BG105764A - Изкуствени пептиди с повърхностна активност и тяхното използване за приготвяне на изкуствен сърфактант - Google Patents

Изкуствени пептиди с повърхностна активност и тяхното използване за приготвяне на изкуствен сърфактант

Info

Publication number
BG105764A
BG105764A BG105764A BG10576401A BG105764A BG 105764 A BG105764 A BG 105764A BG 105764 A BG105764 A BG 105764A BG 10576401 A BG10576401 A BG 10576401A BG 105764 A BG105764 A BG 105764A
Authority
BG
Bulgaria
Prior art keywords
artificial
surface activity
preparation
peptides
surfactant
Prior art date
Application number
BG105764A
Other languages
English (en)
Other versions
BG65196B1 (bg
Inventor
Tore Curstedt
Jan Johansson
Hans Joernvall
Bengt Robertson
Paolo Ventura
Original Assignee
Chiesi Farmaceutici S.P.A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farmaceutici S.P.A filed Critical Chiesi Farmaceutici S.P.A
Publication of BG105764A publication Critical patent/BG105764A/bg
Publication of BG65196B1 publication Critical patent/BG65196B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Изобретението се отнася до изкуствени пептиди, аналози на SP-C, които имат повърхностна активност, и до тяхното използване за приготвяне на изкуствени сърфактанти. Те се прилагат за лечение на респираторен дистрес синдром (RDS) и на други заболявания, свързани със сърфактантна недостатъчност или дисфункция.
BG105764A 1999-02-12 2001-08-01 Изкуствени сърфактантни пептидни sp-с аналози и тяхното използване при получаване на изкуствен сърфактант BG65196B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI000275A IT1308180B1 (it) 1999-02-12 1999-02-12 Peptidi sintetici aventi la capacita' di diminuire la tensionesuperficiale e loro impiego nella preparazione di un surfattante

Publications (2)

Publication Number Publication Date
BG105764A true BG105764A (bg) 2002-03-29
BG65196B1 BG65196B1 (bg) 2007-06-29

Family

ID=11381859

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105764A BG65196B1 (bg) 1999-02-12 2001-08-01 Изкуствени сърфактантни пептидни sp-с аналози и тяхното използване при получаване на изкуствен сърфактант

Country Status (33)

