200100746T2 (hu)
UA (2) UA67800C2 (hu)
WO (1) WO2000016810A1 (hu)
YU (1) YU97502A (hu)

Families Citing this family (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6593148B1 (en) 1994-03-01 2003-07-15 Li-Cor, Inc. Cyanine dye compounds and labeling methods
JP2000095758A (ja) 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
US7547721B1 (en) 1998-09-18 2009-06-16 Bayer Schering Pharma Ag Near infrared fluorescent contrast agent and fluorescence imaging
EA200200635A1 (ru) * 1999-12-15 2002-12-26 Шеринг Акциенгезельшафт Флуоресцентный контрастный агент для ближней инфракрасной области спектра и способ флуоресцентной визуализации
US20080233050A1 (en) * 2000-01-18 2008-09-25 Mallinckrodt Inc. Diagnostic and therapeutic optical agents
US7790144B2 (en) * 2000-01-18 2010-09-07 Mallinckrodt Inc. Receptor-avid exogenous optical contrast and therapeutic agents
US7597878B2 (en) * 2000-09-19 2009-10-06 Li-Cor, Inc. Optical fluorescent imaging
ATE315066T1 (de) * 2000-09-19 2006-02-15 Li Cor Inc Cyaninfarbstoffe
US6663847B1 (en) * 2000-10-13 2003-12-16 Mallinckrodt Inc. Dynamic organ function monitoring agents
US6716413B1 (en) * 2000-10-16 2004-04-06 Mallinckrodt, Inc. Indole compounds as tissue-specific exogenous optical agents
US6656451B1 (en) * 2000-10-16 2003-12-02 Mallinckrodt, Inc. Indole compounds as novel dyes for organ function monitoring
US6733744B1 (en) * 2000-10-16 2004-05-11 Mallinckrodt Inc. Indole compounds as minimally invasive physiological function monitoring agents
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
US7556797B2 (en) 2000-10-16 2009-07-07 Mallinckrodt Inc. Minimally invasive physiological function monitoring agents
US6669926B1 (en) * 2000-10-16 2003-12-30 Mallinckrodt, Inc. Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients
WO2002038190A2 (en) 2000-10-27 2002-05-16 Beth Israel Deaconess Medical Center Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates
BR0318028A (pt) * 2003-01-24 2005-12-06 Schering Ag Corantes hidrofìlicos de cianina reativos a tiol e conjugados dos mesmos com biomoléculas para diagnóstico por fluorescência
JP2005145921A (ja) * 2003-11-19 2005-06-09 Konica Minolta Medical & Graphic Inc 診断用蛍光造影剤及び蛍光造影診断方法
US7682602B2 (en) * 2003-12-19 2010-03-23 Konica Minolta Medical & Graphic, Inc. Near-infrared fluorescent contrast medium
JP2005220045A (ja) * 2004-02-04 2005-08-18 Konica Minolta Medical & Graphic Inc 蛍光造影剤
ATE494913T1 (de) * 2004-11-22 2011-01-15 Ge Healthcare As Kontrastmittel für eine extrazelluläre matrix
EP1679082A1 (en) * 2005-01-07 2006-07-12 Schering AG Use of cyanine dyes for the diagnosis of proliferative diseases
US8227621B2 (en) 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
FR2889700B1 (fr) 2005-08-11 2012-11-23 Synthinnove Lab Marqueurs, leur procede de fabrication et leurs applications
US7947256B2 (en) 2005-09-02 2011-05-24 Visen Medical, Inc. Biocompatible fluorescent imaging agents
US8173819B2 (en) 2005-09-02 2012-05-08 Visen Medical, Inc. Nicotinic and picolinic acid derived near-infrared fluorophores
