BG105557A - Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants - Google Patents

Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants

Info

Publication number
BG105557A
BG105557A BG105557A BG10555701A BG105557A BG 105557 A BG105557 A BG 105557A BG 105557 A BG105557 A BG 105557A BG 10555701 A BG10555701 A BG 10555701A BG 105557 A BG105557 A BG 105557A
Authority
BG
Bulgaria
Prior art keywords
coagulants
aryl
pyrimidine derivatives
heterocyclyl substituted
substituted pyrimidine
Prior art date
Application number
BG105557A
Other languages
Bulgarian (bg)
English (en)
Inventor
David Davey
Gary Phillips
Original Assignee
Berlex Laboratories, Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlex Laboratories, Inc filed Critical Berlex Laboratories, Inc
Publication of BG105557A publication Critical patent/BG105557A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Separation Of Suspended Particles By Flocculating Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BG105557A 1998-12-04 2001-06-01 Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants BG105557A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/205,498 US6127376A (en) 1998-12-04 1998-12-04 Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants
PCT/US1999/028537 WO2000033844A1 (en) 1998-12-04 1999-12-03 Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants

Publications (1)

Publication Number Publication Date
BG105557A true BG105557A (en) 2001-12-29

Family

ID=22762435

Family Applications (1)

Application Number Title Priority Date Filing Date
BG105557A BG105557A (en) 1998-12-04 2001-06-01 Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants

Country Status (26)

Country Link
US (2) US6127376A (no)
EP (1) EP1135131A4 (no)
JP (1) JP2002531506A (no)
KR (1) KR20010093799A (no)
CN (1) CN1329491A (no)
AU (1) AU760370B2 (no)
BG (1) BG105557A (no)
BR (1) BR9915938A (no)
CA (1) CA2354040A1 (no)
CZ (1) CZ20011932A3 (no)
EE (1) EE200100298A (no)
HR (1) HRP20010499A2 (no)
HU (1) HUP0104508A3 (no)
IL (2) IL143347A0 (no)
LT (1) LT4912B (no)
LV (1) LV12783B (no)
MX (1) MXPA01005656A (no)
NO (1) NO20012701L (no)
NZ (1) NZ512104A (no)
PL (1) PL348034A1 (no)
RO (1) RO120971B1 (no)
RU (1) RU2001118466A (no)
SI (1) SI20637A (no)
SK (1) SK7632001A3 (no)
WO (1) WO2000033844A1 (no)
ZA (1) ZA200104235B (no)

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MX363551B (es) 2011-11-23 2019-03-27 Portola Pharmaceuticals Inc Star Compuestos derivados de pirazina como inhibidores de cinasa.
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CN104284584B (zh) 2012-03-15 2019-06-04 西建卡尔有限责任公司 表皮生长因子受体激酶抑制剂的盐
JP6469567B2 (ja) 2012-05-05 2019-02-13 アリアド・ファーマシューティカルズ・インコーポレイテッド Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物
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Also Published As

Publication number Publication date
ZA200104235B (en) 2002-08-23
BR9915938A (pt) 2001-08-21
IL143347A0 (en) 2002-04-21
LT4912B (lt) 2002-04-25
NO20012701D0 (no) 2001-06-01
NZ512104A (en) 2003-10-31
EE200100298A (et) 2002-12-16
SI20637A (sl) 2002-02-28
MXPA01005656A (es) 2002-04-24
RU2001118466A (ru) 2003-04-20
HUP0104508A2 (hu) 2002-05-29
LV12783A (en) 2002-01-20
HUP0104508A3 (en) 2002-07-29
US6372751B1 (en) 2002-04-16
CA2354040A1 (en) 2000-06-15
LT2001061A (en) 2001-12-27
CZ20011932A3 (cs) 2001-10-17
KR20010093799A (ko) 2001-10-29
IL143347A (en) 2006-12-10
CN1329491A (zh) 2002-01-02
JP2002531506A (ja) 2002-09-24
EP1135131A4 (en) 2002-01-02
WO2000033844A1 (en) 2000-06-15
US6127376A (en) 2000-10-03
PL348034A1 (en) 2002-05-06
AU760370B2 (en) 2003-05-15
AU3107500A (en) 2000-06-26
SK7632001A3 (en) 2001-12-03
LV12783B (en) 2002-10-20
NO20012701L (no) 2001-07-25
EP1135131A1 (en) 2001-09-26
RO120971B1 (ro) 2006-10-30
HRP20010499A2 (en) 2003-04-30

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