Country Link
US (1) US7053044B1 (bg)
EP (1) EP1151008B1 (bg)
JP (1) JP4754073B2 (bg)
KR (1) KR100645145B1 (bg)
CN (1) CN1221570C (bg)
AR (1) AR022578A1 (bg)
AT (1) ATE280181T1 (bg)
AU (1) AU758735B2 (bg)
BG (1) BG65196B1 (bg)
BR (1) BR0009964A (bg)
CA (1) CA2362507C (bg)
CO (1) CO5241361A1 (bg)
CZ (1) CZ301108B6 (bg)
DE (1) DE60015082T2 (bg)
EA (1) EA004058B1 (bg)
EE (1) EE04879B1 (bg)
ES (1) ES2228473T3 (bg)
GE (1) GEP20032976B (bg)
HK (1) HK1042500A1 (bg)
HU (1) HU228997B1 (bg)
IL (1) IL144842A0 (bg)
IT (1) IT1308180B1 (bg)
MA (1) MA25381A1 (bg)
NO (1) NO20013888L (bg)
NZ (1) NZ513451A (bg)
PL (1) PL201084B1 (bg)
PT (1) PT1151008E (bg)
SK (1) SK286428B6 (bg)
TR (1) TR200102308T2 (bg)
UA (1) UA72751C2 (bg)
WO (1) WO2000047623A1 (bg)
YU (1) YU57701A (bg)
ZA (1) ZA200106530B (bg)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1308180B1 (it) * 1999-02-12 2001-12-07 Chiesi Farma Spa Peptidi sintetici aventi la capacita' di diminuire la tensionesuperficiale e loro impiego nella preparazione di un surfattante
AU2001233757A1 (en) * 2000-02-11 2001-08-20 Altana Pharma Ag Novel use of pulmonary surfactant for the prophylaxis and treatment of chronic pulmonary diseases
DE60217060T2 (de) * 2002-03-01 2007-06-21 Chiesi Farmaceutici S.P.A. Pharmazeutische Zusammensetzungen, die Lungensurfactants und ein Polymyxin umfassen und verbesserte Oberflächenspannung-senkende Eigenschaften haben
ITMI20021058A1 (it) 2002-05-17 2003-11-17 Chiesi Farma Spa Miscele di lipidi sintetici ottimizzate per la preparazione di un surfattante ricostituito
CA2507613A1 (en) * 2002-12-09 2004-07-08 Jeffrey A. Whitsett Methods of diagnosis and treatment of interstitial lung disease
EP1481665A1 (en) * 2003-05-30 2004-12-01 CHIESI FARMACEUTICI S.p.A. Novel lipid mixtures for synthetic surfactants
WO2005021011A1 (en) * 2003-08-28 2005-03-10 Altana Pharma Ag Use of surfactant preparations for the treatment of surgical adhesions
US20060004185A1 (en) * 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
US8337815B2 (en) * 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
EP2049554A4 (en) 2006-07-20 2011-06-29 Univ Rochester Medical Ct SYNTHETIC PULMONARY SURFACTANT AND USE THEREOF
PL2078038T3 (pl) * 2006-10-13 2014-05-30 Chiesi Farm Spa Rekonstytuowane środki powierzchniowo czynne o ulepszonych właściwościach
EP1997502A1 (en) 2007-06-01 2008-12-03 CHIESI FARMACEUTICI S.p.A. Reconstituted surfactants having improved properties
US8048043B2 (en) 2007-06-08 2011-11-01 Chiesi Farmaceutici S. P. A. Method of administration of a pulmonary surfactant
EP2022798A1 (en) * 2007-08-09 2009-02-11 CHIESI FARMACEUTICI S.p.A. Synthetic pulmonary surfactant peptides
AR074874A1 (es) 2008-12-23 2011-02-16 Biosource Pharm Inc Composiciones antibioticas para el tratamiento de infecciones gram negativas. metodo. uso. compuesto.
BR112012004651B1 (pt) 2009-09-08 2022-02-08 Chiesi Farmaceutici S.P.A. Surfactante pulmonar exógeno, uso de uma combinação terapêutica, medicamento e kit
US8415307B1 (en) 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
PE20150604A1 (es) * 2012-04-23 2015-06-07 Chiesi Farma Spa Sistema para la administracion de un tensioactivo pulmonar mediante atomizacion
CA2891933C (en) 2012-11-21 2022-07-05 Chiesi Farmaceutici S.P.A. Recombinant pulmonary surfactants comprising sp-b and sp-c analogues and a phospholipid mixture
EP3285645B1 (en) 2015-04-22 2020-08-12 Chiesi Farmaceutici S.p.A. System for effective breath-synchronized delivery of medicament to the lungs
EP3106090A1 (en) 2015-06-15 2016-12-21 CHIESI FARMACEUTICI S.p.A. System for effective breath-synchronized delivery of medicament to the lungs
WO2016173634A1 (en) 2015-04-28 2016-11-03 Chiesi Farmaceutici S.P.A Device for facilitating the administration of a medicament to the lung by a catheter
CN107979996A (zh) * 2015-04-30 2018-05-01 不莱梅大学 新的皮肤医疗和美容护理产品
MA45772A (fr) 2016-07-28 2021-04-28 Chiesi Farm Spa Procédé et système d'administration d'un médicament sous forme d'aérosol
JP2019531821A (ja) 2016-10-26 2019-11-07 キエージィ ファーマチェウティチ エス．ペー．アー． カテーテルによる肺に対する薬剤の投与を容易にする装置
ES2902578T3 (es) 2016-12-22 2022-03-29 Chiesi Farm Spa Una combinación terapéutica que comprende un tensioactivo pulmonar y un esteroide para el tratamiento de la BPD evolutiva
TW201927286A (zh) 2017-12-15 2019-07-16 義大利商凱西製藥公司 用於噴霧投藥之包含肺表面張力素的藥學調配物
WO2019115771A1 (en) 2017-12-15 2019-06-20 Pari Pharma Gmbh Nebuliser system, holding system, combination comprising nebuliser system and holding system, and aerosol administration method
US20190321452A1 (en) 2018-04-23 2019-10-24 Chiesi Farmaceutici S.P.A. Therapeutic combination comprising a pulmonary surfactant and a steroid for the prophylaxis of bpd
EP3666315A1 (en) 2018-12-14 2020-06-17 PARI Pharma GmbH Aerosol delivery device and method of operating the aerosol delivery device
EP3666316A1 (en) 2018-12-14 2020-06-17 PARI Pharma GmbH Aerosol delivery device and method of operating the aerosol delivery device
EP3843105A1 (en) 2019-12-23 2021-06-30 PARI Pharma GmbH Control device for aerosol nebulizer system
US20230257446A1 (en) 2020-01-28 2023-08-17 Chiesi Farmaceutici S.P.A. Polypeptides having improved properties
CN114159546A (zh) * 2021-12-20 2022-03-11 双鹤药业(海南)有限责任公司 新一代合成肺表面活性物质制剂及其临床应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5104853A (en) * 1984-12-11 1992-04-14 California Biotechnology Inc. Alveolar surfactant proteins having cys to ser mutations
SE8803713D0 (sv) 1988-10-18 1988-10-18 Kabigen Ab Biologically active lipoprotein and its use
SK71496A3 (en) * 1993-12-08 1996-11-06 Tokyo Tanabe Co Synthetic peptides, preparation method thereof, pharmaceutical composition containing them and its use
DE4418936A1 (de) * 1994-05-31 1996-02-08 Byk Gulden Lomberg Chem Fab Polypeptid
IT1308180B1 (it) * 1999-02-12 2001-12-07 Chiesi Farma Spa Peptidi sintetici aventi la capacita' di diminuire la tensionesuperficiale e loro impiego nella preparazione di un surfattante