WO2007028037A1 (en) * 2005-09-02 2007-03-08 Visen Medical, Inc. Biocompatible n, n-disubstituted sulfonamide-containing fluorescent dye labels
US8838210B2 (en) 2006-06-29 2014-09-16 AccuView, Inc. Scanned laser vein contrast enhancer using a single laser
ITSV20060002A1 (it) 2006-01-19 2007-07-20 Ferrania Technologies Spa Colorante fluorescente di tipo cianinico
EP1815870A1 (en) * 2006-02-01 2007-08-08 DKFZ Deutsches Krebsforschungszentrum Cyanine dye compounds linked to metal chelator for bi-modal diagnostic imaging
JP4958461B2 (ja) * 2006-03-30 2012-06-20 富士フイルム株式会社 近赤外吸収色素含有硬化性組成物
US7745645B2 (en) * 2007-01-22 2010-06-29 Pierce Biotechnology, Inc. Sulfonamide derivatives of xanthene compounds
WO2009023813A1 (en) * 2007-08-15 2009-02-19 Applied Soil Water Technologies Llc Metals recovery from mining heap leach ore
DE102007059752A1 (de) 2007-12-10 2009-06-18 Bayer Schering Pharma Aktiengesellschaft Funktionalisierte, feste Polymernanopartikel enthaltend Epothilone
US20090214436A1 (en) 2008-02-18 2009-08-27 Washington University Dichromic fluorescent compounds
JP5500875B2 (ja) * 2009-01-30 2014-05-21 キヤノン株式会社 新規化合物、該新規化合物を用いたプローブ及び該新規化合物もしくは該プローブを用いた蛍光イメージング用造影剤
US20110313129A1 (en) * 2009-02-11 2011-12-22 Life Technologies Corporation Large stokes shift dyes
CA2809798C (en) 2009-08-28 2018-09-18 Visen Medical, Inc. Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique
JP2011046662A (ja) 2009-08-28 2011-03-10 Fujifilm Corp 近赤外蛍光造影剤
JP2011046663A (ja) 2009-08-28 2011-03-10 Fujifilm Corp 近赤外蛍光造影剤
AU2010298388B2 (en) 2009-09-22 2015-05-28 Visen Medical, Inc. Systems and methods for virtual index-matching of diffusive media
US8273875B2 (en) 2009-11-16 2012-09-25 University Of Notre Dame Du Lac High performance luminescent compounds
JP5817073B2 (ja) * 2010-01-28 2015-11-18 国立大学法人三重大学 新規インドシアニン化合物を用いた診断用組成物及び分析方法
WO2011093098A1 (ja) 2010-01-28 2011-08-04 国立大学法人三重大学 新規インドシアニン化合物、その合成法及びその精製法、そのインドシアニン化合物を用いた診断用組成物、その診断用組成物を使用する生体内動態測定装置、並びに循環可視化装置
EP2686385B1 (en) * 2011-03-15 2019-01-16 Ramot at Tel Aviv University, Ltd. Activatable fluorogenic compounds and uses thereof as near infrared probes
US9610370B2 (en) 2011-10-07 2017-04-04 University Of Virginia Patent Foundation Compositions and methods for tumor imaging and targeting by a class of organic heptamethine cyanine dyes that possess dual nuclear and near-infrared properties
EP3553075A1 (en) 2012-01-23 2019-10-16 Washington University Goggle imaging systems and methods
CN104853669B (zh) 2012-10-15 2017-07-21 文森医学公司 具有荧光及生物发光源的交叉形态加权特征的漫射介质成像的系统、方法及设备
US10376148B2 (en) 2012-12-05 2019-08-13 Accuvein, Inc. System and method for laser imaging and ablation of cancer cells using fluorescence
BR112015022810B1 (pt) 2013-03-15 2021-11-30 Purdue Research Foundation Composto, composição e método para identificar tipo de célula alvo em amostra biológica
CA2912401C (en) 2013-05-15 2019-10-29 The Administrators Of The Tulane Educational Fund Microscopy of a tissue sample using structured illumination
