ZA200104235B - Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants. - Google Patents
Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants. Download PDFInfo
- Publication number
- ZA200104235B ZA200104235B ZA200104235A ZA200104235A ZA200104235B ZA 200104235 B ZA200104235 B ZA 200104235B ZA 200104235 A ZA200104235 A ZA 200104235A ZA 200104235 A ZA200104235 A ZA 200104235A ZA 200104235 B ZA200104235 B ZA 200104235B
- Authority
- ZA
- South Africa
- Prior art keywords
- alkyl
- aryl
- optionally substituted
- halo
- aralkyl
- Prior art date
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- 125000003118 aryl group Chemical group 0.000 title claims description 86
- 125000000623 heterocyclic group Chemical group 0.000 title claims description 15
- 239000003146 anticoagulant agent Substances 0.000 title description 11
- 229940127219 anticoagulant drug Drugs 0.000 title description 11
- 229940083082 pyrimidine derivative acting on arteriolar smooth muscle Drugs 0.000 title description 3
- 150000003230 pyrimidines Chemical class 0.000 title description 2
- -1 nitro, ureido, guanidino Chemical group 0.000 claims description 196
- 125000000217 alkyl group Chemical group 0.000 claims description 88
- 150000001875 compounds Chemical class 0.000 claims description 68
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 62
- 125000001188 haloalkyl group Chemical group 0.000 claims description 48
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 47
- 125000003545 alkoxy group Chemical group 0.000 claims description 45
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 45
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 44
- 125000004663 dialkyl amino group Chemical group 0.000 claims description 42
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims description 38
- 229910052739 hydrogen Inorganic materials 0.000 claims description 28
- 239000001257 hydrogen Substances 0.000 claims description 28
- 150000003839 salts Chemical class 0.000 claims description 25
- 239000000203 mixture Substances 0.000 claims description 16
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 14
- 238000000034 method Methods 0.000 claims description 12
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 11
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Separation Of Suspended Particles By Flocculating Agents (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/205,498 US6127376A (en) | 1998-12-04 | 1998-12-04 | Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200104235B true ZA200104235B (en) | 2002-08-23 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| ZA200104235A ZA200104235B (en) | 1998-12-04 | 2001-05-23 | Aryl and heterocyclyl substituted pyrimidine derivatives as anti-coagulants. |
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| Country | Link |
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| US (2) | US6127376A (no) |
| EP (1) | EP1135131A4 (no) |
| JP (1) | JP2002531506A (no) |
| KR (1) | KR20010093799A (no) |
| CN (1) | CN1329491A (no) |
| AU (1) | AU760370B2 (no) |
| BG (1) | BG105557A (no) |
| BR (1) | BR9915938A (no) |
| CA (1) | CA2354040A1 (no) |
| CZ (1) | CZ20011932A3 (no) |
| EE (1) | EE200100298A (no) |
| HR (1) | HRP20010499A2 (no) |
| HU (1) | HUP0104508A3 (no) |
| IL (2) | IL143347A0 (no) |
| LT (1) | LT4912B (no) |
| LV (1) | LV12783B (no) |
| MX (1) | MXPA01005656A (no) |
| NO (1) | NO20012701L (no) |