Also Published As

Publication number Publication date
BR0009964A (pt) 2002-04-09
DE60015082T2 (de) 2006-02-09
BG65196B1 (bg) 2007-06-29
HK1042500A1 (en) 2002-08-16
HUP0200141A3 (en) 2002-09-30
MA25381A1 (fr) 2002-04-01
AU3279300A (en) 2000-08-29
NO20013888D0 (no) 2001-08-09
CA2362507C (en) 2012-01-03
HU228997B1 (en) 2013-07-29
GEP20032976B (en) 2003-05-27
CZ20012876A3 (cs) 2002-06-12
PL201084B1 (pl) 2009-03-31
ATE280181T1 (de) 2004-11-15
EE04879B1 (et) 2007-08-15
IL144842A0 (en) 2002-06-30
AU758735B2 (en) 2003-03-27
ZA200106530B (en) 2002-10-14
EE200100413A (et) 2002-12-16
KR20010101904A (ko) 2001-11-15
DE60015082D1 (de) 2004-11-25
JP4754073B2 (ja) 2011-08-24
TR200102308T2 (tr) 2002-04-22
AR022578A1 (es) 2002-09-04
YU57701A (sh) 2003-07-07
US7053044B1 (en) 2006-05-30
EP1151008B1 (en) 2004-10-20
EA004058B1 (ru) 2003-12-25
CO5241361A1 (es) 2003-01-31
WO2000047623A1 (en) 2000-08-17
PL349785A1 (en) 2002-09-09
NZ513451A (en) 2003-05-30
CN1221570C (zh) 2005-10-05
EP1151008A1 (en) 2001-11-07
CN1340060A (zh) 2002-03-13
CZ301108B6 (cs) 2009-11-11
PT1151008E (pt) 2005-01-31
ITMI990275A1 (it) 2000-08-12
JP2002541062A (ja) 2002-12-03
IT1308180B1 (it) 2001-12-07
SK11442001A3 (sk) 2001-12-03
HUP0200141A2 (en) 2002-06-29
UA72751C2 (en) 2005-04-15
ES2228473T3 (es) 2005-04-16
CA2362507A1 (en) 2000-08-17
NO20013888L (no) 2001-08-09
EA200100749A1 (ru) 2002-02-28
KR100645145B1 (ko) 2006-11-10
SK286428B6 (sk) 2008-09-05

Similar Documents

Publication Publication Date Title
BG105764A (bg) Изкуствени пептиди с повърхностна активност и тяхното използване за приготвяне на изкуствен сърфактант
BG101028A (bg) Синтетични пептидни аналози на белодробния повърхностноактивен протеин sр-с
GR3019901T3 (en) Osteoinductive pharmaceutical formulations
NZ224992A (en) Factor viii analogues and their preparation
GB9806632D0 (en) Peptide factor
TW240170B (bg)
ATE374618T1 (de) Verwendung von rekombinanten menschlichen uteroglobin zur behandlung von fibrotischen krankheitszuständen
CA2212563A1 (en) Process for obtaining medically active fractions from sea cucumbers
EP0161007A3 (en) Retro - inverso c-terminal hexapeptide analogues of substance p
NO983177L (no) Anvendelse av 1-enantiomeren av centkroman til fremstilling av et farmasaytisk preparat for behandling eller profylakse av brystkreft
KR100488038B1 (ko) 기관 보호 활성을 지닌 신규한 신체 보호 화합물 펩티드염, 이의 제조 방법 및 치료에서의 이의 용도
ES2033212A6 (es) Procedimiento para la obtencion de peptidos puramente glicosilados, parcialmente glicosilados o no glicosilados.
WO2001080811A3 (en) Mmp-2 propeptide for use as antiangiogenic or antitumor agent
WO2000022097A3 (en) Periferal blood mensenchymal precursor cells
NZ509773A (en) Casein formulations for the delivery of bioactive constituents
SI1151008T1 (en) Artificial peptides having surface activity and the use thereof in the preparation of artificial surfactant
AU2717295A (en) Use of trinitrobenzenes or carminic acid in the treatment of cancer or viral diseases
OA09676A (en) Use of trinitrobenzenes or carminic acid in the treatment of cancer or viral diseases
SI1192184T1 (sl) Estri surfakantnega proteina C
DE50006815D1 (de) Verfahren zur herstellung antitumoraler th1-zellen