BG106205A - Полиморфи на кристален (2-бензхидрил-1-азабицикло/2,2,2/окт-3-ил)-(5-изопропил-2-метоксибензил)-амониев хлорид като антагонисти на nk-1 рецептор - Google Patents

Полиморфи на кристален (2-бензхидрил-1-азабицикло/2,2,2/окт-3-ил)-(5-изопропил-2-метоксибензил)-амониев хлорид като антагонисти на nk-1 рецептор Download PDF

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Publication number
BG106205A
BG106205A BG106205A BG10620501A BG106205A BG 106205 A BG106205 A BG 106205A BG 106205 A BG106205 A BG 106205A BG 10620501 A BG10620501 A BG 10620501A BG 106205 A BG106205 A BG 106205A
Authority
BG
Bulgaria
Prior art keywords
dihydrochloride
anhydrous
crystalline
dihydrate
water
Prior art date
Application number
BG106205A
Other languages
Bulgarian (bg)
English (en)
Inventor
Douglas Allen
Troy APPLETON
Michael GUMKOWSKI
David MUEHLBAUER
Timothy Norris
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of BG106205A publication Critical patent/BG106205A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/02—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing not further condensed quinolizine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
BG106205A 1999-06-22 2001-12-10 Полиморфи на кристален (2-бензхидрил-1-азабицикло/2,2,2/окт-3-ил)-(5-изопропил-2-метоксибензил)-амониев хлорид като антагонисти на nk-1 рецептор BG106205A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14023399P 1999-06-22 1999-06-22
PCT/IB2000/000756 WO2000078759A1 (en) 1999-06-22 2000-06-06 Polymorphs of crystalline (2-benzhydryl-1-azabicyclo[2,2,2]oct-3-yl)-(5-isopropyl-2-methoxybenzyl)-ammoniumchloride as nk-1 receptor antagonists

Publications (1)

Publication Number Publication Date
BG106205A true BG106205A (bg) 2002-07-31

Family

ID=22490317

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106205A BG106205A (bg) 1999-06-22 2001-12-10 Полиморфи на кристален (2-бензхидрил-1-азабицикло/2,2,2/окт-3-ил)-(5-изопропил-2-метоксибензил)-амониев хлорид като антагонисти на nk-1 рецептор

Country Status (35)

Country Link
US (1) US6262067B1 (ru)
EP (1) EP1187834A1 (ru)
JP (1) JP2003502425A (ru)
KR (1) KR20020030280A (ru)
CN (1) CN1390216A (ru)
AP (1) AP2001002367A0 (ru)
AR (1) AR024411A1 (ru)
AU (1) AU767336B2 (ru)
BG (1) BG106205A (ru)
BR (1) BR0011835A (ru)
CA (1) CA2375265A1 (ru)
CO (1) CO5190663A1 (ru)
CZ (1) CZ20014458A3 (ru)
DZ (1) DZ3055A1 (ru)
EA (1) EA004264B1 (ru)
EC (1) ECSP003538A (ru)
EE (1) EE200100698A (ru)
HR (1) HRP20010920A2 (ru)
HU (1) HUP0201694A3 (ru)
IL (1) IL146410A0 (ru)
IS (1) IS6161A (ru)
MA (1) MA26744A1 (ru)
MX (1) MXPA02000033A (ru)
NO (1) NO20016187D0 (ru)
NZ (1) NZ515348A (ru)
OA (1) OA11952A (ru)
PA (1) PA8496701A1 (ru)
PE (1) PE20010322A1 (ru)
PL (1) PL352899A1 (ru)
SK (1) SK18672001A3 (ru)
TN (1) TNSN00137A1 (ru)
TR (1) TR200103688T2 (ru)
UY (1) UY26211A1 (ru)
WO (1) WO2000078759A1 (ru)
ZA (1) ZA200110387B (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6387925B1 (en) * 1999-06-01 2002-05-14 Pfizer Inc. Polymorphs of a crystalline azo-bicyclo (2.2.2) oct-3-yl amine citrate and their pharmaceutical compositions
US6756379B2 (en) 2001-07-26 2004-06-29 Taro Pharmaceutical Industries Ltd. Non-sedating barbiturate compounds as neuroprotective agents
US6939873B2 (en) * 2000-07-26 2005-09-06 Taro Pharmaceuticals Industries Limited Non-sedating barbituric acid derivatives
US7683071B2 (en) * 2000-07-26 2010-03-23 Taro Pharmaceuticals Industries Ltd. Composition and method for improved bioavailability and enhanced brain delivery of 5,5-diphenyl barbituric acid
EP1551846A1 (en) * 2002-10-04 2005-07-13 Merck Sharp & Dohme Ltd. Azabicyclic spiroether derivatives as receptor antagonists
JP4739760B2 (ja) 2002-12-11 2011-08-03 タロー・ファーマシューティカル・インダストリーズ・リミテッド バルビツール酸誘導体を使用する運動障害の治療方法
WO2006003651A2 (en) * 2004-07-02 2006-01-12 Taro Pharmaceutical Industries, Ltd A process for preparing 1-methoxymethyl-5,5-diphenylbarbituric acid
EP2081576A4 (en) * 2006-11-14 2010-06-30 Taro Pharmaceuticals North Ame METHOD FOR IMPROVING BIOAVAILABILITY FOR NON-EDMING BARBITURATES
UA102128C2 (en) * 2008-12-05 2013-06-10 Х. Луннбек А/С Nalmefene hydrochloride dihydrate

