BG106286A - Инхибитори на репликацията на респираторно-синцитиалния вирус - Google Patents

Инхибитори на репликацията на респираторно-синцитиалния вирус

Info

Publication number
BG106286A
BG106286A BG106286A BG10628602A BG106286A BG 106286 A BG106286 A BG 106286A BG 106286 A BG106286 A BG 106286A BG 10628602 A BG10628602 A BG 10628602A BG 106286 A BG106286 A BG 106286A
Authority
BG
Bulgaria
Prior art keywords
alkyl
hydrogen
aryl
optionally
substituted
Prior art date
Application number
BG106286A
Other languages
English (en)
Other versions
BG65328B1 (bg
Inventor
Frans Janssens
Kathleen MEERSMAN
Francois Sommen
Koenraad Jozef Lodewijk Marcel Andries
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of BG106286A publication Critical patent/BG106286A/bg
Publication of BG65328B1 publication Critical patent/BG65328B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Изобретението се отнася до съединения с формула@@до техни пролекарства, <I>N<I>-оксиди, присъединителни соли, кватернерни амини, метални комплекси или стереохимични изомерни форми. Във формулата -а1=а2-а3=а4 - означава радикал с формула@-СН=СН-СН=СН-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH-, -CH=CH-CH=N-,@където всеки водороден атом може евентуално да бъде заместен; Q е радикал с формули@@в които Алк е С1-6 алкандиил; Y1 е двувалентен радикал сформула -NR2- или -СН(NR2R4)-; X1 e NR4, S, S(=O), S(=O)2, O, CH2, C(=O), CH(=CH2), CH(OH), CH(CH3), CH(OCH3), CH(SCH3), CH(NR5aR5b), CH2-NR4 или NR4-CH2; X2 е директна връзка, СН2, С(=О), NR4, C1-4 алкил-NR4, NR4-C1-4 алкил; t има стойност от 2 до 5; u - от 1 до 5 и v - 2 или 3; като всеки водороден атом в Алк и във формулите (b-3), (b-4), (b-5),(b-6), (b-7) и (b-8), може евентуално да бъде заместен с R3, при условие, че когато R3 е хидрокси или С1-6 алкилокси, тогава R3 не може да замести водороден атом в положение алфа спрямо азотния атом;Gе заместен С1-10 алкандиил, като заместителят е прикачен през кислороден атом; R1 е евентуално заместен моноциклен хетероцикъл или арил; R2 е водород, формил, С1-6 алкилкарбонил, хет-карбонил, пиролидинил, пиперидинил, хомопиперидинил, С3-7 циклоалкил или С1-10 алкил, заместен с N(R6)2, и евентуално с друг заместител; R3 е водород, хидрокси, С1-6 алкил, С1-6 алкилокси, арилС1-6 алкил или арилС1-6алкилокси; R4 е водород, С1-6 алкил или арилС1-6 алкил; R5a, R5b, R5c и R5d са водород или С1-6 алкил; или R5a и R5b, ил
BG106286A 1999-06-28 2002-01-08 Бензимидазоли и имидазопиридини, фармацевтичен състав, който ги съдържа, метод за тяхното получаване и тяхното приложение BG65328B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99202088 1999-06-28

Publications (2)

Publication Number Publication Date
BG106286A true BG106286A (bg) 2002-10-31
BG65328B1 BG65328B1 (bg) 2008-02-29

Family

ID=8240373

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106286A BG65328B1 (bg) 1999-06-28 2002-01-08 Бензимидазоли и имидазопиридини, фармацевтичен състав, който ги съдържа, метод за тяхното получаване и тяхното приложение

Country Status (33)

Country Link
US (3) US6747028B1 (bg)
EP (1) EP1196409B1 (bg)
JP (1) JP2003503402A (bg)
KR (1) KR100731271B1 (bg)
CN (1) CN1210275C (bg)
AR (1) AR035991A1 (bg)
AT (1) ATE258928T1 (bg)
AU (1) AU778218B2 (bg)
BG (1) BG65328B1 (bg)
BR (1) BR0012047A (bg)
CA (1) CA2376676C (bg)
DE (1) DE60008112T2 (bg)
DK (1) DK1196409T3 (bg)
EA (1) EA005027B1 (bg)
EE (1) EE04591B1 (bg)
ES (1) ES2215683T3 (bg)
HK (1) HK1045997A1 (bg)
HR (1) HRP20010935A2 (bg)
HU (1) HUP0201869A3 (bg)
IL (2) IL147327A0 (bg)
MX (1) MXPA02000120A (bg)
MY (1) MY127687A (bg)
NO (1) NO322458B1 (bg)
NZ (1) NZ515664A (bg)
PL (1) PL200674B1 (bg)
PT (1) PT1196409E (bg)
SI (1) SI1196409T1 (bg)
SK (1) SK19122001A3 (bg)
TR (1) TR200103806T2 (bg)
TW (1) TWI278454B (bg)
UA (1) UA74787C2 (bg)
WO (1) WO2001000612A2 (bg)
ZA (1) ZA200110479B (bg)

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EA005027B1 (ru) 2004-10-28
WO2001000612A2 (en) 2001-01-04
DE60008112D1 (en) 2004-03-11
KR100731271B1 (ko) 2007-06-21
SK19122001A3 (sk) 2003-01-09
ES2215683T3 (es) 2004-10-16
PT1196409E (pt) 2004-06-30
US7179811B2 (en) 2007-02-20
MY127687A (en) 2006-12-29
CA2376676C (en) 2009-01-20
HRP20010935A2 (en) 2003-06-30
HUP0201869A2 (hu) 2002-11-28
EP1196409B1 (en) 2004-02-04
PL200674B1 (pl) 2009-01-30
CN1210275C (zh) 2005-07-13
AU778218B2 (en) 2004-11-25
US6747028B1 (en) 2004-06-08
WO2001000612A3 (en) 2001-03-29
NO322458B1 (no) 2006-10-09
KR20020003884A (ko) 2002-01-15
BR0012047A (pt) 2002-03-12
CA2376676A1 (en) 2001-01-04
US20070135404A1 (en) 2007-06-14
NZ515664A (en) 2004-01-30
BG65328B1 (bg) 2008-02-29
NO20016369L (no) 2002-02-20
ATE258928T1 (de) 2004-02-15
MXPA02000120A (es) 2002-07-02
DK1196409T3 (da) 2004-06-07
UA74787C2 (en) 2006-02-15
HK1045997A1 (zh) 2002-12-20
TR200103806T2 (tr) 2002-06-21
IL147327A (en) 2007-06-03
AR035991A1 (es) 2004-08-04
EE200100688A (et) 2003-04-15
NO20016369D0 (no) 2001-12-27
PL352378A1 (en) 2003-08-25
ZA200110479B (en) 2003-03-20
US20070015747A1 (en) 2007-01-18
US7528149B2 (en) 2009-05-05
HUP0201869A3 (en) 2003-12-29
DE60008112T2 (de) 2004-09-16
AU5816600A (en) 2001-01-31
IL147327A0 (en) 2002-08-14
CN1358181A (zh) 2002-07-10
JP2003503402A (ja) 2003-01-28
EE04591B1 (et) 2006-02-15
EA200200088A1 (ru) 2002-06-27
SI1196409T1 (en) 2004-06-30
EP1196409A2 (en) 2002-04-17
TWI278454B (en) 2007-04-11

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