| NZ (1) | NZ512104A (no) |
| PL (1) | PL348034A1 (no) |
| RO (1) | RO120971B1 (no) |
| RU (1) | RU2001118466A (no) |
| SI (1) | SI20637A (no) |
| SK (1) | SK7632001A3 (no) |
| WO (1) | WO2000033844A1 (no) |
| ZA (1) | ZA200104235B (no) |
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| ATE251141T1 (de) | 1995-03-10 | 2003-10-15 | Berlex Lab | Benzamidin-derivate, deren herstellung und deren verwendung als anti-koagulantien |
| US6686364B2 (en) | 1997-12-08 | 2004-02-03 | Berlex Laboratories, Inc. | Benzamidine derivatives and their use as anti-coagulants |
| US6262088B1 (en) | 1998-11-19 | 2001-07-17 | Berlex Laboratories, Inc. | Polyhydroxylated monocyclic N-heterocyclic derivatives as anti-coagulants |
| US6350761B1 (en) | 1999-07-30 | 2002-02-26 | Berlex Laboratories, Inc. | Benzenamine derivatives as anti-coagulants |
| US7122544B2 (en) | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
| US7129242B2 (en) | 2000-12-06 | 2006-10-31 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as JNK pathway inhibitors and compositions and methods related thereto |
| TWI329105B (en) * | 2002-02-01 | 2010-08-21 | Rigel Pharmaceuticals Inc | 2,4-pyrimidinediamine compounds and their uses |
| WO2003075917A1 (en) | 2002-03-08 | 2003-09-18 | Signal Pharmaceuticals, Inc. | Combination therapy for treating, preventing or managing proliferative disorders and cancers |
| GB0206215D0 (en) | 2002-03-15 | 2002-05-01 | Novartis Ag | Organic compounds |
| NZ537752A (en) | 2002-07-29 | 2006-12-22 | Rigel Pharmaceuticals Inc | Use of 2,4-pyrimidinediamine compounds in the preparation of medicaments for treating autoimmune diseases |
| CN1694873A (zh) * | 2002-08-08 | 2005-11-09 | 安姆根有限公司 | 辣椒素受体配体及其治疗用途 |
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| KR101201603B1 (ko) | 2003-07-30 | 2012-11-14 | 리겔 파마슈티칼스, 인크. | 자가면역 질환의 치료 또는 예방에 사용하기 위한2,4-피리미딘디아민 화합물 |
| US8455489B2 (en) * | 2003-11-10 | 2013-06-04 | Exelixis, Inc. | Substituted pyrimidine compositions and methods of use |
| ATE540035T1 (de) * | 2004-11-24 | 2012-01-15 | Rigel Pharmaceuticals Inc | Spiro-2,4-pyrimidindiamin-verbindungen und ihre verwendungen |
| BRPI0606318B8 (pt) | 2005-01-19 | 2021-05-25 | Rigel Pharmaceuticals Inc | composto, composição, e, uso de um composto |
| JP2008540436A (ja) * | 2005-05-03 | 2008-11-20 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ｊａｋキナーゼインヒビターおよびそれらの使用 |
| KR101400632B1 (ko) * | 2006-07-21 | 2014-05-27 | 노파르티스 아게 | 피리미딘 유도체 및 살충제로서의 그의 용도 |
| US8138339B2 (en) | 2008-04-16 | 2012-03-20 | Portola Pharmaceuticals, Inc. | Inhibitors of protein kinases |
| US8063058B2 (en) | 2008-04-16 | 2011-11-22 | Portola Pharmaceuticals, Inc. | Inhibitors of syk and JAK protein kinases |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| NO2300013T3 (no) | 2008-05-21 | 2018-02-03 | ||
| US8450335B2 (en) | 2008-06-27 | 2013-05-28 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| WO2010093787A2 (en) * | 2009-02-11 | 2010-08-19 | Northwestern University | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition |
| US8932842B2 (en) | 2009-02-11 | 2015-01-13 | Northwestern University | Aminopyridine dimer compounds, compositions and related methods for neuronal nitric oxide synthase inhibition |
| JP5918693B2 (ja) | 2009-05-05 | 2016-05-18 | ダナ ファーバー キャンサー インスティテュート インコーポレイテッド | Ｅｇｆｒ阻害剤及び疾患の治療方法 |
| EP2603081B1 (en) | 2010-08-10 | 2016-10-05 | Celgene Avilomics Research, Inc. | Besylate salt of a btk inhibitor |