US11001562B2 (en) 2013-10-31 2021-05-11 Beth Israel Deaconess Medical Center Near-infrared fluorescent nerve contrast agents and methods of use thereof
AU2014342254B2 (en) 2013-10-31 2020-03-26 Beth Israel Deaconess Medical Center Near-infrared fluorescent contrast bioimaging agents and methods of use thereof
CN113349707A (zh) 2013-12-31 2021-09-07 纪念斯隆-凯特琳癌症中心 用于荧光源实时多通道成像的系统、方法和设备
AR102743A1 (es) * 2014-11-26 2017-03-22 Li Cor Inc Medios de contraste ir para imágenes por fluorescencia
BR112017012621A2 (pt) 2014-12-15 2018-01-02 Univ Cornell peptídeos cíclicos com seletividade de ligação nervosa melhorada, nanopartículas ligadas com os referidos peptídeos cíclicos, e o uso dos mesmos para a produção de imagens de tecido nervoso in vivo em tempo real
CA2973128C (en) * 2015-01-07 2020-07-28 Synaptive Medical (Barbados) Inc. Optical probes for corridor surgery
KR20160086481A (ko) * 2015-01-09 2016-07-20 차의과학대학교 산학협력단 신규 유기 화합물 및 이를 포함하는 근적외선 형광 조영제, 그리고 조영제의 나노입자화 방법
WO2016179350A1 (en) 2015-05-06 2016-11-10 Washington University Compounds having rd targeting motifs and methods of use thereof
CN107949385B (zh) 2015-06-03 2021-04-09 瑟吉麦博股份公司 荧光缀合物
US10405753B2 (en) * 2015-11-10 2019-09-10 Intuitive Surgical Operations, Inc. Pharmaceutical compositions of near IR closed chain, sulfo-cyanine dyes
EP3389726A1 (en) 2015-12-15 2018-10-24 Memorial Sloan Kettering Cancer Center Imaging systems and methods for tissue differentiation, e.g., for intraoperative visualization
FR3058148A1 (fr) 2016-10-31 2018-05-04 Compagnie Generale Des Etablissements Michelin Composition de caoutchouc comprenant une charge renforcante specifique
CN110167601A (zh) 2016-11-30 2019-08-23 纪念斯隆凯特琳癌症中心 抑制剂-功能化超微小纳米粒子和其方法
US10758631B2 (en) * 2017-04-11 2020-09-01 Li-Cor, Inc. Solid cyanine dyes
EP3609543A1 (en) * 2017-04-11 2020-02-19 Li-Cor, Inc. Solid cyanine dyes
KR101980292B1 (ko) * 2017-08-03 2019-05-20 (주)바이오액츠 형광 화합물 및 이의 제조방법
WO2019067180A1 (en) * 2017-09-29 2019-04-04 Perkinelmer Health Sciences, Inc. NIR-SWIR FLUORESCENT COMPOUNDS FOR IMAGING AND DETECTION
CN109959612A (zh) * 2017-12-14 2019-07-02 深圳先进技术研究院 一种光声探针在制备ntr光声检测试剂中的应用
EP3773153A4 (en) 2018-03-30 2021-11-17 Perkinelmer Health Sciences Inc. SYSTEMS AND METHODS FOR THREE-DIMENSIONAL (3D) RECONSTRUCTION OF ORGANS AND ANATOMIC INCLUSIONS USING SHORT WAVELENGTH INFRARED PROJECTION (SCRI) TOMOGRAPHY
KR102034113B1 (ko) * 2019-06-13 2019-10-18 나우비젼 주식회사 종양특이성을 증가시킨 신장배출형 형광 조영제 및 이를 이용한 영상화 방법
EP4072598A4 (en) 2019-12-13 2024-02-21 Washington University St Louis NEAR-INFRARED FLUORESCENT DYES, FORMULATIONS AND ASSOCIATED METHODS
EP4015004A1 (en) 2020-12-18 2022-06-22 Phi Pharma SA Proteoglycan specific branched peptides
WO2022163807A1 (ja) * 2021-01-29 2022-08-04 国立大学法人北海道大学 光音響イメージング剤
EP4352167A1 (en) 2021-06-07 2024-04-17 SurgVision GmbH Stable liquid phantom for near-infrared fluorescence verification