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990005525A1 (en) * 1988-11-23 1990-05-31 Pfizer Inc. Quinuclidine derivatives as substance p antagonists
KR100214905B1 (ko) * 1991-05-31 1999-08-02 디. 제이. 우드, 스피겔 알렌 제이 퀴누클리딘 유도체
EP0668863B1 (en) * 1992-11-12 1997-01-08 Pfizer Inc. Quinuclidine derivative as substance p antagonist
US5393762A (en) * 1993-06-04 1995-02-28 Pfizer Inc. Pharmaceutical agents for treatment of emesis

Also Published As

Publication number Publication date
AP2001002367A0 (en) 2001-12-31
EE200100698A (et) 2003-02-17
OA11952A (en) 2006-04-13
PE20010322A1 (es) 2001-03-14
EA004264B1 (ru) 2004-02-26
CO5190663A1 (es) 2002-08-29
EP1187834A1 (en) 2002-03-20
WO2000078759A1 (en) 2000-12-28
ECSP003538A (es) 2002-01-25
TNSN00137A1 (fr) 2002-05-30
NO20016187L (no) 2001-12-18
AR024411A1 (es) 2002-10-02
CA2375265A1 (en) 2000-12-28
HUP0201694A3 (en) 2002-10-28
AU767336B2 (en) 2003-11-06
KR20020030280A (ko) 2002-04-24
MA26744A1 (fr) 2004-12-20
HRP20010920A2 (en) 2003-02-28
IS6161A (is) 2001-11-13
PL352899A1 (en) 2003-09-22
TR200103688T2 (tr) 2002-12-23
JP2003502425A (ja) 2003-01-21
CZ20014458A3 (cs) 2002-03-13
HUP0201694A2 (en) 2002-09-28
NZ515348A (en) 2003-07-25
BR0011835A (pt) 2002-03-05
NO20016187D0 (no) 2001-12-18
IL146410A0 (en) 2002-07-25
SK18672001A3 (sk) 2002-08-06
UY26211A1 (es) 2001-01-31
CN1390216A (zh) 2003-01-08
ZA200110387B (en) 2002-12-19
MXPA02000033A (es) 2002-07-02
AU4774500A (en) 2001-01-09
DZ3055A1 (fr) 2004-03-27
EA200101179A1 (ru) 2002-06-27
US6262067B1 (en) 2001-07-17
PA8496701A1 (es) 2002-07-30

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