| MX2013004894A (es) | 2010-11-01 | 2013-10-17 | Celgene Avilomics Res Inc | Compuestos heterociclicos y usos de los mismos. |
| EP2635285B1 (en) | 2010-11-01 | 2017-05-03 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| EP2637502B1 (en) | 2010-11-10 | 2018-01-10 | Celgene CAR LLC | Mutant-selective egfr inhibitors and uses thereof |
| WO2012151561A1 (en) | 2011-05-04 | 2012-11-08 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
| TW201325593A (zh) | 2011-10-28 | 2013-07-01 | Celgene Avilomics Res Inc | 治療布魯頓（ｂｒｕｔｏｎ’ｓ）酪胺酸激酶疾病或病症之方法 |
| BR112014012396B1 (pt) | 2011-11-23 | 2020-08-25 | Portola Pharmaceuticals, Inc | inibidores de pirazina quinase, composição, método in vitro para inibição de quinase syk ou via de transdução de sinal, uso dos referidos inibidores e kit |
| WO2013138495A1 (en) | 2012-03-15 | 2013-09-19 | Celgene Avilomics Research, Inc. | Solid forms of an epidermal growth factor receptor kinase inhibitor |
| TR201816244T4 (tr) | 2012-03-15 | 2018-11-21 | Celgene Car Llc | Epidermal büyüme faktörü reseptörü kinaz inhibitörü tuzları. |
| WO2013169401A1 (en) | 2012-05-05 | 2013-11-14 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
| US9126950B2 (en) | 2012-12-21 | 2015-09-08 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| US9145387B2 (en) | 2013-02-08 | 2015-09-29 | Celgene Avilomics Research, Inc. | ERK inhibitors and uses thereof |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| US9492471B2 (en) | 2013-08-27 | 2016-11-15 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase |
| US9415049B2 (en) | 2013-12-20 | 2016-08-16 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| EP3179858B1 (en) | 2014-08-13 | 2019-05-15 | Celgene Car Llc | Forms and compositions of an erk inhibitor |
| CN109897005B (zh) * | 2019-04-12 | 2022-07-22 | 湖南省农业生物技术研究所 | 含取代苯氧基的苯基嘧啶类似物及其制备方法和应用 |
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| GB824908A (en) * | 1958-06-03 | 1959-12-09 | May & Baker Ltd | Improvements in or relating to triazine derivatives |
| JPS5922697B2 (ja) * | 1976-01-13 | 1984-05-28 | エーザイ株式会社 | ビス−（メタ−アミジノフエノキシ）−化合物 |
| EP0518818A3 (en) * | 1991-06-11 | 1993-04-28 | Ciba-Geigy Ag | Arylethers, their manufacture and use as medicament |
| US5451700A (en) * | 1991-06-11 | 1995-09-19 | Ciba-Geigy Corporation | Amidino compounds, their manufacture and methods of treatment |
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| US5849759A (en) | 1995-12-08 | 1998-12-15 | Berlex Laboratories, Inc. | Naphthyl-substituted benzimidazole derivatives as anti-coagulants |
| US5994375A (en) | 1996-02-12 | 1999-11-30 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by amino acid and hydroxy acid derivatives and their use as anti-coagulants |
| US5693641A (en) * | 1996-08-16 | 1997-12-02 | Berlex Laboratories Inc. | Bicyclic pyrimidine derivatives and their use as anti-coagulants |
| US5753635A (en) * | 1996-08-16 | 1998-05-19 | Berlex Laboratories, Inc. | Purine derivatives and their use as anti-coagulants |
| US6008234A (en) | 1996-09-12 | 1999-12-28 | Berlex Laboratories, Inc. | Benzamidine derivatives substituted by cyclic amino acid and cyclic hydroxy acid derivatives and their use as anti-coagulants |
| WO1998011094A1 (en) * | 1996-09-12 | 1998-03-19 | Schering Aktiengesellschaft | Benzamidine derivatives substituted by cyclic amino acid or cycl ic hydroxy acid derivatives and their use as anti-coagulants |