CN113717089B (zh) * 2021-09-22 2023-05-05 中国科学院精密测量科学与技术创新研究院 一种氟化Cy7化合物及其合成方法和应用
KR102414554B1 (ko) * 2022-02-27 2022-06-30 (주)바이오액츠 생체물질을 검출하기 위한 형광 화합물 및 이의 제조방법

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62123454A (ja) * 1985-08-08 1987-06-04 Fuji Photo Film Co Ltd ハロゲン化銀写真感光材料
US4871656A (en) 1987-04-24 1989-10-03 Eastman Kodak Company Photographic silver halide elements containing infrared filter dyes
DE69132750T2 (de) 1990-05-15 2002-06-20 Hyperion Inc Fluoreszierende porphyrin- und fluoreszierende phthalocyanin-polyethylenglykol-, polyol- und saccharidderivate als fluoreszierende sonden
US5298379A (en) 1992-06-30 1994-03-29 Eastman Kodak Company Radiation sensitive element with absorber dye to enhance spectral sensitivity range
JP2955803B2 (ja) * 1992-07-22 1999-10-04 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
EP0591820A1 (en) * 1992-10-05 1994-04-13 E.I. Du Pont De Nemours And Company Near-infrared absorbing dyes prepared from Stenhouse salts
JPH06145539A (ja) 1992-11-04 1994-05-24 Fuji Photo Film Co Ltd シアニン化合物
US5658751A (en) 1993-04-13 1997-08-19 Molecular Probes, Inc. Substituted unsymmetrical cyanine dyes with selected permeability
US5440042A (en) 1993-05-26 1995-08-08 E. I. Du Pont De Nemours And Company Thioheterocyclic near-infrared dyes
DE4426892A1 (de) * 1994-07-29 1996-02-15 Riedel De Haen Ag Verwendung von Indolenincyanindisulfonsäure-Derivaten
DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
EP0800831B9 (en) 1995-01-30 2004-11-10 Daiichi Pure Chemicals Co., Ltd. Diagnostic marker
IT1276833B1 (it) * 1995-10-09 1997-11-03 Sorin Biomedica Cardio Spa Coloranti fluorescenti della famiglia della solfo benz e indocianina
DE19539409C2 (de) 1995-10-11 1999-02-18 Diagnostikforschung Inst Kontrastmittel für die Nahinfrarot-Diagnostik
US5723204A (en) 1995-12-26 1998-03-03 Xerox Corporation Two-sided electrical paper
CA2251985A1 (en) 1996-04-19 1997-10-30 Alan Lewis Hamilton Squarate dyes and their use in fluorescent sequencing method
US5709845A (en) 1996-05-13 1998-01-20 Rajagopalan; Raghavan Tricyclic functional dyes for contrast enhancement in optical imaging
US5672332A (en) 1996-05-13 1997-09-30 Mallinckrodt Medical, Inc. Delta 1,2 bicyclo 4,4,0! functional dyes for contrast enhancement in optical imaging
US5672333A (en) 1996-05-13 1997-09-30 Mallinckrodt Medical, Inc. Delta1,6 bicyclo 4,4,0! functional dyes for contrast enhancement in optical imaging
DE19649971A1 (de) * 1996-11-19 1998-05-28 Diagnostikforschung Inst Optische Diagnostika zur Diagnostik neurodegenerativer Krankheiten mittels Nahinfrarot-Strahlung (NIR-Strahlung)
DE19717904A1 (de) 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
GB9710049D0 (en) 1997-05-19 1997-07-09 Nycomed Imaging As Method
US6083486A (en) 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
JP2000095758A (ja) 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
US6114350A (en) 1999-04-19 2000-09-05 Nen Life Science Products, Inc. Cyanine dyes and synthesis methods thereof
US6159657A (en) 1999-08-31 2000-12-12 Eastman Kodak Company Thermal imaging composition and member containing sulfonated ir dye and methods of imaging and printing
US6663847B1 (en) 2000-10-13 2003-12-16 Mallinckrodt Inc. Dynamic organ function monitoring agents
US6673334B1 (en) 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function

Also Published As

Publication number Publication date
EA004249B1 (ru) 2004-02-26
BR9913849A (pt) 2001-06-12
EA200100318A1 (ru) 2001-10-22
JP2000095758A (ja) 2000-04-04
IL141656A0 (en) 2002-03-10
EA005070B1 (ru) 2004-10-28
NO20025819D0 (no) 2002-12-04
SK3742001A3 (en) 2001-09-11
DE69911034T2 (de) 2004-07-08
US7488468B1 (en) 2009-02-10
ATE248608T1 (de) 2003-09-15
PT1113822E (pt) 2004-01-30
UA75360C2 (en) 2006-04-17
KR100585370B1 (ko) 2006-06-01
PL193411B1 (pl) 2007-02-28
HK1042855B (zh) 2005-12-02
BG105337A (en) 2001-10-31
MXPA01002194A (es) 2003-03-27
IL141656A (en) 2006-06-11
NZ510019A (en) 2003-07-25
CN1515552A (zh) 2004-07-28
BG65173B1 (bg) 2007-05-31
CA2344315A1 (en) 2000-03-30
EA200201216A1 (ru) 2003-06-26
KR20010075203A (ko) 2001-08-09
HUP0103503A3 (en) 2003-04-28
NO20011338L (no) 2001-05-16
DE69911034D1 (de) 2003-10-09
YU97502A (sh) 2006-01-16
DK1113822T3 (da) 2003-12-22
NO322559B1 (no) 2006-10-23
AU763991B2 (en) 2003-08-07
RS50203B (sr) 2009-07-15
TR200100746T2 (tr) 2001-07-23
HUP0103503A2 (hu) 2002-02-28
NO20025819L (no) 2001-05-16
HK1042855A1 (en) 2002-08-30
WO2000016810A8 (en) 2001-03-15
UA67800C2 (uk) 2004-07-15
YU19801A (sh) 2005-06-10
AU5981499A (en) 2000-04-10
NO20011338D0 (no) 2001-03-16
PL346709A1 (en) 2002-02-25
ES2207338T3 (es) 2004-05-16
WO2000016810A1 (en) 2000-03-30
ID29455A (id) 2001-08-30
CN1196497C (zh) 2005-04-13
BG65172B1 (bg) 2007-05-31
CN1328471A (zh) 2001-12-26
EE200100162A (et) 2002-08-15
KR20040096646A (ko) 2004-11-16
EP1113822B1 (en) 2003-09-03
EP1113822A1 (en) 2001-07-11
KR100531708B1 (ko) 2006-01-11
JP2002526458A (ja) 2002-08-20

Similar Documents

Publication Publication Date Title
BG107411A (en) Near infrared fluorescent contrast agent and fluorescence imaging
YU44402A (sh) Fluorescentno kontrastno sredstvo u bliskoj infracrvenoj oblasti i fluorescentno snimanje
MX336033B (es) Formulaciones de inmunoconjugado.
EP1067376A3 (en) Fluorescence measuring apparatus
WO2004032621A3 (en) Techniques for identifying molecular structures and treating cell types lining a body lumen using fluorescence
DE60225669D1 (de) Erlumina
DE69726135D1 (de) Fluoreszierende chelate als gewebespezifische bildgebende mittel
WO2003000129A3 (en) Microdialysis probes and methods of use
WO2003055379A3 (en) Method using a surface-selective nonlinear optical technique for imaging of biological samples
DE60207288D1 (de) Gewebespezifische fluoreszierende chelate
AU2001294165A1 (en) Apparatus for prostate cancer diagnose
NO991317L (no) Preparat for immunohistokjemisk farging
TR200202652T2 (tr) Kızılötesine yakın fluoresan kontrast maddesi ve fluoresans görüntüsü elde etme
JP2011209068A (ja) 生体試料の調製法