| US6004985A (en) * | 1996-10-09 | 1999-12-21 | Berlex Laboratories, Inc. | Thio acid derived monocylic N-heterocyclics as anticoagulants |
| EP0993448A1 (en) * | 1997-06-19 | 2000-04-19 | The Du Pont Merck Pharmaceutical Company | (AMIDINO)6-MEMBERED AROMATICS AS FACTOR Xa INHIBITORS |
| CA2315070A1 (en) | 1997-12-17 | 1999-07-01 | Schering Aktiengesellschaft | Ortho-anthranilamide derivatives as anti-coagulants |
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1998
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1999
- 1999-12-03 RO ROA200100606A patent/RO120971B1/ro unknown
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- 1999-12-03 AU AU31075/00A patent/AU760370B2/en not_active Ceased
- 1999-12-03 WO PCT/US1999/028537 patent/WO2000033844A1/en not_active Application Discontinuation
- 1999-12-03 PL PL99348034A patent/PL348034A1/xx not_active Application Discontinuation
- 1999-12-03 RU RU2001118466/14A patent/RU2001118466A/ru not_active Application Discontinuation
- 1999-12-03 CZ CZ20011932A patent/CZ20011932A3/cs unknown
- 1999-12-03 KR KR1020017006934A patent/KR20010093799A/ko not_active Application Discontinuation
- 1999-12-03 EE EEP200100298A patent/EE200100298A/xx unknown
- 1999-12-03 NZ NZ512104A patent/NZ512104A/en unknown
- 1999-12-03 SI SI9920090A patent/SI20637A/sl not_active IP Right Cessation
- 1999-12-03 HU HU0104508A patent/HUP0104508A3/hu unknown
- 1999-12-03 CN CN99814024A patent/CN1329491A/zh active Pending
- 1999-12-03 IL IL14334799A patent/IL143347A0/xx active IP Right Grant
- 1999-12-03 CA CA002354040A patent/CA2354040A1/en not_active Abandoned
- 1999-12-03 EP EP99965087A patent/EP1135131A4/en not_active Withdrawn
- 1999-12-03 JP JP2000586336A patent/JP2002531506A/ja active Pending
- 1999-12-03 SK SK763-2001A patent/SK7632001A3/sk unknown
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2000
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2001
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- 2001-07-04 LV LVP-01-100A patent/LV12783B/xx unknown
- 2001-07-04 HR HR20010499A patent/HRP20010499A2/hr not_active Application Discontinuation
Also Published As
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| LV12783A (en) | 2002-01-20 |
| US6372751B1 (en) | 2002-04-16 |
| CA2354040A1 (en) | 2000-06-15 |
| SI20637A (sl) | 2002-02-28 |
| LT4912B (lt) | 2002-04-25 |
| MXPA01005656A (es) | 2002-04-24 |
| RU2001118466A (ru) | 2003-04-20 |
| HUP0104508A3 (en) | 2002-07-29 |
| US6127376A (en) | 2000-10-03 |
| NO20012701L (no) | 2001-07-25 |
| EP1135131A4 (en) | 2002-01-02 |
| BG105557A (en) | 2001-12-29 |
| EP1135131A1 (en) | 2001-09-26 |
| IL143347A0 (en) | 2002-04-21 |
| HUP0104508A2 (hu) | 2002-05-29 |
| LV12783B (en) | 2002-10-20 |
| AU3107500A (en) | 2000-06-26 |
| PL348034A1 (en) | 2002-05-06 |
| WO2000033844A1 (en) | 2000-06-15 |
| CN1329491A (zh) | 2002-01-02 |
| KR20010093799A (ko) | 2001-10-29 |
| NO20012701D0 (no) | 2001-06-01 |
| EE200100298A (et) | 2002-12-16 |
| CZ20011932A3 (cs) | 2001-10-17 |
| AU760370B2 (en) | 2003-05-15 |
| NZ512104A (en) | 2003-10-31 |
| IL143347A (en) | 2006-12-10 |
| HRP20010499A2 (en) | 2003-04-30 |
| LT2001061A (en) | 2001-12-27 |
| BR9915938A (pt) | 2001-08-21 |
| RO120971B1 (ro) | 2006-10-30 |
| SK7632001A3 (en) | 2001-12-03 |
| JP2002531506A (ja) | 2002-09-24 |
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